A process for operating a continuous removal of a target product X in the form of fine crystals of a liquid phase P comprising the target product X and constituents other than the target product X by cooling suspension crystallization in the secondary chamber of an indirect heat exchanger to which liquid phase P flows continuously with simultaneous continuous flow through the primary chamber of the indirect heat exchanger with a coolant, and continuous withdrawal of a crystal suspension S ...
]]> 8106240 http://www.patentstorm.us/patents/8106239/description.html

A coalescent composition for coating compositions such as paints, adhesives, and coatings comprising a blend of dibasic esters, specifically (i) esters of adipic, glutaric, and/or succinic diacids and/or (ii) esters of isomers of adipic acid have advantages, including efficiency and low ...
]]> 8106239 http://www.patentstorm.us/patents/8106238/description.html

Provided is a production method of glycolic acid having a first step of preparing glycolonitrile from formaldehyde and hydrocyanic acid and a second step of hydrolyzing the glycolonitrile into glycolic acid directly or via a glycolate salt, which method can produce glycolic acid in easy production and purification steps while consuming less energy. In the production method, by carrying out the first and second steps continuously or by storing the glycolonitrile obtained in the first step at ...
]]> 8106238 http://www.patentstorm.us/patents/8106237/description.html

The present invention provides a process for producing methionine, which comprises steps of:

• • hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound in a non-stirred continuous first reaction tank, and
  • heat-treating the reaction solution after hydrolysis in a second reaction tank. According to the process of the present invention, a methionine crystal with a higher bulk density can be ...
    ]]> 8106237 http://www.patentstorm.us/patents/8106236/description.html
  • Patent Number:  8106236
  • Publication Date:  2012-01-31
  • Inventors:  Hernandez-Perni, Remedios; Reader, Valerie; Sunose, Mihiro; Smelt, Kathryn; Wilson, Francis; Harrison, Richard John; Reid, Alison; Boussard, Cyrille; Major, Jeremy; Zhang, Yan; Burckhardt, Svenja; Ho, Chih Yung; Taylor, Jess; LeFormal, Adeline; Cansfield, Andrew

  The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R₁, R₂, R₃, R₄, R₉, R₁₀ given below, and solvates, hydrates, esters, and pharmaceutically acceptable salts thereof.

  Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase ...
  ]]> 8106236 http://www.patentstorm.us/patents/8106235/description.html

• Patent Number:  8106235
• Publication Date:  2012-01-31
• Inventors:  Biadatti, Thibaud; Thoreau, Etienne

Biphenyl compounds having the formula (I):

are useful for preventing/treating pathologies linked to a deficiency of the activation of the RAR gamma receptor, e.g., for treating a pathology linked to a cell differentiation and/or proliferation disorder, for treating acne, for treating ...
]]> 8106235 http://www.patentstorm.us/patents/8101798/description.html

A process for the manufacture of substantially pure monochloroacetic acid from a liquid chloroacetic acid mixture comprising monochloroacetic acid and dichloroacetic acid, in particular in an amount of 2 to 40 percent by weight, wherein said mixture, further mixed with a suspended hydrogenation catalyst, is mixed with hydrogen gas and the resulting mixture is brought to reaction in a reactor, which is characterized in that the reactor is a loop reactor comprising a gas and liquid ...
]]> 8101798 http://www.patentstorm.us/patents/8101797/description.html

A process for producing methionine advantageously in view of cost, while efficiently recovering useful components, is provided including the following steps: (1) hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound; (2) introducing carbon dioxide into the reaction solution obtained in the step (1) to thereby precipitate methionine, and separating the resulting slurry into a precipitate and a mother liquor; (3) concentrating the mother ...
]]> 8101797 http://www.patentstorm.us/patents/8101796/description.html

Process for producing acetic acid by carbonylating methanol and/or a reactive derivative thereof with carbon monoxide in at least one carbonylation reaction zone containing a liquid reaction composition containing an iridium carbonylation catalyst, methyl iodide co-catalyst, a finite concentration of water, acetic acid, methyl acetate. Indium and rhenium are present as ...
]]> 8101796 http://www.patentstorm.us/patents/8101795/description.html

According to the present invention, there is provided a process for preparing corosolic acid comprising the steps of (1) dissolving crude extract of Japanese loquat leaves in alkali and aqueous alcohol and (2) applying the solution to a nonpolar adsorption resin to obtain corosolic ...
]]> 8101795 http://www.patentstorm.us/patents/8101794/description.html

The invention provides crystalline solid forms of (S)-4-((2S,3S)-7-carbamoyl-1,1 -diethyl-3-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylamino)-2-cyclohexylmethyl-butyric acid. The invention also provides pharmaceutical compositions comprising such crystalline solid forms, methods of using such crystalline solid forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline solid ...
]]> 8101794 http://www.patentstorm.us/patents/8101793/description.html

Are described compounds of Formula (I) in which R, R′, R″, A, and D have the meanings described in the text, as useful agents in the cure of pathologies characterized by altered angiogenesis and as ...
]]> 8101793 http://www.patentstorm.us/patents/8097757/description.html

The present invention relates to an improved method for preparing (meth)acrylic anhydride (A(M)A₂O) by transanhydrification between (meth)acrylic acid and acetic anhydride in the presence of at least one polymerization inhibitor, in which reaction to the point of partial conversion of the reagents is carried out, followed by continuous distillation. With the method according to the invention, it is possible to produce I1A(M)A₂O of very high purity under improved ...
]]> 8097757 http://www.patentstorm.us/patents/8097756/description.html

A process for producing carboxylic acid anhydrides by the carbonylation reaction of a carboxylic acid ester, derived from an alcohol and a carboxylic acid, with carbon monoxide containing a small amount of hydrogen in a liquid reaction medium in the presence of a Group VIII B catalyst to produce a carboxylic acid anhydride. The reaction medium comprises the Group VIII B catalyst, an organic halide, the carboxylic acid ester, an alkali metal salt, the carboxylic acid anhydride, the ...
]]> 8097756 http://www.patentstorm.us/patents/8097754/description.html

Provided are syntheses of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin via a chiral intermediate of the following formula 4

wherein Ar is a C_6-10 aromatic group, R is a straight or branched C_1-4 alkyl, ester, or carboxylic acid, and R₁ is a straight or branched C_1-5 alkyl, aralkyl, or substituted ...
]]> 8097754 http://www.patentstorm.us/patents/8097753/description.html

The invention relates to mixtures composed of monocarboxy-functionalized dialkylphosphinic acids and of further components, which comprise

• • A) from 98 to 100% by weight of monocarboxy-functionalized dialkylphosphinic acids of the formula (I)

in which R₁, R₂, R₃, R₄, R₅, R₆, and R₇ are identical or different ...
]]> 8097753 http://www.patentstorm.us/patents/8097752/description.html

Disclosed are novel ring containing phospholipids represented by the structural formula A-X—PO₃—W and physiologically acceptable salts thereof and a process for the preparation of these compounds. The compounds can be used for the treatment of protozoal diseases and especially ...
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