Benzanilides of the formula:

in which X represents hydrogen, halogen, nitro, C_1-6 alkylthio, C_1-6 alkylsulfinyl, C_1-6 alkylsulfonyl or C_1-6 alkylsulfonyloxy; Y represents halogen or C_1-6 alkyl; R¹ represents C_1-6 alkyl, C_1-6 alkylthio-C_1-6 alkyl, C_1-6 alkylsulfinyl-C_1-6 alkyl or C_1-6 alkylsulfonyl-C_{1-6 ...
]]> 8110689 http://www.patentstorm.us/patents/8110688/description.html}

It is possible to commercially advantageously prepare 1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-y)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide by coupling (7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)acetaldehyde, which is obtained by oxidizing 8-(2-hydroxyethyl)-7-methoxy-2,2-dimethylchroman-4-one, with ...
]]> 8110688 http://www.patentstorm.us/patents/8110687/description.html

The present invention provides novel bicyclic compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various ...
]]> 8110687 http://www.patentstorm.us/patents/8110686/description.html

The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These ...
]]> 8110686 http://www.patentstorm.us/patents/8110685/description.html

A novel azafluorene derivative and an organic light-emitting device having the derivative are provided. The organic light-emitting device includes a pair of electrodes composed of an anode and a cathode one of which is a transparent or semi-transparent electrode, and an organic compound layer interposed between the pair of electrodes. The organic compound layer contains the azafluorene derivative represented by the following general formula ...
]]> 8110685 http://www.patentstorm.us/patents/8110684/description.html

A method of combating and controlling insects, acarines, nematodes or molluscs which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I) wherein Y is a single bond, C═O, C═S or S(O)_m where m is 0, 1 or 2; and R¹, R³, R² and R⁸ are defined organic, groups, p is 0, 1, 2, 3 or 4 ...
]]> 8110684 http://www.patentstorm.us/patents/8106212/description.html

The present invention relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular ...
]]> 8106212 http://www.patentstorm.us/patents/8106211/description.html

The present invention relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular ...
]]> 8106211 http://www.patentstorm.us/patents/8106210/description.html

The present invention relates to a high assayed esomeprazole magnesium dihydrate substantially free of its trihydrate form. The present invention further provides an improved and commercially viable process for preparation of high assayed esomeprazole magnesium dihydrate substantially free of its trihydrate form. The present invention also provides an improved process for preparation of pure amorphous esomeprazole magnesium. The present invention further provides an improved and ...
]]> 8106210 http://www.patentstorm.us/patents/8106209/description.html

The invention provides amino-substituted aminothiazole compounds of Formula I and Formula II

where A is a group of the formula:

and the variables X, Y, R, and R₁ to R₇ are described herein. These compounds are prodrugs of compounds useful as inhibitors of viral replication. Compositions containing such compounds, and methods of treating viral infections with these compounds, as well ...
]]> 8106209 http://www.patentstorm.us/patents/8106208/description.html

The present invention relates to new compounds of formula I, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of compounds of formula ...
]]> 8106208 http://www.patentstorm.us/patents/8106207/description.html

The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also ...
]]> 8106207 http://www.patentstorm.us/patents/8106206/description.html

Provided is a solid luminescent quinoline compound capable of emitting light in a crystalline state, capable of changing the luminescent color not requiring modification of molecular configuration and capable of emitting light in response to external pressure such as heat, physical pressure, etc. The quinoline compound is represented by the following general formula (1):

wherein R₁ may be the same or different, each representing any of ...
]]> 8106206 http://www.patentstorm.us/patents/8106205/description.html

A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives.

are provided, where Q is CO₂H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV ...
]]> 8106205 http://www.patentstorm.us/patents/8106204/description.html

The invention relates to NHE-3 inhibitor compounds of formula I:

In which R1-R11 are more specifically defined herein. These substituted 2-amino-4-phenyl-dihydroquinolines are useful the treatment of various renal and respiratory disorders such as acute or chronic renal failure, for impairments of biliary function and respiratory impairments such as snoring, sleep apneas or stroke. Formulations comprising them and methods for their use are also ...
]]> 8106204 http://www.patentstorm.us/patents/8106203/description.html

Methods for generating chemiluminescence rapidly by reaction of at least one compound comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups with a peroxidase enzyme and a peroxide are disclosed. The chemiluminescence thus produced can be used as a detectable signal in assays for peroxidase enzymes or peroxide-producing enzymes and in assays employing enzyme-labeled specific binding pairs. Use of the methods provides rapid signal generation, ...
]]> 8106203 http://www.patentstorm.us/patents/8106202/description.html

The present invention concerns a method for manufacturing 1-substituted 1H-imidazo[4,5-c]quinolin-4-amine compounds through their corresponding formamides. The invention also concerns new formamide ...
]]> 8106202 http://www.patentstorm.us/patents/8106201/description.html

This invention relates to intermediates useful in the preparation of opiate alkaloids, particularly morphinane compounds. The invention also relates to processes for preparing such intermediates and to processes which utilise such intermediates in the synthesis of morphinane ...
]]> 8106201 http://www.patentstorm.us/patents/8106200/description.html

The present invention relates to new borane complexes with substituted pyridines, a process for the synthesis of new borane complexes with substituted pyridines, solutions comprising new borane complexes with substituted pyridines and a method of using new borane complexes with substituted pyridines for organic ...
]]> 8106200 http://www.patentstorm.us/patents/8106199/description.html

A near infrared phosphorescent organometallic complex includes a cyclometalating ligand and a transition metal. The cyclometalating ligand includes a fused aromatic ring structure with carbon atoms, and a heteronuclear aromatic ring with a nitrogen atom. The transition metal is bonded to the nitrogen atom in the heteronuclear aromatic ring and one of the carbon atoms in the fused aromatic ring structure. The heteronuclear ring can be part of the fused aromatic ring. The organometallic ...
]]> 8106199 http://www.patentstorm.us/patents/8106198/description.html

A theme of the present invention is to provide a new transition metal complex, useful as a photosensitizer dye for a photoelectric conversion element having an excellent durability and a high photoelectric conversion characteristic. The present invention provides a bivalent transition metal complex constituted of (i) a bipyridyl polyacidic ligand, such as a dicarboxybipyridyl (dcbpy) ligand, as an adsorption site for adsorption onto titanium dioxide particle surfaces; (ii) a ligand, ...
]]> 8106198 http://www.patentstorm.us/patents/8101774/description.html

The present invention relates to an ester represented by the formula [1]:

or its pharmaceutically acceptable salt, or use of the same.

The compound represented by the formula [1] or its pharmaceutically acceptable salt is useful as an agent for the treatment or prophylaxis of hyperlipidemia or the like, since it disappears very rapidly in the living body and has an excellent MTP inhibitory ...
]]> 8101774 http://www.patentstorm.us/patents/8101773/description.html

The compound 4-{4-[({3-tert-Butyl-1-[3-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide and alternative forms thereof (e.g., salts, solvates, hydrates, prodrugs, polymorphs and metabolites); pharmaceutical compositions which contain them; and methods for treating cancer using ...
]]> 8101773 http://www.patentstorm.us/patents/8101772/description.html

The present invention relates to novel active compound combinations comprising a known oxime ether derivative (trifloxystrobin) and imidacloprid, which combinations are highly suitable for controlling phytopathogenic fungi and ...
]]> 8101772 http://www.patentstorm.us/patents/8101771/description.html

A novel triazole derivative which has a large energy gap and can be used for electron-transporting layer of a light-emitting element or as a host material. In addition, a light-emitting element which has higher emission efficiency by using the novel triazole derivative. Furthermore, a low power consumption light-emitting device and electronic device.

A triazole derivative having a structure represented by the formula (G1).

In the formula, Py ...
]]> 8101771 http://www.patentstorm.us/patents/8101770/description.html

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention and intermediate compounds useful in these ...
]]> 8101770 http://www.patentstorm.us/patents/8101769/description.html

Described herein is an improved, commercially viable and industrially advantageous process for the preparation of Repaglinide intermediate, ethyl (S)-2-ethoxy-4-[N-(1-(2-piperidino-phenyl)-3-methyl-1-butyl)-aminocarbonylmethyl]-benzoate. The process provides the Repaglinide intermediate in higher yield and purity compared to the previously disclosed processes, thereby providing for production of Repaglinide and its pharmaceutically acceptable salts in high purity and in high ...
]]> 8101769 http://www.patentstorm.us/patents/8101768/description.html

A chemical compound represented by the formula [I]:

(wherein R¹ represents a hydroxyl group or the like, m represents 0 or an integer of 1 to 5, R² represents a halogen atom or the like, k represents 0 or an integer of 1 to 4, R³, R³¹, R⁴, R⁴¹, R⁵, R⁵¹, R⁶, R⁶¹, and R⁷ each independently represents a hydrogen atom or the like, X ...
]]> 8101768 http://www.patentstorm.us/patents/8101767/description.html

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such ...
]]> 8101767 http://www.patentstorm.us/patents/8101766/description.html

The invention provides a crystalline 1,2-ethanedisulfonic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositions comprising such a salt or prepared using such a salt; processes and intermediates for preparing such a salt; and methods of using such a salt to treat a pulmonary ...
]]> 8101766 http://www.patentstorm.us/patents/8101765/description.html

Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection:

The disclosed processes use S_NAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula:

and halogenated or sulfonated bromoquinoline ...
]]> 8101765 http://www.patentstorm.us/patents/8101764/description.html

The present invention relates to a melanin concentrating hormone antagonist compound of formula (I): wherein R¹, R^a, R^b, R², L¹, R³, R⁴ and R⁵ are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related ...
]]> 8101764 http://www.patentstorm.us/patents/8101763/description.html

The invention relates to a novel method for producing scopine esters of the general formula (1), wherein X—, R, R1, R2, R3, R4, R3′, R4′, R6 and R6′ can have the meanings indicated in the claims and in the ...
]]> 8101763 http://www.patentstorm.us/patents/8101762/description.html

The present invention describes novel nitrogen-containing organic compounds obtained by reacting a compound X of substituted pyridine type comprising at least one ketone function with a compound Y belonging to the aminoquinoleine family and derivatives thereof. Said organic compounds can be used as precursors in a catalytic ...
]]> 8101762 http://www.patentstorm.us/patents/8101761/description.html

The present invention provides Compound (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising Compound (I) in combination with one or more pharmaceutically acceptable carriers, excipients, or diluents; and discloses methods for the treatment of inflammatory and immune disorders comprising administering to a patient in need thereof an effective amount of Compound (I) or a pharmaceutically acceptable salt ...
]]> 8101761 http://www.patentstorm.us/patents/8101760/description.html

The present invention provides Compound (I): Compound (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising Compound (I) in combination with one or more pharmaceutically acceptable carriers, excipients, or diluents; and methods for the treatment of inflammatory and immune disorders comprising administering to a patient in need thereof an effective amount of Compound (I) or a pharmaceutically acceptable salt ...
]]> 8101760 http://www.patentstorm.us/patents/8101759/description.html

It is an object to provide a new compound which is suitable for a material of an electron-transporting layer of a light-emitting element. In particular, it is an object to provide a compound which can be used for forming a light-emitting element capable of emitting light at a low drive voltage. An acenaphthopyridine derivative represented by the following general formula (G1) is provided. In the formula, Het represents a pyridyl group or a quinolyl ...
]]> 8101759 http://www.patentstorm.us/patents/8101758/description.html

A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective ...
]]> 8101758 http://www.patentstorm.us/patents/8101757/description.html

The invention provides a process for the conversion of opioid derivatives into normorphinan compounds useful for making “nal” compound analgesics and antagonists. In particular, the process may be used for the production of pure normorphinan salts from crude opioid ...
]]> 8101757 http://www.patentstorm.us/patents/8101756/description.html

The present invention relates to a process for the preparation of quaternary N-alkyl morphin or morphinan alkaloid derivatives. This is achieved by using a nucleophilic nitrogen, phosphor or sulfur containing base in the reaction ...
]]> 8101756 http://www.patentstorm.us/patents/8097729/description.html

Processes for the purification of lercanidipine hydrochloride are provided which uses a binary system of an alcohol-containing solvent such as methanol and an aliphatic ester-containing solvent such as isopropyl acetate. Processes for the preparation of substantially amorphous lercanidipine hydrochloride are also provided. Also provided is lercanidipine hydrochloride substantially in polymorph form ...
]]> 8097729 http://www.patentstorm.us/patents/8097728/description.html

An anti-viral compounds effective against viruses belonging to the Flaviviridae family, wherein the anti-viral compounds are 1,5-dideoxy-1,5-imino-D-glucitol derivative compounds having the general formula (I)

wherein R², R³, R⁴ and R⁵ are the same or different and are selected from the group consisting of hydrogen, acyl, benzyl, alkyl, aryl, sulfonyl, phosphonyl, silyl, R₆ is at least one of ...
]]> 8097728 http://www.patentstorm.us/patents/8097727/description.html

Compounds of the formula (I), in which R^1a-R^1e, R^2a, R^2b, R³ and R⁵ have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of ...
]]> 8097727 http://www.patentstorm.us/patents/8097726/description.html

A huperzine A compound is provided. The huperzine A compound has following formula:

• • wherein X comprises O or S, Y comprises —O—, —S—, —CH(R₄)—, —C(R₄)(R₅)—, —C(R₄)═C(R₅)—, —C≡C—, —NH— or —N(R₄)—, n is 0, 1 or 2, R₃ is C(═X)—(Y)_n—R₁ provided that R₂ is H or R₂ and ...
    ]]> 8097726 http://www.patentstorm.us/patents/8097725/description.html
  • Patent Number:  8097725
  • Publication Date:  2012-01-17
  • Inventors:  He, Huarui; Mortellaro, Mark A.; Young, Susanne T.

  The present invention relates to a chemical compound that has applications as a luminescent indicator dye, and to an optical sensor, typically employed for determination of near-neutral pH values of aqueous samples. The optical sensor has particular application in the pH determination of body liquids such as, for example, blood, plasma and ...
  ]]> 8097725