The present invention discloses an optically active quarternary ammonium salt having axial asymmetry and a method for producing an α-amino acid and a derivative thereof using the same. The optically active quarternary ammonium salt having axial asymmetry of the present invention is a chiral phase-transfer catalyst that has a simple structure and that can be produced in a smaller number of process steps. The compound of the present invention is very useful as a phase-transfer catalyst in ...
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Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm may be prepared by depositing or attaching an oriented layer to a substrate. A nanofilm may also be prepared by coupling the oriented macrocyclic modules to provide a ...
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This invention is the design and synthesis of a caprolactone monomer which bears a pendant protected carboxyl group. This monomer has been copolymerized with caprolactone in varying ratios. After polymerization, the protecting group can be removed and an antibiotic can be attached as a new pendant group. The bioactivity of the antibiotic-bound poly(caprolactone) polymer is ...
]]> 8110678 http://www.patentstorm.us/patents/8106189/description.html

An improved process for preparation of triazol-benzodiazepine derivatives, such as alprazolam, triazolam, brotizolam and etizolam, is presented. The process comprises a cyclization reaction of compound Formula B in toluene with catalytic amount of p-toluene sulphonic acid to obtain the triazol-benzodiazepine derivative of Formula C:

wherein R is,

and X is hydrogen or ...
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An improved for preparing Olanzapine Form I of Formula 1 in the presence of one solvent or a mixture of ...
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The present invention relates to a new process for the preparation of macrocyclic HCV protease inhibitor compounds of the formula

wherein R¹ is an amino protecting group and X is halogen by way of a ring closing metathesis ...
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There is provided a novel transition metal phosphine complex having excellent anticancer activity. The transition metal phosphine complex is represented by general formula (1):

(wherein R¹s and R³s each represent an alkyl group, a cycloalkyl group, an aryl group, an aralkyl group, a pyridyl group, or a pyrimidyl group; R²s and R⁴s each represent an alkyl group or a cycloalkyl group, provided that each ...
]]> 8106186 http://www.patentstorm.us/patents/8101748/description.html

The fluorinated derivatives of catharanthine according to the invention respond to the general formula I:

in which:

• • the dotted line expresses the possibility of the presence of a double bond when the substitution —X is absent or else a single bond when —X designates a substitution for a group:
    • H,
    • OR,
    • NR′R″,
    • SR, ...
      ]]> 8101748 http://www.patentstorm.us/patents/8101747/description.html
    • Patent Number:  8101747
    • Publication Date:  2012-01-24
    • Inventors:  Dessinges, Aimee; Serkiz, Bernard; Peglion, Jean-Louis

    Process for the synthesis of ivabradine of formula (I):

    
    
    and addition salts thereof with a pharmaceutically acceptable ...
    ]]> 8101747 http://www.patentstorm.us/patents/8097721/description.html

  • Patent Number:  8097721
  • Publication Date:  2012-01-17
  • Inventors:  Huang, Junmin; Armstrong, Daniel W.

  Polyionic liquid salts are provided comprising polycationic or polyanionic molecules. Further provided are solvents comprising one or more polyionic liquid salts, and the use of such polyionic liquid salts as stationary phases in gas chromatography, and as a reagent in electrospray ionization-mass spectrometry ...
  ]]> 8097721 http://www.patentstorm.us/patents/8097720/description.html

• Patent Number:  8097720
• Publication Date:  2012-01-17
• Inventors:  Dessinges, Aimee; Serkiz, Bernard; Lecouve, Jean-Pierre; Peglion, Jean-Louis; Lerestif, Jean-Michel

Process for the synthesis of ivabradine of formula (I):

and addition salts thereof with a pharmaceutically acceptable ...
]]> 8097720 http://www.patentstorm.us/patents/8097719/description.html

The present invention relates to novel crystalline form of (4-Nitrobenzyl (4R,5S,6S)-(3-{(3S,5S)-5-[(dimethylamino)carbonyl]-1-[(4-nitrophenoxy)carbonxyl]pyrrolidin-3-yl}thio-6-[(1R)-1-hydorxyehtyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0].hept-2-ene-2-carboxylate) of compound Formula I as well as an improved process for the preparation of meropenem trihydrate of compound Formula II

wherein, PNB represent P-nitro benzyl group and PNZ represent ...
]]> 8097719