patentstorm.us 258 85 http://www.patentstorm.us/ http://www.patentstorm.us/images/logo.gif PatentStorm -> Patents -> Organic compounds -- part of the class 532-570 series http://www.patentstorm.us/rss/class/patents/rss-536.xml Recent patents filings in USPTO Class 536 Organic compounds -- part of the class 532-570 series. Tue, 7 Feb 2012 16:00:43 patents@patentstorm.us en <![CDATA[Microwave-assisted extraction of polysaccharide from ]]> http://www.patentstorm.us/patents/8110677/description.html
  • Patent Number:  8110677
  • Publication Date:  2012-02-07
  • Inventors:  Zhang, Ji; Yao, Jian; Liang, Junyu; Wang, Yunpu; Wang, Junlong; Wu, Yiqian; Zhang, Yanan; Wang, Xiaodong; Xu, Xiaoqing

    • This invention relates to a method of extracting crude polysaccharide by microwave-assisted from Artemisia sphaerocephala seed de-oiling dregs. In particular, the invention comprising: microwave-assisted extraction, enzymatic hydrolysis, dialysis et. al. It provides a technique whereby the polysaccharide can be extracted effectively, in a relatively short period of time (20-30 min) with respect to conventional extraction methods and allows for an enhanced extraction yield (more than ...
    ]]> 8110677 <![CDATA[Prodrugs activated by RNA-dependent DNA-polymerases]]> http://www.patentstorm.us/patents/8110676/description.html

  • Patent Number:  8110676
  • Publication Date:  2012-02-07
  • Inventors:  Quattrone, Alessandro; Bertini, Ivano; Luchinat, Claudio; Calamante, Massimo; Mordini, Alessandro

    • The invention provides prodrugs activated by RNA-dependent DNA-polymerases, and methods for treating hematological tumors, blood, and blood derivatives from patients affected by retroviral infections by administering the prodrugs. The invention also provides methods for the preparation of pharmaceutical compositions containing the ...
    ]]> 8110676 <![CDATA[TP expression-inhibiting compound and siRNA sequence thereof]]> http://www.patentstorm.us/patents/8110675/description.html

  • Patent Number:  8110675
  • Publication Date:  2012-02-07
  • Inventors:  Chen, Lih-Chyang; Chang, Yu-Sun

    • The present invention discloses a TP expression-inhibiting compound and a TP expression-inhibiting siRNA sequence, wherein a siRNA sequence partially or completely complementary to the sequence of TP is used to inhibit TP expression, whereby is effectively reduced the survival rate of cancer cells in an anoxic ...
    ]]> 8110675 <![CDATA[Therapeutic compositions]]> http://www.patentstorm.us/patents/8110674/description.html

  • Patent Number:  8110674
  • Publication Date:  2012-02-07
  • Inventors:  Bumcrot, David; Manoharan, Muthiah

    • Therapeutic sRNA agents and methods of making and using are ...
    ]]> 8110674 <![CDATA[Aggregation sensor and solutions and kits comprising the same]]> http://www.patentstorm.us/patents/8110673/description.html

  • Patent Number:  8110673
  • Publication Date:  2012-02-07
  • Inventors:  Liu, Bin; Bazan, Guillermo C.

    • This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, ...
    ]]> 8110673 <![CDATA[Promoter engineering and genetic control]]> http://www.patentstorm.us/patents/8110672/description.html

  • Patent Number:  8110672
  • Publication Date:  2012-02-07
  • Inventors:  Fischer, Curt; Alper, Hal S.; Nevoigt, Elke; Stephanopoulos, Gregory

    • The present invention relates to expression cassettes libraries of expression vectors comprising the same, wherein each vector comprises at least one gene of interest and a promoter operatively linked thereto wherein each promoter comprises a nucleic acid, whose sequence is randomly mutated with respect to that of another in the library and cells comprising the same. Methods utilizing either the libraries or cells of this invention, in optimizing gene expression, protein expression, or ...
    ]]> 8110672 <![CDATA[Isolated human chromosome 14 fragment encoding immunoglobulin genes]]> http://www.patentstorm.us/patents/8110671/description.html

  • Patent Number:  8110671
  • Publication Date:  2012-02-07
  • Inventors:  Ishida, Isao; Yoshida, Hitoshi; Tomizuka, Kazuma; Hanaoka, Kazunori; Oshimura, Mitsuo

    • The specification relates to a method for producing a chimeric non-human animal, which comprises preparing a microcell containing a foreign chromosome(s) or a fragment(s) thereof and transferring the foreign chromosome(s) or fragment(s) thereof into a pluripotent cell by fusion with the microcell; a chimeric non-human animal which can be produced by the above method and its progeny; tissues and cells derived therefrom; and a method for using the same. Further, a pluripotent cell containing ...
    ]]> 8110671 <![CDATA[Enhanced production of fatty acid derivatives]]> http://www.patentstorm.us/patents/8110670/description.html

  • Patent Number:  8110670
  • Publication Date:  2012-02-07
  • Inventors:  Hu, Zhihao; Valle, Fernando

    • Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as ...
    ]]> 8110670 <![CDATA[Apparatus and methods for detecting DNA in biological samples]]> http://www.patentstorm.us/patents/8110669/description.html

  • Patent Number:  8110669
  • Publication Date:  2012-02-07
  • Inventors:  Lau, Lok-Ting; Yu, Cheung Hoi; Lin, Selma Sau Wah; Chan, Duncan Ka-Yun

    • Apparatus and methods are described for detecting target DNA in a biological sample using capture probes and electrically-assisted hybridization. The reaction cell is formed with an attachment surface of aluminum oxide for better thermal and physical properties, and the aluminum oxide surface is coated with anti-DIG antibody to provide a convenient attachment layer for the capture probes allowing their correct orientation, while the capture probes are formed with a DIG-label so that they ...
    ]]> 8110669 <![CDATA[Sperm-specific cation channel, catsper-3 and uses therefor]]> http://www.patentstorm.us/patents/8110668/description.html

  • Patent Number:  8110668
  • Publication Date:  2012-02-07
  • Inventors:  Ramsey, Ian Scott; Moran, Magdalene M.; Chong, Jayhong A.; Clapham, David E.

    • Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper3) are disclosed. The CatSper3 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper3 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper3 activity, methods of genotyping subjects with ...
    ]]> 8110668 <![CDATA[Method for conversion of carbohydrate polymers to value-added chemical products]]> http://www.patentstorm.us/patents/8110667/description.html

  • Patent Number:  8110667
  • Publication Date:  2012-02-07
  • Inventors:  Zhang, Zongchao C.; Brown, Heather M.; Su, Yu

    • Methods are described for conversion of carbohydrate polymers in ionic liquids, including cellulose, that yield value-added chemicals including, e.g., glucose and 5-hydroxylmethylfurfural (HMF) at temperatures below 120° C. Catalyst compositions that include various mixed metal halides are described that are selective for specified products with yields, e.g., of up to about 56% in a single step ...
    ]]> 8110667 <![CDATA[Modified hydroxypolymer conjugates with killing effect on tumor cells]]> http://www.patentstorm.us/patents/8106185/description.html

  • Patent Number:  8106185
  • Publication Date:  2012-01-31
  • Inventors:  Meurling, Lennart; Holmberg, Anders

    • The present invention is related to a modified hydroxypolymer conjugates preferably a guanidine-dextran conjugate having a tumor cell killing activity. The modified hydroxypolymer conjugate is used as medicine, particularly for manufacturing a medicine or tumor killing composition for treating tumors. A method for producing said hydroxypolymer conjugate and a method for killing cancer cells and treating tumors is also disclosed. The invention is also related to a method for killing tumor ...
    ]]> 8106185 <![CDATA[Nicotinoyl riboside compositions and methods of use]]> http://www.patentstorm.us/patents/8106184/description.html

  • Patent Number:  8106184
  • Publication Date:  2012-01-31
  • Inventors:  Sauve, Anthony Andrew; Yang, Tianle

    • The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the ...
    ]]> 8106184 <![CDATA[Process for preparing an A-adenosine receptor agonist and its polymorphs]]> http://www.patentstorm.us/patents/8106183/description.html

  • Patent Number:  8106183
  • Publication Date:  2012-01-31
  • Inventors:  Elzein, Elfaith; Zablocki, Jeff

    • Disclosed is a synthesis suitable for large scale manufacture of an A2A-adenosine receptor agonist, and also relates to polymorphs of that compound, and to methods of isolating a specific ...
    ]]> 8106183 <![CDATA[Antisense oligonucleotides (ODN) against Smad7 and uses thereof in medical field]]> http://www.patentstorm.us/patents/8106182/description.html

  • Patent Number:  8106182
  • Publication Date:  2012-01-31
  • Inventor:  Monteleone, Giovanni

    • The invention relates to antisense oligonucleotidic sequences (ODN) against Smad7 suitably modified, and their uses in medical field as therapeutic biological agents, in particular in the treatment of chronic inflammatory bowel disease, such as Crohn's disease and ulcerative ...
    ]]> 8106182 <![CDATA[Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules]]> http://www.patentstorm.us/patents/8106181/description.html

  • Patent Number:  8106181
  • Publication Date:  2012-01-31
  • Inventors:  Lee, Nan-Sook; Rossi, John J.

    • Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also ...
    ]]> 8106181 <![CDATA[Methods and products for expression of micro RNAs]]> http://www.patentstorm.us/patents/8106180/description.html

  • Patent Number:  8106180
  • Publication Date:  2012-01-31
  • Inventors:  Bartel, David; Lodish, Harvey; Chen, Chang-Zheng

    • The invention relates to microRNAs, methods of producing microRNAs and methods for using ...
    ]]> 8106180 <![CDATA[Small interfering RNA specific to sub-units α, α′and β of the Kinase Protein ck2, and the applications of the same]]> http://www.patentstorm.us/patents/8106179/description.html

  • Patent Number:  8106179
  • Publication Date:  2012-01-31
  • Inventors:  Filhol-Cochet, Odile; Cochet, Claude; Schaack, Béatrice; Fouque, Brigitte

    • The invention relates to small interfering RNA specific to sub-units α, α′ and β of the kinase protein CK2, and to the applications of the same, especially for treating cancer and viral ...
    ]]> 8106179 <![CDATA[Probe, probe set, probe-immobilized carrier, and genetic testing method]]> http://www.patentstorm.us/patents/8106178/description.html

  • Patent Number:  8106178
  • Publication Date:  2012-01-31
  • Inventors:  Yoshii, Hiroto; Kuribayashi, Hideto; Fukui, Toshifumi

    • A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 81 to 83 and complementary or modified sequences thereof or a combination of at least two of them is used for detecting the gene of an infectious disease pathogenic ...
    ]]> 8106178 <![CDATA[Nucleic acids encoding human anti-IL-23 antibodies]]> http://www.patentstorm.us/patents/8106177/description.html

  • Patent Number:  8106177
  • Publication Date:  2012-01-31
  • Inventors:  Carton, Jill; Orlovsky, Yevgeniya I.; Rauchenberger, Robert; Benson, Jacqueline; Sweet, Raymond; Cunningham, Mark

    • A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and ...
    ]]> 8106177 <![CDATA[Matrix metalloproteinase 11 vaccine]]> http://www.patentstorm.us/patents/8106176/description.html

  • Patent Number:  8106176
  • Publication Date:  2012-01-31
  • Inventors:  Ciliberto, Gennaro; La Monica, Nicola; Lazzaro, Domenico; Aurisicchio, Luigi; Peruzzi, Daniela; Mori, Federica

    • Compositions comprising matrix metalloproteinase 11 (MMP-11) or stromelysin-3 (ST-3) or the nucleic acid encoding the MMP-11 for use in vaccines for treating tumors and cancers, which overexpress MMP-11, are described. In particular embodiments, the compositions comprise a nucleic acid encoding a fusion polypeptide that includes the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element wherein the codons encoding the MMP-11 and the immunoenhancing element ...
    ]]> 8106176 <![CDATA[Internal controls for isolation of small RNAs]]> http://www.patentstorm.us/patents/8106175/description.html

  • Patent Number:  8106175
  • Publication Date:  2012-01-31
  • Inventors:  Devor, Eric J.; Behlke, Mark A.; Huang, Lingyan

    • This invention pertains to methods for cloning microRNA (miRNA) and other small ribonucleic acid (RNA) species from relevant cell ...
    ]]> 8106175 <![CDATA[Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement]]> http://www.patentstorm.us/patents/8106174/description.html

  • Patent Number:  8106174
  • Publication Date:  2012-01-31
  • Inventors:  Cao, Yongwei; Andersen, Scott E.; Liu, Jingdong; Zhou, Yihua; Kovalic, David K.; Edgerton, Michael D.

    • Recombinant polynucleotides and recombinant polypeptides useful for improvement of plants are provided. The disclosed recombinant polynucleotides and recombinant polypeptides find use in production of transgenic plants to produce plants having improved ...
    ]]> 8106174 <![CDATA[Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8]]> http://www.patentstorm.us/patents/8106173/description.html

  • Patent Number:  8106173
  • Publication Date:  2012-01-31
  • Inventors:  Li, Yukui; Wang, Daqing; Yu, Dong; Lan, Tao; Kandimalla, Ekambar R.; Agrawal, Sudhir; Putta, Mallikarjuna Reddy

    • The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or ...
    ]]> 8106173 <![CDATA[Nucleic acid sequences that can be used as primers and probes in the amplification and detection of SARS coronavirus]]> http://www.patentstorm.us/patents/8106172/description.html

  • Patent Number:  8106172
  • Publication Date:  2012-01-31
  • Inventors:  Overdijk, Marlieke; van de Laar, Saskia; Sillekens, Peter T. G.

    • The present invention is related to nucleic acid sequences that can be used in the field of virus diagnostics, more specifically the diagnosis of infections with a novel human coronavirus causing Severe Acute Respiratory Syndrome (SARS). With the present invention nucleotide sequences are provided that can be used as primers and probes in the amplification and detection of SARS nucleic acid. The oligonucleotide sequences provided with the present invention are located in the replicase gene, ...
    ]]> 8106172 <![CDATA[Method for inhibiting the activity of mir-155]]> http://www.patentstorm.us/patents/8106025/description.html

  • Patent Number:  8106025
  • Publication Date:  2012-01-31
  • Inventors:  Bennett, C. Frank; Griffey, Richard H.; Freier, Susan M.

    • Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also ...
    ]]> 8106025 <![CDATA[Method of treating cancer with an RPN2 gene expression inhibitor]]> http://www.patentstorm.us/patents/8106024/description.html

  • Patent Number:  8106024
  • Publication Date:  2012-01-31
  • Inventors:  Ochiya, Takahiro; Kato, Kikuya; Honma, Kimi; Ueda, Yasuji

    • The present invention uses an RPN2 gene expression inhibitor as a cancer cell growth inhibitor, which further includes a drug showing an anti-cancer action if desired, and is administered in combination with atelocollagen if desired. In addition, the present invention is an anti-cancer agent including such cancer cell growth ...
    ]]> 8106024 <![CDATA[Aptamers and methods for their in vitro selection and uses thereof]]> http://www.patentstorm.us/patents/8105982/description.html

  • Patent Number:  8105982
  • Publication Date:  2012-01-31
  • Inventors:  Doyle, Sharon A.; Murphy, Michael B.

    • The present method is an improved in vitro selection protocol that relies on magnetic separations for DNA aptamer production that is relatively easy and scalable without the need for expensive robotics. The ability of aptamers selected by this method to recognize and bind their target protein with high affinity and specificity, and detail their uses in a number of assays is also described. Specific TTF1 and His6 aptamers were selected using the method described, and shown to be useful for ...
    ]]> 8105982 <![CDATA[Compositions and methods for detecting the presence of in a test sample]]> http://www.patentstorm.us/patents/8105779/description.html

  • Patent Number:  8105779
  • Publication Date:  2012-01-31
  • Inventors:  Weisburg, William G.; Stull, Paul D.; Cunningham, Melissa M.

    • The present invention describes novel oligonucleotides targeted to nucleic acid sequences derived from Cryptosporidium organisms, and Cryptosporidium parvum organisms in particular, which are useful for determining the presence of Cryptosporidium organisms in a test sample. The oligonucleotides of the present invention include hybridization assay probes, helper probes and amplification primers. The present invention further describes a novel method for obtaining ...
    ]]> 8105779 <![CDATA[Oligonucleotides for cancer diagnosis]]> http://www.patentstorm.us/patents/8105773/description.html

  • Patent Number:  8105773
  • Publication Date:  2012-01-31
  • Inventors:  Sharma, Praveen; Lönneborg, Anders

    • The present invention provides sets of oligonucleotides corresponding to genes encoding proteins involved in protein synthesis and/or stability or genes encoding proteins involved in the regulation of defence and/or chromatin remodelling for use in preparing transcript patterns particularly for cancer diagnosis. The invention also extends to such sets and kits containing such sets as well as related methods reliant on analysis of marker polypeptides encoded by the genes to develop ...
    ]]> 8105773 <![CDATA[DNA detection method using molecular beacon with the use of monomer emission/excimer emission switching of fluorescent molecule]]> http://www.patentstorm.us/patents/8105772/description.html

  • Patent Number:  8105772
  • Publication Date:  2012-01-31
  • Inventors:  Inouye, Masahiko; Fujimoto, Kazuhisa; Shimizu, Hisao

    • It is intended to provide a means and a method whereby a molecule for DNA detection at an elevated accuracy can be provided, different form the existing DNA detection system with the use of a molecular beacon. A molecular beacon wherein fluorescent organic groups capable of forming an excimer are bonded to the 3′ and 5′ ends of a single-stranded oligonucleotide to be hybridizable with a subject oligonucleotide and the switching of monomer emission/excimer emission is utilized; and a ...
    ]]> 8105772 <![CDATA[Granular sucralose, and method of making it]]> http://www.patentstorm.us/patents/8101746/description.html

  • Patent Number:  8101746
  • Publication Date:  2012-01-24
  • Inventors:  Skelding, William R.; Bailey, Alexandria L.; Elmore, Roy O.; Nehmer, Warren L.

    • Granular sucralose-containing particles are produced by the methods of the invention, which involve coating sucralose from solution to form granules with this coated sucralose on an outer region thereof. The granules may incorporate agglomerated sucralose particles, with the solution-coated sucralose adding mass and generally resulting in a granule having a relatively smoothed and rounded. The granules have good flow properties, are low dusting, and resist caking. Methods of making the ...
    ]]> 8101746 <![CDATA[Lung-targeted drugs]]> http://www.patentstorm.us/patents/8101745/description.html

  • Patent Number:  8101745
  • Publication Date:  2012-01-24
  • Inventors:  Beadle, James R.; Hostetler, Karl Y.

    • Methods and compositions are provided for treating lung diseases, including but not limited to infections and small cell and non-small cell lung cancer, by conjugating a drug of interest to glycerol ethers or glycerol phosphate ...
    ]]> 8101745 <![CDATA[Isolation and purification of nucleic acids with a solid phase]]> http://www.patentstorm.us/patents/8101744/description.html

  • Patent Number:  8101744
  • Publication Date:  2012-01-24
  • Inventors:  Birkner, Christian; Von der Eltz, Herbert

    • Disclosed are water-soluble ionic liquids suitable for promoting adsorption of nucleic acids to a solid phase. The use thereof, particularly methods for the isolation of nucleic acids from an aqueous solution, as well as kits for performing those methods are ...
    ]]> 8101744 <![CDATA[Modulation of transthyretin expression]]> http://www.patentstorm.us/patents/8101743/description.html

  • Patent Number:  8101743
  • Publication Date:  2012-01-24
  • Inventors:  Jain, Ravi; Brown-Driver, Vickie L.

    • Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are ...
    ]]> 8101743 <![CDATA[Method and medicament for inhibiting the expression of a given gene]]> http://www.patentstorm.us/patents/8101742/description.html

  • Patent Number:  8101742
  • Publication Date:  2012-01-24
  • Inventors:  Limmer, Stefan; Kreutzer, Roland

    • The invention relates to an isolated RNA that mediates RNA interference of an mRNA to which it corresponds and a method of mediating RNA interference of mRNA of a gene in a cell or organism using the isolated ...
    ]]> 8101742 <![CDATA[Modified siRNA molecules and uses thereof]]> http://www.patentstorm.us/patents/8101741/description.html

  • Patent Number:  8101741
  • Publication Date:  2012-01-24
  • Inventors:  MacLachlan, Ian; Judge, Adam

    • The present invention provides chemically modified siRNA molecules and methods of using such siRNA molecules to silence target gene expression. Advantageously, the modified siRNA of the present invention is less immunostimulatory than its corresponding unmodified siRNA sequence and retains RNAi activity against the target sequence. The present invention also provides nucleic acid-lipid particles comprising a modified siRNA, a cationic lipid, and a non-cationic lipid, which can further ...
    ]]> 8101741 <![CDATA[Positron emission tomography probes for imaging immune activation and selected cancers]]> http://www.patentstorm.us/patents/8101740/description.html

  • Patent Number:  8101740
  • Publication Date:  2012-01-24
  • Inventors:  Satyamurthy, Nagichettiar; Radu, Caius G.; Witte, Owen N.; Nair-Gill, Evan David; Shu, Chengyi J.; Czernin, Johannes

    • Compounds for use as PET probes and methods for synthesizing and using these, comprising [18F]D-FAC and other cytosine and adenosine ...
    ]]> 8101740 <![CDATA[Recombinant expression vectors comprising a human codon-optimized marburg virus (MARV) angola glycoprotein gene insert and method of immunization employing said vector]]> http://www.patentstorm.us/patents/8101739/description.html

  • Patent Number:  8101739
  • Publication Date:  2012-01-24
  • Inventors:  Pau, Maria Grazia; Goudsmit, Jaap; Nabel, Gary; Sullivan, Nancy; Yang, Zhi-Yong; Chakrabarti, Bimal

    • The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine ...
    ]]> 8101739 <![CDATA[ABFB-2 gene from ]]> http://www.patentstorm.us/patents/8101738/description.html

  • Patent Number:  8101738
  • Publication Date:  2012-01-24
  • Inventors:  Francois, Jean Marie; Parrou, Jean-Luc; Tourrasse, Olivier; Nore, Olivier

    • The invention relates to the abfB-2 gene of Penicillium funiculosum that codes for a type B α-L-arabinofuranosidase and has a cellulose binding domain. The enzyme α-L-arabinofuranosidase can be incorporated in nutritional additives or in foods for animals for which it improves the digestibility and thus the nutritional ...
    ]]> 8101738 <![CDATA[Parallel preparation of high fidelity probes in an array format]]> http://www.patentstorm.us/patents/8101737/description.html

  • Patent Number:  8101737
  • Publication Date:  2012-01-24
  • Inventors:  Kuimelis, Robert G.; McGall, Glenn H.

    • The present invention provides massively parallel oligonucleotide synthesis and purification for applications that utilize large collections of defined high-fidelity oligonucleotides (e.g., from about 101 to about 105 different sequences, generally between 25-160 bases in ...
    ]]> 8101737 <![CDATA[Polynucleotides and polypeptide of human KV1.3, compositions comprising same and methods of using same]]> http://www.patentstorm.us/patents/8101736/description.html

  • Patent Number:  8101736
  • Publication Date:  2012-01-24
  • Inventors:  Gepstein, Lior; Marom, Shimon; Feld, Yair; Bresler, Tal; Miari, Reem

    • An isolated polypeptide comprising, contiguously, a first amino acid sequence being at least 90% homologous to amino acid coordinates 1-398 of SEQ ID NO: 2, a tryptophan residue and a second amino acid sequence being at least 90% homologous to amino acid coordinates 400-523 of SEQ ID NO:2. Also provided are polynucleotide sequences encoding this polypeptide and uses of same in the treatment of medical conditions associated with ion channel ...
    ]]> 8101736 <![CDATA[Preparation of protective antigen]]> http://www.patentstorm.us/patents/8101735/description.html

  • Patent Number:  8101735
  • Publication Date:  2012-01-24
  • Inventors:  Arroyo, Juan; Brehm, John; Allison, Nigel; McEntee, Ian; Vincent, Philip; Brehm, Rossalyn; Jack, George; Herbert, Michael; Solow, Barbara T.; Lapcevich, Randall K.

    • A polynucleotide sequence is provided comprising a nucleic acid sequence encoding recombinant Protective Antigen (rPA).

    Also provided are expression vectors and host cells comprising the polynucleotide sequence of the invention, and methods for producing ...
    ]]> 8101735 <![CDATA[Ghrelin binding nucleic acids]]> http://www.patentstorm.us/patents/8101734/description.html

  • Patent Number:  8101734
  • Publication Date:  2012-01-24
  • Inventors:  Helmling, Steffen; Klussmann, Sven; Jarosch, Florian; Eulberg, Dirk; Maasch, Christian

    • The present invention is related to a nucleic acid, preferably binding to ghrelin, whereby the nucleic acid comprises

      • a first stretch Box A, and
      • a second stretch Box B,

        whereby
      • the first stretch Box A comprises about 25 consecutive nucleotides,
      • the second stretch Box B comprises about six to eight consecutive nucleotides,

        whereby
      • a 3′-terminal stretch of nucleotides ...
        ]]> 8101734 <![CDATA[Methods of evaluating mixtures of polysaccharides]]> http://www.patentstorm.us/patents/8101733/description.html
      • Patent Number:  8101733
      • Publication Date:  2012-01-24
      • Inventors:  Gunay, Nur Sibel; Liu, Cuihua; Shriver, Zachary; Venkataraman, Ganesh; Capila, Ishan

      Methods for analyzing mixtures of polysaccharides, for example heparin or a LMWH, using reduce end labeling are described. In general, the mixture of polysaccharides includes polysaccharides having a desired structural moiety. In some instances, one or more polysaccharides in the mixture are chemically modified prior to ...
      ]]> 8101733 <![CDATA[Methods of producing validamycin A analogs and uses thereof]]> http://www.patentstorm.us/patents/8101732/description.html

    • Patent Number:  8101732
    • Publication Date:  2012-01-24
    • Inventors:  Xu, Hui; Deng, Zixin; Mahmud, Taifo; Bai, Linquan; Yang, Jongtae

    This disclosure relates to validamycin A biosynthesis and in particular, to methods of producing validamycin A analogs and uses thereof. In a particular example, a method for making a validamycin A analog includes transforming a host cell with one or more recombinant DNA vectors to produce a valN-inactivated mutant; and culturing the valN-inactivated mutant in a culture medium to produce a validamycin A analog, such as 1,1′-bis-valienamine and validienamycin, and their conversion to ...
    ]]> 8101732 <![CDATA[Process for typing of HCV isolates]]> http://www.patentstorm.us/patents/8101351/description.html

  • Patent Number:  8101351
  • Publication Date:  2012-01-24
  • Inventors:  Maertens, Geert; Van Heuverswyn, Hugo; Stuyver, Lieven; Rossau, Rudi

    • The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of:

      • contacting said sample in which the ribonucleotides or deoxyribonucleotides have been made accessible, if need be, under suitable denaturation, with at least one probe from about 10 to about 40 ...
        ]]> 8101351 <![CDATA[Modulation of exportin 5 expression]]> http://www.patentstorm.us/patents/8101350/description.html
      • Patent Number:  8101350
      • Publication Date:  2012-01-24
      • Inventor:  Dobie, Kenneth W.

      Compounds, compositions and methods are provided for modulating the expression of exportin 5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding exportin 5. Methods of using these compounds for modulation of exportin 5 expression and for diagnosis and treatment of diseases and conditions associated with expression of exportin 5 are ...
      ]]> 8101350 <![CDATA[RNA-interference by single-stranded RNA molecules]]> http://www.patentstorm.us/patents/8101348/description.html

    • Patent Number:  8101348
    • Publication Date:  2012-01-24
    • Inventors:  Martinez, Javier; Tuschl, Thomas; Patkaniowska, Agnieszka; Urlaub, Henning; Luehrmann, Reinhard

    The present invention relates to sequence and structural features of single-stranded (ss) RNA molecules required to mediate target-specific nucleic acid modifications by RNA-interference (RNAi), such as target mRNA degradation and/or DNA ...
    ]]> 8101348 <![CDATA[3,5-disubstituted and 3,5,7-trisubstituted-3-oxazolo and 3-thiazolo[4,5-]pyrimidin-2-one compounds and prodrugs thereof]]> http://www.patentstorm.us/patents/8097718/description.html

  • Patent Number:  8097718
  • Publication Date:  2012-01-17
  • Inventors:  Xiang, Alan X.; Haley, Gregory J.; Webber, Stephen E.; Lennox, Joseph R.; Rueden, Erik J.

    • The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and ...
    ]]> 8097718