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Direct catalytic conversion of sugars to ethanol

Application Number: 20120041238
Publication Date: 2012-02-16
Inventor: Carter, Melvin Keith

Sugars comprising the monosaccharides glucose and fructose, and the disaccharides sucrose and mannose are catalytically converted to ethanol in a sulfate fortified acid medium in the presence of transition metal compounds possessing a degree of symmetry. This is not a fermentation process but is a catalytic chemical process where conversion efficiency is improved by saturating the acidic reaction mixture with inorganic sulfate salts to reduce competitive reactions. Ethanol formed during the ...

Process for Producing Fluoromethyl Hexafluoroisopropyl Ether

Application Number: 20120041237
Publication Date: 2012-02-16
Inventors: Takahashi, Hiroshi; Katsuhara, Yutaka; Ishida, Michio

There is provided according to the present invention a process for producing fluoromethyl hexafluoroisopropyl ether ((CF₃)₂CH—O—CH₂F), including: reacting bisfluoromethyl ether with hexafluoroisopropyl alcohol in a solvent substantially immiscible with hydrogen fluoride in the presence of a catalytic amount of a strong acid selected from sulfuric acid and any other acids stronger in acidity than sulfuric acid. The process of the present invention enables ...

MICROWAVE INDUCED SINGLE STEP GREEN SYNTHESIS OF SOME NOVEL 2-ARYL ALDEHYDES AND THEIR ANALOGUES

Application Number: 20120041234
Publication Date: 2012-02-16
Inventors: Sinha, Arun Kumar; Sharma, Abhishek; Kumar, Rakesh; Sharma, Naina

The present invention provides a process for the preparation of some novel 2-aryl and 2,2-diaryl aldehydes and analogues which are privileged intermediates for commercially important nonsteroidal anti-inflammatory drugs including naproxen, flurbiprofen and potent anticancer drug candidates, including phenstatin through a unique single step synthetic methodology utilizing easily available substrates in the form of aryl alkenes as well as environmentally benign aqueous reaction conditions in the ...

PHOSPHINATE RUTHENIUM COMPLEXES

Application Number: 20120041191
Publication Date: 2012-02-16
Inventors: Parsy, Christophe Claude; Alexandre, Francois-Rene; Surleraux, Dominique; Bonnaterre, Florence Marie-Emilie

Provided herein are ruthenium complexes of Formula (I), and processes of preparation thereof. Also provided are methods of their use as a metathesis catalyst.

SILICON OR ELEMENTARY METALS AS ENERGY CARRIERS

Application Number: 20120041083
Publication Date: 2012-02-16
Inventor: Grauer, Peter

A method for providing storable and transportable energy carriers (103, 104) is described. In one step, a transformation of silicon-dioxide-containing or metal-oxide-containing starting material (101) to silicon (103) or a metal occurs in a reduction process (105), wherein the primary energy for this reduction process (105) is provided from a renewable energy source. Then, a portion of the reaction products (102) from the reduction process (105) ...

ORGANOLEPTIC COMPOUNDS AND THEIR USE IN PERFUME COMPOSITIONS

Application Number: 20120041077
Publication Date: 2012-02-16
Inventor: Smith, Catherine Marie

The present invention a method of improving, enhancing or modifying a fragrance formulation through the addition of an olfactory acceptable amount of the following compound:

wherein R¹and R²independently represent a straight, branched or cyclic hydrocarbon moiety consisting of less than 10, preferably less than 4, most preferably 1 of 2 carbon ...

CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF

Application Number: 20120040932
Publication Date: 2012-02-16
Inventors: Boyer, Serge; Dudley, Michael N.; Griffith, David C.; Totrov, Maxim; Hirst, Gavin; Reddy, Raja; Hecker, Scott; Rodny, Olga

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to 1 cyclic boronic acid ester derivatives and their use as therapeutic ...

PROCESS FOR THE HYDROLYSIS OF CELLULOSE

Application Number: 20120040411
Publication Date: 2012-02-16
Inventors: Lindstrom, Mikael; Henriksson, Gunnar

There is disclosed a process for the hydrolysis of cellulose comprising the sequential steps (a) mixing cellulose with a viscosity below 900 ml/g with an aqueous solution to obtain a liquid, wherein particles comprising cellulose in said liquid have a diameter of maximum 200 nm, wherein the temperature of the aqueous solution is below 35° C., and wherein the pH of the aqueous solution is above 12, (b) subjecting the liquid to at least one of the steps: (i) decreasing the pH of the liquid with ...

SURFACE TREATING AGENT, ARTICLE AND FLUORINATED ETHER COMPOUND

Application Number: 20120040189
Publication Date: 2012-02-16
Inventors: Gozu, Yoshiyuki; Shirakawa, Daisuke; Hoshino, Taiki

To provide a surface treating agent and a composition for surface treatment capable of forming a coating film excellent in the water/oil repellency, the efficiency for removal of oil-and-fat stains, alkali resistance and heat resistance and having a low coefficient of friction; a method for treating the surface of an article by using the surface treating agent or the composition for surface treatment; an article having surface treatment applied; and a novel fluorinated ether compound useful as ...

ALKYNES AND METHODS OF REACTING ALKYNES WITH 1,3-DIPOLE-FUNCTIONAL COMPOUNDS

Application Number: 20120040011
Publication Date: 2012-02-16
Inventors: Boons, Geert-Jan; Guo, Jun; Ning, Xinghai; Wolfert, Margaretha

1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a ...

HIGH CONSISTENCY ENZYMATIC HYDROLYSIS FOR THE PRODUCTION OF ETHANOL

Application Number: 20120036768
Publication Date: 2012-02-16
Inventors: Phillips, Richard; Chang, Hou-Min; Jameel, Hasan

The presently disclosed subject matter related to methods of converting lignocellulosic materials to alcohol that include increasing the fiber consistency of enzymatic hydrolysis mixtures. More particularly, the methods involve contacting lignocellulosic biomass with an enzyme composition for a period of time, and then thickening the mixture and further hydrolyzing the thickened mixture. The thickening can be performed by filtration, optionally reusing the filtrate and/or any enzymes contained ...

PROCESS FOR PURIFYING ETHANOL

Application Number: 20120035400
Publication Date: 2012-02-09
Inventors: Grusendorf, Gerald; Chapman, Josefina; Horton, Trinity; Pan, Tianshu; Sarager, Lincoln; Warner, R. Jay; Johnston, Victor J.; Weiner, Heiko; Cunningham, Robert; Jevtic, Radmila

In one embodiment, the invention is to a process for producing ethanol. The process comprises the step of hydrogenating an acetic acid feed stream in a first reactor to form a crude ethanol product. The crude ethanol product may comprise, among other components, ethanol, acetaldehyde, and residual acetic acid. The process further comprises the step of recovering acetaldehyde from the crude ethanol product. The process further comprises the steps of feeding a first portion of the recovered ...

METHOD FOR PRODUCING 1,6-HEXANEDIOL BY HYDROGENATION OF OLIGO- AND POLYESTERS

Application Number: 20120035399
Publication Date: 2012-02-09
Inventors: Tebben, Gerd-Dieter; Sirch, Tilman; Urtel, Heiko; Abillard, Olivier; Pinkos, Rolf; Urbanczyk, Daniel; Tompers, Rolf

The present invention relates to a process for hydrogenating oligo- and/or polyesters obtainable by esterifying a DCS with a diol or diol mixture, said hydrogenation being performed in the presence of a catalyst whose catalyst precursor comprises copper oxide, aluminum oxide and at least one oxide of lanthanum, of iron, of tungsten, of molybdenum, of titanium or of zirconium, and to a process for preparing 1,6-hexanediol by catalytically hydrogenating ester mixtures which comprise, as main ...

PROCESS TO REMOVE PRODUCT ALCOHOL FROM A FERMENTATION BY VAPORIZATION UNDER VACUUM

Application Number: 20120035398
Publication Date: 2012-02-09
Inventors: Grady, Michael Charles; Parten, William D.; Zaher, Joseph J.; Sylvester, Robert W.

A fermentation liquid feed including water and a product alcohol and optionally CO₂is at least partially vaporized such that a vapor stream is produced. The vapor stream is contacted with an absorption liquid under suitable conditions wherein an amount of the product alcohol is absorbed. The portion of the vapor stream that is absorbed can include an amount of each of the water, the product alcohol and optionally the CO₂. The temperature at the onset of the absorption of ...

PROCESS FOR THE HYDROXYLATION OF PHENOLS AND OF PHENOL ETHERS

Application Number: 20120035397
Publication Date: 2012-02-09
Inventor: Garel, Laurent

A process for the hydroxylation of phenols and of phenol ethers by hydrogen peroxide is described. More particularly a process for the hydroxylation of phenol by hydrogen peroxide is described. The described process can include hydroxylation of a phenol or of a phenol ether having at least one hydrogen atom at the ortho and para position of the hydroxyl group or of the ether group, by reaction of said phenol or phenol ether, with hydrogen peroxide, in the presence of an acid catalyst, wherein ...

PROCESS FOR THE PREPARATION OF POLYISOCYANATES AND USE THEREOF

Application Number: 20120035391
Publication Date: 2012-02-09
Inventors: Richter, Frank; Brahm, Martin

The invention relates to a process for isocyanate modification which includes reacting a) at least one organic isocyanate having an NCO functionality greater than or equal to 1, b) a catalyst comprising at least one phosphonium salt comprising at least one cycloalkyl substituent bonded directly to a P atom of a phosphonium cation, c) optionally a solvent, and d) optionally additives. The present invention also relates to a catalyst for isocyanate modification comprising at least one phosphonium ...

METHOD FOR PREPARATION OF AND COMPOSITIONS OF LOW FOAM, NON-GELLING, SURFACTANTS

Application Number: 20120035386
Publication Date: 2012-02-09
Inventor: Nguyen, Giao Vinh

Low foam, non-gelling surfactants include certain non-ionic alcohol ethoxylate surfactants and anionic ether sulfate surfactants formed therefrom, and processes for preparing the same. Also included are agricultural formulations including agriculturally active ingredients in combination with certain anion ether sulfate ...

ORGANOPHOSPHORUS COMPOUNDS, CATALYTIC SYSTEMS COMPRISING SAID COMPOUNDS AND METHOD OF HYDROCYANATION OR OF HYDROFORMYLATION USING SAID CATALYTIC SYSTEMS

Application Number: 20120035377
Publication Date: 2012-02-09
Inventors: Mastroianni, Sergio; Mikhel, Igor; Pringle, Paul

Organophosphorus compounds, catalytic systems comprising a metallic element forming a complex with the organophosphorus compounds and methods of hydrocyanation and of hydroformylation employed in the presence of the catalytic systems are ...

METHODS OF MAKING 6-HYDROXYHEXANOPHENONE AND 5-BENZOYLPENTANOIC ACID AND MONO OR DIESTERS THEREOF

Application Number: 20120035308
Publication Date: 2012-02-09
Inventors: Godwin, Allen David; Mozeleski, Edmund John; Smirnova, Diana S.; Baugh, Lisa Saunders; Zushma, Stephen; Dakka, Jihad Mohammed; Benitez, Francisco Manuel; Wang, Kun

Mono- or diester plasticizers of the formula:

wherein A is either —OC(O)R′ or ═O, and X is either —COC(O)R or —C(O)OR, and R and R′ are C₃to C₁₃alkyl, which are the same or different, formed from cyclohexylbenzene and processes of making ...

Stereoisomers Propofol Therapeutic Compounds

Application Number: 20120035271
Publication Date: 2012-02-09
Inventor: Jenkins, Thomas E.

A (−)-stereoisomer of formula (I): [insert formula (I) wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.

OXADIAZOLE DERIVATIVES

Application Number: 20120035226
Publication Date: 2012-02-09
Inventors: Crosignani, Stefano; Sauer, Wolfgang; Quattropani, Anna; Montagne, Cyril; Bombrun, Agnés

The invention relates to oxadiazole compounds of formula I. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple ...

NOVEL UNSATURATED TETRACYCLIC TETRAHYDROFURAN DERIVATIVES

Application Number: 20120035170
Publication Date: 2012-02-09
Inventors: Megens, Antonius Adrianus Hendrikus Petrus; Trabanco-Suárez, Andrés Avelino; Núñez, José Maria

This invention concerns novel substituted unsaturated tetracyclic tetrahydrofuran derivatives with binding affinities towards serotonine receptors, in particular 5-HT_2Aand 5-HT_2Creceptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment ...

ENZYMATIC METHOD FOR PRODUCING ALDEHYDES

Application Number: 20120034665
Publication Date: 2012-02-09
Inventors: Schaffer, Steffen; Haas, Thomas; Tacke, Thomas; Vorlop, Klaus-Dieter; Klasovsky, Florian; Krauter, Hendrik; Schoebel, Rene; Willke, Thomas; Wessel, Mirja

The invention relates to methods for producing aldehydes and the oxidation and reduction products ...

PROCESS TO PRODUCE ORGANIC COMPOUNDS FROM SYNTHESIS GASES

Application Number: 20120034664
Publication Date: 2012-02-09
Inventors: Kohn, Richard Allen; Kim, Seon-Woo

At least one isolated microorganism and a fermentation method to convert hydrogen gas, carbon dioxide gas, and/or carbon monoxide gas to a lower alkyl alcohol and/or carboxylic acid and to produce at least 2% by volume of the lower alkyl alcohol or carboxylic acid in an aqueous-based ...

Trophic Conversion of Obligate Phototrophic Algae Through Metabolic Engineering

Application Number: 20120034653
Publication Date: 2012-02-09
Inventors: Lippmeier, James Casey; Kyle, David J.; APT, Kirk Emil; Allnutt, F.C. Thomas

Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga Phaeodaclylurn tricornutum can be engineered to import glucose and grow in the dark through the introduction of genes encoding glucose transporters. Both the human and Chlorella kessleri glucose transporters facilitated the uptake of glucose by P. tricornutum, allowing the cells to metabolize ...

DIAMOND PARTICLES HAVING ORGANIC COMPOUNDS ATTACHED THERETO, COMPOSITIONS THEREOF, AND RELATED METHODS

Application Number: 20120034464
Publication Date: 2012-02-09
Inventors: Agrawal, Gaurav; DiGiovanni, Anthony A.; Chakraborty, Soma

A substance includes diamond particles having a maximum linear dimension of less than about 1 μm and an organic compound attached to surfaces of the diamond particles. The organic compound may include a surfactant or a polymer. A method of forming a substance includes exposing diamond particles to an organic compound, and exposing the diamond particles in the presence of the organic compound to ultrasonic energy. The diamond particles may have a maximum linear dimension of less than about 1 ...

PREVENTION OF EXTRACT DARKENING AND MALODOR FORMATION DURING SOLUBILIZATION OF PLANT CELL WALL MATERIAL

Application Number: 20120034343
Publication Date: 2012-02-09
Inventors: Sørensen, Jens Frisbæk; Mikkelsen, René

The present invention relates to methods for reducing color and/or unpleasant taste and/or malodor development in a composition comprising at plant material, such a ceral bran, in particular during solubilization processes of the plant material. The invention further relates to optimised methods of solubilization, wherein color and/or unpleasant taste and/or malodor development is controlled. Solubilised plant material, kit of parts, the use of such solubilised plant material, e.g. in food ...

4-ISOPROPYL-3-METHYLPHENOL FOR THE TREATMENT OF INFLAMMATION

Application Number: 20120034312
Publication Date: 2012-02-09
Inventor: Yang, Jingjun

This invention relates to the use of 4-isopropyl-3-methylphenol (IPMP) for combating inflammation and compositions comprising IPMP for such ...

SULPHURATED DERIVATIVES OF RESORCINOL, PREPARATION OF SAME AND COSMETIC USES THEREOF

Application Number: 20120034176
Publication Date: 2012-02-09
Inventor: Poigny, Stéphane

The present invention relates to a compound of the general formula (I) where: X═S, SO or SO₂; and one of the radicals R₁and R₂is a hydrogen atom and the other is a radical: a C₁to C₁₈linear or branched alkyl, optionally substituted by one or more halogen atom(s); a C₂to C₁₈linear or branched alkenyl, optionally substituted by one or more halogen atom(s); an aralkyl, optionally substituted by one or more C_{1 ...}

DEOXYGENATION OF FATTY ACIDS FOR PREPARATION OF HYDROCARBONS

Application Number: 20120029250
Publication Date: 2012-02-02
Inventors: Brown, Heather M.; Hallen, Richard T.; White, James F.; Albrecht, Karl O.

Embodiments of methods for making renewable diesel by deoxygenating (decarboxylating/decarbonylating/dehydrating) fatty acids to produce hydrocarbons are disclosed. Fatty acids are exposed to a catalyst selected from a) Pt and MO₃on ZrO₂(M is W, Mo, or a combination thereof), or b) Pt/Ge or Pt/Sn on carbon, and the catalyst decarboxylates at least 10% of the fatty acids. In particular embodiments, the catalyst consists essentially of 0.7 wt % Pt and 12 wt % ...

METHOD OF HYDROGENOLYSIS OF SUGAR ALCOHOLS

Application Number: 20120029249
Publication Date: 2012-02-02
Inventor: Hronec, Milan

The method for hydrogenolysis of sugar or sugar alcohols comprises the steps of: mixing in the absence of any phosphine a suspension of a supported osmium catalyst, water, a sugar or sugar alcohol, and a base; pressurizing the suspension with hydrogen to a range of 30 to 90 bar at room temperature; heating the suspension to a temperature in the range of 180° C. to 250° C.; and mixing the suspension for an amount of time ranging from 1 to 6 ...

CONSTRUCTS, VECTORS AND CYANOBACTERIA FOR THE SYNTHESIS OF FATTY ALCOHOLS, AND METHODS FOR PRODUCING FATTY ALCOHOLS IN CYANOBACTERIA

Application Number: 20120029248
Publication Date: 2012-02-02
Inventors: LU, Xuefeng; TAN, Xiaoming; GAO, Qianqian; YAO, Lun; QI, Fengxia

Constructs, vectors and cyanobacteria for the synthesis of fatty alcohols, and methods for producing fatty alcohols in cyanobacteria is ...

CONVERSION METHOD

Application Number: 20120029247
Publication Date: 2012-02-02
Inventors: Fanselow, Markus; Seddon, Kenneth Richard; Holbrey, John; Vanoye, Laurent; Zheng, Anna

A process is described for the preparation of water-soluble cellulose hydrolysis products, which comprises admixing cellulose with an ionic liquid capable of solvating or dissolving at least some of the cellulose, said ionic liquid being a compound comprised solely of cations and anions and which exists in a liquid state at a temperature at or below 15O° C., the cations in said ionic liquid having the general formula (I), in which Z represents a nitrogen or phosphorus atom, R^{1 ...}

ALKOXYLATION PROCESSES AND CATALYSTS THEREFOR

Application Number: 20120029246
Publication Date: 2012-02-02
Inventors: Flick, Derrick W.; Elowe, Paul R.; Arrowood, Tina L.; MacDonald, Jason C.

A process of contacting an alkylene oxide with 2-methoxy-1-propanol (PM1) in the presence of an oligomeric Schiff base metal complex catalyst is disclosed. Further, a process involving contacting an alkylene oxide with an alkyl alcohol using an oligomeric Schiff base metal complex as a catalyst is also disclosed. Additionally, novel compositions which can be used as catalysts in processes involving the contacting of an alkyl alcohol with an alkylene oxide are also ...

CATALYTIC REACTIONS USING IONIC LIQUIDS

Application Number: 20120029245
Publication Date: 2012-02-02
Inventors: Corradini, Andrew; McComick, Jarod

A method of catalytically forming reaction products can include providing an ionic liquid phase. The ionic liquid phase can include a catalyst and an ionic liquid. At least one reactant can be reacted (14,16) in the ionic liquid phase to produce reaction products which include at least one of methanol and dimethyl ether. In particular, the ionic liquid can be hydrophobic sufficient to prevent substantial water in the ionic liquid phase. The use of ionic liquids can substantially reduce ...

METHOD FOR PRODUCING FLUORENE DERIVATIVE

Application Number: 20120029244
Publication Date: 2012-02-02
Inventors: Kato, Hiroyuki; Fujii, Katsuhiro; Hata, Suguru; Fukui, Kohta; Numata, Yuki

A method for producing a fluorene derivative by reacting fluorenone with a phenol or a phenoxyalcohol in the presence of an acid catalyst includes: adding an alkali to an obtained reaction liquid containing a fluorene derivative; and concentrating a resultant mixture liquid without removing the alkali thus added and a reaction product of the alkali, thereby separating an unreacted phenol or unreacted ...

CATALYST- AND LIGNIN-COMPRISING COMPOSITION AND ITS USE FOR PREPARING AN AROMATICS COMPOSITION

Application Number: 20120029243
Publication Date: 2012-02-02
Inventors: Prochazka, Roman; Schunk, Stephan; PANTOUFLAS, Emmanouil

The present invention relates to a composition (“composite”) comprising lignin and at least one catalyst dispersed in the composition. The invention further provides a process for producing such a catalyst- and lignin-comprising composition and its use for preparing an aromatics ...

HYDROFORMYLATION PROCESS WITH DOUBLY OPEN-ENDED BISPHOSPHITE LIGAND

Application Number: 20120029242
Publication Date: 2012-02-02
Inventor: Brammer, Michael A.

A continuous hydroformylation process for producing at least one aldehyde product by utilizing a transition metal and a ligand mixture comprising an organopolyphosphite and an organomonophosphine, with improved stability of the organopolyphosphite ligand. The process involves reacting one or more olefinically-unsaturated compounds with carbon monoxide and hydrogen in the presence of an organopolyphosphite ligand and an organomonophosphine ligand, at least one of such ligands being bonded to a ...

METHOD FOR PRODUCING CARBONYL COMPOUND, CATALYST, AND METHOD FOR PRODUCING CATALYST

Application Number: 20120029241
Publication Date: 2012-02-02
Inventors: Kobayashi, Shu; Matsubara, Ryosuke; Miyamura, Hiroyuki; Yamada, Jun

The method for producing a carbonyl compound according to the invention comprises a step of obtaining a carbonyl compound by oxidation of a secondary alcohol in the presence of a catalyst, wherein the catalyst comprises a carrier obtained by the use of a styrene-based polymer with side chains containing crosslinkable functional groups, wherein the crosslinkable functional groups in the carrier are crosslinked, gold-platinum nanosize clusters supported on the carrier and carbon black supported ...

ALLYL AND PROPARGYL ETHERS

Application Number: 20120029240
Publication Date: 2012-02-02
Inventors: Bonrath, Werner; Kuenzi, Rolf

Allyl and propargyl ethers of the formula X—C(R¹)(R²)—O—C(CH₃)(R³)—OCH₃(I), wherein X is an ethynyl or vinyl group, R¹is methyl or ethyl, R²is a saturated or unsaturated linear or cyclic aliphatic hydrocarbon residue and R³is methyl or ethyl, a method for their preparation and their use in the manufacture of β-ketoallenes, α,β-unsaturated carbonyl compounds and γ,δ-unsaturated ...

RECOVERY OF ACETOPHENONE DURING THE PRODUCTION OF PHENOL

Application Number: 20120029239
Publication Date: 2012-02-02
Inventors: Payne, Larry Wayne; Black, Jesse Raymond; Unger, Phillip Edward

A method for producing acetophenone comprising: treating one or more alkylbenzenes comprising s-butylbenzene to produce a feed comprising phenol and acetophenone; separating a crude phenol stream from the feed under crude phenol separation conditions effective to produce a crude phenol heavies; and, separating an acetophenone stream directly from the crude phenol heavies under azeotropic distillation ...

PROCESS FOR THE PREPARATION OF CRYSTALLINE MIXTURES OF ALPHA-HYDROXYCARBONYL DERIVATIVES OF ALPHA-METHYLSTYRENE DIMERS

Application Number: 20120029238
Publication Date: 2012-02-02
Inventors: Norcini, Gabriele; Li Bassi, Giuseppe; Federici, Leonardo

Process for the preparation of the powdery crystalline mixtures of alpha-hydroxycarbonyl derivatives of alpha-methylstyrene dinners comprising the use of a solvent having polarity from 0 to ...

Autocatalytic Process for the Synthesis of Chiral Propargylic Alcohols

Application Number: 20120029237
Publication Date: 2012-02-02
Inventors: Carreira, Erick; Chinkov, Nicka; Warm, Aleksander

An autocatalytic process for the synthesis of chiral propargylic ...

COMPOUNDS FOR USE IN THE TREATMENT OF PAIN

Application Number: 20120029235
Publication Date: 2012-02-02
Inventors: Leuwer, Martin; O'Neill, Paul; Berry, Neil; Haeseler, Gertrud

The present invention concerns compounds derived from the anaethetic propofol. The compounds may be useful in the treatment of pain, particularly, but not exclusively, chronic pain and central pain ...

METHOD FOR PRODUCING HIGH PURITY TERMINAL OLEFIN COMPOUND

Application Number: 20120029229
Publication Date: 2012-02-02
Inventors: Miyoshi, Kei; Asanuma, Goro

An industrially advantageous method for producing a high purity terminal olefin is disclosed, comprising the steps of (a) contacting a mixture comprising a terminal olefin represented by formula (1):

and one or more corresponding internal olefins as impurities, with a brominating agent in the presence of water or an alcohol, to convert the internal olefin(s) to compound(s) having a higher boiling point than the terminal olefin; and ...

SCALABLE SYNTHETIC PROCESS FOR MAKING TERAMEPROCOL

Application Number: 20120029216
Publication Date: 2012-02-02
Inventors: Chen, Qingqi; Blomburg, Jessica Andrea

A manufacturing process for making terameprocol (1) which includes the following reaction scheme, wherein a first general reaction is the formation of a furan intermediate (39) and a second general reaction is the ring-reduction and ring-opening of the furan intermediate (39) to form the terameprocol (1):

METHOD FOR PRODUCING ALCOHOL COMPOUND AND CATALYST THEREFOR

Application Number: 20120029195
Publication Date: 2012-02-02
Inventors: Hagiya, Koji; Souda, Hiroshi; Aoyagi, Yasutaka

A method for producing an alcohol compound, wherein a carboxylic acid ester compound is reduced with hydrogen in the presence of a ruthenium complex which is obtained by reacting a pyridine compound having at least one optionally substituted amino group with a ruthenium ...

LIQUID CRYSTAL COMPOUND HAVING DIFLUOROPROPENYLENEOXY BONDING GROUP

Application Number: 20120029194
Publication Date: 2012-02-02
Inventor: Tanaka, Hiroyuki

The invention provides a liquid crystal compound having general physical properties necessary for the compound, namely stability to heat, light and so forth, a wide temperature range of a liquid crystal phase, a high clearing point, a good compatibility with other compounds, a large optical anisotropy and a large dielectric anisotropy; a compound represented by formula (1):

wherein, for example, R¹is alkyl having 1 to 20 ...

Pyrazole Derivatives

Application Number: 20120029192
Publication Date: 2012-02-02
Inventors: Jones, Lyn Howard; Price, David Anthony; Selby, Matthew Duncan; Mowbray, Charles Eric; Stupple, Paul Anthony

This invention relates to pyrazole derivatives of formula (I)

or pharmaceutically acceptable salts, solvates or derivatives thereof, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such, the ...

POLYGLYCEROL ALDEHYDES

Application Number: 20120029149
Publication Date: 2012-02-02
Inventor: Chenault, Henry Keith

Novel polyglycerol aldehyde polymers are described. The polymers comprise glycerol monomers connected by ether linkages and have 3 to about 170 aldehyde groups per molecule. The polyglycerol aldehydes may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular ...