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Imaging Agents

Application Number: 20130123618
Publication Date: 2013-05-16
Inventor: EMORY UNIVERSITY,

This invention provides amino acid derivatives useful in detecting and evaluating brain and body tumors, including (1S,2S) anti-2-[¹⁸F]FACPC and (1R,2R) ...

Beta-Ketocarbonylquat Compounds and Process for the Preparation thereof

Application Number: 20130123535
Publication Date: 2013-05-16
Inventor: Herzig, Christian

β-ketocarbonylquats contain at least one quaternary ammonium salt group, and may be prepared by the reaction of an alkyl ketene dimer with a tertiary amine group-containing compound also containing a protic group, followed by ...

METHOD FOR SYNTHESIZING RARE EARTH METAL EXTRACTANT

Application Number: 20130123534
Publication Date: 2013-05-16
Inventors: Ohashi, Masaki; Kume, Tetsuya; Naganawa, Hirochika; Shimojo, Kojiro; Sakaki, Kazuaki; Sugahara, Hiroto

A rare earth metal extractant containing, as the extractant component, dialkyldiglycol amide acid which is excellent in breaking down light rare earth elements is reacted in diglycolic acid (X mol) and an esterification agent (Y mol) at a reaction temperature of 70° C. or more and for a reaction time of one hour or more such that the mol ratio of Y/X is 2.5 or more, and is subjected to vacuum concentration. Subsequently, a reaction intermediate product is obtained by removing unreacted ...

PROCESS FOR PREPARING FORMIC ACID BY REACTION OF CARBON DIOXIDE WITH HYDROGEN

Application Number: 20130123526
Publication Date: 2013-05-16
Inventor: BASF SE,

The invention relates to a process for preparing formic acid by reaction of carbon dioxide with hydrogen in a hydrogenation reactor in the presence of a transition metal complex as a catalyst comprising at least one element from group 8, 9 or 10 of the Periodic Table and at least one phosphine ligand with at least one organic radical having at least 13 carbon atoms, of a tertiary amine and of a polar solvent to form a formic acid-amine, adduct, which is subsequently dissociated thermally to ...

ARYL UREA DERIVATIVES AS N-FORMYL PEPTIDE RECEPTORS LIKE-1 (FPRL-1) RECEPTOR MODULATORS

Application Number: 20130123496
Publication Date: 2013-05-16
Inventor: Allergan, Inc.,

The present invention relates to novel aryl urea derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) ...

N6-(1-IMINOETHYL)-L-LYSINE FOR REGENERATION OF ALVEOLI IN LUNGS

Application Number: 20130123364
Publication Date: 2013-05-16
Inventor: Weissmann, Norbert

The present invention describes the use of N⁶-(1-iminoethyl)-L-lysine for the manufacture of a medicament for the treatment of pulmonary alveolar damage or destruction in mammals, including in ...

MEDICINAL AGENT FOR PREVENTION AND/OR TREATMENT OF HEPATOCELLULAR CARCINOMA

Application Number: 20130123363
Publication Date: 2013-05-16
Inventors: Uesugi, Ken; Sano, Tetsuro; Ozawa, Takatoshi; Shimada, Kazuhide

The present invention relates to provision of a pharmaceutical agent useful for the prevention and treatment of hepatocellular carcinoma, and the pharmaceutical agent for the prevention and/or treatment of hepatocellular carcinoma contains an acyclic retinoid, a salt thereof, or a solvate of any of these, in combination with a branched-chain amino acid, a salt thereof, or a solvate of any of ...

MODULATOR

Application Number: 20130123356
Publication Date: 2013-05-16
Inventors: Baker, David; Pryce, Gareth; Selwood, David; Visintin, Cristina; Okuyama, Masahiro

The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof,

CONTROL AGENT FOR SOFT ROT AND CONTROL METHOD FOR THE SAME

Application Number: 20130123287
Publication Date: 2013-05-16
Inventors: Sugimoto, Koji; Hayashi, Hiroyuki

Providing a novel control agent for soft rot and a novel control method for the same. A compound having no antibacterial activity against Erwinia carotovora but having a control activity against fungi on soil surface, specifically containing, as the active ingredient, a fungicide comprising any of a strobilurin compound such as azoxystrobin and kresoxim-methyl, an azole compound such as triflumizol, cyazofamid, amisulbrom, and thiophanate-methyl, a carboxamide compound such as ...

DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE

Application Number: 20130123243
Publication Date: 2013-05-16
Inventor: Celtaxsys, Inc.,

This invention is directed to compounds of formula (I):

where r, q, R, R², R³, R⁴, R^5a, R^5b, R^5c, R^6a, R^6b, R^6c, R⁷, R⁸, and R⁹are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or ...

TUNABLE LCST POLYMERS AND METHODS OF PREPARATION

Application Number: 20130123144
Publication Date: 2013-05-16
Inventors: Putnam, David; Huang, Lihong

Polymer compositions having the chemical structure: as well as monomer compositions for producing said polymers are described. Methods for preparing these polymers and combinatorial libraries of these polymers are also described.

PROCESS FOR THE SPECIFIC ISOTOPIC LABELING OF METHYL GROUPS OF VAL, LEU AND ILE

Application Number: 20130122598
Publication Date: 2013-05-16
Inventors: Gans, Pierre; Boisbouvier, Jerome; Ayala, Isabel; Hamelin, Olivier

The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3-oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in particular by ...

MOLECULAR GAUGE BLOCKS FOR BUILDING ON THE NANOSCALE

Application Number: 20130122297
Publication Date: 2013-05-16
Inventor: NORTHWESTERN UNIVERSITY,

Disclosed herein is a way to produce a series of discrete sized slender, rigid oligoparaxylene molecules ranging from 1-5 nm in length. Molecules, based on 1-7, 9-11 paraxylene rings, have been synthesized as part of a homologous series of oligoparaxylenes (OPXs) with a view to providing a molecular tool box for the construction of nano architectures—such as spheres, cages, capsules, metal-organic frameworks (MOFs), metal-organic polyhedrons (MOPs) and covalent-organic frameworks (COFs), to ...

FLAVOR CONTAINING L-GLUTAMIC ACID AND METHOD THEREOF

Application Number: 20130122141
Publication Date: 2013-05-16
Inventor: CJ CHEILJEDANG CORPORATION,

Disclosed herein is a method for producing a flavoring containing L-glutamic acid derived from natural foods by adjusting the content of ammonia remaining in a final fermentation broth after completion of culture to be in the range of 0 to 10 g/L in cultivation of L-glutamic acid producing microorganisms, thereby facilitating drying of the fermentation liquor containing L-glutamic acid. A flavoring produced by the method is also ...

NANODIAMOND MATERIAL, METHOD AND DEVICE FOR PURIFYING AND MODIFYING A NANODIAMOND

Application Number: 20130121909
Publication Date: 2013-05-16
Inventors: Skryabin, Yuriy Alekseevich; Shenderova, Olga Alexander; Petrov, Igor Leonidovich

A method of purification and modification of carbon nanoproduct involves forcing a mixture of the dehydrated air or oxygen or ozone or any combination thereof through the carbon nanoproduct under pressure up to 0.8 MPa accompanied by mixing of the carbon nanoproduct and heating in the temperature range from +20 to +550° C. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this ...

PROCESS FOR PREPARING LONG-CHAIN DICARBOXYLIC ACIDS AND THE PRODUCTION THEREOF

Application Number: 20130116471
Publication Date: 2013-05-09
Inventors: YAN, LIMING; Yang, Yong; Fu, Shenzhan; Chen, Yuantong; Wang, Zhizhou; Cao, Wubo

An organic solvent free method for purifying and refining of a long-chain dicarboxylic acid or a salt thereof is disclosed. This method avoids problems caused by organic solvents which have been used in the purifying process of the prior art. This method reduces effectively the content of such impurities as proteins and coloring materials in the product. The purity of the crystallized long-chain dicarboxylic acid product is greater than 99 wt ...

PROCESS FOR PRODUCING ACETIC ACID

Application Number: 20130116470
Publication Date: 2013-05-09
Inventors: Miura, Hiroyuki; Ueno, Takashi; Yamaguchi, Kazuo; Goto, Kensuke; Shimizu, Masahiko

A production process of acetic acid comprises a reaction step for continuously allowing at least one member selected from the group consisting of methanol, dimethyl ether, and methyl acetate to react with carbon monoxide in a catalyst system comprising a rhodium catalyst, an iodide salt, and methyl iodide in the presence of acetic acid and water in a plant compromising a reactor 1; a flasher 2; and a distillation column 3; wherein part of the vaporized stream is introduced ...

PROCESS FOR PRODUCING N-ACYL AMINO ACIDS

Application Number: 20130116469
Publication Date: 2013-05-09
Inventor: Sumitomo Chemical Company, Limited,

An object of the present invention is to provide a process for producing an N-acyl amino acid (1) in a good yield. The present invention provides a process for producing an N-acyl amino acid (1) by reacting an aldehyde compound (2), an amide compound (3), and carbon monoxide in the solvent in a reactor in the presence of a cobalt compound and hydrogen, characterized in the aldehyde compound (2), the amide compound (3) and the solvent are supplied to the reactor in which the solvent, the cobalt ...

PROCESS FOR PRODUCING AMINOALKYLTHIOSULFURIC ACID COMPOUND

Application Number: 20130116468
Publication Date: 2013-05-09
Inventor: Ozturk, Orhan

An aminoalkylthiosulfuric acid compound represented by formula (1):

is produced. In step (A1), a hydrochloride of a chloroalkylamine compound represented by formula (2):

is reacted with an alkali metal salt of thiosulfuric acid in the presence of 2 to 6 parts by weight of water with respect to 1 part by weight of the hydrochloride between 50° C. and 100° C. R^{1 ...}

PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS

Application Number: 20130116437
Publication Date: 2013-05-09
Inventors: Chen, Xi; Dowdy, Eric; Pfeiffer, Steven

The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting ...

METHOD FOR PRODUCING BIOBASED CHEMICALS FROM PLANT BIOMASS

Application Number: 20130116424
Publication Date: 2013-05-09
Inventors: Wu, Jian; Peterson, John R.; Yost, Christopher M.

A method for utilizing biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from biomass for producing derivative products while minimizing waste ...

COMPOSITIONS AND METHODS FOR TREATING ANHIDROSIS

Application Number: 20130116325
Publication Date: 2013-05-09
Inventors: Herthel, Mark; Stratton-Phelps, Meri

Provided herein are compositions and methods useful for the treatment of anhidrosis in mammals, for example, ...

PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF INFLAMMATORY DISEASES OR IMMUNE DISEASES CONTAINING RAMALIN

Application Number: 20130116324
Publication Date: 2013-05-09
Inventors: Yim, Joung Han; Kim, Il Chan; Kim, Doc Kyu; Han, Se Jong; Lee, Hyoung Seok; Kim, Sung Jin; Kim, Tai Kyoung; Kang, Pil-Sung; Park, Heeyong; Park, Ha Ju; Pyo, Suhkneung; Lee, Sung Gu

The present invention relates to the novel use (anti-inflammatory activity) of Ramalin isolated from the Antarctic lichen Ramalina terebrata, and more specifically to a pharmaceutical composition containing Ramalin as an active ingredient. Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric ...

ALKENYL NAPHTHYLACETIC ACIDS

Application Number: 20130116322
Publication Date: 2013-05-09
Inventor: Hoffmann-La Roche Inc.,

The invention is concerned with the compounds of formula (I):

and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 ...

COMPOSITION CONTAINING SERINE AS AN ACTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF FATTY LIVER DISEASES, AND THE USE THEREOF

Application Number: 20130116321
Publication Date: 2013-05-09
Inventors: Lee, Byung-Hoon; Yin, Hu-Quan

The present invention is related to a composition comprising a serine as an active ingredient for treating or preventing fatty liver diseases. The inventive compound significantly inhibits the SREBP-1 transcription activity involved in lipid synthesis and reduced the fatty liver formation through various in vitro test and in vivo test therefore it can be useful in the prevention and treatment of the fatty liver diseases as a medicament or health functional ...

Novel Salts Of Boswellic Acids And Selectively Enriched Boswellic Acids And Processes For The Same

Application Number: 20130116211
Publication Date: 2013-05-09
Inventors: Somepalli, Venkateswarlu; Gokaraju, Rama Raju; Gokaraju, Ganga Raju; Golakoti, Trimurtulu; Gottumukkala, Venkata Subbaraju

New salts or ion-pair complexes obtained by a reaction between boswellic acids or selectively enriched 3-O-acetyl-11-keto-β-boswellic acid (AKBA) or 11-keto-β-boswellic acid (KBA) compounds obtained through a new improved process, and an organic amine, more particularly with glucosamine. These salts or ion pair complexes are useful in nutraceuticals and in food supplements for anti-inflammatory and analgesic treatment of joints and cancer prevention or cancer therapeutic agents. These salts ...

N-(AMINOACYL)-AMINO COMPOUND

Application Number: 20130116192
Publication Date: 2013-05-09
Inventor: Weth, Gosbert

N-(aminoacyl)-amino compound, represented by the following formula

Wherein R1 denotes hydrogen, low alkyl or carbonyl, and N1 denotes an NH group and
R2 denotes hydrogen or low alkylphenyl or aralkyl or imidazoalkyl or indolylalkyl,
R1 and R2 together may complete a pyrrolidine or piperidine or thiazolidine ring and
R3 denotes hydrogen or methyl or low alkyl and R4 denotes hydrogen or alkyl or the group remaining on ...

METHOD FOR PRODUCING BIOBASED CHEMICALS FROM CULTIVATED PLANT BIOMASS

Application Number: 20130115661
Publication Date: 2013-05-09
Inventors: Wu, Jian; Peterson, John R.; Yost, Christopher M.

A method for utilizing cultivated plant biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from cultivated plant biomass for producing derivative products while minimizing waste ...

METHOD FOR PRODUCING BIOBASED CHEMICALS FROM AGRICULTURAL BIOMASS

Application Number: 20130115654
Publication Date: 2013-05-09
Inventors: Wu, Jian; Peterson, John R.; Yost, Christopher M.

A method for utilizing agricultural biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from agricultural biomass for producing derivative products while minimizing waste ...

METHOD FOR PRODUCING BIOBASED CHEMICALS FROM WOODY BIOMASS

Application Number: 20130115653
Publication Date: 2013-05-09
Inventors: Wu, Jian; Peterson, John R.; Yost, Christopher M.

A method for utilizing woody biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from woody biomass for producing derivative products while minimizing waste ...

PROCESS FOR PREPARING DICARBOXYLIC ACIDS

Application Number: 20130109886
Publication Date: 2013-05-02
Inventors: Rousseau, Simon; Sarrazin, Flavie; Mastroianni, Sergio; Mignani, Gérard; Chouzier, Sandra

A process for preparing dicarboxylic acids is described. More particularly a process is described for preparing adipic acid (1,6-hexanedioic acid), by the action of nitric acid, starting from cyclic ketones or alcohols which are the corresponding compounds from the standpoint of the number of carbon atoms, in the presence of one or more oxides of nitrogen at a molar concentration in the reaction mixture of greater than 2.5 mmol per kg of reaction ...

POST PROTEIN HYDROLYSIS REMOVAL OF A POTENT RIBONUCLEASE INHIBITOR AND THE ENZYMATIC CAPTURE OF DNA

Application Number: 20130109885
Publication Date: 2013-05-02
Inventor: University of South Florida,

The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The present invention also concerns materials and methods for removing aurintricarboxylic acid (ATA) from a ...

PROCESS FOR PRODUCING ALPHA-KETOCARBOXYLIC ACID

Application Number: 20130109884
Publication Date: 2013-05-02
Inventor: Hagiya, Koji

The present invention relates to a process for producing an α-ketocarboxylic acid, comprising a step of oxidizing an α-ketoaldehyde by mixing a base, carbon dioxide, the α-ketoaldehyde and a compound represented by formula (2-1).

PHENYL-N-ACYL DERIVATIVES OF AMINES AND AMINO ACIDS, A PROCESS FOR THE PREPARATION THEREOF, A PHARMACEUTICAL COMPOSITION AND USE THEREOF

Application Number: 20130109880
Publication Date: 2013-05-02
Inventor: Obschestvo S Ogranichennoi Otvetstvennostiyu,

The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory properties and devoid of side effects in particular ulcerogeneity and pro-spasmodic actions, as well as capability to potentiate effect of other analgetics, and possessing in addition antihypoxic, antidepressant and anti-Parkinsonistic action; as well as to the processes for the preparation novel and ...

AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS

Application Number: 20130109866
Publication Date: 2013-05-02
Inventor: ALLERGAN, INC.,

The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) ...

PARTICLES, PARTICLE DISPERSION, PARTICLE-DISPERSED RESIN COMPOSITION, PRODUCING METHOD THEREFOR, RESIN MOLDED ARTICLE, PRODUCING METHOD THEREFOR, CATALYST PARTICLES, CATALYST SOLUTION, CATALYST COMPOSITION, CATALYST MOLDED ARTICLE, TITANIUM COMPLEX, TITANIUM OXIDE PARTICLES AND PRODUCING METHOD THEREFOR

Application Number: 20130109770
Publication Date: 2013-05-02
Inventors: Hatakeyama, Yoshiharu; Fukuoka, Takahiro; Nagatsuka, Tatsuki; Fukuzaki, Saori; Nagase, Junichi; Shibata, Shusaku

Organic-inorganic composite particles that can be dispersed in a solvent and/or a resin as primary particles having an organic group on the surface of inorganic particles, the organic-inorganic composite particles having negative ...

SPIRO COMPOUNDS AND PHARMACEUTICAL USE THEREOF

Application Number: 20130109710
Publication Date: 2013-05-02
Inventors: Ueno, Hiroshi; Tsutsumi, Kazuhiro; Manabe, Tomoyuki; Sasaki, Shin-Ya; Katoh, Susumu; Aoyagi, Kouichi; Shimada, Takashi

The spiro compound represented by the following general formula [Ia], its pharmaceutically acceptable salt or a solvate thereof

NEPRILYSIN INHIBITORS

Application Number: 20130109639
Publication Date: 2013-05-02
Inventors: FENSTER, Erik; GENDRON, Roland; FLEURY, Melissa; HUGHES, Adam D.

In one aspect, the invention relates to compounds having the formula:

where R¹-R⁶, a, b, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such ...

HERBICIDAL COMPOSITIONS AND METHODS OF USE

Application Number: 20130109572
Publication Date: 2013-05-02
Inventors: Tadeusz, Praczyk; Syguda, Anna; Janiszewska, Dominika; Daly, Daniel T.; Rogers, Robin D.; Gurau, Gabriela; Shamshina, Julia; Smiglak, Marcin; Pernak, Juliusz

Disclosed are compositions and methods of preparing compositions of active herbicidal ingredients. Also disclosed are methods of using the compositions described herein to improve herbicide delivery and efficacy, enhance herbicidal penetration, reduce herbicide volatility and drift, diminish environmental damage from herbicides, decrease water solubility and volatility of herbicides, and introduce additional biological function to ...

PREVENTION OF CRYSTAL FORMATION IN LIQUID SOLUTIONS DURING STORAGE BY ADDING A BETAINE

Application Number: 20130109025
Publication Date: 2013-05-02
Inventors: Offermans, Paul; Meijering, Bernadet; Sillekens, Peter; Stapert, Henk; Pierik, Anke

The present invention relates to the field of improving and stabilizing concentrated solutions and in particular to improving and stabilizing concentrated solutions for the extraction of nucleic acids from sample material. Thus, the present invention, further, relates to the field of molecular biology. The present invention describes the use of betaines for stabilizing organic salts or chaotropic agents in solution which is particularly useful in cases where organic salts or chaotropic agents ...

Inhibition of Microbial Growth by Aconitase Inhibition

Application Number: 20130108610
Publication Date: 2013-05-02
Inventors: SCHWARTZ, James Robert; Youngquist, Robert Scott; Xu, Jun; Saunders, Charles Winston

The present invention is directed to a method of inhibiting aconitase activity of fungal cells in an individual, the method comprising administering an inhibitor of aconitase activity to the fungal cell in an amount effective to inhibit activity of aconitase by said fungal ...

Chemical Treatments for the Disruption of Dental Plaque Biofilms and Related Methods

Application Number: 20130108560
Publication Date: 2013-05-02
Inventors: Davidson, Robert; Allen, Eric; Maliski, Ed

A thin film composition for oral administration that adheres to and dissolves in a mouth of a user, wherein the thin film is a single layered water-soluble solid comprising at least one D-amino acid contained in a plurality of hydrophobic carriers dispersed throughout the thin film. The hydrophobic carriers comprise oil and the composition further comprises a phospholipid, an emulsifier, and a water soluble polymer. The preferred D-amino acids are D-leucine, D-tryptophan, D-methionine, and ...

AMINOGUANIDINEPHENYLPHOSPHINATE FLAME RETARDANT COMPOSITIONS

Application Number: 20130105745
Publication Date: 2013-05-02
Inventors: Xalter, Rainer; Weiss, Thomas

The present invention relates to flame retardant polymer compositions which comprise aminoguanidine phenylphosphinates and mixtures with additional flame retardants. The compositions are especially useful for the manufacture of flame retardant compounds based on polyfunctional epoxides or polycondensates like polyesters, polyamides and ...

Methanol Carbonylation Process with Rhodium Catalyst and a Lanthanide Metal Co-Catalyst

Application Number: 20130102810
Publication Date: 2013-04-25
Inventor: CELANESE INTERNATIONAL CORPORATION,

A carbonylation process for making acetic acid using a metallic co-catalyst composition, effective as a rhodium stabilizer and/or rate promoter, at molar ratios of metal/rhodium of about 0.5 to 40. The process includes reacting methanol with carbon monoxide in the presence of a rhodium-based catalytic metal complex with about 1 to 20 weight percent methyl iodide, less than about 8 weight % water and about 0.5 to about 30 weight percent methyl acetate. The crude acetic acid is flashed and ...

Methanol Carbonylation Process with Rhodium Catalyst, an Iodide Salt and a Metallic Co-Catalyst Selected from Transition Metals, Indium, Strontium, Barium, Zinc, Tin and Heteropoly Acids

Application Number: 20130102809
Publication Date: 2013-04-25
Inventor: Celanese International Corporation,

A carbonylation process for making acetic acid uses a metallic co-catalyst composition effective as a rhodium stabilizer and rate promoter at molar ratios of metal/rhodium of from about 0.5 to 30. A preferred process includes: (a) reacting methanol with a carbon monoxide feedstock in a rhodium-based catalytic reaction mixture having: (i) a rhodium catalyst metal, (ii) methyl iodide maintained from about 1 to 20 weight percent, (iii) a lithium iodide co-catalyst, (iv) a metallic co-catalyst ...

METHOD FOR THE MANUFACTURE OF PHOSPHONOALKYL IMINODIACETIC ACID

Application Number: 20130102808
Publication Date: 2013-04-25
Inventors: Lemin, David; Pirard, Cedric Nicolas; Notté, Patrick

An improved method for the manufacture of phosphonoalkyl iminodiacetic acid M₂PO₃—X—N—(CH₂COOM)₂wherein X is a C_1-6linear or branched alkyl group; and M is selected from hydrogen, alkali, earth-alkali, ammonium and protonated amine is disclosed. The iminodiacetic acid starting material is reacted with a substantially stoichiometric amount of phosphorous acid, in the presence of a large excess of phosphoric acid to thereby yield a ...

SUBSTITUTED BIARYL ALKYL AMIDES

Application Number: 20130102649
Publication Date: 2013-04-25
Inventor: BioTheryX, Inc.,

Disclosed herein are substituted biaryl alkyl amide compounds, methods of synthesizing substituted biaryl alkyl amide compounds and methods of treating diseases and/or conditions with substituted biaryl alkyl amide ...

BIARYL OXYACETIC ACID COMPOUNDS

Application Number: 20130102609
Publication Date: 2013-04-25
Inventor: Ligand Pharmaceuticals Inc.,

The present invention provides biaryl oxyacetic acid compounds which may be useful for treating inflammatory disorders, including disorders affecting the respiratory system and skin. The compounds provided include those of the general formula I:

PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR DIABETES OR OBESITY

Application Number: 20130102570
Publication Date: 2013-04-25
Inventor: AJINOMOTO CO., INC,

A medicament having an excellent CaSR agonist action which enables the prevention or treatment of diabetes or obesity is provided by a composition comprising the compound represented by general formula (I) as defined, or a salt ...

COMPOSITIONS AND METHODS FOR DETECTING AMYLOID-BETA-DEGRADING ENZYME ACTIVITY

Application Number: 20130102498
Publication Date: 2013-04-25
Inventors: Wang, Steven Sheng-Shih; Hu, Chaur-Jong; CHEN, Po-Ting; Chen, Rita P.-Y.

Novel substrates for detection of activity of amyloid beta degrading enzyme, such as Neprilysin (NEP) and insulin degrading enzyme (IDE), associated with Alzheimer's disease, are provided. A quenched fluorogenic peptide substrate containing the first seven residues of the Aβpeptide plus a C-terminal Cys residue to detect neprilysin activity with a fluorophore attached to the C-terminal Cys and a quencher linked to the N-terminus of the peptide is disclosed. An assay system sensitive to ...