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PROCESS FOR PRODUCING PHTHALIC ACID COMPOUND INCLUDING CHLORINATED AROMATIC RING

Application Number: 20120035395
Publication Date: 2012-02-09
Inventors: Hagiya, Koji; Souda, Hiroshi

Provided is a process for producing a phthalic acid compound whose aromatic ring has been chlorinated, the process reacting a phthalic acid compound and chlorine in a mixture of chlorosulfonic acid and thionyl chloride in the presence of an iodine ...

PROCESS FOR THE RECOVERY OF BETAINES FROM ELECTRODIALYSIS WASTE STREAMS

Application Number: 20120035394
Publication Date: 2012-02-09
Inventors: Bicker, Markus; Caraucan Davila, Miguel Angel

The present invention discloses a process for the recovery of betaines from electrodialysis (ED) waste streams, whereby said waste streams are treated with a pressure driven membrane ...

METHOD FOR PRODUCING ALIPHATIC CARBOXYLIC ACIDS FROM ALDEHYDES BY MICROREACTION TECHNOLOGY

Application Number: 20120035393
Publication Date: 2012-02-09
Inventors: Weber, Tonia; Borgmeier, Oliver; Strutz, Heinz; Kreickmann, Thorsten; Kaufmann, Alexander; Utz, Diana; Klemm, Elias; Liebold, Claudia

A process for preparing aliphatic carboxylic acids having 3 to 10 carbon atoms by oxidizing the corresponding aldehydes with oxygen or oxygen-containing gases, characterized in that (i) the oxidation is performed in a microreactor at elevated pressure and with an oxygen excess based on the stoichiometrically required amount of oxygen, and (ii) in that the reaction mixture removed from the microreactor is passed through at least one postreactor without further addition of oxygen, and (iii) ...

TUBULAR FLOW TYPE REACTOR

Application Number: 20120035392
Publication Date: 2012-02-09
Inventors: Kobayashi, Eiichiro; Fukuzawa, Norihira

A tubular flow type reactor comprising: (1) inflow channels for respective inflow of at least two kinds of fluids to be used in a reaction, (2) an outer tube having a lumen that is capable of merging the fluids and of distributing the merged fluids for the reaction, (3) an outflow channel for outflow of a reaction product from the outer tube, and (4) an inner tube disposed in the lumen of the outer tube, wherein an annular flow channel is formed between the outer tube and the inner tube, and ...

Hydroxycarboxylic Acids and Salts

Application Number: 20120035356
Publication Date: 2012-02-09
Inventors: Hash, Kirk R.; Kiely, Donald E.; Kramer-Presta, Kylie; Smith, Tyler

Compositions which inhibit corrosion and alter the physical properties of concrete (admixtures) are prepared from salt mixtures of hydroxycarboxylic acids, carboxylic acids, and nitric acid. The salt mixtures are prepared by neutralizing acid product mixtures from the oxidation of polyols using nitric acid and oxygen as the oxidizing agents. Nitric acid is removed from the hydroxycarboxylic acids by evaporation and diffusion ...

Histone Deacetylase Inhibitors

Application Number: 20120035257
Publication Date: 2012-02-09
Inventors: Lan-Hargest, Hsuan-Yin; Kaufman, Robert J.; Wiech, Norbert L.

Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, and genetic related ...

OXADIAZOLE DERIVATIVES

Application Number: 20120035226
Publication Date: 2012-02-09
Inventors: Crosignani, Stefano; Sauer, Wolfgang; Quattropani, Anna; Montagne, Cyril; Bombrun, Agnés

The invention relates to oxadiazole compounds of formula I. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple ...

CARBOXYLIC ACID COMPOUND

Application Number: 20120035196
Publication Date: 2012-02-09
Inventors: Watanabe, Hideyuki; Ohnuki, Kei; Urano, Yasuharu; Kuramoto, Kazuyuki; Yonetoku, Yasuhiro; Negoro, Kenji

[Problem]

The present invention has an object to provide a compound having a GPR40 agonistic activity, which is useful as a pharmaceutical composition, an insulin secretion promoter, or an agent for preventing/treating diabetes.

[Means for Solution]

The present inventors have extensively studied a compound having a GPR40 agonistic activity, and as a result, they have found that the compound (I) of the ...

ANALOGS OF 3-O-ACETYL-11-KETO-BETA-BOSWELLIC ACID

Application Number: 20120035176
Publication Date: 2012-02-09
Inventors: Sengupta, Krishanu; Gokaraju, Rama Raju; Gokaraju, Ganga Raju; Golakoti, Trimurtulu; Gottumukkala, Venkata Subbaraju

Analogs of 3-O-acetyl-11-keto-beta-boswellic acid and their method of preparation are presented. The analogs may be used as anti-inflammatory and anti-cancer agents. The compounds inhibit 5-lipoxygenase enzyme and various cell lines related to inflammation as well as to cancer showing a significantly better efficacy when compared to the normal boswellic acids. The analogs are capable of controlling and treating various inflammatory diseases and ...

Novel salts as Anti-Inflammatory, Immunomodulatory and Anti-Proliferatory Agents

Application Number: 20120035175
Publication Date: 2012-02-09
Inventors: VITT, Daniel; AMMENDOLA, Aldo; DIEDERICHS, Julia; LEBAN, Johann

The present invention relates to a salt selected from the group comprising the N-methyl-D-glucamine salt (NMG), the diethylamine salt (DEA) salt, the magnesium salt, the tromethamine salt, the choline salt, the L-arginine salt, the zinc salt, and the 4-(2-hydroxyethyl)morpholine (HEM) salt of compounds of the general formula (I)

Modulators of Cellular Adhesion

Application Number: 20120035154
Publication Date: 2012-02-09
Inventors: ZHONG, Min; SHEN, Wang; OSLOB, Johan D.; BARR, Kenneth

The present invention provides compounds having formula (I):

and pharmaceutically acceptable derivatives thereof, wherein R₁-R₄, n, p, A, B, D, E, L and AR¹are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion ...

CARBAMOYLPHOSPHONATES AS INHIBITORS AND USES THEREOF

Application Number: 20120035140
Publication Date: 2012-02-09
Inventors: Breuer, Eli; Reich, Reuven; Hoffman, Amnon; Frant, Julia; Ainelly, Veerendhar

The present invention relates to novel metalloproteinase inhibitors having an aryloxybenzenesulfonamide moiety and a carbamoylphosphonic acid moiety, to pharmaceutical compositions comprising them, and to their uses in the prevention and/or treatment of disease or disorder associated with ...

GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAB RECEPTOR LIGANDS

Application Number: 20120035139
Publication Date: 2012-02-09
Inventors: Phan, Thu; Xu, Feng; Peng, Ge; Wustrow, David J.; Gallop, Mark A.; Dilip, Usha

Gamma-amino-butyric acid derivatives that are GABA_Breceptor ligands, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives and pharmaceutical compositions thereof for treating diseases are ...

METHODS TO RADIOLABEL NATURAL ORGANIC MATTER BY REDUCTION WITH HYDROGEN LABELED REDUCING AGENTS

Application Number: 20120034700
Publication Date: 2012-02-09
Inventors: Honeyman, Bruce D.; Tinnacher, Ruth M.

Methods to radiolabel natural organic matter by reduction with a hydrogen labeled reducing agent, and compositions, are ...

DIAMOND PARTICLES HAVING ORGANIC COMPOUNDS ATTACHED THERETO, COMPOSITIONS THEREOF, AND RELATED METHODS

Application Number: 20120034464
Publication Date: 2012-02-09
Inventors: Agrawal, Gaurav; DiGiovanni, Anthony A.; Chakraborty, Soma

A substance includes diamond particles having a maximum linear dimension of less than about 1 μm and an organic compound attached to surfaces of the diamond particles. The organic compound may include a surfactant or a polymer. A method of forming a substance includes exposing diamond particles to an organic compound, and exposing the diamond particles in the presence of the organic compound to ultrasonic energy. The diamond particles may have a maximum linear dimension of less than about 1 ...

USE OF PEPTIDES FOR IMPARTING KOKUMI

Application Number: 20120034364
Publication Date: 2012-02-09
Inventors: Miyamura, Naohiro; Sato, Seiichi; Yasuda, Reiko; FUTAKI, FUMIE; Miyaki, Takashi; Eto, Yuzuru

The inventors of this invention have conducted the search for a variety of compounds which may possess a desired CaSR agonist activity to thus find out a substance capable of imparting a kokumi, which shows a more excellent kokumi-imparting effect, in particular, a kokumi-imparting effect of the initial taste-imparting type one, which is excellent in the stability and which can easily be produced at a low cost and the present invention thus provide a kokumi-imparting agent consisting of such a ...

METHOD FOR ADSORBING FLUOROCARBOXYLIC ACID HAVING ETHER BOND AND METHOD FOR COLLECTING SAME

Application Number: 20120029232
Publication Date: 2012-02-02
Inventors: Kuramitsu, Masaki; Ichiba, Takuya

Disclosed are an adsorption process whereby a fluorocarboxylic acid having an ether bond can be adsorbed to a high extent by using active carbon without changing the form thereof, and a desorption process whereby the adsorbed material can be desorbed from the active carbon to thereby enable the reuse of the active carbon and the adsorbed material. In the aforesaid processes, a solution containing a fluorocarboxylic acid having an ether bond is contacted with active carbon and thus the active ...

METHODS FOR REMOVING VICINAL DIOLS FROM LACTIC ACID FERMENTATION BROTH

Application Number: 20120029231
Publication Date: 2012-02-02
Inventors: Evans, Chana W.; Revis, Anthony; Hand, James H.; Fogg, Ralph B.

Embodiments of a method for removing vicinal diols from a lactic acid fermentation broth comprise the steps of contacting the lactic acid fermentation broth with functionalized silica comprising at least one hydrophobic ligand to facilitate binding of the vicinal diols to the hydrophobic ligand, and separating the contacted lactic acid fermentation broth from the functionalized silica to remove the vicinal ...

METHOD FOR PREPARING CHIRAL BACLOFEN

Application Number: 20120029230
Publication Date: 2012-02-02
Inventors: Kuo, Jen-Huang; Wong, Wei-chyun

The present invention provides a novel method for preparing chiral Baclofen with higher yield, higher e.e. value, and lower cost via chiral Michael ...

CHEMICAL RECYCLING OF PLA BY ALCOHOLYSIS

Application Number: 20120029228
Publication Date: 2012-02-02
Inventors: Bogaert, Jean-Christophe; Coszach, Philippe; Willocq, Jonathan

A process for recycling a polymer blend necessarily containing PLA, comprising grinding, compacting, dissolving in a solvent of PLA, removing the undissolved contamining polymers, alcoholysis depolymerisation reaction and purification ...

METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES

Application Number: 20120029226
Publication Date: 2012-02-02
Inventors: Kaptein, Bernardus; Vlieg, Elias; Noorduin, Willem Lieuwe

The present invention provides a method for the synthesis of optically pure α-aryl propionic acid derivatives comprising subjecting the corresponding racemic α-aryl propionic acid derivatives to high sheer or impact forces, such as ...

Substituted Aniline Derivatives

Application Number: 20120029188
Publication Date: 2012-02-02
Inventors: Carr, Andrew David; Neuss, Judi Charlotte; Orchard, Michael Glen; Porter, David William

The present invention relates to novel aniline derivatives and their use in therapy, in particular their use in the treatment of fungal ...

AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND

Application Number: 20120029167
Publication Date: 2012-02-02
Inventors: Eguchi, Haruki; ISHIKAWA, Yoshihiro

A drug using the magnetic properties of a metal salen complex as represented by the following general formula in order to magnetize the intended drug by chemically binding the drug to a metal salen complex so that the drug can be delivered to the target diseased site. The drug can be delivered to the diseased site using the magnetic properties of the drug per se without using a carrier made of a magnetic substance as in the conventional methods.

PROTON CONDUCTING MATERIALS

Application Number: 20120029098
Publication Date: 2012-02-02
Inventors: Schaberg, Mark S.; Hamrock, Steven J.; Sharma, Neeraj; Abulu, John E.

Materials are provided that may be useful as ionomers or polymer ionomers, including compounds including bis sulfonyl imide groups which may be highly fluorinated and may be ...

Novel calcium salts of Compound as Anti-Inflammatory, Immunomodulatory and Anti-Proliferatory Agents

Application Number: 20120029034
Publication Date: 2012-02-02
Inventors: VITT, Daniel; AMMENDOLA, Aldo; DIEDERICHS, Julia; LEBAN, Johann

The present invention relates to calcium salts of compounds of the general formula (I)

- wherein
- X is selected from the group consisting of CH₂, S, or O;
- D is O or S;

COMBINATIONAL THERAPY FOR TREATING AUTOIMMUNE DISEASE

Application Number: 20120028985
Publication Date: 2012-02-02
Inventors: Gröppel, Manfred; Leban, Johann

The present invention relates to the treatment and prevention of immunological and inflammatory disorders with a compound of formula (I) in combination with methotrexate,

Subunit Selective NMDA Receptor Potentiators For The Treatment Of Neurological Conditions

Application Number: 20120028977
Publication Date: 2012-02-02
Inventors: Traynelis, Stephen F.; Liotta, Dennis C.; Santangelo, Rose M.; Garnier, Ethel C.

Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive disorders, depression, neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds of the general Formulas A-J, and pharmaceutically acceptable salts, esters, prodrugs or derivatives thereof are ...

Inhibitors Of The Influenza A Virus M2 Proton Channel

Application Number: 20120028957
Publication Date: 2012-02-02
Inventors: Wang, Jun; DeGrado, William F.

Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 ...

Novel Triazene Compounds For The Treatment Of Cancer

Application Number: 20120028927
Publication Date: 2012-02-02
Inventors: Forster, Heinz; Kalbe, Jochen; Reiter, Rudolf

The present invention relates to novel triazene compounds, to a process for their preparation, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans. The novel triazene compounds are distinguished, as compared with the known triazene compounds, by improved activity while at the same time having reduced toxicity, that is to say by fewer ...

Phosphate Management with Small Molecules

Application Number: 20120028926
Publication Date: 2012-02-02
Inventors: Saha, Uttam; Petkovich, P. Martin; Helvig, Christian F.

This invention relates to methods and small molecules having a phosphate group that can be used to inhibit phosphate transport and to treat or prevent diseases that are related to disorders in the maintenance of normal serum phosphate ...

PEPTIDES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND USES THEREOF

Application Number: 20120028894
Publication Date: 2012-02-02
Inventors: Frenkel, Dan; Kopelevich, Adi; Lifshitz, Veronica; Benromano, Tali; Borenstein, Nofit

Use of an isolated peptide comprising an amino acid sequence being no more than 25 amino acids in length, the amino acid sequence comprising at least one aspartate or a homolog thereof, the peptide having an Insulin-Degrading Enzyme (IDE) inhibitory activity, for the manufacture of a medicament identified for treating a disease selected from the group consisting of diabetes, obesity, hyperglycemia, retinal damage, renal failure, nerve damage, microvascular damage and varicella-zoster virus ...

TRAPPING COMPOUNDS AND METHOD FOR IDENTIFYING REACTIVE METABOLITES

Application Number: 20120028284
Publication Date: 2012-02-02
Inventors: Shinkyo, Raku; Ishida, Tomomi

A compound of formula (I) is useful to identify reactive metabolites.

[X is CH₂, and p, q and r are each independently 0 or 1 with a proviso that the compound wherein p is 0, q is 0 and r is 1 is ...

Cinnamic Acid-Based Oligomers and Uses Thereof

Application Number: 20120027691
Publication Date: 2012-02-02
Inventors: Spiess, Bruce D.; Desai, Umesh R.; Henry, Brian L.; Liang, Aiye; Thakkar, Jay; Mangrum, John B.; Filho, Ivo Torres; Sakagami, Masahiro; Saluja, Bhawana

Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. β-O4 and β-5 trimers and tetramers) are used as ...

Compositions and methods for detecting and treating tumors containing acidic areas

Application Number: 20120022371
Publication Date: 2012-01-26
Inventor: Summerton, James Edward

Improved compounds have been developed which are structured to be sequestered with very high specificity in acidic areas of tissues. When the compounds contain a radioisotope effective to report the presence of the compound the compounds are for detecting tumors containing hypoxic/acidic areas. When the compounds contain radioisotopes effective to kill cells the compounds are for treating tumors containing hypoxic/acidic areas. Methods for detecting and treating tumors with such compounds are ...

CATALYST FOR PRODUCTION OF ACROLEIN AND ACRYLIC ACID BY MEANS OF DEHYDRATION REACTION OF GLYCERIN, AND PROCESS FOR PRODUCING SAME

Application Number: 20120022291
Publication Date: 2012-01-26
Inventors: Magatani, Yasuhiro; Okumura, Kimito; Dubois, Jean Luc

A process for converting glycerin into valuable chemical raw material. A catalyst for use in the production of acrolein and acrylic acid by a dehydration reaction of glycerin, which enables the production of acrolein and acrylic acid in high yield. Glycerin dehydration catalyst which mainly comprises a phosphorus-vanadium complex oxide that contains phosphorus and vanadium as the essential constituent ...

Process for Preparing Formic Acid by Reaction of Carbon Dioxide with Hydrogen

Application Number: 20120022290
Publication Date: 2012-01-26
Inventors: Paciello, Rocco; Schäfer, Martin; Schaub, Thomas; Fries, Donata Maria; Rittinger, Stefan; Mohl, Klaus-Dieter; Schneider, Daniel

A process for preparing formic acid by reaction of carbon dioxide (1) with hydrogen (2) in a hydrogenation reactor (I) in the presence of

- a catalyst comprising an element of group 8, 9 or 10 of the Periodic Table,
- a tertiary amine comprising at least 12 carbon atoms per molecule and

Controlling decanter phase separation of acetic acid production process

Application Number: 20120022289
Publication Date: 2012-01-26
Inventors: Hallinan, Noel; Fitzpatrick, Michael E.; Hearn, John D.; Patel, Miraj S.

Disclosed is a method for controlling the decanter phase separation of an acetic acid production by methanol carbonylation. The method comprises measuring the methyl acetate concentration of the reactor mixture, calculating the density of the decanter heavy, organic phase according to the measured methyl acetate concentration, and adjusting the conditions in the reactor or in the decanter to ensure phase separation of the ...

PROCESS FOR THE PRODUCTION OF CARNITINE FROM BETA-LACTONES

Application Number: 20120022288
Publication Date: 2012-01-26
Inventors: Hanselmann, Paul; Klegraf, Ellen

The invention relates to a method for the production of L-carnitine, wherein a β-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into carnitine with trimethylamine (TMA), wherein the β-lactone is not subjected to a basic hydrolysis step before being contacted with the trimethylamine. The invention also relates to a carnitine having a unique impurity ...

Spray Process for Selective Oxidation

Application Number: 20120022287
Publication Date: 2012-01-26
Inventors: Busch, Daryle H.; Subramaniam, Bala; Niu, Fenghul

Oxidation process can include: introducing small droplets of liquid reaction mixture having oxidizable reactant, catalyst, and solvent into a reaction zone containing oxygen and diluent gas; and oxidizing the reactant with the oxygen at a suitable reaction temperature and a suitable reaction pressure to produce an oxidized product. The liquid reaction mixture can have an aromatic feedstock having an oxidizable substituent as the oxidizable reactant. The oxidized product can include an aromatic ...

METHODS FOR MAKING VALERENIC ACID DERIVATIVES AND THEIR USE

Application Number: 20120022283
Publication Date: 2012-01-26
Inventors: Hering, Steffen; Mulzer, Johann; Ramharter, Jürgen; Khom, Sophia

The present invention is directed to compounds, intermediates and methods for making valerenic acid and its derivatives as well as the use of such compounds as GABA_Areceptor ...

PROCESS FOR THE PREPARATION OF 2,4,6-OCTATRIENE-1-OIC ACID AND 2,4,6-OCTATRIENE-1-OL

Application Number: 20120022282
Publication Date: 2012-01-26
Inventors: Giuliani, Giammaria; Benedusi, Anna; Milanese, Aberto

The present invention concerns a process for synthesis of 2,4,6-octatriene-1-oic acid and 2,4,6-octatriene-1-ol, which comprises the following stages:

- a) reaction between 2,4-trans-hexadienal and triethyl phosphonoacetate to give ethyl 2,4,6-trans-octatrienoate;
- b) alkaline hydrolysis of ethyl ...

PROCESS FOR THE PRODUCTION OF CARNITINE BY CYCLOADDITION

Application Number: 20120022275
Publication Date: 2012-01-26
Inventors: Hanselmann, Paul; Quittmann, Wilhelm; Klegraf, Ellen; Elzner, Stephan; Fischer, Daniel Friedrich

The invention relates to a method for the production of L-carnitine, wherein a chiral β-lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X—CH₂—CHO, wherein X is selected from Cl, Br, I and trimethylamine, in the presence of a chiral ...

PURIFICATION OF AMPHOTERIC PRODUCTS, OR OF PRODUCTS LIABLE TO BE CONVERTED INTO AMPHOTERIC PRODUCTS

Application Number: 20120022228
Publication Date: 2012-01-26
Inventors: GIRAUD, Matthieu; MCGARRITY, John; RENAULT, Jean-Hugues; BOUDESOCQUE, Leslie

A process for purifying at least one product from a substrate containing at least one product, includes subjecting the substrate to centrifugal partition chromatography in an ion exchange displacement mode to purify the at least one product from the substrate, the at least one product being an amphoteric ...

Mixed Amino Acid/Mineral Compounds Having Improved Solubility

Application Number: 20120022162
Publication Date: 2012-01-26
Inventors: Ericson, Clayton; Ashmead, Stephen; Thompson, R. Charles; Bortz, Jonathan

Mixed amino acid/mineral compounds can include at least two amino acids bound to a central mineral atom. The combination of amino acids can be tailored to provide improved solubility, absorption, and/or bioavailability of the mineral. Optionally, organic acids can be bound to the mineral or combined with the chelate in order to further improve solubility, absorption, and/or bioavailability. Compositions including one or more mixed amino acid/mineral compounds can be included in therapeutic ...

N-HYDROXY C29-AMIDE DERIVATIVES OF OLEANDRANE

Application Number: 20120022154
Publication Date: 2012-01-26
Inventors: Czollner, Laszlo; Jordis, Ulrich; Classenhouben, Dirk; Kueenburg, Bernhard; Kosma, Paul; Stanetty, Christian

The present invention encompasses novel triterpene compounds of general formula I, wherein R^3a, R^3b, R^11a, R^11b, R³¹and R³²are defined as in claim 1, which are suitable for the prevention and/or treatment of diseases mediated by 11 β-HSD and the use thereof for preparing a medicament having the above-mentioned properties.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX

Application Number: 20120022116
Publication Date: 2012-01-26
Inventors: Sun, Haiyan; Niu, Weijun; Fang, Ye; He, Mingqian; Deng, Huayun; Hu, Haibei

Disclosed are compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically related to GPR35, and/or GPR35-hERG signaling complex. For example, disclosed are compounds for preventing and/or treating diseases which are pathophysiologically related to GPR35 in a subject. The compounds having a formula (I), (II) or (III):

Plasminogen Activator Inhibitor-1 Inhibitor

Application Number: 20120022080
Publication Date: 2012-01-26
Inventors: Miyata, Toshio; Murano, Kenji; Yamaoka, Nagahisa; Maeda, Akihisa

The present invention provides a novel compound having plasminogen activator inhibitor-1 inhibitory activity, and an inhibitor of PAI-1 comprising the compound as an active ingredient. The present invention also provides a pharmaceutical composition having an inhibitory action on PAI-1 activity and being efficacious in the prevention and treatment of various diseases whose onset is associated with PAI-1 ...

ANTI-BACTERIAL COMPOSITIONS AND METHODS INCLUDING TARGETING VIRULENCE FACTORS OF STAPHYLOCOCCUS AUREUS

Application Number: 20120022024
Publication Date: 2012-01-26
Inventors: Oldfield, Eric; Song, Yongcheng

This disclosure relates to compositions and methods including for the inhibition, prevention, and/or treatment of microbial infections, including infections from such pathogens as Staphylococcus aureus. ...

(4-HALOALKYL-3-THIOBENZOYL)CYCLOHEXANEDIONES AND USE THEREOF AS HERBICIDES

Application Number: 20120021904
Publication Date: 2012-01-26
Inventors: AHRENS, Hartmut; FEUCHT, Dieter; ROSINGER, Christopher Hugh; GATZWEILER, Elmar; HAUSER-HAHN, Isolde
A description is given of (4-haloalkyl-3-thiobenzoyl)cyclohexanediones of the formula (I) and of their use as herbicides.

In this formula (I), X, Y, R¹, R², R³, and R⁴are radicals such as hydrogen and organic radicals such as alkyl. A and Z are oxygen or ...

4-(4-HALOALKYL-3-THIOBENZOYL)PYRAZOLES AND USE THEREOF AS HERBICIDES

Application Number: 20120021903
Publication Date: 2012-01-26
Inventors: AHRENS, HARTMUT; GATZWEILER, ELMAR; HÄEUSER-HAHN, ISOLDE; ROSINGER, CHRISTOPHER HUGH
A description is given of 4-(4-haloalkyl-3-thiobenzoyl)pyrazoles of the formula (I) and of their use as herbicides.

In this formula (I), X, Y, R¹, R², R³, and R⁴are radicals such as hydrogen and organic radicals such as ...