patentstorm.us 258 85 http://www.patentstorm.us/ http://www.patentstorm.us/images/logo.gif PatentStorm -> Applications -> Organic compounds -- part of the class 532-570 series http://www.patentstorm.us/rss/class/applications/rss-546.xml Recent patent applications filings in USPTO Class 546 Organic compounds -- part of the class 532-570 series. Thu, 9 Feb 2012 15:00:28 patents@patentstorm.us en <![CDATA[BI- AND TRICYCLIC INDAZOLE-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND USES THEREOF]]> http://www.patentstorm.us/applications/20120035409/description.html
  • Application Number:  20120035409
  • Publication Date:  2012-02-09
  • Inventors:  Lobell, Mario; Yuan, Shendong; Follmann, Markus; Michels, Martin; Teusch, Nicole; Zimmermann, Katja; Vakalopoulos, Alexandros
    • This invention relates to novel bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative ...
    ]]>     20120035409     <![CDATA[ METHOD FOR PRODUCING 2-HALOGENO-6-SUBSTITUTED-4-TRIFLUOROMETHYLPYRIDINE]]> http://www.patentstorm.us/applications/20120035372/description.html
  • Application Number:  20120035372
  • Publication Date:  2012-02-09
  • Inventor:  IKEGUCHI, Masahiko
    • The present invention relates to a process of a process for producing a 2-halogeno-6-substituted-4-trifluoromethylpyridine. Specifically, the present invention provides a process for producing a 2-halogeno-6-substituted-4-trifluoromethylpyridine represented by the formula (I):

      • in which X is a chlorine atom, a ...
        ]]> 20120035372 <![CDATA[PROCESS FOR THE MANUFACTURE OF NON-STEROIDAL ANTI-INFLAMMATORY AGENTS AND INTERMEDIATES THEREOF]]> http://www.patentstorm.us/applications/20120035371/description.html
      • Application Number:  20120035371
      • Publication Date:  2012-02-09
      • Inventor:  SCHWEIZER, Steffen
      The current invention describes novel chiral synthetic routes and intermediates for the manufacture of chiral anti-inflammatory agents of general formula VIII

      in which at least one of the groups X1, X2, X3 is selected from

      • fluoro, chloro, bromo, hydroxy, methoxy, ethoxy, trifluoromethyl, amino
      • ]]> 20120035371 <![CDATA[Azaindazole Compounds As CCR1 Receptor Antagonists]]> http://www.patentstorm.us/applications/20120035370/description.html
      • Application Number:  20120035370
      • Publication Date:  2012-02-09
      • Inventors:  NEU, Jochen; RAUDENBUSH, Brian Christopher; COOK, Brian Nicholas; DiSALVO, Darren; SWINAMER, Alan David; KUZMICH, Daniel; TAN, Zhulin; SONG, Jinhua J.; RAZAVI, Hossein; FANDRICK, Daniel Robert; HARCKEN, Christian; LEE, Thomas Wai-Ho; LIU, Pingrong; LORD, John; MAO, Can; REEVES, Jonathan Timothy
      Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.

      Also disclosed are intermediates thereof, and methods of making and methods of using ...
      ]]> 20120035370 <![CDATA[METHOD FOR PRODUCING OPTICALLY ACTIVE DIAMINE DERIVATIVE]]> http://www.patentstorm.us/applications/20120035369/description.html

    • Application Number:  20120035369
    • Publication Date:  2012-02-09
    • Inventor:  Kawanami, Koutarou
    The problem to be solved is to provide an important intermediate for production of an FXa inhibitor. The solution thereto is a method for industrially producing a compound (1) or a compound (4), comprising: [Step 1]: adding a quaternary ammonium salt and a metal azide salt to water to prepare an aqueous solution of an azidification reagent complex comprising quaternary ammonium salt-metal azide salt, and subsequently dehydrating the aqueous solution using an aromatic hydrocarbon solvent to form ...
    ]]>     20120035369     <![CDATA[PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES]]> http://www.patentstorm.us/applications/20120035368/description.html
  • Application Number:  20120035368
  • Publication Date:  2012-02-09
  • Inventors:  Abrecht, Stefan; Adam, Jean-Michel; Fettes, Alec
    • The present invention relates to a novel process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula

    wherein R2, R3 and R4 are each independently selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy and lower alkenyl, wherein lower alkyl, lower alkoxy and lower alkenyl may optionally be substituted by a group consisting of lower ...
    ]]> 20120035368 <![CDATA[Tandem Process for Preparing N-Alkyl Morphinans]]> http://www.patentstorm.us/applications/20120035367/description.html

  • Application Number:  20120035367
  • Publication Date:  2012-02-09
  • Inventors:  Miller, Douglas C.; Berberich, David W.; Liao, Subo; Wang, Peter X.
    • The present invention provides processes for the preparation of N-alkyl morphinans without the isolation of nor-morphinan intermediates. In particular, the invention provides tandem hydrolysis/alkylation reactions for the synthesis of N-alkyl ...
    ]]>     20120035367     <![CDATA[N-Demethylation of 6-Keto Morphinans]]> http://www.patentstorm.us/applications/20120035366/description.html
  • Application Number:  20120035366
  • Publication Date:  2012-02-09
  • Inventors:  Berberich, David W.; Jiang, Tao; Liao, Subo; Wang, Peter X.
    • The present invention provides processes for the demethylation of an N-methyl morphinan comprising a ketone functional group. In particular, the invention provides methods for the protection of the ketone functional group such that impurities are not generated during the demethylation of the N-methyl ...
    ]]>     20120035366     <![CDATA[Method for Manufacturing Porous Materials from Waste PET Bottle]]> http://www.patentstorm.us/applications/20120035365/description.html
  • Application Number:  20120035365
  • Publication Date:  2012-02-09
  • Inventors:  Wang, Sue-Lein; Huang, Yu-Ting
    • A method for manufacturing porous material from waste PET bottle, the method comprising: providing transition metal or d10 metal source, amine source, polyethylene terephthalate (PET) source, phosphate derivative source, and water to be reacted in a closed container under temperature between 120 to 200° C., and pressure between 1 to 100 atm for between 48 to 168 hours, for forming a reaction mixture; and precipitating the porous material from the reaction mixture. The method of the ...
    ]]>     20120035365     <![CDATA[SELECTIVE INHIBITORS OF EXCITATORY AMINO ACID TRANSPORTER SUBTYPE 1 (EAAT1/GLAST)]]> http://www.patentstorm.us/applications/20120035361/description.html
  • Application Number:  20120035361
  • Publication Date:  2012-02-09
  • Inventors:  Bunch, Lennart; Jensen, Anders Asbjørn
    • The invention is the discovery of the use of the class of compounds represented by Formula I, as selective inhibitors of excitatory amino acid transporter (EAAT) subtype 1 (EAAT1) and its rodent ortholog L-glutamate/L-aspartate transporter (GLAST) for the study of function and distribution of EAAT1/GLAST in the central nervous system and studies of the physiological and pathological functions of the EAAT1/GLAST subtype in native tissues, cultured neurons, and/or animal models for CNS ...
    ]]>     20120035361     <![CDATA[Volatile Imidazoles and Group 2 Imidazole Based Metal Precursors]]> http://www.patentstorm.us/applications/20120035351/description.html
  • Application Number:  20120035351
  • Publication Date:  2012-02-09
  • Inventors:  Kim, Moo-Sung; Norman, John Anthony Thomas; Perez, Melanie K.
    • Sterically hindered imidazole ligands are described, along with their synthesis, which are capable of coordinating to Group 2 metals, such as: calcium, magnesium, strontium, in an eta-5 coordination mode which permits the formation of monomeric or dimeric volatile complexes.

    A compound comprising one or more polysubstituted imidazolate anions coordinated to a metal selected from the group consisting of barium, strontium, magnesium, radium or calcium or mixtures ...
    ]]> 20120035351 <![CDATA[Betulin derived compounds as anti-feedants for plant pests]]> http://www.patentstorm.us/applications/20120035224/description.html

  • Application Number:  20120035224
  • Publication Date:  2012-02-09
  • Inventors:  Yli-Kauhaluoma, Jari; Bergström, Pia; Alakurtti, Sami; Mäkelä, Taru; Koskimies, Salem; Hokkanen, Heikki; Menzler-Hokkanen, Ingeborg
    • The invention relates to compounds derived from betulin, and to the use thereof in plant pest control, particularly as antifeedants for butterfly larvae, beetles and snails. Further, the invention relates to novel betulin derivatives and methods for the production thereof either directly from betulin, or via intermediates derived ...
    ]]>     20120035224     <![CDATA[Solid forms of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine]]> http://www.patentstorm.us/applications/20120035222/description.html
  • Application Number:  20120035222
  • Publication Date:  2012-02-09
  • Inventors:  Moog, Regina; Meier, Roland; Rohrer, Franziska E.; Cleary, Thomas; Kuang, Shan-Ming; Glomme, Alexander; Miller, Doreen; Yang, Jason; Grassmann, Olaf
    • The present invention relates to mono-sulfate and hemi-sulfate salts of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine, to crystalline and amorphous forms thereof and to their use in pharmaceutical ...
    ]]>     20120035222     <![CDATA[Compound for the Treatment of Tuberculosis]]> http://www.patentstorm.us/applications/20120035219/description.html
  • Application Number:  20120035219
  • Publication Date:  2012-02-09
  • Inventors:  Das, Kaveri; Melnick, David Alan; Radha, Shandil
    • (5R)-3-[4-[1-[(2S)-2,3-dihydroxypropanoyl]-3,6-dihydro-2H-pyridin-4-yl]-3,5-difluoro-phenyl]-5-(isoxazol-3-yloxymethyl)oxazolidin-2-one, or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, for use in the treatment of Mycobacterium tuberculosis. ...
    ]]>     20120035219     <![CDATA[Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors]]> http://www.patentstorm.us/applications/20120035217/description.html
  • Application Number:  20120035217
  • Publication Date:  2012-02-09
  • Inventors:  Nilsson, Peter; Pelcman, Benjamin; Katkevics, Martins; Suna, Edgars; Popovs, Ilya
    • There is provided compounds of formula I,

    wherein Y, ring A, D1, D2a, D2b, D3, L1, Y1, L2 and Y2 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the ...
    ]]> 20120035217 <![CDATA[RENIN INHIBITORS]]> http://www.patentstorm.us/applications/20120035214/description.html

  • Application Number:  20120035214
  • Publication Date:  2012-02-09
  • Inventors:  Han, Yongxin; Mellon, Christophe; Laliberte, Sebastien; Lacombe, Patrick; MacDonald, Dwight; Gallant, Michel; Simard, Daniel; Aspiotis, Renee; McKay, Daniel J.; Arbour, Melissa; Chen, Austin; Fournier, Pierre-Andre; Juteau, Helene; Lauzon, Sophie; Molinaro, Carmela; O'Shea, Paul; Ramtohul, Yeeman; Mackay, Bruce; Morley, Krista; Tsui, Chit; Dolman, Sarah Jennifer; Hughes, Greg; Janey, Jacob
    • The present invention relates to biaryl piperidine-based renin inhibitor compounds, and their use in treating cardiovascular events and renal ...
    ]]>     20120035214     <![CDATA[Quinoline derivative]]> http://www.patentstorm.us/applications/20120035213/description.html
  • Application Number:  20120035213
  • Publication Date:  2012-02-09
  • Inventors:  Murata, Toshiki; Kamaura, Masahiro
    • The present invention provides a compound having a melanin-concentrating hormone receptor antagonistic action and low toxicity, which is useful as an agent for the prophylaxis or treatment of obesity and the like.

    The present invention relates to a compound represented by the formula (I):

    wherein each symbol is as defined in the specification, or a salt ...
    ]]> 20120035213 <![CDATA[(L)-Malate salt of N-(4-phenyl)-N"-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide]]> http://www.patentstorm.us/applications/20120035212/description.html

  • Application Number:  20120035212
  • Publication Date:  2012-02-09
  • Inventors:  Lamb, Peter; Brown, Adrian St. Clair; Gallagher, William P.
    • Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, including a (L)-malate salt, a (D)-malate salt, a (DL) malate salt, and mixtures thereof; and crystalline and amorphous forms of the malate salts. Also disclosed are pharmaceutical compositions comprising at least one malate salts of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)-cyclopropane-1,1-dicarboxamide; and methods ...
    ]]>     20120035212     <![CDATA[NOVEL POLYMORPHS OF SAQUINAVIR]]> http://www.patentstorm.us/applications/20120035211/description.html
  • Application Number:  20120035211
  • Publication Date:  2012-02-09
  • Inventors:  Parthasaradhi Reddy, Bandi; Subash Chander Reddy, Kesireddy; Rathnakar Reddy, Kura; Raji Reddy, Rapolu; Muralidhara reddy, Dasari; Srinivasa Reddy, Bhimireddy
    • The present invention provides novel polymorphs of saquinavir, processes for their preparation and pharmaceutical compositions comprising them. The present invention also provides a process for purification of saquinavir. The present invention further provides a novel process for preparation of known saquinavir crystalline form ...
    ]]>     20120035211     <![CDATA[2,3-DIHYDROBENZO(1,4) DIOXIN-2-YLMETHYL DERIVATIVES AS ALPHA2C ANTAGONISTS FOR USE IN THE TREATMENT OF PERIPHERIC AND CENTRAL NERVOUS SYSTEME DISEASES]]> http://www.patentstorm.us/applications/20120035210/description.html
  • Application Number:  20120035210
  • Publication Date:  2012-02-09
  • Inventors:  Din Belle, David; Tolvanen, Arto; Wohlfahrt, Gerd; Holm, Patrik; Karljalainen, Arto; Rummakko, Petteri
    • Compounds of formula I

      • wherein X, Z, R1-R4, and m are as defined in the claims, exhibit alpha2C antagonistic activity, and are thus useful as alpha2C antagonists. Methods for the treatment of diseases and conditions of the peripheric system and the central nervous system are also ...
        ]]> 20120035210 <![CDATA[Hydroxy Substituted 1H-Imidazopyridines and Methods]]> http://www.patentstorm.us/applications/20120035209/description.html
      • Application Number:  20120035209
      • Publication Date:  2012-02-09
      • Inventors:  Moser, William H.; Dellaria, JR., Joseph F.; Radmer, Matthew R.; Griesgraber, George W.
      Hydroxy substituted 1H-imidazo[4,5-c]pyridin-4-amines, with a hydroxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are ...
      ]]> 20120035209 <![CDATA[PYRAZOLOPYRIDINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE]]> http://www.patentstorm.us/applications/20120035208/description.html
    • Application Number:  20120035208
    • Publication Date:  2012-02-09
    • Inventors:  Zhu, Bing-Yan; Wan, Nan Chi; Sutherlin, Daniel P.; Dotson, Jennafer; Wang, Shumei; Olivero, Alan G.; Heffron, Timothy; Staben, Steven; Chuckowree, Irina S.; Folkes, Adrian J.
    Compounds of Formula (I), and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer or inflammation mediated by lipid kinases. Methods of using compounds of Formula (I) for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated ...
    ]]>     20120035208     <![CDATA[PREPARATION AND APPLICATION OF NOVEL ANTIBACTERIAL AND ANTICANCER COMPOUNDS AND THEIR DERIVATIVES]]> http://www.patentstorm.us/applications/20120035206/description.html
  • Application Number:  20120035206
  • Publication Date:  2012-02-09
  • Inventors:  Yang, Chunliu; Yang, Gengliang; Ma, Zhengyue; Tian, Wei; Fang, Baoling; Wang, Ge; Li, Linbo; Bai, Ligai
    • Novel antibiotic and anticancer compounds of formula I, II, III, IV, derivatives, ostereoisomer, racemic and noracemic mixture of ostereoisomer, or the pharmaceutically acceptable salts or solvates of these compounds are disclosed. The preparation, pharmaceutical composition and biological activity of these compounds are disclosed.

    ]]> 20120035206 <![CDATA[SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES USED AS PESTICIDES]]> http://www.patentstorm.us/applications/20120035201/description.html

  • Application Number:  20120035201
  • Publication Date:  2012-02-09
  • Inventors:  Muehlebach, Michel; Hueter, Ottmar Franz
    • Compounds of the formula (I) wherein the substituents are as defined in claim 1 are useful as pesticides.

    ]]> 20120035201 <![CDATA[GRISEOFULVIN ANALOGUES FOR THE TREATMENT OF CANCER BY INHIBITION OF CENTROSOMAL CLUSTERING]]> http://www.patentstorm.us/applications/20120035200/description.html

  • Application Number:  20120035200
  • Publication Date:  2012-02-09
  • Inventors:  Leber, Blanka; Kraemer, Alwin; Clausen, Mads; Larsen, Thomas; Roennest, Mads; Worm, Kasper
    • The invention relates to compounds of the formula (I), where the symbols have the meaning given in the specification, for use in a method for treating cancer, to use of these compounds for the manufacture of a pharmaceutical composition for the treatment of cancer, and to methods of treatment for said diseases employing a compound of formula (I).

    ]]> 20120035200 <![CDATA[SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS]]> http://www.patentstorm.us/applications/20120035199/description.html

  • Application Number:  20120035199
  • Publication Date:  2012-02-09
  • Inventors:  Chowdhury, Sultan; Chafeev, Mikhail; Bagherzadeh, Mehran Seid; Liu, Shifeng; Kamboj, Rajender; Fu, Jianmin; Sviridov, Serguei; Fraser, Robert; Sun, Jianyu
    • This invention is directed to spiroheterocyclic compounds of formula (I):

    wherein

    k, j, p, Q, R1, R3a, R3b, R3e, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, that are useful for the treatment and/or ...
    ]]> 20120035199 <![CDATA[ANTI-NEURODEGENERATIVE DISEASE AGENT]]> http://www.patentstorm.us/applications/20120035187/description.html

  • Application Number:  20120035187
  • Publication Date:  2012-02-09
  • Inventors:  Akita, Kenji; Ohta, Tsunetaka; Kawata, Toshio; Fukuda, Shigeharu; Ohta, Hitomi
    • The present invention has an object to provide a novel agent for anti-neurodegenerative diseases and solves the object by providing an agent for anti-neurodegenerative diseases containing, as an effective ingredient, the compound(s) represented by the following General formula 1:

    wherein in General formula 1, R1 through R3 independently represent a hydrogen atom or an appropriate substituent; Z1 ...
    ]]> 20120035187 <![CDATA[Novel salts as Anti-Inflammatory, Immunomodulatory and Anti-Proliferatory Agents]]> http://www.patentstorm.us/applications/20120035175/description.html

  • Application Number:  20120035175
  • Publication Date:  2012-02-09
  • Inventors:  VITT, Daniel; AMMENDOLA, Aldo; DIEDERICHS, Julia; LEBAN, Johann
    • The present invention relates to a salt selected from the group comprising the N-methyl-D-glucamine salt (NMG), the diethylamine salt (DEA) salt, the magnesium salt, the tromethamine salt, the choline salt, the L-arginine salt, the zinc salt, and the 4-(2-hydroxyethyl)morpholine (HEM) salt of compounds of the general formula (I)

      • ]]> 20120035175 <![CDATA[DI-SUBSTITUTED AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES]]> http://www.patentstorm.us/applications/20120035173/description.html
      • Application Number:  20120035173
      • Publication Date:  2012-02-09
      • Inventors:  Mueller, Rudolf; Lee, Steven; Street, Leslie
      This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain ...
      ]]> 20120035173 <![CDATA[BICYCLIC HETEROCYCLYL DERIVATIVES AS FGFR KINASE INHIBITORS FOR THERAPEUTIC USE]]> http://www.patentstorm.us/applications/20120035171/description.html
    • Application Number:  20120035171
    • Publication Date:  2012-02-09
    • Inventors:  Embrechts, Werner Constant Johan; Berdini, Valerio; Freyne, Eddy Jean Edgard; Saxty, Gordon; Papanikos, Alexandra; Benderitter, Pascal; Wroblowski, Berthold; Akkari, Rhalid
    The invention relates to new bicyclic heterocyclyl derivatives of formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. ...
    ]]>     20120035171     <![CDATA[NOVEL UNSATURATED TETRACYCLIC TETRAHYDROFURAN DERIVATIVES]]> http://www.patentstorm.us/applications/20120035170/description.html
  • Application Number:  20120035170
  • Publication Date:  2012-02-09
  • Inventors:  Megens, Antonius Adrianus Hendrikus Petrus; Trabanco-Suárez, Andrés Avelino; Núñez, José Maria
    • This invention concerns novel substituted unsaturated tetracyclic tetrahydrofuran derivatives with binding affinities towards serotonine receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment ...
    ]]>     20120035170     <![CDATA[N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES]]> http://www.patentstorm.us/applications/20120035168/description.html
  • Application Number:  20120035168
  • Publication Date:  2012-02-09
  • Inventors:  BRANDL, Trixi; FLOHR, Stefanie; KOPEC, Sebastian; LACHAL, Julie; MARKERT, Christian; NAMOTO, Kenji; NGANGA, Perle; PIRARD, Bernard; RENATUS, Martin; SEDRANI, Richard; ZOLLER, Thomas
    • The invention relates to compound of the formula I

    in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising ...
    ]]> 20120035168 <![CDATA[INDOLE AND BENZOXAZINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS]]> http://www.patentstorm.us/applications/20120035167/description.html

  • Application Number:  20120035167
  • Publication Date:  2012-02-09
  • Inventors:  Trabanco-Suarez, Andres Avelino; Cid-Nunez, Jose Maria; Macdonald, Gregor James
    • The present invention relates to novel indole and benzoxazine derivatives which are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (“mGluR2”) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to ...
    ]]>     20120035167     <![CDATA[CHEMICAL COMPOUNDS]]> http://www.patentstorm.us/applications/20120035164/description.html
  • Application Number:  20120035164
  • Publication Date:  2012-02-09
  • Inventors:  DENG, Jianghe; KERNS, Jeffrey K.; JIN, Qi; LIN, Guoliang; LIN, Xichen; LINDENMUTH, Michael; NEIPP, Christopher; NIE, Hong; THOMAS, Sonia M.; WIDDOWSON, Katherine L.
    • The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I:

    where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof.

    The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, ...
    ]]> 20120035164 <![CDATA[NOVEL FUSED RING COMPOUND AND USE THEREOF]]> http://www.patentstorm.us/applications/20120035163/description.html

  • Application Number:  20120035163
  • Publication Date:  2012-02-09
  • Inventors:  Takakura, Nobuyuki; Miyamoto, Yasufumi; Yasuma, Tsuneo
    • The present invention provides an agent for the prophylaxis or treatment of diabetes, obesity and the like, a glucokinase activator, containing a compound represented by the formula (I):

    wherein each symbol is as defined in the description, or a salt thereof or a prodrug ...
    ]]> 20120035163 <![CDATA[SUBSTITUTED ISOQUINOLINE DERIVATIVE]]> http://www.patentstorm.us/applications/20120035159/description.html

  • Application Number:  20120035159
  • Publication Date:  2012-02-09
  • Inventors:  Hidaka, Hiroyoshi; Takahashi, Kouichi; Inoue, Yoshihiro; Sumi, Kengo; Nakamura, Ryohei
    • The present invention provides an isoquinoline-6-sulfonamide derivative that is useful as a novel pharmaceutical agent. The present invention provides an isoquinoline-6-sulfonamide derivative represented by Formula (1), a salt thereof, or a solvate of the derivative or the salt: wherein X and Y each independently represent a direct bond, NH, CH═CH, O, or S; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, an alkyl group, or the like; ...
    ]]>     20120035159     <![CDATA[2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE]]> http://www.patentstorm.us/applications/20120035157/description.html
  • Application Number:  20120035157
  • Publication Date:  2012-02-09
  • Inventors:  Andersson, Marjana; Lönn, Hans; Hansen, Peter; Nikitidis, Antonios; Sjölin, Petter
    • There are provided novel compounds of formula (I),

    wherein R1, R2, R4, G1, G2, L, Y and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil ...
    ]]> 20120035157 <![CDATA[INDOLE-2-CARBOXAMIDE DEIVATIVE]]> http://www.patentstorm.us/applications/20120035155/description.html

  • Application Number:  20120035155
  • Publication Date:  2012-02-09
  • Inventors:  Haga, Yuji; Sato, Nagaaki; Mizutani, Sayaka
    • To provide an indole compound having a human QRFP receptor antagonistic activity and useful as a preventive or a remedy for various disorders. A compound of a formula (I) or a pharmaceutically-acceptable salt thereof is provided: [wherein, R1 represents a hydrogen atom, a halogen, a C1-6 alkyl, etc,; R2 represents a C1-6 alkyl, or a halo-C1-6 alkyl; R3 represents a hydrogen atom, a C1-6 alkyl, etc.; R4 ...
    ]]>     20120035155     <![CDATA[Modulators of Cellular Adhesion]]> http://www.patentstorm.us/applications/20120035154/description.html
  • Application Number:  20120035154
  • Publication Date:  2012-02-09
  • Inventors:  ZHONG, Min; SHEN, Wang; OSLOB, Johan D.; BARR, Kenneth
    • The present invention provides compounds having formula (I):

    and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion ...
    ]]> 20120035154 <![CDATA[BICYCLIC HETEROCYCLIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS]]> http://www.patentstorm.us/applications/20120035153/description.html

  • Application Number:  20120035153
  • Publication Date:  2012-02-09
  • Inventors:  SAXTY, Gordon; BERDINI, Valerio; MURRAY, Christopher William; GRIFFITHS-JONES, Charlotte Mary; VICKERSTAFFE, Emma; BESONG, Gilbert Ebai; CARR, Maria Grazia
    • The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, A, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

    ]]> 20120035153 <![CDATA[MIF INHIBITORS AND THEIR USES]]> http://www.patentstorm.us/applications/20120035150/description.html

  • Application Number:  20120035150
  • Publication Date:  2012-02-09
  • Inventors:  Gaweco, Anderson; Walker, John K.; Monahan, Joseph B.; Cubbage, Jerry W.; Carroll, Jeffery
    • The invention relates to MIF inhibitors; compositions comprising an effective amount of a MIF inhibitor; and methods for treating or preventing diseases associated with ...
    ]]>     20120035150     <![CDATA[Prokineticin Receptor Antagonists And Uses Thereof]]> http://www.patentstorm.us/applications/20120035149/description.html
  • Application Number:  20120035149
  • Publication Date:  2012-02-09
  • Inventors:  Zhou, Qun-Yong; Li, Jia-Da; Huang, Qi
    • Contemplated compounds, compositions, and methods of prokineticin antagonists are presented where a prokineticin antagonist is used in the treatment and prevention of various conditions and disorders, and especially type II ...
    ]]>     20120035149     <![CDATA[GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAB RECEPTOR LIGANDS]]> http://www.patentstorm.us/applications/20120035139/description.html
  • Application Number:  20120035139
  • Publication Date:  2012-02-09
  • Inventors:  Phan, Thu; Xu, Feng; Peng, Ge; Wustrow, David J.; Gallop, Mark A.; Dilip, Usha
    • Gamma-amino-butyric acid derivatives that are GABAB receptor ligands, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives and pharmaceutical compositions thereof for treating diseases are ...
    ]]>     20120035139     <![CDATA[CHEMICAL COMPOUNDS]]> http://www.patentstorm.us/applications/20120035134/description.html
  • Application Number:  20120035134
  • Publication Date:  2012-02-09
  • Inventors:  DIEBOLD, Robert Bruce; GERO, Thomas; GROVER, Paul; HUANG, Shan; IOANNIDIS, Stephanos; OGOE, Claude Afona; SAEH, Jamal Carlos; VARNES, Jeffrey Gilbert
    • The present invention relates to compounds of Formula (I):

    and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit Bcl-2 and/or Bcl-XL activities and may be used for the treatment of ...
    ]]> 20120035134 <![CDATA[BORON-CONTAINING SMALL MOLECULES]]> http://www.patentstorm.us/applications/20120035132/description.html

  • Application Number:  20120035132
  • Publication Date:  2012-02-09
  • Inventors:  Jarnagin, Kurt; Akama, Tsutomu
    • Compounds, pharmaceutical formulations, and methods of treating anti-inflammatory conditions and/or helminth-associated diseases are ...
    ]]>     20120035132     <![CDATA[PYRAZOLINE COMPOUNDS]]> http://www.patentstorm.us/applications/20120035131/description.html
  • Application Number:  20120035131
  • Publication Date:  2012-02-09
  • Inventors:  Long, Scott A.; Chen, Xiangyang; Hockerman, Susan; Mahoney, Matthew W.; Rico, Joseph G.; Meyers, Marvin J.; Arhancet, Graciela B.; Reitz, David B.
    • Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I:

      • wherein R1, R2, R3A, R3B, R4, R5, R6, R7, R8, and X are as defined in the detailed ...
        ]]> 20120035131 <![CDATA[ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS]]> http://www.patentstorm.us/applications/20120035122/description.html
      • Application Number:  20120035122
      • Publication Date:  2012-02-09
      • Inventors:  Chubb, Nathan Anthony Logan; Menon, Sanjay; Vaillancourt, Valerie A.; Curtis, Michael; Howson, William; Kyne, Graham M.; Sheehan, Susan M. K.; Skalitzky, Donald J.; Wendt, John A.
      This invention recites isoxazoline substituted azetidine derivatives of Formula (1)

      stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, and their use as a parasiticide in mammals and birds. R1a, R1b, R1c, R2, R3, R4, R6, and n are as described ...
      ]]> 20120035122 <![CDATA[NOVEL HERBICIDES]]> http://www.patentstorm.us/applications/20120035053/description.html

    • Application Number:  20120035053
    • Publication Date:  2012-02-09
    • Inventors:  Mathews, Christopher John; Tyte, Melloney; Robinson, Louisa; Clough, John Martin; Beautement, Kevin; Jeanmart, Stephane André Marie
    Cyclohexanedione compounds, which are suitable for use as herbicides.

    ]]> 20120035053 <![CDATA[Diaryl Ethers]]> http://www.patentstorm.us/applications/20120034678/description.html

  • Application Number:  20120034678
  • Publication Date:  2012-02-09
  • Inventors:  Last, Stefaan Julien; Raboisson, Pierre Jean-Marie Bernard; Demin, Samuel Dominique; Mc Gowan, David
    • Compounds of the formula I:

    including any possible stereoisomers thereof, or a pharmaceutically acceptable salt and/or solvate thereof, as well as pharmaceutical formulations and the use of compounds of formula I as HCV ...
    ]]> 20120034678 <![CDATA[SOLID FORMS OF AN AZOCYCLIC AMIDE]]> http://www.patentstorm.us/applications/20120034315/description.html

  • Application Number:  20120034315
  • Publication Date:  2012-02-09
  • Inventors:  Oberholzer, Matthew Richard; Shapiro, Rafael; Hanagan, Mary Ann; Pasteris, Robert James
    • Disclosed are solid forms of 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (Compound 1). Methods for the preparation of solid forms of Compound 1 and for the conversion of one solid form of Compound 1 into another are disclosed.

    Disclosed are fungicidal compositions comprising a fungicidally effective amount of a solid form of Compound 1 and at least one additional ...
    ]]> 20120034315