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PERILLA-DERIVED PROMOTER FUNCTIONING IN PETALS

Application Number: 20120042421
Publication Date: 2012-02-16
Inventors: Mizutani, Masako; Tanaka, Yoshikazu

There is provided a novel promoter useful for altering flow color of plants. The present invention relates to a nucleic acid selected from the group consisting of:

- (1) a nucleic acid containing the nucleotide sequence indicated in SEQ ID NO. 1;
- (2) a nucleic acid able to function as a transcriptional ...

Engineering NF-YB Transcription Factors for Enhanced Drought Resistance and Increased Yield in Transgenic Plants

Application Number: 20120042418
Publication Date: 2012-02-16
Inventor: Kulkarni, Resham

Polynucleotides are disclosed which are capable of enhancing yield of a plant transformed to contain such polynucleotides. Also provided are methods of using such polynucleotides and transgenic plants and agricultural products, including seeds, containing such polynucleotides as ...

Antibody fusion-mediated plant resistance against Oomycota

Application Number: 20120042416
Publication Date: 2012-02-16
Inventors: Fischer, Rainer; Schillberg, Stefan; Schleker, Sylvia; Peschen, Dieter

The present invention relates to fusion proteins comprising anti-Oomycotic proteins or peptides linked to an antibody or fragment thereof specifically recognising an epitope of an Oomycota. The invention is also directed to polynucleotides coding for the fusion proteins. The embodiments of the present invention are particularly useful for the protection of plants against Oomycota. The invention therefore comprises transgenic plants expressing the fusion proteins of the present ...

CHIMERIC PROMOTERS AND METHODS OF USE

Application Number: 20120042414
Publication Date: 2012-02-16
Inventors: Castle, Linda A.; Albert, Henrik; Lu, Jian; Tao, Yumin

Compositions and methods comprising promoters from the 4-hydroxyphenylpyruvate dioxygenase (HPPD) gene and active variants and fragments thereof, as well as chimeric promoters employing regulatory regions of the HPPD promoters are provided. Further provided are expression cassettes and plants comprising the various promoters disclosed herein operably linked to a polynucleotide of interest. Methods employing the various promoters described herein to modulate the expression of polynucleotides of ...

Compositions And Methods Comprising Sequences Having Hydroxyphenylpyruvate Dioxygenase (HPPD) Activity

Application Number: 20120042413
Publication Date: 2012-02-16
Inventors: Siehl, Daniel L.; Castle, Linda A.; Albert, Henrik; Bermudez, Ericka R.; Dong, Yuxia; Heckert, Matthew J.; Hou, Jingtong; Hou, Zhenglin; Lu, Jian; Tao, Yumin

Compositions and methods comprising polynucleotides and polypeptides having 4-hydroxyphenylpyruvate dioxygenase (HPPD) activity and having insensitivity to an HPPD inhibitor are provided. Further provided are nucleic acid constructs, plants, plant cells, explants, seeds and grain having the HPPD sequences. Various methods of employing the HPPD sequences are provided. Such methods include, for example, methods for producing an HPPD inhibitor tolerant plant, plant cell, explant or seed and ...

Methods And Compositions For Targeting Sequences Of Interest To The Chloroplast

Application Number: 20120042412
Publication Date: 2012-02-16
Inventors: Siehl, Daniel L.; Castle, Linda A.; Albert, Henrik; Heckert, Matthew; Lu, Jian; Tao, Yumin

Chimeric polynucleotides comprising a nucleotide sequence encoding a chloroplast transit peptide operably linked to a heterologous polynucleotide of interest are provided, wherein the chloroplast transit peptide comprises an amino acid sequence having the chloroplast transit peptide sequence as set forth in SEQ ID NO:1 or a biologically active variant or fragment thereof or wherein the chloroplast transit peptide comprises the sequence set forth in SEQ ID NO: 58 or an active variant or fragment ...

GENE TARGETING IN PLANTS

Application Number: 20120042411
Publication Date: 2012-02-16
Inventors: Malcuit, Isabelle; Sorokin, Alexander

An isolated polynucleotide sequence that encodes for a multi domain recombination protein, comprising a donor DNA-Binding domain (BDB); and a chromosomal binding domain (CBD). A plant cell can be transformed by introducing into the cell a first nucleic acid sequence, which comprises a plant nuclear promoter operably linked to a first nucleic acid sequence comprising the stated polynucleotide sequence, and a second nucleic acid sequence, which comprises a donor nucleic acid sequence and at least ...

ABSCISIC ACID CARRIER GENE AND TRANSGENIC PLANT EXPRESSING THE SAME

Application Number: 20120042410
Publication Date: 2012-02-16
Inventors: Lee, Young-Sook; Lee, Mi-Young; Martionia, Enrico; Kang, Joo-Hyun

The present invention relates to carrier genes of abscisic acid and the transgenic plant prepared using such genes, and more specifically to genes that enhance resistance to salt or dryness in relation to abscisic acid transport and the recombinant vectors including the genes, the transgenic plant prepared using the recombinant vector, a transgenic plant that is superior in terms of resistance to base and dryness, a method for environmental purification in arid regions based on the plants, and ...

CORN EVENT 5307

Application Number: 20120042407
Publication Date: 2012-02-16
Inventors: De Framond, Annick Jeanne; Meghji, Moez R.; New, Stephen L.; Prairie, Anna Underwood

A novel transgenic com event designated 5307, is disclosed. The invention ivlates to UNA sequences of the re- combinant constructs inserted into Uie corn genome and of genomic sequences flanking flic insertion site that resulted in the 5307 event. The invention further relates to assays for detecting the presence of the DNA sequences of 5307. to com plants and com seeds comprising the genotype of and to methods for producing a com plant by crossing a com plant comprising the 5307 geno- type ...

RTD RECEPTOR

Application Number: 20120042400
Publication Date: 2012-02-16
Inventors: Gurney, Austin; Ashkenazi, Avi J.

Novel polypeptides, designated RTD, which are capable of binding Apo-2 ligand are provided. Compositions including RTD chimeras, nucleic acid encoding RTD, and antibodies to RTD are also ...

IMMUNOGENIC PEPTIDES

Application Number: 20120042399
Publication Date: 2012-02-16
Inventors: Banham, Alison; Pulford, Karen; Anderson, Amanda; Ait-Taho-ar, Kamel

The present invention relates to immunogenic peptides and their various applications. In particular the invention relates to immunogenic peptides derived from the PASD1 protein and their use in therapeutic, diagnostic and prognostic ...

PENTASACCHARIDE CRISTALLISE, SON PROCEDE D"OBTENTION ET SON UTILISATION POUR LA PREPARATION D"IDRAPARINUX

Application Number: 20120041189
Publication Date: 2012-02-16
Inventors: Potier, Pierre; Clavel, Philippe; Lubeigt, Xavier; Trouilleux, Patrick

The Invention relates to the methyl pentasaccharide O-2,3,4-tri-O-methyl-α-D-glucopyranosyl-(1→4)-O-2,3-di-O-methyl-β-D-glucopyranosyluronic acid-(1→4)-O-α-D-glucopyranosyl-(1→4)-O-2,3-di-O-méthyl-α-L-idopyranosyluronic acid-(1→4)-O-α-D-glucopyranose in crystallised form, to a method for obtaining the same and to the use thereof for the preparation of idraparinux.

METHOD FOR OBTAINING INULIN FROM PLANTS

Application Number: 20120041188
Publication Date: 2012-02-16
Inventors: Meuser, Friedrich; Laufenberg, Günther

The invention describes a method for obtaining inulin which comprises: a) finely comminuting inulin-containing plant material, wherein particle sizes of the plant material are generated which are smaller than the size of the inulin-containing plant cells, b) suspending the finely comminuted plant material in a liquid, wherein inulin is released from the plant material and suspended in particulate form in the liquid, c) separating off plant particles from the liquid, wherein the inulin which is ...

Process for Improved Production of Alkali Cellulose and Cellulose Derivatives

Application Number: 20120041187
Publication Date: 2012-02-16
Inventors: Sprehe, Matthias; Hoelzer, Bettina

The present invention relates to a process for the production of alkali cellulose for the production of alkali cellulose and, optionally, cellulose ethers from cellulose in the presence of alkali and, if applicable, with alkylating and/or hydroxyalkylating agent(s) comprising the reaction of a cellulose with an alkali metal hydroxide, wherein the alkali metal hydroxide is mixed with cellulose in a mixing apparatus, the mixing apparatus (1) having an upper region (20, 102a, ...

SYSTEM AND METHOD FOR PREEXTRACTION OF HEMICELLULOSE THROUGH USING A CONTINUOUS PREHYDROLYSIS AND STEAM EXPLOSION PRETREATMENT PROCESS

Application Number: 20120041186
Publication Date: 2012-02-16
Inventors: Stromberg, Bertil; Pschorn, Thomas; Shin, Namshee
A method including: pretreating biomass feed stock in a first pressurized reactor, wherein the feed stock undergoes hydrolysis in the first pressurized reactor; discharging the feed stock from the first pressurized reactor to a pressurized sealing device having a first pressurized coupling to a feedstock discharge port of the first pressurized reactor; maintaining a vapor phase in the first pressurized reactor by injecting steam; washing the feed stock; draining dissolved hemi-cellulosic ...

dTDP-BETA-D-FUCOFURANOSE, ITS PREPARATION METHOD AND USE

Application Number: 20120041185
Publication Date: 2012-02-16
Inventors: Wang, Lei; Wang, Quan; Feng, Lu
Provided is a dTDP-β-D-fucofuranose, which is also referred to as dTDP-β-6-deoxy-D-galactofuranose. The dTDP-β-D-fucofuranose is synthesized by using reductase Fcf1 and mutase Fcf2 in the gram-negative bacteria. Also provided are the preparation method of the dTDP-β-D-fucofuranose and use of the dTDP-β-D-fucofuranose for manufacturing a medicament for the treatment of ...

RNA INTERFERENCE MEDIATED INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

Application Number: 20120041184
Publication Date: 2012-02-16
Inventors: McSwiggen, James; Beigelman, Leonid
This invention relates to compounds, compositions, and methods useful for modulating human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of human immunodeficiency virus (HIV) gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the ...

CELLULOSE MATERIALS WITH NOVEL PROPERTIES

Application Number: 20120041183
Publication Date: 2012-02-16
Inventors: Hu, Thomas Q.; Hayek, Ali
A molecule possessing a primary or secondary amino group and an additional functionality capable of providing a novel or improved property to a cellulose material has been permanently attached to the cellulose material in aqueous media using a water-soluble carbodiimide as the coupling agent/activator. One such molecule is 5-aminofluorescein (abbreviated as “A-fluo”) and one such cellulose material is a papermaking pulp. Papers made from a pulp furnish containing, for example, 0.01 wt. % of ...

Water Soluble Cholesterol Derivatives

Application Number: 20120041182
Publication Date: 2012-02-16
Inventors: Travis, Benjamin R.; Huang, Lijun M.
Four novel water soluble cholesterol derivative compounds are disclosed. These compounds have various applications in studies of membrane proteins, including drug screening and studies of receptor stability and folding. In one aspect the water soluble cholesterol derivatives disclosed may be used to replace cholesterol in micelle-solubilized membrane protein ...

NOVEL AUTOGRAPHY REGULATORS ATG14L AND RUBICON

Application Number: 20120041175
Publication Date: 2012-02-16
Inventor: Yue, Zhenyu
The present invention provides for up- and down-regulation of cellular autophagy, e.g., for treating cancer or neurological disease. The invention results, in part, from discovery of two novel proteins, ATG14L (previously called “BISC”) and Rubicon (previously called “BIRC”), which bind to a Class III phophatidylinositol 3′-kinase (PI3K)/Vps34-Beclin 1 autophagic complex. ATG14L and Rubicon each regulate autophagic activity in an opposing manner. ATG14L and Rubicon can be used, for ...

PROCESS FOR THE PRODUCTION OF A RECOMBINANT POLYPEPTIDE OF INTEREST

Application Number: 20120041171
Publication Date: 2012-02-16
Inventors: Stam, Hein; Roubos, Johannes Andries; Van Peij, Noel Nicolaas Maria Elisabeth; Van De Vondervoort, Peter Jozef Ida
The present invention relates to a process for the production of a recombinant polypeptide of interest, a polypeptide obtained by said process, a recombinant polynucleotide, an expression vector, an expression construct and to the use of a specific signal peptide and of a polynucleotide encoding said specific signal peptide for the production of a recombinant polypeptide of ...

DEXTRAN FUNCTIONALIZED BY HYDROPHOBIC AMINO ACIDS

Application Number: 20120041079
Publication Date: 2012-02-16
Inventors: SOULA, Gerard; Soula, Olivier; Soula, Remi; Charvet, Richard
Dextran of the following general formula I:

is described, wherein

R represents a chain containing from 1 to 15 carbon atoms and having at least one acid functional group prior to attachment to AA, the chain optionally being branched and/or unsaturated and containing one or more ...

SYNTHESIS AND CHARACTERIZATION OF C8 ANALOGS OF c-di-GMP

Application Number: 20120041057
Publication Date: 2012-02-16
Inventors: Jones, Roger A.; Veliath, Elizabeth
The invention provides analogs cyclic diguanosine monophosphate (c-di-GMP) having different substituents at the guanine C8 ...

NUCLEIC ACIDS SPECIFICALLY BINDING WITH HUMAN FACTOR VII/VIIA AND USES THEREOF

Application Number: 20120041056
Publication Date: 2012-02-16
Inventors: Duconge, Frederic; Perret, Gerald
A nucleic acid includes at least 15 nucleotides with a length specifically binding with the human factor ...

COMPOSITE POLYNUCLEIC ACID THERAPEUTICS

Application Number: 20120041055
Publication Date: 2012-02-16
Inventor: Mathison, Brian H.
Compositions comprising therapeutic polynucleic acids and method of use. The compositions comprise one or more polynucleic acid sequences having two or more features useful for treating diseases associated with cellular proliferation or ...

COMPOSITIONS AND METHODS FOR THE TREATMENT OF SEPSIS AND OTHER DISORDERS INVOLVING PHOSPHOLIPASE A2 INDUCTION

Application Number: 20120041054
Publication Date: 2012-02-16
Inventor: Liu, Maw-Shung
The present invention provides antisense oligomers to PLA₂to inhibit PLA₂protein expression and enzyme activity, and to treat diseases and disorders associated with induced expression of PLA₂. In particular, the invention provides for the simultaneous inhibition of cPLA₂and ...

Compositions and Methods to Treat Muscular & Cardiovascular Disorders

Application Number: 20120041052
Publication Date: 2012-02-16
Inventors: BEUVINK, Iwan; HALL, Jonathan; WEILER, Jan; SCHNELL, Christian Rene; MUELLER, Matthias; SCHINKE-BRAUN, Martina; SERLUCA, Fabrizio
The present invention relates to a novel microRNA, mir-208-2, implicated in muscular and cardiovascular disorders. The present invention also relates to oligonucleotide therapeutic agents (antisense oligonucleotides and/or double stranded oligonucleotides such as dsRNA) and their use in the treatment of muscular and cardiovascular disorders resulting from dysregulation of ...

Compositions And Methods For Inhibiting Expression Of MIG-12 Gene

Application Number: 20120041051
Publication Date: 2012-02-16
Inventors: Hinkle, Gregory; Fitzgerald, Kevin
The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting MIDI interacting G12-like protein (MIG 12) gene, and methods of using the dsRNA to inhibit expression of MIG ...

ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF

Application Number: 20120041050
Publication Date: 2012-02-16
Inventors: Wilton, Stephen Donald; Fletcher, Sue; McClorey, Graham
An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to ...

DESIGN OF SMALL-INTERFERING RNA

Application Number: 20120041049
Publication Date: 2012-02-16
Inventor: Rohayem, Jacques
The present invention relates to small-interfering RNA molecules displaying an increased thermodynamic stability at the 3′ end of the antisense strand (guide strand) and the 5′ end of the sense strand (passenger strand), respectively, in comparison to the base pairing in the seed region. The siRNAs of the present invention display an increased knock-down activity against targeted genes and show an improved resistance to RNAses, in particular serum RNAses. The present invention also relates ...

COMPOSITIONS AND METHODS RELATING TO miR-31

Application Number: 20120041048
Publication Date: 2012-02-16
Inventors: Weinberg, Robert A.; Valastyan, Scott J.
MicroRNA-31 (miR-31), targets of miR-31, the role of miR-31 in inhibiting tumor metastasis, and the role of miR-31 target genes in promoting tumor metastasis are ...

Process For Obtaining Polysaccharides From Jatoba (Hymenea Courbaril L) Seeds, Cosmetic Composition Comprising Said Polysaccharides And Uses Thereof

Application Number: 20120040926
Publication Date: 2012-02-16
Inventors: Araujo Rodrigues Muchiutti, Pamela; Ferrari, Cintia Rosa J.; Serafim Lisboa, César Gustavo; Luz Moreira, Patrícia da; Arrotela, Kelen Fabiola; Moura Sá Rocha, Vanessa de
The present invention relates to a process for obtaining polysaccharides from jatoba seeds, comprising the steps of: a) seed processing (dry process); b) aqueous extraction at 1% to 5% of powder mass per volume, preferably 2% of powder mass per volume; c) precipitation with ethanol 969GL using 1 to 3 times the aqueous extract volume; d) press filtration of the precipitate obtained in (c); e) solublization of the polysaccharides obtained in step (d) with water; and f) drying the polysaccharides ...

PURINE NUCLEOSIDE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF CANCER AND VIRAL INFECTIONS

Application Number: 20120040924
Publication Date: 2012-02-16
Inventors: Schinazi, Raymond F.; Cho, Jong Hyun; Coats, Steven J.; Zhang, Hongwang; Zhou, Longhu
The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV in human patients or other animal hosts. The compounds are certain 6-substituted purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1, HIV-2, HCV, ...

ANTIBIOTIC MACROCYCLE COMPOUNDS AND METHODS OF MANUFACTURE AND USE THEREOF

Application Number: 20120040922
Publication Date: 2012-02-16
Inventors: Chiu, Yu-Hung; Shue, Youe-Kong; Ichikawa, Yoshi; Babakhani, Farah Kondori
The invention encompasses an active metabolite of the 18-membered macrocyclic antimicrobial agents, specifically, a metabolite of tiacumicin B and in certain embodiments, R-Tiacumicin B or and its related compounds. In particular, the invention encompasses a compound that acts as a potent antibiotic agent for the treatment of bacterial infections, specifically GI infections caused by toxin producing strains of Clostridium difficile (C. difficile) and Clostridium perfringens ...

Splice Switching Oligomers for TNF Superfamily Receptors and Their Use in Treatment of Disease

Application Number: 20120040917
Publication Date: 2012-02-16
Inventors: SAZANI, PETER L.; ØRUM, HENRIK
The present invention relates to compositions and methods for preparing splice variants of TNFalpha receptor (TNFR) in vivo or in vitro, and the resulting TNFR protein variants. Such variants may be prepared by controlling the splicing of pre-mRNA molecules and regulating protein expression with splice switching oligonucleotides or splice switching oligomers (SSOs). The preferred SSOs according to the invention target exon 7 or 8 of TNFR1 (TNFRSF1A) or TNFR2 (TNFRSF1A) pre-mRNA, typically ...

IDENTIFICATION OF NOVEL ANTAGONIST TOXINS OF T-TYPE CALCIUM CHANNEL FOR ANALGESIC PURPOSES

Application Number: 20120040909
Publication Date: 2012-02-16
Inventors: Escoubas, Pierre; Bourinet, Emmanuel; Marger, Fabrice; Nargeot, Joel; Lazdunski, Michel
A peptide with the following sequence YCQKFLWTCDSERPCCEGLVCRLWCKIN (SEQ ID NO 1) or a derivative thereof, and nucleic acids coding for the peptide having the sequence (SEQ ID NO 1). Also the use of this peptide as an antagonist and/or reverse agonist of T-type calcium channels. A use of the peptide for preparing a drug, in particular an analgesic ...

PROTEIN TARGETS IN DISEASE

Application Number: 20120040906
Publication Date: 2012-02-16
Inventors: Samali, Afshin; Gupta, Sanjeev
MicroRNAs have been shown to be critically involved in control of cell survival and cell death decisions. By identifying microRNAs implicated in Endoplasmic Reticulum stress-induced cardiomyocyte apoptosis, it is envisaged that protein targets involved in same can be identified through specifically selected microRNAs. The microRNAs targeted are miR-351, miR-322, miR-125, miR-424 and miR-7a. Furthermore, the potential application of these identified proteins in the treatment of cardiovascular ...

MEANS FOR PURIFYING A COAGULATION PROTEIN, AND METHODS FOR IMPLEMENTING SAME

Application Number: 20120040905
Publication Date: 2012-02-16
Inventors: Nogre, Michel; Perret, Gerald
An affinity substrate for selectively binding a coagulation protein, includes a substrate solid on which nucleic aptamers binding specifically to the coagulation protein are ...

NOVEL DERIVATIVES OF ACYL CYANOPYRROLIDINES

Application Number: 20120040897
Publication Date: 2012-02-16
Inventors: Thennati, Rajamannar; Samanta, Biswajit; Pal, Ranjan Kumar; Adhyapak, Jay Prakashchandra; Akolkar, Nakul Pramod; Aradhye, Javraj Dilipbhai; Kumbhani, Anil Savajihai; Panchal, Bhavesh Mohanbhai; Jivani, Jignesh Kantilal
A compound of formula (I) or a tautomeric form, regioisomer, stereoisomer, solvate, N-oxide or pharmaceutically acceptable salts thereof; wherein ‘a’—is selected from the group consisting of substituted or unsubstituted heterocycloalkyl ring and substituted or unsubstituted carbohydrate moiety y is a member selected from —O—, —CO—, —S02-, aminoalkyl or formula (II) wherein, R_wis hydrogen, substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, ...

HIV FUSION INHIBITOR PEPTIDES WITH IMPROVED BIOLOGICAL PROPERTIES

Application Number: 20120040891
Publication Date: 2012-02-16
Inventors: Dwyer, John J.; Johnston, Barbara E.; Bray, Brian L.; Friedrich, Paul E.; Tvermoes, Nicolai A.; Zhang, Huyi; Schneider, Stephen E.
Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these ...

Methods and Reagents for Treatment and Diagnosis of Vascular Disorders and Age-Related Macular Degeneration

Application Number: 20120040884
Publication Date: 2012-02-16
Inventor: Hageman, Gregory S.
Disclosed are screening methods for determining a human subject's propensity to develop a vascular disorder and/or age-related macular degeneration (AMD), therapeutic or prophylactic compounds for treating disease or inhibiting its development, and methods of treating patients to alleviate symptoms of the disease, prevent or delay its onset, or inhibit its progression. The inventions are based on the discovery that persons with a genome having a deletion of the CFHR-1 and/or CFHR-3 gene, which ...

TARGET SUBSTANCE DETECTION METHOD USING APTAMER

Application Number: 20120040865
Publication Date: 2012-02-16
Inventor: Kim, So Youn
The present invention relates to a method and kit of detecting a target material using an aptamer, and more particularly to a method and kit for detecting a target material, in which a sample and a second aptamer are added to a first aptamer immobilized on a solid phase so as to form a bond sandwiched between the first aptamer, the target material and the second aptamer, to an FET sensor-based method and kit for detecting a target material, and to an AAO sensor-based method and kit for ...

METHOD FOR DETECTING AND QUANTIFYING ENDOGENOUS WHEAT DNA SEQUENCE

Application Number: 20120040862
Publication Date: 2012-02-16
Inventors: Iida, Mayu; Yamakawa, Hirohito; Nozaki, Satomi; Hayakawa, Katsuyuki; Kodama, Takashi; Hino, Akihiro
A circular DNA is provided comprising endogenous DNA common to both genetically modified wheat and non-genetically modified wheat along with one or more pieces of DNA each having a sequence present specifically in a strain of genetically modified wheat. Also provided is a method for determining a mix rate of genetically modified wheat in a test ...

ISOLATION OF FACTORS THAT ASSOCIATE DIRECTLY OR INDIRECTLY WITH CHROMATIN

Application Number: 20120040857
Publication Date: 2012-02-16
Inventors: Kingston, Robert; Dejardin, Jerome; Simon, Matthew
Methods for isolating non-coding nucleic acids that are associated with chromatin at a target genomic locus are provided. The methods comprise the steps of obtaining a sample that comprises a target genomic DNA sequence and one or more non-coding nucleic acids associated with that DNA sequence; contacting the sample with at least one oligonucleotide probe that comprises a sequence that is complimentary to and capable of hybridising with at least a portion of the target DNA sequence, wherein the ...

Method for in vitro diagnosis or prognosis of testicular cancer

Application Number: 20120040854
Publication Date: 2012-02-16
Inventors: Mallet, François; Arsac, Maud; Bonnaud, Bertrand; Pichon, Jean-Philippe
The invention relates to a method for in vitro diagnosis or prognosis of testicular cancer which comprises a step of detecting the presence or absence of at least one expression product from at least one nucleic acid sequence selected from the sequences identified in SEQ ID NOS: 1 to 6 or from the sequences which exhibit at least 99% identity with one of the sequences identified in SEQ ID NOS: 1 to 6, to isolated nucleic acid sequences and to the use thereof as a testicular cancer ...

miRNA TARGETS

Application Number: 20120040851
Publication Date: 2012-02-16
Inventors: Lieberman, Judy; Lal, Ashish
The present invention provides systems for identifying, isolating, and/or characterizing targets of micro ...

TEMPLATE-SUPPORTED METHOD OF FORMING PATTERNS OF NANOFIBERS IN THE ELECTROSPINNING PROCESS AND USES OF SAID NANOFIBERS

Application Number: 20120040581
Publication Date: 2012-02-16
Inventor: Kim, Gyeong-Man
The invention relates to a method for producing two- and three-dimensionally structured, microporous and nanoporous webs made up of nanofibers in any form with a very high covering or depositing degree of the fibers by means of a predefined conductive mold (template) as a collector and to the use of the webs according to the invention. The three-dimensional structure formation can be influenced in a directed manner by the deposition density of the nanofibers generated by means of an ...

REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS

Application Number: 20120040459
Publication Date: 2012-02-16
Inventors: Woolf, Tod M.; Kamens, Joanne; Salomon, William; Khvorova, Anastasia; Samarsky, Dmitry; Cardia, James
The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene ...

METHODS OF GENE THERAPY USING NUCLEIC ACID SEQUENCES FOR ATP-BINDING CASSETTE TRANSPORTER

Application Number: 20120040456
Publication Date: 2012-02-16
Inventors: Dean, Michael; Lupski, James R.; Singh, Nanda; Leppert, Mark; Li, Yixin; Nathans, Jeremy; Rattner, Amir; Sun, Hui; Allikmets, Rando; Anderson, Kent L.; Lewis, Richard A.; Shroyer, Noah F.; Smallwood, Philip
The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. ...

GLYPICAN-3 (GPC3)-DERIVED TUMOR REJECTION ANTIGENIC PEPTIDES USEFUL FOR HLA-A2-POSITIVE PATIENTS AND PHARMACEUTICAL COMPRISING THE SAME

Application Number: 20120040452
Publication Date: 2012-02-16
Inventors: NISHIMURA, Yasuharu; NAKATSURA, Tetsuya; KOMORI, Hiroyuki
It is an object of the present invention to identify a glypican-3-derived peptide which can bind to HLA-A2 and activate human killer T cells, so as to provide a means for carrying out an immunotherapy which is able to target approximately 40% of Japanese patients suffering from several types of cancers, which express GPC3 at a high level. The present invention provides a peptide of any of the following (A) or (B):

(A) a ...