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Electromagnetic treatment of tissues and cells

Application Number: 20120035608
Publication Date: 2012-02-09
Inventors: Marchitto, Kevin S.; Flock, Stephen T.

Provided herein are methods, devices and compositions to conductively or to inductively fix substrates, including tissues, using electromagnetic energy. Also provided is a method of controlling the fixing process via feedback monitoring of a property of the composition and/or of the electromagnetic energy ...

Modulators of Cellular Adhesion

Application Number: 20120035154
Publication Date: 2012-02-09
Inventors: ZHONG, Min; SHEN, Wang; OSLOB, Johan D.; BARR, Kenneth

The present invention provides compounds having formula (I):

and pharmaceutically acceptable derivatives thereof, wherein R₁-R₄, n, p, A, B, D, E, L and AR¹are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion ...

KASPP (LRRK2) GENE, ITS PRODUCTION AND USE FOR THE DETECTION AND TREATMENT OF NEURODEGENERATIVE DISORDERS

Application Number: 20120035072
Publication Date: 2012-02-09
Inventors: Kremmer, Elisabeth; Farrer, Matthew J.; Meitinger, Thomas; Strom, Tim Matthias; Zimprich, Alexander; Biskup, Saskia; Gloeckner, Christian Johannes; Gasser, Thomas; Patenge, Nadja; Lincoln, Sara J.; Ueffing, Marius; Herzig, Petra (Leitner); Asmus, Friedrich; Kachergus, Jennifer M.; Hulihan, Mary M.; Wszolek, Zibigniew; Uitti, Ryan

The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as ...

COELENTERAZINE ANALOGS AND MANUFACTURING METHOD THEREOF

Application Number: 20120035070
Publication Date: 2012-02-09
Inventors: Inouye, Satoshi; Sahara, Yuiko; Hosoya, Takamitsu; Iimori, Rie

There has been a need for coelenterazine analogs that exhibit luminescence properties different from those of known coelenterazine analogs. The present invention provides the compound represented by general formula (1).

PROGNOSIS OF BREAST CANCER PATIENTS BY MONITORING THE EXPRESSION OF TWO GENES

Application Number: 20120035069
Publication Date: 2012-02-09
Inventors: Piccolo, Stefano; Cordenonsi, Michelangelo; Adorno, Maddalena; Bicciato, Silvio

The present invention relates to the expression of two genes, CyclinG2 and Sharp1, which correlates with prognosis in individuals having breast cancer. Specifically, this invention provides a method to stratify samples from breast cancer patients in a high or low recurrence risk in the years following primary tumor removal. This classification can be achieved through the analysis of protein or mRNA expression levels for the two identified genes. The invention also illustrates how CyclinG2 and ...

CONJUGATED POLYMERS FOR USE IN HOMOGENEOUS AND SOLID STATE ASSAYS

Application Number: 20120035066
Publication Date: 2012-02-09
Inventors: Liu, Bin; Bazan, Guillermo C.

The invention further relates to multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed ...

Digital immunochromatographic test strip for semi-quantitative detection of aflatoxin B1 and preparation method thereof

Application Number: 20120034711
Publication Date: 2012-02-09
Inventors: LI, Peiwu; Zhang, Daohong; Zhang, Qi; Zhang, Wen; Ding, Xiaoxia; Jiang, Jun; Chen, Xiaomei

The present invention belongs to the field of biological detection. Multi-line immunochromatographic test strip for semi-quantitative detection of aflatoxin B₁comprises a paperboard, wherein a water-absorbing pad, a detection pad, a gold-labeled pad and a sample pad are adhered sequentially on one surface of the paperboard from top to bottom, wherein each adjacent pads is overlapped and connected, the detection pad uses a nitrocellulose film as a backing pad, the nitrocellulose film ...

Detection of Degradation Products of NT-proBNP

Application Number: 20120034710
Publication Date: 2012-02-09
Inventors: Yerramilli, Murthy V.S.N.; Yerramilli, Mahalakshmi; Atkinson, Michael

A method for determining the amount of NT-proBNP in blood samples from animals. The method includes detecting degradation products of NT-proBNP by various methods, including using antibodies, kits and ...

SURFACE MODIFIED SUBSTRATE, BIOTIP AND A METHOD FOR PRODUCING THEREOF

Application Number: 20120034709
Publication Date: 2012-02-09
Inventor: Maeno, Katsuyuki

A surface modified substrate is produced by a method including reacting a substrate having a reactive functional group on a surface thereof with a functional group being reactive to the reactive functional group, and reacting the substrate with a compound represented by the general formula,

- wherein R¹, ...

Sample Carrier for Effecting Chemical Assays

Application Number: 20120034708
Publication Date: 2012-02-09
Inventor: Porter, Robert Andrew

There is disclosed apparatus and a system for effecting testing on a sample, such as for medical testing. The apparatus includes a sample chip (30) provided with at least two chambers (48, 50) within which analyte and a sample to be tested can be located, one chamber being a mixing chamber (48) and the other a detection chamber (50), the latter being provided with a sensor or means to enable sensing of one or more parameters pertaining to the sample. A detector unit ...

ATOMICALLY PRECISE NANORIBBONS AND RELATED METHODS

Application Number: 20120034707
Publication Date: 2012-02-09
Inventors: Johnson, JR., Alan T.; Dan, Yaping; Strachan, Douglas R.; Khamis, Samuel M.; Datta, Sujit S.

Disclosed are atomically precise nanoribbons formed by gradient-driven catalytic etching of crystalline substrates to produce edges formed along specific crystallographic axes by thermally-activated particles. Also provided are related methods for fabrication of these nanoribbon structures. Further provided are devices and related methods for power generation and for detection of specific targets using the disclosed ...

METHOD FOR ASSESSING INFLAMMATORY CONDITION

Application Number: 20120034706
Publication Date: 2012-02-09
Inventors: Miyazawa, Chihiro; Sudo, Yukio; Ueki, Yukitaka; Masuda, Nobuhito; Miyamoto, Kyoko

Provided a method for correctly assessing an inflammatory condition of a patient who is receiving a therapy with an IL-6 inhibitor. The method for assessing an inflammatory condition of a patient who is receiving an IL-6 inhibitor, including determining a PTX3 level of a sample derived from a patient who is receiving an IL-6 ...

FLUID PROCESSING AND CONTROL

Application Number: 20120034705
Publication Date: 2012-02-09
Inventors: Chang, Ronald; Dority, Douglas B.

A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one ...

DISSOLUTION TEST EQUIPMENT

Application Number: 20120034704
Publication Date: 2012-02-09
Inventors: Wright, Donald Frederick; Hughes, Lyn

Apparatus and method for dissolution testing of active substances in various dosage forms is provided. The apparatus has filtration cells equipped and configured to simulate bodily functions, operate continuously and facilitate testing various types of dosage forms including, but not limited to, tablets, capsules and those having non-disintegrating ...

Devices, Systems and Methods for Processing of Magnetic Particles

Application Number: 20120034703
Publication Date: 2012-02-09
Inventors: Nguyen, Cung-Tuong; Crawford, Kimberly L.; Lu, Binh M.

Devices, systems and methods for separation of magnetic particles with either hand held devices or automated instruments. Specifically, the production of magnetic fields for the separation of the particles within containers such as microtiter plates with a magnetic field that is substantially consistent for each well. Certain embodiments produce a magnetic field that is substantially uniform across each well bottom, while other embodiments produce a magnetic field that is stronger toward the ...

METHOD AND APPARATUS FOR MEASURING FLUORESCENCE IN LIQUIDS

Application Number: 20120034702
Publication Date: 2012-02-09
Inventors: Croud, Vincent Brian; McCallien, Duncan William John; Edworthy, Ian Stuart

A method of measuring the fluorescence of a fluorescent marker compound dissolved or dispersed in a bulk material includes: (a) measuring a characteristic of the fluorescence of a mixture of said bulk material and said fluorescent marker compound; (b) quenching the fluorescence of the fluorescent marker compound to produce a quenched mixture; (c) measuring the characteristic of the fluorescence of the quenched mixture; (d) comparing the fluorescent characteristic of the mixture with the ...

DEVICE FOR ASSAY OF A LIQUID SAMPLE

Application Number: 20120034701
Publication Date: 2012-02-09
Inventors: Hofmann, Oliver; Ryu, Gihan; Mosley, Alan; Walshe, Claire

Device and detection system comprising two polarising elements and a measuring zone located between said polarising elements, wherein the measuring zone is being bounded on one side by the first polarising element. The device further comprises an inlet reservoir, an outlet reservoir and a flow channel. Method of fabricating said device, comprising the step of depositing an antibody into the measuring ...

METHODS TO RADIOLABEL NATURAL ORGANIC MATTER BY REDUCTION WITH HYDROGEN LABELED REDUCING AGENTS

Application Number: 20120034700
Publication Date: 2012-02-09
Inventors: Honeyman, Bruce D.; Tinnacher, Ruth M.

Methods to radiolabel natural organic matter by reduction with a hydrogen labeled reducing agent, and compositions, are ...

NUCLEIC ACID-LABELED TAGS ASSOCIATED WITH ODORANT

Application Number: 20120034699
Publication Date: 2012-02-09
Inventor: Bronchetti, Mary F.

A nucleic acid tag comprising a nucleotide-support platform attached to a nucleic acid molecule, an odorant, and an encapsulant. Unique nucleic acid-containing tags containing an odorant are seeded at one or more geographic locations. Using odorant-detection systems, the person or object of interest is examined for the presence of one or more of the odorant, thereby revealing the presence of the seeded nucleic acids and eliminating the expense and time associated with unnecessary screening. The ...

CHEMICAL SENSING DEVICE

Application Number: 20120034636
Publication Date: 2012-02-09
Inventors: Wright, John Dalton; Carter, Timothy Joseph Nicholas; Colin, Florence; Ross, Steven Andrew

This invention relates to a chemical sensing device for detecting an analyte. The device comprises a light source, at least one luminescent reagent which is capable of luminescing when irradiated by the light source wherein the luminescence of the luminescent reagent is modifiable by the analyte thereby changing the generation of heat, which change in heat generation is proportional to the concentration of the analyte, a transducer having a pyroelectric or piezoelectric element and electrodes ...

MAGNETIC IMMUNOSENSOR AND METHOD OF USE

Application Number: 20120034633
Publication Date: 2012-02-09
Inventors: MILLER, Cary James; Hu, Jinghua

The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic ...

TWO-PHASE OPTICAL ASSAYS FOR ANALYTES OF NO INTRINSIC OPITCAL CONTRAST

Application Number: 20120034632
Publication Date: 2012-02-09
Inventors: Saunders, Alex M.; SAUNDERS, Paul A.

Methods and kits for performing a two-phase optical assay for one or more than one analyte without intrinsic optical contrast in a sample are disclosed. The method requires use of a functionalized microparticle immobilized with two or more than functional components and an additional set of one or more than one functional component. The assay can be performed in one single container and does not need a wash ...

ANTI-LYSOPHOSPHOLIPID ANTIBODY DESIGN USING ANTIBODY STRUCTURES

Application Number: 20120034631
Publication Date: 2012-02-09
Inventor: WOJCIAK, Jonathan Michael

The present invention provides crystalline forms of an anti-LPA antibody or fragment thereof, which may further comprise a lipid ligand of said antibody and/or salts, metals, or co-factors. Methods for making such crystals and co-crystals are provided, as are methods of using structural information in antibody design or optimization. Methods for designing a humanized antibody to a lipid are provided. These methods may be performed in silico and may be intended to enhance binding affinity of an ...

Circovirus Sequences Associated With Piglet Weight Loss Disease (PWD)

Application Number: 20120034630
Publication Date: 2012-02-09
Inventors: Le Cann, Pierre; Jestin, André; Blanchard, Philippe; Hutet, Evelyne; Arnauld, Claire; Truong, Catherine; Mahe, Dominique; Cariolet, Roland; Madec, François; Albina, Emmanuel

The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, ...

OSCILLATING IMMUNOASSAY METHOD AND DEVICE

Application Number: 20120034624
Publication Date: 2012-02-09
Inventors: Miller, Cary James; Campbell, John Lewis Emerson

HIFU INDUCED CAVITATION WITH REDUCED POWER THRESHOLD

Application Number: 20120034615
Publication Date: 2012-02-09
Inventors: Van Doorn, Arie R.; De Jong, Michiel

An apparatus for irradiating a liquid sample with acoustic energy to generate cavitation in the liquid sample is provided. The apparatus includes a source and is adapted to receive a cartridge in such a way, that the apparatus focuses the HIFU waves emitted from the source onto a liquid air interface that is present within the cartridge. This focusing is performed when the cartridge is inserted into a receiving section of the ...

Porous Materials for Biological Sample Collection

Application Number: 20120034601
Publication Date: 2012-02-09
Inventors: Zenhausern, Frederic; Yang, Jianing; Lenigk, Ralf; Kinder, James

Methods, apparatuses, and systems for collecting samples using hybrid porous materials that include an organic material and an inorganic material. A method for sample collection includes contacting a hybrid porous material and a biological sample to the porous material. The hybrid porous material includes an inorganic material and an organic material. The method includes placing the porous material with the attached sample in a liquid medium, wherein the sample is separated from the porous ...

Prediction of Response to Platinum-Based Therapy

Application Number: 20120034317
Publication Date: 2012-02-09
Inventors: Jirström, Karin; Eberhard, Jakob

Method for determining whether a mammalian subject having a cancer belongs to a first or a second group, wherein subjects of the first group are more likely to respond to a platinum-based therapy than subjects of the second group, comprising the steps of: evaluating the amount of RBM3 protein or RBM3 mRNA present in at least part of a sample earlier obtained from said subject, and determining a sample value corresponding to said amount; comparing the sample value with a reference value; and, if ...

RBM3 in Colorectal Cancer Prognostics

Application Number: 20120034218
Publication Date: 2012-02-09
Inventors: Uhlen, Mathias; Jirström, Karin; Pontén, Fredrik

The present invention provides means, such as a method, for determining whether a mammalian subject having a colorectal cancer belongs to a first or a second group, wherein the prognosis of subjects of the first group is better than the prognosis of subjects of the second group. The method comprises the steps of: evaluating an amount of RBM3 protein or RBM3 mRNA molecule in at least part of a sample earlier obtained from the subject and determining a sample value corresponding to the evaluated ...

AMYLOID BETA(1-42) OLIGOMERS, DERIVATIVES THEREOF AND ANTIBODIES THERETO, METHODS OF PREPARATION THEREOF AND USE THEREOF

Application Number: 20120034166
Publication Date: 2012-02-09
Inventors: Striebinger, Andreas; Mueller, Reinhold; Hillen, Heinz; Krantz, Carsten; Moeller, Achim

The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery ...

NON-INVASIVE TOOLS FOR DETECTING VULNERABLE ATHEROSCLEROTIC PLAQUES

Application Number: 20120034163
Publication Date: 2012-02-09
Inventors: Boturyn, Didier; Riou, Laurent; Ghezzi, Catherine; Fagret, Daniel; Dumy, Pascal

The present invention relates to a polypeptide comprising the sequence RILAR (SEQ ID NO: 3), the use thereof in imaging methods, in diagnostic or prognostic methods and for use as a ...

DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF

Application Number: 20120034160
Publication Date: 2012-02-09
Inventors: Ghayur, Tariq; Liu, Junjian; Isakson, Peter C.

Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are ...

PHARMACEUTICAL COMPOSITIONS CONTAINING FLUORINATED OR PERFLUORINATED CARBOXYLIC ACIDS

Application Number: 20120029079
Publication Date: 2012-02-02
Inventors: ELCOMBE, CLIFFORD R.; WOLF, CHARLES R.

The molecules of formula (I) are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipis of eicosanoid status or functions may be desirable. Formula (I): Z¹—Z¹—Z²wherein a) Z¹represents CO₂H or a derivative thereof; b) Z²represents F, H, —CO₂H or a derivative thereof; and c) X represents fluorinated alkylene; or a ...

GAS SENSOR INCORPORATING A POROUS FRAMEWORK

Application Number: 20120028846
Publication Date: 2012-02-02
Inventors: Yaghi, Omar M.; Furukawa, Hiroyasu; Wang, Bo; Wang, Kang L.; Czaja, Alexander U.; Galatsis, Kosmas

The disclosure provides sensor for gas sensing including CO₂gas sensors comprising a porous framework sensing area for binding an analyte ...

USE OF PROTEIN SATB2 AS A MARKER FOR COLORECTAL CANCER

Application Number: 20120028836
Publication Date: 2012-02-02
Inventors: Pontén, Fredrik; Uhlén, Mathias

The invention provides new methods, means and uses in connection with detection, characterization and prognosis of colo-rectal cancer, via the identification of the SATB2 protein as a marker for this cancer ...

SECERNIN-1 AS A MARKER FOR CANCER

Application Number: 20120028835
Publication Date: 2012-02-02
Inventors: Karl, Johann; Kloeckner, Julia; Wild, Norbert; Hagmann, Marie-Luise; Roessler, Markus; Tacke, Michael

Disclosed is a method aiding in the assessment of cancer. It involves the use of the secernin-1 protein (SCRN1) as a universal marker of different cancer types. More specifically disclosed is a method for assessing cancer from a liquid sample derived from an individual by measuring SCRN1 in the sample. Measurement of SCRN1 can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo ...

MICROFLUIDIC DEVICE FOR SIMULTANEOUSLY CONDUCTING MULTIPLE ANALYSES

Application Number: 20120028830
Publication Date: 2012-02-02
Inventors: PARK, Jong-myeon; LEE, Jeong-gun; CHO, Yoon-kyoung; LEE, Beom-seok

Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from ...

pH MODULATION METHOD TO DETECT LIGAND-RECEPTOR BINDING

Application Number: 20120028823
Publication Date: 2012-02-02
Inventors: Jung, Hyunsook; Robison, Aaron D.; Cremer, Paul S.

The present disclosure relates to detecting receptor-ligand binding by measuring local pH modulation using a pH-sensitive ...

MICRO FLUIDIC STRUCTURES

Application Number: 20120028818
Publication Date: 2012-02-02
Inventors: Mendel-Hartvig, Ib; Öhman, Ove Per

A micro fluidic system includes a substrate, and, provided on said substrate, at least one flow path interconnecting with functional means in which liquid samples can be treated by desired procedures. The flow paths are laid out to form a pattern for the transport of liquid samples to and from said functional means. These flow paths comprise a plurality of micro posts protruding upwards from said substrate, the spacing between the micro posts being small enough to induce a capillary action in a ...

RAPID DETECTION AND IDENTIFICATION OF ENERGETIC MATERIALS WITH SURFACE ENHANCED RAMAN SPECTROMETRY (SERS)

Application Number: 20120028372
Publication Date: 2012-02-02
Inventors: Satcher, JR., Joe H.; Valdez, Carlos A.; Han, Thomas Yong-Jin; Olson, Tammy Y.; Kim, Sung Ho

In one embodiment, a system includes a plurality of metal nanoparticles functionalized with a plurality of organic molecules tethered thereto, wherein the plurality of organic molecules preferentially interact with one or more analytes when placed in proximity therewith. According to another embodiment, a method for detecting analytes includes contacting a fluid having one or more analytes of interest therein with a plurality of metal nanoparticles, each metal nanoparticle having a plurality of ...

METHOD AND KIT FOR DETECTING THE EARLY ONSET OF RENAL TUBULAR CELL INJURY

Application Number: 20120028371
Publication Date: 2012-02-02
Inventors: BARASCH, Jonathan M.; DEVARAJAN, Prasad

A method and kit for detecting the early onset of renal tubular cell injury, utilizing NGAL as an early urinary biomarker. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine following renal tubule cell injury. NGAL protein expression is detected predominantly in proximal tubule cells, in a punctate cytoplasmic distribution reminiscent of a secreted protein. The appearance of NGAL in the urine is related to the dose and duration of ...

REAGENT FOR ASSAYING D-DIMER AND KIT OF REAGENT FOR ASSAYING D-DIMER

Application Number: 20120028370
Publication Date: 2012-02-02
Inventors: NAGAI, Keisuke; YAMASHITA, Kazuaki; HOSHIKO, Susumu; SUZUKI, Takeshi

The present invention provides a reagent for assaying D-dimer which includes carriers sensitized to first and second monoclonal antibodies which react with D-dimer, but have different reactivity to D-dimer in which the first monoclonal antibody reacts with high- and low-molecular fractions of D-dimer, the second monoclonal antibody reacts with the high-molecular fraction, but reactivity of the second monoclonal antibody with the low-molecular fraction is different from that of the first ...

QUANTIFYING LOCAL INFLAMMATORY ACTIVITY AND ITS USE TO PREDICT DISEASE PROGRESSION AND TAILOR TREATMENTS

Application Number: 20120028369
Publication Date: 2012-02-02
Inventors: Kraus, Virginia Byers; BAND, Philip A.; WISNIEWSKI, Hans-Georg

This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting the medium with a fluid sample from a subject with an inflammatory condition, where the fluid sample comprises proteins or proteoglycans and a transfer agent; incubating the fluid sample with the medium under conditions effective for the transfer agent in the fluid sample to mediate transfer of heavy ...

SAMPLE PRETREATMENT AND EXTRACTION

Application Number: 20120028368
Publication Date: 2012-02-02
Inventors: Srinivasan, Kannan; Pohl, Christopher A.; Richter, Bruce; Murphy, Brett; Dorich, Brian; Ullah, S.M. Rahmat

A method for pretreating and extracting a liquid sample by sorbing an aqueous liquid sample, including an organic analyte and an acid or a base, in a solid sorbent material, and at least partially neutralizing the acid or base by reaction with neutralizing ions retained on a support surface, and contacting the liquid sample-sorbed sorbent material at elevated temperature and pressure with an organic solvent to extract the analyte into said solvent, preferably in a vessel having an extraction ...

REMOVING POLYPEPTIDES FROM STOOL

Application Number: 20120028367
Publication Date: 2012-02-02
Inventors: Ahlquist, David A.; Harrington, Jonathan J.; Quint, Patrick S.; Bergen, Harold R.

This document provides methods and materials involved in removing polypeptides (e.g., high abundance polypeptides) from stool samples. For example, methods and materials for preparing a stool sample for detecting polypeptides of low abundance are ...

FLOW CYTOMETER AND FLUIDIC LINE ASSEMBLY WITH MULTIPLE INJECTION NEEDLES

Application Number: 20120028366
Publication Date: 2012-02-02
Inventors: Krager, Jarden E.; Roth, Wayne D.; Deicher, William R.; Schilffarth, Adam Richard; Pempsell, Paul

A flow cytometer is provided which includes an interrogation flow cell and a plurality of assay fluidic lines extending into the interrogation flow cell. A method of operating such a flow cytometer includes priming the interrogation flow cell with a sheath fluid and injecting different assay fluids into a flow of the sheath fluid through the plurality of fluidic lines. A fluidic line assembly is provided which includes a plurality of capillary tubes coupled to a base section configured for ...

PORTABLE BIOCHEMICAL TESTING APPARATUS AND OPERATING METHOD THEREOF

Application Number: 20120028365
Publication Date: 2012-02-02
Inventors: Wang, William; Chou, Chung-Cheng

A portable biochemical testing apparatus and operating method thereof are disclosed. The portable biochemical testing apparatus includes a light source module, a sample module, a photoconductive material layer, a touch module, and a control module. At least one sample is disposed in the sample module. The photoconductive material layer is disposed between the sample module and the light source module. The touch module generates a driving signal according to a touch action of the user to drive ...

Stop-Flow Analytical Systems and Methods

Application Number: 20120028364
Publication Date: 2012-02-02
Inventors: Christensen, William M.; Kraus, Paul R.

Analytical systems and methods are provided for simultaneously dispensing metered volumes of fluids at different rates and mixing the fluids to generate a mixed sample having the fluids in proportion to the different rates at which they were dispensed. In some cases two or more of the fluids are premixed prior to mixing with other fluids. In some cases a use composition and diluent are simultaneously dispensed at different rates and premixed to form a diluted sample. One or more reagents may be ...

METAL POROUS MATERIAL, METHOD FOR PREPARING THE SAME AND METHOD FOR DETECTING NITROGEN-CONTAINING COMPOUNDS

Application Number: 20120028363
Publication Date: 2012-02-02
Inventors: Li, Shou-Nan; Hsu, Jung-Nan; Kuo, Chun-Nan; Yen, Shaw-I; Lai, Yu-Lun

The invention provides a metal porous material, a method for preparing the same, and a method for detecting nitrogen-containing compounds. The method for fabricating metal porous material includes: mixing a siloxane, a metal or metallic compound, and water, to obtain a mixture after stirring; modifying the mixture to a pH value of less than 7; subjecting the mixture to a first dry treatment to obtain a solid; after polishing the solid to obtain a powder, subjecting the powder to a second dry ...

2-QUINOXALINOL SALEN COMPOUNDS AND USES THEREOF

Application Number: 20120028362
Publication Date: 2012-02-02
Inventors: Gorden, Anne E. V.; Wu, Xianghong

Disclosed are 2-quinoxalinol salen compounds and in particular 2-quinoxalinol salen Schiff-base ligands. The disclosed 2-quinoxalinol salen compounds may be utilized as ligands for forming complexes with cations, and further, the formed complexes may be utilized as catalysts for oxidation reactions. The disclosed 2-quinoxalinol salen compounds also may be conjugated to solid supports and utilized in methods for selective solid-phase extraction or detection of ...