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PERILLA-DERIVED PROMOTER FUNCTIONING IN PETALS

Application Number: 20120042421
Publication Date: 2012-02-16
Inventors: Mizutani, Masako; Tanaka, Yoshikazu

There is provided a novel promoter useful for altering flow color of plants. The present invention relates to a nucleic acid selected from the group consisting of:

- (1) a nucleic acid containing the nucleotide sequence indicated in SEQ ID NO. 1;
- (2) a nucleic acid able to function as a transcriptional ...

ENHANCED ACCUMULATION OF CAROTENOIDS IN PLANTS

Application Number: 20120042417
Publication Date: 2012-02-16
Inventors: Drake, Caroline Rachel; Paine, Jacqueline Ann Mary; Shipton, Catherine Ann

The present invention relates to polynucleotides and their use in methods of increasing the carotenoid content of seeds. In particular the invention provides a polynucleotide comprising: (a) a region which comprises as operably linked components (i) a promoter which provides for seed preferred expression; and (ii) a nucleotide sequence derived from a bacterium which sequence encodes a carotene desaturase; and (iii) a transcription termination region; and (b) a further region which comprises as ...

Antibody fusion-mediated plant resistance against Oomycota

Application Number: 20120042416
Publication Date: 2012-02-16
Inventors: Fischer, Rainer; Schillberg, Stefan; Schleker, Sylvia; Peschen, Dieter

The present invention relates to fusion proteins comprising anti-Oomycotic proteins or peptides linked to an antibody or fragment thereof specifically recognising an epitope of an Oomycota. The invention is also directed to polynucleotides coding for the fusion proteins. The embodiments of the present invention are particularly useful for the protection of plants against Oomycota. The invention therefore comprises transgenic plants expressing the fusion proteins of the present ...

CHIMERIC PROMOTERS AND METHODS OF USE

Application Number: 20120042414
Publication Date: 2012-02-16
Inventors: Castle, Linda A.; Albert, Henrik; Lu, Jian; Tao, Yumin

Compositions and methods comprising promoters from the 4-hydroxyphenylpyruvate dioxygenase (HPPD) gene and active variants and fragments thereof, as well as chimeric promoters employing regulatory regions of the HPPD promoters are provided. Further provided are expression cassettes and plants comprising the various promoters disclosed herein operably linked to a polynucleotide of interest. Methods employing the various promoters described herein to modulate the expression of polynucleotides of ...

Compositions And Methods Comprising Sequences Having Hydroxyphenylpyruvate Dioxygenase (HPPD) Activity

Application Number: 20120042413
Publication Date: 2012-02-16
Inventors: Siehl, Daniel L.; Castle, Linda A.; Albert, Henrik; Bermudez, Ericka R.; Dong, Yuxia; Heckert, Matthew J.; Hou, Jingtong; Hou, Zhenglin; Lu, Jian; Tao, Yumin

Compositions and methods comprising polynucleotides and polypeptides having 4-hydroxyphenylpyruvate dioxygenase (HPPD) activity and having insensitivity to an HPPD inhibitor are provided. Further provided are nucleic acid constructs, plants, plant cells, explants, seeds and grain having the HPPD sequences. Various methods of employing the HPPD sequences are provided. Such methods include, for example, methods for producing an HPPD inhibitor tolerant plant, plant cell, explant or seed and ...

Methods And Compositions For Targeting Sequences Of Interest To The Chloroplast

Application Number: 20120042412
Publication Date: 2012-02-16
Inventors: Siehl, Daniel L.; Castle, Linda A.; Albert, Henrik; Heckert, Matthew; Lu, Jian; Tao, Yumin

Chimeric polynucleotides comprising a nucleotide sequence encoding a chloroplast transit peptide operably linked to a heterologous polynucleotide of interest are provided, wherein the chloroplast transit peptide comprises an amino acid sequence having the chloroplast transit peptide sequence as set forth in SEQ ID NO:1 or a biologically active variant or fragment thereof or wherein the chloroplast transit peptide comprises the sequence set forth in SEQ ID NO: 58 or an active variant or fragment ...

GENE TARGETING IN PLANTS

Application Number: 20120042411
Publication Date: 2012-02-16
Inventors: Malcuit, Isabelle; Sorokin, Alexander

An isolated polynucleotide sequence that encodes for a multi domain recombination protein, comprising a donor DNA-Binding domain (BDB); and a chromosomal binding domain (CBD). A plant cell can be transformed by introducing into the cell a first nucleic acid sequence, which comprises a plant nuclear promoter operably linked to a first nucleic acid sequence comprising the stated polynucleotide sequence, and a second nucleic acid sequence, which comprises a donor nucleic acid sequence and at least ...

ABSCISIC ACID CARRIER GENE AND TRANSGENIC PLANT EXPRESSING THE SAME

Application Number: 20120042410
Publication Date: 2012-02-16
Inventors: Lee, Young-Sook; Lee, Mi-Young; Martionia, Enrico; Kang, Joo-Hyun

The present invention relates to carrier genes of abscisic acid and the transgenic plant prepared using such genes, and more specifically to genes that enhance resistance to salt or dryness in relation to abscisic acid transport and the recombinant vectors including the genes, the transgenic plant prepared using the recombinant vector, a transgenic plant that is superior in terms of resistance to base and dryness, a method for environmental purification in arid regions based on the plants, and ...

PLANT TRANSFORMATION USING DNA MINICIRCLES

Application Number: 20120042409
Publication Date: 2012-02-16
Inventors: Deroles, Simon; Conner, Anthony; Pringle, Julie; Lokerse, Annemarie; Jacobs, Johanna; Barrell, Philippa; Boase, Murray

The invention provides methods and compositions for producing and using minicircle DNA molecules that are useful for plant transformation. The invention also provides methods for transforming plant cells and plants with such minicircle DNA molecules, plant cells and plants produced by such methods, and plants transformed with minicircle DNA molecules. The methods and compositions of the invention are particularly useful for producing “intragenic plants” which do not contain any non-native ...

PLANTS PRODUCING 2N GAMETES OR APOMEIOTIC GAMETES

Application Number: 20120042408
Publication Date: 2012-02-16
Inventors: D'Erfurth, Isabelle; Cromer, Laurence; Mercier, Raphael; Froger, Nicole; Jolivet, Sylvie

The invention relates to plants wherein the protein OSD1, involved in the transition from meiosis I to meiosis II is inactive. These plants produce Second Division Restitution (SDR) 2n gametes. The invention further relates to plants wherein the inactivation of OSD1 is combined with the inactivation of a gene involved in meiotic recombination in plants, and of a gene involved in the monopolar orientation of the kinetochores during meiosis. These plants produce apomeiotic gametes. These plants ...

CORN EVENT 5307

Application Number: 20120042407
Publication Date: 2012-02-16
Inventors: De Framond, Annick Jeanne; Meghji, Moez R.; New, Stephen L.; Prairie, Anna Underwood

A novel transgenic com event designated 5307, is disclosed. The invention ivlates to UNA sequences of the re- combinant constructs inserted into Uie corn genome and of genomic sequences flanking flic insertion site that resulted in the 5307 event. The invention further relates to assays for detecting the presence of the DNA sequences of 5307. to com plants and com seeds comprising the genotype of and to methods for producing a com plant by crossing a com plant comprising the 5307 geno- type ...

PEPPER HYBRID PS 11446271

Application Number: 20120042404
Publication Date: 2012-02-16
Inventor: BERKE, TERRY G.

The invention provides seed and plants of pepper hybrid PS 11446271 and the parent lines thereof, such as inbred parent line HAP 114-1128. The invention thus relates to the plants, seeds and tissue cultures of pepper hybrid PS 11446271 and the parent lines thereof, and to methods for producing a pepper plant produced by crossing such plants with themselves or with another pepper plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such ...

METHOD FOR INTRODUCING MUTANT GENE, GENE HAVING MUTATION INTRODUCED THEREIN, CASSETTE FOR INTRODUCING MUTATION, VECTOR FOR INTRODUCING MUTATION, AND KNOCK-IN NON-HUMAN MAMMALIAN ANIMAL

Application Number: 20120042401
Publication Date: 2012-02-16
Inventors: Hirose, Shinichi; Araki, Kimi; Deshimaru, Masanobu

Disclosed is a method for introducing a mutation into a gene, which comprises the following steps: a homologous recombination step of carrying out the homologous recombination between a target gene into which the mutation is to be introduced and a target recombinant vector, thereby substituting an exon in the target gene into which the mutation is to be introduced by a target DNA sequence in the target recombinant vector; and a mutation introduction step of carrying out the specific ...

RTD RECEPTOR

Application Number: 20120042400
Publication Date: 2012-02-16
Inventors: Gurney, Austin; Ashkenazi, Avi J.

Novel polypeptides, designated RTD, which are capable of binding Apo-2 ligand are provided. Compositions including RTD chimeras, nucleic acid encoding RTD, and antibodies to RTD are also ...

IMMUNOGENIC PEPTIDES

Application Number: 20120042399
Publication Date: 2012-02-16
Inventors: Banham, Alison; Pulford, Karen; Anderson, Amanda; Ait-Taho-ar, Kamel

The present invention relates to immunogenic peptides and their various applications. In particular the invention relates to immunogenic peptides derived from the PASD1 protein and their use in therapeutic, diagnostic and prognostic ...

COMPOSITIONS FOR LABELING AND IDENTIFYING AUTOPHAGOSOMES AND METHODS FOR MAKING AND USING THEM

Application Number: 20120042398
Publication Date: 2012-02-16
Inventors: Gottlieb, Roberta A.; Cole, Thomas E.; Perry-Garza, Cynthia N.; Carreira, Raquel Sousa; Bartlett, Bryan J.; Finley, Kim

The invention provides methods and compositions for detecting and measuring the amount of autophagosomes in cells or tissues, including biopsy samples, in vitro, in situ and/or in vivo. By detecting and measuring the amount of autophagosomes in cells or tissues, the methods and compositions of the invention also measure the amount of autophagic activity in a cell or a tissue. In one aspect, the invention can be adapted to a plate-reader format for high-throughput screening of drugs that ...

PHAGE ANTIBODIES TO RADIATION-INDUCIBLE NEOANTIGENS

Application Number: 20120041303
Publication Date: 2012-02-16
Inventors: Hallahan, Dennis E.; Mernaugh, Raymond

A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind ...

CANCER BIOMARKERS

Application Number: 20120041274
Publication Date: 2012-02-16
Inventors: Reid, Julia; Wagner, Susanne; Gutin, Alexander; Stone, Steven

Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are ...

COMPOSITIONS AND METHODS FOR 3-HYDROXYPROPIONATE BIO-PRODUCTION FROM BIOMASS

Application Number: 20120041232
Publication Date: 2012-02-16
Inventor: Lynch, Michael D.

Methods of obtaining mutant nucleic acid sequences that demonstrate elevated oxaloacetate α-decarboxylase activity are provided. Compositions, such as genetically modified microorganisms that comprise such mutant nucleic acid sequences, are described, as are methods to obtain the ...

METHOD FOR PRODUCING MULTICYCLICAL RING SYSTEMS CARRYING AMINO GROUPS

Application Number: 20120041216
Publication Date: 2012-02-16
Inventors: Skerra, Arne; Sieber, Volker; Haas, Thomas; Doderer, Kai; Grammann, Katrin; Ruehmann, Broder; Pfeffer, Jan Christoph; Rollmann, Claudia; Rausch, Christian; Lerchner, Alexandra

The invention relates to a method for the amination of at least one keto group in a multicyclic ring system comprising at least one keto group into an amino group, using at least one enzyme E having transaminase ...

dTDP-BETA-D-FUCOFURANOSE, ITS PREPARATION METHOD AND USE

Application Number: 20120041185
Publication Date: 2012-02-16
Inventors: Wang, Lei; Wang, Quan; Feng, Lu

Provided is a dTDP-β-D-fucofuranose, which is also referred to as dTDP-β-6-deoxy-D-galactofuranose. The dTDP-β-D-fucofuranose is synthesized by using reductase Fcf1 and mutase Fcf2 in the gram-negative bacteria. Also provided are the preparation method of the dTDP-β-D-fucofuranose and use of the dTDP-β-D-fucofuranose for manufacturing a medicament for the treatment of ...

METHOD OF PRODUCING POLYMERS OF SPIDER SILK PROTEINS

Application Number: 20120041177
Publication Date: 2012-02-16
Inventors: Johansson, Jan; Rising, Anna; Hedhammar, My; Nordling, Kerstin

A method of producing polymers of an isolated spider silk protein involves providing a solution of said spider silk protein in a liquid medium at pH 6.4 or higher and/or an ion composition that prevents polymerisation of the spider silk protein. The properties of the liquid medium are adjusted to a pH of 6.3 or lower and an ion composition that allows polymerisation of the spider silk protein. The spider silk protein is allowed to form polymers in the liquid medium, and the resulting spider ...

UCP4

Application Number: 20120041176
Publication Date: 2012-02-16
Inventors: Pan, James; Zhong, Alan; Adams, Sean

The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins (“UCPs”) and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the ...

PROCESS FOR THE PRODUCTION OF A RECOMBINANT POLYPEPTIDE OF INTEREST

Application Number: 20120041171
Publication Date: 2012-02-16
Inventors: Stam, Hein; Roubos, Johannes Andries; Van Peij, Noel Nicolaas Maria Elisabeth; Van De Vondervoort, Peter Jozef Ida

The present invention relates to a process for the production of a recombinant polypeptide of interest, a polypeptide obtained by said process, a recombinant polynucleotide, an expression vector, an expression construct and to the use of a specific signal peptide and of a polynucleotide encoding said specific signal peptide for the production of a recombinant polypeptide of ...

Biogenic Silica from Silica-Containing Plant Material Such as Rice Hulls

Application Number: 20120041081
Publication Date: 2012-02-16
Inventors: Hammond, Neal A.; Peirce, J. Steve

A biogenic silica from a plant material such as rice hulls, rice straw and so forth containing a significant amount of silica for use as an anti-caking agent, excipient or flavor carrier. When the plant material is certified as organic, the silica may also be certified as organic. The plant material is ground and the silica may be concentrated by carbon reduction through enzymatic treatment or burning. In some instances an antimicrobial treatment of the silica may be ...

GEL FORMING SOLUTION AND METHOD FOR PRODUCING GEL

Application Number: 20120041076
Publication Date: 2012-02-16
Inventor: HIRUMA, Kei

A method for producing a gel includes a liquid droplet ejection step in which a first liquid is ejected in the form of a droplet to a second liquid to allow the first liquid and the second liquid to react with each other, thereby producing a gel. The first liquid is a gel forming solution containing an alcohol-based solvent, wherein the alcohol-based solvent is contained therein in an amount of 4% or more by weight and less than 70% by weight of the total amount of the gel forming ...

METHODS OF TREATING CANCER HAVING AN ABERRANT EGFR OR KRAS GENOTYPE

Application Number: 20120041070
Publication Date: 2012-02-16
Inventors: Jin, Shengfang; Su, Shinsan; Van Der Heiden, Matthew

The invention relates to the treating cancer having an aberrant EGFR or KRAS genotype, with an AMPK activator, as well as related methods, compounds and ...

NUCLEIC ACIDS SPECIFICALLY BINDING WITH HUMAN FACTOR VII/VIIA AND USES THEREOF

Application Number: 20120041056
Publication Date: 2012-02-16
Inventors: Duconge, Frederic; Perret, Gerald

A nucleic acid includes at least 15 nucleotides with a length specifically binding with the human factor ...

COMPOSITE POLYNUCLEIC ACID THERAPEUTICS

Application Number: 20120041055
Publication Date: 2012-02-16
Inventor: Mathison, Brian H.

Compositions comprising therapeutic polynucleic acids and method of use. The compositions comprise one or more polynucleic acid sequences having two or more features useful for treating diseases associated with cellular proliferation or ...

COMPOSITIONS AND METHODS FOR THE TREATMENT OF SEPSIS AND OTHER DISORDERS INVOLVING PHOSPHOLIPASE A2 INDUCTION

Application Number: 20120041054
Publication Date: 2012-02-16
Inventor: Liu, Maw-Shung

The present invention provides antisense oligomers to PLA₂to inhibit PLA₂protein expression and enzyme activity, and to treat diseases and disorders associated with induced expression of PLA₂. In particular, the invention provides for the simultaneous inhibition of cPLA₂and ...

Compositions and Methods to Treat Muscular & Cardiovascular Disorders

Application Number: 20120041052
Publication Date: 2012-02-16
Inventors: BEUVINK, Iwan; HALL, Jonathan; WEILER, Jan; SCHNELL, Christian Rene; MUELLER, Matthias; SCHINKE-BRAUN, Martina; SERLUCA, Fabrizio

The present invention relates to a novel microRNA, mir-208-2, implicated in muscular and cardiovascular disorders. The present invention also relates to oligonucleotide therapeutic agents (antisense oligonucleotides and/or double stranded oligonucleotides such as dsRNA) and their use in the treatment of muscular and cardiovascular disorders resulting from dysregulation of ...

Compositions And Methods For Inhibiting Expression Of MIG-12 Gene

Application Number: 20120041051
Publication Date: 2012-02-16
Inventors: Hinkle, Gregory; Fitzgerald, Kevin

The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting MIDI interacting G12-like protein (MIG 12) gene, and methods of using the dsRNA to inhibit expression of MIG ...

ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF

Application Number: 20120041050
Publication Date: 2012-02-16
Inventors: Wilton, Stephen Donald; Fletcher, Sue; McClorey, Graham

An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to ...

DESIGN OF SMALL-INTERFERING RNA

Application Number: 20120041049
Publication Date: 2012-02-16
Inventor: Rohayem, Jacques

The present invention relates to small-interfering RNA molecules displaying an increased thermodynamic stability at the 3′ end of the antisense strand (guide strand) and the 5′ end of the sense strand (passenger strand), respectively, in comparison to the base pairing in the seed region. The siRNAs of the present invention display an increased knock-down activity against targeted genes and show an improved resistance to RNAses, in particular serum RNAses. The present invention also relates ...

COMPOSITIONS AND METHODS RELATING TO miR-31

Application Number: 20120041048
Publication Date: 2012-02-16
Inventors: Weinberg, Robert A.; Valastyan, Scott J.

MicroRNA-31 (miR-31), targets of miR-31, the role of miR-31 in inhibiting tumor metastasis, and the role of miR-31 target genes in promoting tumor metastasis are ...

AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS

Application Number: 20120041039
Publication Date: 2012-02-16
Inventors: Hong, Feng; Scott, Ian L.; Orme, Mark W.; Little, JR., Thomas L.; Kuksa, Vladimir A.; Kubota, Ryo

Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and ...

AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS

Application Number: 20120041038
Publication Date: 2012-02-16
Inventors: Hong, Feng; Scott, Ian L.; Orme, Mark W.; Little, JR., Thomas L.; Kuksa, Vladimir A.; Kubota, Ryo

SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION

Application Number: 20120041023
Publication Date: 2012-02-16
Inventors: Wilson, Robert B.; Cotticelli, Maria Grazia; Benedetti, Phillip A.; Smith, Amos; Melvin, Jason E.; Huryn, Donna M

Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula (I) are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects ...

PYRIDOCARBAZOLE TYPE COMPOUNDS AND APPLICATIONS THEREOF

Application Number: 20120041017
Publication Date: 2012-02-16
Inventors: Rivalle, Christian; Lafanechere, Laurence; Vassal, Emilie; Barette, Caroline; Nguyen, ChiHung; Prudent, Renaud

Pyridocarbazole-type compounds of formula (I):

are provided as a medicament, and more particularly for application in anticancer chemotherapy. Also provided is a pharmaceutical composition with the compound and methods for preventing and/or treating neurodegenerative-type pathologies, such as Alzheimer's disease and schizophrenia, parasitoses, such as malaria, or ...

CARBONYLAMINO-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE

Application Number: 20120041001
Publication Date: 2012-02-16
Inventors: Van Brandt, Sven Franciscus Anna; Backx, Leo Jacobus Jozef; Van Emelen, Kristof; Verdonck, Marc Gustaaf Celine

This invention comprises the novel compounds of formula (I)

wherein n, m, t, R¹, R², R³, R⁴, R⁵, L, Q, X, Y and

have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a ...

VINYL-ARYL DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES

Application Number: 20120040997
Publication Date: 2012-02-16
Inventor: Chen, Shoujun

The invention relates to compounds that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune ...

DESIGN, SYNTHESIS AND EVALUATION OF PROCASPASE ACTIVATING COMPOUNDS AS PERSONALIZED ANTI-CANCER DRUGS

Application Number: 20120040995
Publication Date: 2012-02-16
Inventors: Hergenrother, Paul J.; Peterson, Quinn Patrick; Hsu, Danny Chung; West, Diana C.; Fan, Timothy M.; Novotny, Chris J.

Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed that have lower neurotoxicity effects than other ...

TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY

Application Number: 20120040985
Publication Date: 2012-02-16
Inventors: Flatt, Brenton T.; Morrissey, Michael; Boren, Brant Clayton; Gu, Xiao-Hui; Martin, Richard; Wang, Tie-Lin; Mohan, Raju; Bollu, Venkataiah; Julien, Jackaline Dalgard; Haq, Nadia; Hudson, Sarah; Pratt, Benjamin

The present invention comprises TGR5 agonists of structural formula I,

wherein X, R¹, R², and R⁵are defined herein, as well as N-oxides of them and pharmaceutically acceptable salts thereof. The invention further comprises composition comprising the compounds, N-oxides, and/or pharmaceutically acceptable salts thereof. The invention also comprises use of the compounds and compositions for treating ...

SMALL MOLECULE IMMUNOMODULATORS FOR ALZHEIMER"S DISEASE

Application Number: 20120040976
Publication Date: 2012-02-16
Inventors: Abel, Kenneth J.; Cashman, John R.

Disclosed are methods for identifying individuals suffering from a CNS disorder (including Alzheimer's Disease, ALS, behavioral disorders, and the like) that could be treated with a CNS drug with greater therapeutic efficacy and lower side effects and the compounds useful for such treatment. Also disclosed are methods for predicting the efficacy of a drug candidate for the treatment of a CNS disorder. The technology is also applicable to drug discovery for evaluation in animal models of ...

BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS

Application Number: 20120040971
Publication Date: 2012-02-16
Inventor: Glick, Gary D.

The present invention provides a family of benzodiazepinone compounds and pharmaceutical compositions thereof. The present invention also provides methods of treating certain skin conditions, e.g., atopic dermatitis, rosacea, or psoriasis, by administering a benzodiazepinone and methods of reducing the proliferation of keratinocyte cells by exposing such cells to a ...

Pyrazin-2-yl-pyridin-2-yl-amine and pyrazin-2-yl-pyrimidin-4-yl-amine Compounds and Their Use

Application Number: 20120040967
Publication Date: 2012-02-16
Inventors: Cherry, Michael; Collins, Ian; Reader, John Charles; Matthews, Thomas Peter; Cheung, Kwai Ming; Proisy, Nicolas; Klair, Sukhbinder Singh; Scanlon, Jane Elizabeth; Williams, David Hugh; Piton, Nelly; Addison, Glynn Jonathan

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain biarylamine compounds (referred to herein as BAA compounds), and especially certain pyrazin-2-yl-pyridin-2-yl-amine and pyrazine-2-yl-pyrimidin-4-yl-amine compounds, which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in ...

ANTI-VIRAL COMPOUNDS, TREATMENT, AND ASSAY

Application Number: 20120040966
Publication Date: 2012-02-16
Inventors: Maddry, Joseph A.; Severson, Bill; Jonsson, Colleen B.; Noah, James W.; Noah, Diana L.; Chen, Xi

The compounds provided herein are suitable for inhibiting a virus in a patient and for treating a patient suffering from a viral infection such as an influenza virus. Also provided is a method for screening of compounds for use in treating and preventing viral infections. The assay screens compounds for activity against an influenza virus by measuring the cytopathogenic effect (CPE) of the compound on influenza infected-cells using percent cell viability as the end ...

PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING DISORDERS

Application Number: 20120040961
Publication Date: 2012-02-16
Inventors: Kwiatkowski, Nicholas Paul; Gray, Nathanael S.; Deng, Xianming

The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), polo kinase 1, 2, 3, or 4, Ack1, Ack2, AbI, DCAMKL1, ABL1, AbI mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS 1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, AxI, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and ...

HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS

Application Number: 20120040951
Publication Date: 2012-02-16
Inventors: Chuaqui, Claudio; Kumaravel, Gnanasambandam; Vessels, Jeffrey; Raimundo, Brian; Tanaka, Hiroko; Guan, Bing; Ishchenko, Alexey; Jones, John Howard; Peng, Hairuo; Powell, Noel; Xin, Zhili; Cossrow, Jennifer; Dowling, James; Hoemann, Michael; Kabigting, Lori; van Vloten, Kurt

The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE

Application Number: 20120040950
Publication Date: 2012-02-16
Inventors: Cao, Jingrong; Messersmith, David; Wang, Jian; Aronov, Alex; Come, Jon H.; Davies, Robert J.; Henderson, James A.; Grillot, Anne-Laure; Le Tiran, Arnaud; Pierce, Albert Charles; Collier, Philip N.; Grey, JR., Ronald Lee; O'Dowd, Hardwin; Krueger, Elaine B.; Liao, Yusheng; Nanthakumar, Suganthini S.; Bandarage, Upul Keerthi

The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or ...