Patent 7867704 Issued on January 11, 2011. Estimated Expiration Date: September 3, 2024. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
The present invention provides nucleic acid molecules unique to M. paratuberculosis. The invention also provides the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules of the invention, and antibodies having specific binding affinity for the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules. The invention further provides for methods of detecting M. paratuberculosis in a sample using nucleic acid molecules, polypeptides, and antibodies of the invention. The invention additionally provides methods of preventing a M. paratuberculosis infection in an animal.
Other References
Notice of reasons for Rejection, JP Application No. 2004-568446 mailed May 12, 2009, 7 pages.
Vary et al., “Use of Highly Specific DNA Probes and the Polymerase Chain Reaction to Detect Mycobacterium paratuberculosis in Johne's Disease,” J. Clin. Microbiol., 1990, 28(3):933-937.
Van der Giessen et al., “Comparison of the 23S ribosomal RNA genes and the spacer region between the 16S and 23S rRNA genes of the closely related Mycobacterium avium and Mycobacterium paratuberculosis and the fast-growing Mycobacterium phlei,” Microbiology, 1994, 140:1103-1108.
Whipple et al., “Isolation and Analysis of Restriction Endonuclease Digestive Patterns of Chromosomal DNA from Mycobacterium paratuberculosis and Other Mycobacterium Species,” J. Clin. Microbiol., 1987, 25(8):1511-1515.
Stabel et al., “Comparison of polyclonal antibodies to three different preparations of Mycobacterium paratuberculosis in immunohistochemical diagnosis of Johne's disease in cattle,” J. Vet. Diagn. Invest., 1996, 8:469-473.
Stabel and Whitlock, “An evaluation of a modified interferon-γ assay for the detection of paratuberculosis in dairy herds,” Vet. Immunol. Immunopathol., 2001, 79:69-81.
Marsh et al., “Quality control and optimized procedure of hybridization capture-PCR for the identification of Mycobacterium avium subsp. paratuberculosis in faeces,” Mol. Cell. Probes, 2000, 14:219-232.
Mahairas et al., “Molecular Analysis of Genetic Differences between Mycobacterium bovis BCG and Virulent M. bovis,” J. Bacteriol., 1996, 178(5):1274-1282.
Harris and Barletta, “Mycobacterium avium subsp. paratuberculosis in Veterinary Medicine,” Clin. Microbiol. Rev., 2001, 14(3):489-512.
Eriks et al., “Rapid Differentiation of Mycobacterium avium and M. paratuberculosis by PCR and Restriction Enzyme Analysis,” J. Clin. Microbiol., 1996, 34(3):734-737.
Ellingson et al., “Identification of a gene unique to Mycobacterium avium subspecies paratuberculosis and application to diagnosis of paratuberculosis,” Mol. Cell. Probes, 1998, 12:133-142.
Ellingson et al., “Evaluation of the accuracy and reproducibility of a practical PCR panel assay for rapid detection and differentation of Mycobacterium avium subspecies,” Mol. Cell. Probes, 2000, 14:153-161.
Dubash et al., “Evaluation of an enzyme-linked immunosorbent assay licensed by the USDA for use in cattle for diagnosis of ovine paratuberculosis,” J. Vet. Diagn. Invest., 1995, 7:347-351.
Cousins et al., “Mycobacteria distinct from Mycobacterium avium subsp. paratuberculosis isolated from the faeces of ruminants possess IS900-like sequences detectable by IS900 polymerase chain reaction: implications for diagnosis,” Mol. Cell. Probes, 1999, 14:431-442.
Collins and Sockett, “Accuracy and economics of the USDA-licensed enzyme-linked immunosorbent assay for bovine paratuberculosis,” J. Am. Vet. Med. Assoc., 1993, 203(10):1456-1463.
Cole et al., “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence,” Nature, 1998, 393:537-544.
Brosch et al., “Comparative genomics of the mycobacteria,” Int. J. Med. Microbiol., 2000, 290:143-152.
Bannantine et al., “Identification of Mycobacterium paratuberculosis gene expression signals,” Microbiology, 1997, 143:921-928.
Bannantine et al., “Genome Scale Comparison of Mycobacterium avium subsp. paratuberculosis with Mycobacterium avium subsp. avium Reveals Potential Diagnostic Sequences,”J, Clin. Microbiol., 2002, 40(4):1303-1310.
Bannantine and Stabel, “Identification of two Mycobacterium avium subspecies paratuberculosis gene products differentially recognised by sera from rabbits immunised with live mycobacteria but not heat-killed mycobacteria,” J. Med. Microbiol., 2001, 50:795-804.
Bannantine and Stabel, “HspX is present within Mycobacterium paratuberculosis-infected macrophages and is recognized by sera from some infected cattle,” Vet. Microbiol., 2000, 76:343-358.
September 3, 2024. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
