U.S. patents available from 1976 to present.
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Thrombopoetin receptor activator and process for producing the same

Patent 7851503 Issued on December 14, 2010. Estimated Expiration Date: Icon_subject August 14, 2023. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method of inhibiting tumor growth using xanthocillin X dimethylether Patent #: 5312833
Issued on: 05/17/1994
Inventor: Tsuruoka, et al.

Inventors

Assignee

Application

No. 10524666 filed on 08/14/2003

US Classes:

514/525Two or more of the cyano groups

Examiners

Primary: Wilson, James O.
Assistant: Sackey, Ebenezer

Attorney, Agent or Firm

Foreign Patent References

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  • 94/20456 WO 09/01/1994
  • 96/40189 WO 12/01/1996
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  • 98/25965 WO 06/01/1998
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  • 02/062775 WO 08/01/2002
  • 02/085343 WO 10/01/2002

International Class

A61K 31/275

Abstract

A preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective or a platelet increasing agent, which contains a thrombopoietin receptor activator represented by the formula (1):

[wherein each of R1 and R3 is independently a hydrogen atom, SO3H, a C1-6 alkyl group, a C1-6 alkylcarbonyl group or a C6-18 arylcarbonyl group (the C1-6 alkyl group, the C1-6 alkylcarbonyl group and the C6-18 arylcarbonyl group may be optionally substituted with a halogen atom, a hydroxyl group, a C2-6 alkenyl group, a C1-6 alkoxy group, a C1-6 alkoxycarbonyl group, a C6-18 aryl group, a 2-pyridyl group, a 3-pyridyl group, a 4-pyridyl group, a 2-furanyl group, a 3-furanyl group, a 2-thienyl group, a 3-thienyl group or NR9R10) , and each of R2, R4 and Ra is independently a hydrogen atom, a hydroxyl group or a C1-6 alkoxy group].

Other References

  • U.S. Appl. No. 12/492,435, filed Jun. 26, 2009, Owada, et al.
  • Andrews, S. et al. “Further Studies on the Water Relations of Xerophilic Fungi, Including Some Halophiles”, Journal of General Microbiology, vol. 133, pp. 233-238 1987.
  • Morino, Tomio et al. “NK372135s, Novel Antifungal Agents Produced by Neosartoila fischeri”, Journal of Antibiotics, vol. 47, No. 12, pp. 1546-1548 1994.
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  • Brizzi, Maria et al. “Thrombopoietin Stimulates Endothelial Cell Motility and Neoangiogenesis by a Platelet-Activating Factor-Dependent Mechanism”, Circ Res., vol. 84, pp. 785-796 1999.
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  • Andrews, S., “Further Studies on the Water Relations of Xerophilic Fungi Including Some Halophiles.”, J.Gen.Microbiol., vol. 133, No. 2, pp. 233-238, 1987.
  • Morino, T., “NK372135s, novel antifungal agents produced by Neosartoria fischeri.”, J.Antibiot., vol. 47, No. 12, pp. 1546-1548, 1994.
  • Saroj Vadhan-Raj et al., Stimulation of Megakaryocyte and Platelet Production by Single Dose of Recombinant Human Thrombopoietin in patients With Cancer,. Annals of Internal Medicine; vol. 126, Issue 9; May 1, 1997; pp. 673-681.
  • K. Pavithran, Thrombopoietin, Medicine On-Line.
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