Thrombopoetin receptor activator and process for producing the same
Patent 7851503 Issued on December 14, 2010. Estimated Expiration Date: August 14, 2023. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
A preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective or a platelet increasing agent, which contains a thrombopoietin receptor activator represented by the formula (1): [wherein each of R1 and R3 is independently a hydrogen atom, SO3H, a C1-6 alkyl group, a C1-6 alkylcarbonyl group or a C6-18 arylcarbonyl group (the C1-6 alkyl group, the C1-6 alkylcarbonyl group and the C6-18 arylcarbonyl group may be optionally substituted with a halogen atom, a hydroxyl group, a C2-6 alkenyl group, a C1-6 alkoxy group, a C1-6 alkoxycarbonyl group, a C6-18 aryl group, a 2-pyridyl group, a 3-pyridyl group, a 4-pyridyl group, a 2-furanyl group, a 3-furanyl group, a 2-thienyl group, a 3-thienyl group or NR9R10) , and each of R2, R4 and Ra is independently a hydrogen atom, a hydroxyl group or a C1-6 alkoxy group].
U.S. Appl. No. 12/492,435, filed Jun. 26, 2009, Owada, et al.
Andrews, S. et al. “Further Studies on the Water Relations of Xerophilic Fungi, Including Some Halophiles”, Journal of General Microbiology, vol. 133, pp. 233-238 1987.
Morino, Tomio et al. “NK372135s, Novel Antifungal Agents Produced by Neosartoila fischeri”, Journal of Antibiotics, vol. 47, No. 12, pp. 1546-1548 1994.
“Blood”, Journal of the American Society of Hematology, vol. 98, No. 11, pp. 71a-72a 2001.
Brizzi, Maria et al. “Thrombopoietin Stimulates Endothelial Cell Motility and Neoangiogenesis by a Platelet-Activating Factor-Dependent Mechanism”, Circ Res., vol. 84, pp. 785-796 1999.
Cardier, Jose E. “Effects of Megakaryocyte Growth and Development Factor (Thrombopoietin) on Liver Endothelial Cells in Vitro”, Microvascular Research, vol. 58, pp. 108-113 1999.
U.S. Appl. No. 11/721,252, filed Jun, 8, 2007, Miyaji, et al.
U.S. Appl. No. 11/721,786, filed Jun. 14, 2007, Miyaji, et al.
Andrews, S., “Further Studies on the Water Relations of Xerophilic Fungi Including Some Halophiles.”, J.Gen.Microbiol., vol. 133, No. 2, pp. 233-238, 1987.
Morino, T., “NK372135s, novel antifungal agents produced by Neosartoria fischeri.”, J.Antibiot., vol. 47, No. 12, pp. 1546-1548, 1994.
Saroj Vadhan-Raj et al., Stimulation of Megakaryocyte and Platelet Production by Single Dose of Recombinant Human Thrombopoietin in patients With Cancer,. Annals of Internal Medicine; vol. 126, Issue 9; May 1, 1997; pp. 673-681.