Method for making analgesics

Patent 7851482 Issued on December 14, 2010. Estimated Expiration Date:

October 3, 2027. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

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Inventors

Assignee

Johnson Matthey Public Limited Compnay

Application

No. 11866840 filed on 10/03/2007

US Classes:

514/282One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)

Examiners

Primary: Aulakh, Charanjit S

Attorney, Agent or Firm

Ratnerprestia

Foreign Patent References

0 359 647 EP 03/01/1990
WO 99/02529 WO 01/01/1999
WO 01/29048 WO 04/01/2001
WO 2005/028483 WO 03/01/2005
WO 2007/103105 WO 09/01/2007

International Classes

A61K 31/485
C07D 489/04

Abstract

Improved analgesic oxymorphone hydrochloride contains less than 10 ppm of alpha, beta unsaturated ketones and pharmaceutical preparations comprising such oxymorphone hydrochloride. The oxymorphone hydrochloride is produced by reducing a starting material oxymorphone hydrochloride using gaseous hydrogen and under specified acidity, solvent system and temperature conditions. A specific polymorph of oxymorphone hydrochloride may be obtained by hydration.

Other References

Marton et al., “Herstellung von 6, 14-Ethenomorphinan-Derivaten,” Monatshefte für Chemie, vol. 125, pp. 1229-1239 (1994).
Hosztafi et al., “Reactions of Azodicarboxylic Esters with Amines,” Scientia Pharmaceutica, vol. 55, pp. 61-75 (1987).
Andre et al., “O-Demethylation of Opioid Derivatives with Methane Sulfonic Acid / Methionine: Application to the Synthesis of Naloxone and Analogues,” Synthetic Communications, vol. 22, No. 16, pp. 2313-2327 (1992).
U.S. Appl. No. 12/446,172 which is the National Stage of PCT/US07/81513 to Bao-Shan Huang, filed Oct. 16, 2007 and entitled “Process for Preparing Oxymorphone, Naltrexone, and Buprenorphine”.
U.S. Appl. No. 12/446,171 which is a National Stage of PCT/US07/68009 to Bao-Shan Huang, filed May 2, 2007 and entitled “Process for Preparing Oxymorphone”.
Ulrich Weiss, Derivatives of Morphine. II. Demethylation of 14-hydroxycodeinone. 14-Hydroxymorphinone and 8,14-Dihydroxydihydromorphinone, J. Org. Chem., 1957, 22 (11), pp. 1505-1508.
Andrew Coop et al., “L-Selectride as a General Reagent for the O-Demethylation and N-Decarbomethoxylation of Opium Alkaloids and Derivatives,” J. Org. Chem., 1998, 63 (13), pp. 4392-4396.