Compositions and methods for modification of biomolecules

Patent 7807619 Issued on October 5, 2010. Estimated Expiration Date:

October 31, 2025. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Substituted heterocyclic compounds
Patent #: 6077954
Issued on: 06/20/2000
Inventor: Cook, et al.

Compounds having a plurality of nitrogenous substitutents Patent #: 6329523
Issued on: 12/11/2001
Inventor: Cook, et al.

Inventors

Assignee

The Regents Of The University Of California

Application

No. 11264463 filed on 10/31/2005

US Classes:

514/2Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI

Examiners

Primary: Tate, Christopher R.
Assistant: Teller, Roy

Attorney, Agent or Firm

International Class

C07K 14/705

Abstract

The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

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