Transgenic bovines capable of human antibody production
Patent 7414170 Issued on August 19, 2008. Estimated Expiration Date: May 19, 2023. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
800/15, Bovine800/5, The protein is isolated or extracted from blood or serum800/6, The protein is an immunoglobulin800/25Via microinjection of DNA into an embryo, egg cell, or embryonic cell
The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.
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May 19, 2023. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
