Matrix protein composition for dentin regeneration

Patent 7304030 Issued on December 4, 2007. Estimated Expiration Date:

June 19, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Enamel matrix related polypeptide
Patent #: 6300062
Issued on: 10/09/2001
Inventor: Cerny, et al.

Matrix protein compositions for wound healing Patent #: 6503539
Issued on: 01/07/2003
Inventor: Gestrelius, et al.

Inventors

Assignee

Biora AB

Application

No. 09885725 filed on 06/19/2001

US Classes:

514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI530/300, PEPTIDES OF 3 TO 100 AMINO ACID RESIDUES424/435, Mouth435/6, Involving nucleic acid424/549Skeleton (e.g., bone, teeth, etc.)

Examiners

Primary: Bragdon, Kathleen Kerr
Assistant: Desai, Anand

Attorney, Agent or Firm

Rissman Jobse Hendricks & Oliverio LLP

Foreign Patent References

WO 97/02730 WO 01/01/1997
WO 99/43344 WO 09/01/1999

International Classes

A61K 38/00
C07K 14/00

Abstract

The present invention relates to the surprising finding that enamel matrix, enamel matrix derivatives and/or enamel matrix proteins induce dentin regeneration. The invention thus relates to the use of a preparation of an active enamel substance for the preparation of a pharmaceutical composition for the formation or regeneration of dentin following dental procedures involving exposure of vital dental pulp tissue. In another aspect, the invention relates to a method of promoting the formation or regeneration of dentin following dental procedures involving exposure of vital dental pulp tissue, the method comprising applying an effective amount of an active enamel substance on exposed vital dental pulp tissue after dental procedures.

Other References

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James T. Mellonig; “Enamel Matrix Derivative for Periodontal Reconstructive Surgery; Technique and Clinical and Histologic Case Report” International Journal of Peridontics & Restorative Dentistry, vol. 19, No. 1, Feb. 1999, pp. 9-19.
T. Inai et al.: “Demonstration of amelogenin in the enamel-free cusps of rat molar tooth germs: Immunofluorescent and immunoelectron microscopic studies.” The Anatomical Record, vol. 233 No. 4, Aug. 1992, pp. 588-596.
Lyngstadaas SP, Lundberg E, Ekdahl H, Andersson C, Gestrelius S (2001). Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative. J. Clin Periodontol, Feb;28(2):181-8.
Gestrelius S. Andersson C, Johansson AC, Persson E, Brodin A, Rydhag L, Hammarstrom L (1997). Formulation of enamel matrix derivative for surface coating. Kinetics and cell colonization. J. Clin Periodontol, 24: 678-684.
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