U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Vagus nerve stimulation via unidirectional propagation of action potentials

Patent 7292890 Issued on November 6, 2007. Estimated Expiration Date: Icon_subject June 20, 2022. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Method for artificially inducing urination, defecation, or sexual excitation
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Method for non-invasive electrical stimulation of epiphyseal plate growth
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Surgically implantable electrode for nerve bundles
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Implantable cuff, method of manufacture, and method of installation
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Antidromic pulse generating wave form for collision blocking
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Asymmetric shielded two electrode cuff
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Inventors

Assignee

Application

No. 10176722 filed on 06/20/2002

US Classes:

607/45, Treating mental or emotional disorder128/903, RADIO TELEMETRY607/2, Electrical therapeutic systems607/72, Pulse signal600/544, Detecting brain electric signal607/55, Promoting auditory function600/375, Anchored607/118, Applicator placed around stimulated nerve607/40, Stimulating bladder or gastrointestinal tract607/46, Electrical treatment of pain607/3, Combined with nonelectrical therapy607/62, Output controlled by sensor responsive to body or interface condition607/5Cardioverting/defibrillating

Examiners

Primary: Layno, Carl H.
Assistant: Malamud, Deborah

Attorney, Agent or Firm

Foreign Patent References

  • WO-98/37926 WO 09/01/1998
  • WO-98/43700 WO 10/01/1998
  • WO-98/43701 WO 10/01/1998
  • WO-01/60445 WO 08/01/2001
  • WO-01/76690 WO 10/01/2001
  • WO-02/058782 WO 08/01/2002
  • WO-02/068042 WO 09/01/2002
  • WO-02/092165 WO 11/01/2002
  • 03/018113 WO 03/01/2003
  • WO-03/018113 WO 03/01/2003

International Class

A61N 1/05

Abstract

Methods of stimulating a vagus nerve include providing at least one implantable stimulator with at least two electrodes, configuring the electrodes to apply stimulation that unidirectionally propagates action potentials along a vagus nerve, and applying the stimulation to the vagus nerve to effectively select afferent fibers, thereby treating at least one of epilepsy and depression while limiting side effects of bidirectional stimulation. At least one of the electrodes comprises a leadsless electrode.

Other References

  • Veraart, et al., “Selective Control of Muscle Activation with a Multipolar Nerve Cuff Electrode”, IEEE Transactions on Biomedical Engineering, vol. 40, No. 7, (Jul. 1993), pp. 640-653.
  • Van Den Honert, et al., “Generation of Unidirectionally Propagated Action Potentials in a Peripheral Nerve by Brief Stimuli”, Science, vol. 206, (Dec. 14, 1979), pp. 1311-1312.
  • Van Den Honert, et al., “A Technique for Collision Block of Peripheral Nerve: Single Stimulus Analysis”, IEEE Transactions on Biomedical Engineering, vol. BME-28, No. 5, (May 1981), pp. 372-378.
  • Van Den Honert, et al., “A Technique for Collision Block of Peripheral Nerve: Frequency Dependence”, IEEE Transactions on Biomedical Engineering, vol. BME-28, No. 5, (May 1981), pp. 379-382.
  • Uthman, et al., “Treatment of Epilepsy by Stimulation of the Vagus Nerve”, Neurology, vol. 43(1), (1993), pp. 338-345.
  • Ungar, et al. “Generation of Unidirectionally Propagating Action Potentials Using a Monopolar Electrode Cuff”, Annals of Biomedical Engineering, vol. 14(5), (1986), pp. 437-450.
  • Sweeney, et al., “An Asymmetric Two Electrode Cuff for Generation of Unidirectionally Progagated Action Potentials”, IEEE Transactions on Biomedical Engineering, vol. BME-33, No. 6, (Jun. 1986), pp. 541-549.
  • Schoonhoven,.et al., “The Inverse Problem in Electroneurography-I: Conceptual Basis and Mathematical Formulation”, Biomedical Engineering, vol. 35(10), (1988), pp. 769-777.
  • Lesser, et al., “Unexpected Places How did Vagus Nerve Stimulation Become a Treatment for Epilepsy?”, Neurology, vol. 52, (1999), pp. 1117-1118.
  • Cameron, et al., “Micromodular Implants to Provide Electrical Stimulation of Paralyzed Muscles and Limbs”, IEEE Transactions on Biomedical Engineering, vol. 44, No. 9, (Sep. 1997), pp. 781-790.
  • Bilgutay, et al., “Vagal Tuning: A New concept in the Treatment of Supraventricular Arrhythmias, Angina Pectoris, and Heart Failure”, Journal of Thoracic and Cardiovascular Surgery, vol. 56, No. 1, (Jul. 1968), pp. 71-82.
  • Barker, et al., “Determination of the Distribution of Conduction Velocities in Human Nerve Trunks”, Biomedical Engineering, vol. 26(2), (1979), pp. 76-81.
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