C10 carbamoyloxy substituted taxane compositions
Patent 7230013 Issued on June 12, 2007. Estimated Expiration Date: 
February 28, 2025. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 28, 2025. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMethod for preparation of taxol using ଲ-lactam Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them Certain alkoxy substituted taxanes and pharmaceutical compositions containing them Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them 10-desacetoxytaxol derivatives Preparation of substituted isoserine esters using ଲ-lactams and metal or ammonium alkoxides Ɗ6,7 -taxols antineoplatic use and pharmaceutical compositions containing them Enzymatic processes for resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes C10 taxane derivatives and pharmaceutical compositions C7 taxane derivatives and pharmaceutical compositions containing them InventorsAssigneeApplicationNo. 11067882 filed on 02/28/2005US Classes:514/337, The additional hetero ring is one of the cyclos in a polycyclo ring system514/449, Oxygen containing hetero ring514/473, Chalcogen bonded directly to the hetero ring549/60, Ring oxygen in the additional hetero ring549/510, The hetero ring is four-membered549/511, Sulfur or halogen attached directly or indirectly to the hetero ring by nonionic bonding546/281.7, Ring oxygen in the additional hetero ring514/468, Polycyclo ring system having the hetero ring as one of the cyclos250/282MethodsExaminersPrimary: Owenk, Amelia A.Attorney, Agent or FirmForeign Patent References
International ClassA61K 31/44DescriptionBACKGROUND OF THE INVENTION The present invention is directed to novel taxanes which have exceptional utility as antitumor agents. The taxane family of terpenes, of which baccatin III and taxol are members, has been the subject of considerable interest in both the biological and chemical arts. Taxol itself is employed as a cancer chemotherapeutic agent and possesses a broadrange of tumor-inhibiting activity. Taxol has a 2'R, 3'S configuration and the following structural formula: ##STR00001## wherein Ac is acetyl. Colin et al. reported in U.S. Pat. No. 4,814,470 that certain taxol analogs have an activity significantly greater than that of taxol. One of these analogs, commonly referred to as docetaxel, has the following structural formula: ##STR00002## Although taxol and docetaxel are useful chemotherapeutic agents, there are limitations on their effectiveness, including limited efficacy against certain types of cancers and toxicity to subjects when administered at various doses. Accordingly,a need remains for additional chemotherapeutic agents with improved efficacy and less toxicity. SUMMARY OF THE INVENTION Among the objects of the present invention, therefore, is the provision of taxanes which compare favorably to taxol and docetaxel with respect to efficacy as anti-tumor agents and with respect to toxicity. In general, these taxanes possess acarbamoyloxy substituent at C-10, a hydroxy substituent at C-7 and a range of C-3' substituents. Briefly, therefore, the present invention is directed to the taxane composition, per se, to pharmaceutical compositions comprising the taxane and a pharmaceutically acceptable carrier, and to methods of administration. Other objects and features of this invention will be in part apparent and in part pointed out hereinafter. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS In one embodiment of the present invention, the taxanes of the present invention correspond to structure (1): ##STR00003## wherein R2 is acyloxy; R7 is hydroxy; R9 is keto, hydroxy, or acyloxy; R10 is carbamoyloxy; R14 is hydrido or hydroxy; X3 is substituted or unsubstituted alkyl, alkenyl, alkynyl, phenyl or heterocyclo; X5 is --COX10, --COOX10, or --CONHX10; X10 is hydrocarbyl, substituted hydrocarbyl, or heterocyclo; Ac is acetyl; and R7, R9, and R10 independently have the alpha or beta stereochemical configuration. In one embodiment, R2 is an ester (R2aC(O)O--), a carbamate (R2aR.sub.2bNC(O)O--), a carbonate (R2aOC(O)O--), or a thiocarbonate (R2aSC(O)O--) wherein R2a and R2b are independently hydrogen, hydrocarbyl,substituted hydrocarbyl or heterocyclo. In a preferred embodiment, R2 is an ester (R2aC(O)O--), wherein R2a is aryl or heteroaromatic. In another preferred embodiment, R2 is an ester (R2aC(O)O--), wherein R2a issubstituted or unsubstituted phenyl, furyl, thienyl, or pyridyl. In one particularly preferred embodiment, R2 is benzoyloxy. While R9 is keto in one embodiment of the present invention, in other embodiments R9 may have the alpha or beta stereochemical configuration, preferably the beta stereochemical configuration, and may be, for example, α- orβ-hydroxy or α- or β-acyloxy. For example, when R9 is acyloxy, it may be an ester (R9aC(O)O--), a carbamate (R9aR.sub.9bNC(O)O--), a carbonate (R9aOC(O)O--), or a thiocarbonate (R9aSC(O)O--) wherein R9a andR9b are independently hydrogen, hydrocarbyl, substituted hydrocarbyl or heterocyclo. If R9 is an ester (R9aC(O)O--), R9a is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted arylor substituted or unsubstituted heteroaromatic. Still more preferably, R9 is an ester (R9aC(O)O--), wherein R9a is substituted or unsubstituted phenyl, substituted or unsubstituted furyl, substituted or unsubstituted thienyl, orsubstituted or unsubstituted pyridyl. In one embodiment R9 is (R9aC(O)O--) wherein R9a is methyl, ethyl, propyl (straight, branched or cyclic), butyl (straight, branched or cyclic), pentyl, (straight, branched or cyclic), or hexyl(straight, branched or cyclic). In another embodiment R9 is (R9aC(O)O--) wherein R9a is substituted methyl, substituted ethyl, substituted propyl (straight, branched or cyclic), substituted butyl (straight, branched or cyclic),substituted pentyl, (straight, branched or cyclic), or substituted hexyl (straight, branched or cyclic) wherein the substituent(s) is/are selected from the group consisting of heterocyclo, alkoxy, alkenoxy, alkynoxy, aryloxy, hydroxy, protected hydroxy,keto, acyloxy, nitro, amino, amido, thiol, ketal, acetal, ester and ether moieties, but not phosphorous containing moieties. In one embodiment, R10 is R10aR.sub.10bNCOO-- wherein R10a and R10b are independently hydrogen, hydrocarbyl, substituted hydrocarbyl, or heterocyclo. Exemplary preferred R10 substituents include R10aR.sub.10bNCOO--wherein (a) R10a and R10b are each hydrogen, (b) one of R10a and R10b is hydrogen and the other is (i) substituted or unsubstituted C1 to C8 alkyl such as methyl, ethyl, or straight, branched or cyclic propyl, butyl, pentyl,or hexyl; (ii) substituted or unsubstituted C2 to C8 alkenyl such as ethenyl or straight, branched or cyclic propenyl, butenyl, pentenyl or hexenyl; (iii) substituted or unsubstituted C2 to C8 alkynyl such as ethynyl or straight orbranched propynyl, butynyl, pentynyl, or hexynyl; (iv) substituted or unsubstituted phenyl, or (v) substituted or unsubstituted heteroaromatic such as furyl, thienyl, or pyridyl, or (c) R10a and R10b are independently (i) substituted orunsubstituted C1 to C8 alkyl such as methyl, ethyl, or straight, branched or cyclic propyl, butyl, pentyl, or hexyl; (ii) substituted or unsubstituted C2 to C8 alkenyl such as ethenyl or straight, branched or cyclic propenyl, butenyl,pentenyl or hexenyl; (iii) substituted or unsubstituted C2 to C8 alkynyl such as ethynyl or straight or branched propynyl, butynyl, pentynyl, or hexynyl; (iv) substituted or unsubstituted phenyl, or (v) substituted or unsubstitutedheteroaromatic such as furyl, thienyl, or pyridyl. The substituents may be those identified elsewhere herein for substituted hydrocarbyl. In one embodiment, preferred R10 substituents include R10aR.sub.10bNCOO-- wherein one of R10a andR10b is hydrogen and the other is methyl, ethyl, or straight, branched or cyclic propyl. Exemplary X3 substituents include substituted or unsubstituted C2 to C8 alkyl, substituted or unsubstituted C2 to C8 alkenyl, substituted or unsubstituted C2 to C8 alkynyl, substituted or unsubstitutedheteroaromatics containing 5 or 6 ring atoms, and substituted or unsubstituted phenyl. Exemplary preferred X3 substituents include substituted or unsubstituted ethyl, propyl, butyl, cyclopropyl, cyclobutyl, cyclohexyl, isobutenyl, furyl, thienyl,and pyridyl. Exemplary X5 substituents include --COX10, --COOX10 or --CONHX10 wherein X10 is substituted or unsubstituted alkyl, alkenyl, phenyl or heteroaromatic. Exemplary preferred X5 substituents include --COX10,--COOX10 or --CONHX10 wherein X10 is (i) substituted or unsubstituted C1 to C8 alkyl such as substituted or unsubstituted methyl, ethyl, propyl (straight, branched or cyclic), butyl (straight, branched or cyclic), pentyl(straight, branched or cyclic), or hexyl (straight, branched or cyclic); (ii) substituted or unsubstituted C2 to C8 alkenyl such as substituted or unsubstituted ethenyl, propenyl (straight, branched or cyclic), butenyl (straight, branched orcyclic), pentenyl (straight, branched or cyclic) or hexenyl (straight, branched or cyclic); (iii) substituted or unsubstituted C2 to C8 alkynyl such as substituted or unsubstituted ethynyl, propynyl (straight or branched), butynyl (straight orbranched), pentynyl (straight or branched), or hexynyl (straight or branched); (iv) substituted or unsubstituted phenyl, or (v) substituted or unsubstituted heteroaromatic such as furyl, thienyl, or pyridyl, wherein the substituent(s) is/are selectedfrom the group consisting of heterocyclo, alkoxy, alkenoxy, alkynoxy, aryloxy, hydroxy, protected hydroxy, keto, acyloxy, nitro, amino, amido, thiol, ketal, acetal, ester and ether moieties, but not phosphorous containing moieties. In one embodiment of the present invention, the taxanes of the present invention correspond to structure (2): ##STR00004## wherein R7 is hydroxy; R10 is carbamoyloxy; X3 is substituted or unsubstituted alkyl, alkenyl, alkynyl, or heterocyclo, wherein alkyl comprises at least two carbon atoms; X5 is --COX10, --COOX10, or --CONHX10; and X10 is hydrocarbyl, substituted hydrocarbyl, or heterocyclo. For example, in this preferred embodiment in which the taxane corresponds to structure (2), R10 may be R10aR.sub.10bNCOO-- wherein one of R10a and R10b is hydrogen and the other is (i) substituted or unsubstituted C1 toC8 alkyl such as methyl, ethyl, or straight, branched or cyclic propyl, butyl, pentyl, or hexyl; (ii) substituted or unsubstituted C2 to C8 alkenyl such as ethenyl or straight, branched or cyclic propenyl, butenyl, pentenyl or hexenyl;(iii) substituted or unsubstituted C2 to C8 alkynyl such as ethynyl or straight or branched propynyl, butynyl, pentynyl, or hexynyl; (iv) phenyl or substituted phenyl such as nitro, alkoxy or halosubstituted phenyl, or (v) substituted orunsubstituted heteroaromatic such as furyl, thienyl, or pyridyl. The substituents may be those identified elsewhere herein for substituted hydrocarbyl. In one embodiment, preferred R10 substituents include R10aR.sub.10bNCOO-- wherein one ofR10a and R10b is hydrogen and the other is substituted or unsubstituted, preferably unsubstituted methyl, ethyl, or straight, branched or cyclic propyl. In another embodiment, preferred R10 substituents include R10aR.sub.10bNCOO--wherein one of R10a and R10b is hydrogen and the other is substituted or unsubstituted phenyl or heterocyclo. While R10a and R10b are selected from among these, in one embodiment X3 is selected from substituted or unsubstitutedalkyl, alkenyl, phenyl or heterocyclo, more preferably substituted or unsubstituted alkenyl, phenyl or heterocyclo, still more preferably substituted or unsubstituted phenyl or heterocyclo, and still more preferably heterocyclo such as furyl, thienyl orpyridyl. While R10a, R10b, and X3 are selected from among these, in one embodiment X5 is selected from --COX10 wherein X10 is phenyl, alkyl or heterocyclo, more preferably phenyl. Alternatively, while R10a, R10b,and X3 are selected from among these, in one embodiment X5 is selected from --COX10 wherein X10 is phenyl, alkyl or heterocyclo, more preferably phenyl, or X5 is --COOX10 wherein X10 is alkyl, preferably t-butyl. Amongthe more preferred embodiments, therefore, are taxanes corresponding to structure 2 in which (i) X5 is --COOX10 wherein X10 is tert-butyl or X5 is --COX10 wherein X10 is phenyl, (ii) X3 is substituted or unsubstitutedcycloalkyl, alkenyl, phenyl or heterocyclo, more preferably substituted or unsubstituted isobutenyl, phenyl, furyl, thienyl, or pyridyl, still more preferably unsubstituted isobutenyl, furyl, thienyl or pyridyl, and (iii) R10 isR10aR.sub.10bNCOO--, one of R10a and R10b is hydrogen and the other is substituted or unsubstituted substituted or unsubstituted C1 to C8 alkyl, phenyl or heterocyclo. Among the preferred embodiments, therefore, are taxanes corresponding to structure 1 or 2 wherein R10 is R10aR.sub.10bNCOO-- wherein R10a is methyl and R10b is hydrido. In this embodiment, X3 is preferably cycloalkyl,isobutenyl, phenyl, substituted phenyl such as p-nitrophenyl, or heterocyclo, more preferably heterocyclo, still more preferably furyl, thienyl or pyridyl; and X5 is preferably benzoyl, alkoxycarbonyl, or heterocyclocarbonyl, more preferablybenzoyl, t-butoxycarbonyl or t-amyloxycarbonyl. In one alternative of this embodiment, X3 is heterocyclo; X5 is benzoyl, alkoxycarbonyl, or heterocyclocarbonyl, more preferably benzoyl, t-butoxycarbonyl or t-amyloxycarbonyl, still morepreferably t-butoxycarbonyl; R2 is benzoyl, R9 is keto and R14 is hydrido. In another alternative of this embodiment, X3 is heterocyclo; X5 is benzoyl, alkoxycarbonyl, or heterocyclocarbonyl, more preferably benzoyl,t-butoxycarbonyl or t-amyloxycarbonyl, still more preferably t-butoxycarbonyl; R2 is benzoyl, R9 is keto and R14 is hydrido. In another alternative of this embodiment, X3 is heterocyclo; X5 is benzoyl, alkoxycarbonyl, orheterocyclocarbonyl, more preferably benzoyl, t-butoxycarbonyl or t-amyloxycarbonyl, still more preferably t-butoxycarbonyl; R2 is benzoyl, R9 is keto and R14 is hydroxy. In another alternative of this embodiment, X3 is heterocyclo;X5 is benzoyl, alkoxycarbonyl, or heterocyclocarbonyl, more preferably benzoyl, t-butoxycarbonyl or t-amyloxycarbonyl, still more preferably t-butoxycarbonyl; R2 is benzoyl, R9 is hydroxy and R14 is hydroxy. In another alternative ofthis embodiment, X3 is heterocyclo; X5 is benzoyl, alkoxycarbonyl, or heterocyclocarbonyl, more preferably benzoyl, t-butoxycarbonyl or t-amyloxycarbonyl, still more preferably t-butoxycarbonyl; R2 is benzoyl, R9 is hydroxy andR14 is hydrido. In another alternative of this embodiment, X3 is heterocyclo; X5 is benzoyl, alkoxycarbonyl, or heterocyclocarbonyl, more preferably benzoyl, t-butoxycarbonyl or t-amyloxycarbonyl, still more preferably t-butoxycarbonyl;R2 is benzoyl, R9 is acyloxy and R14 is hydroxy. In another alternative of this embodiment, X3 is heterocyclo; X5 is benzoyl, alkoxycarbonyl, or heterocyclocarbonyl, more preferably benzoyl, t-butoxycarbonyl ort-amyloxycarbonyl, still more preferably t-butoxycarbonyl; R2 is benzoyl, R9 is acyloxy and R14 is hydrido. In each of the alternatives of this embodiment when the taxane has structure 1, R7 and R10 may each have the betastereochemical configuration, R7 and R10 may each have the alpha stereochemical configuration, R7 may have the alpha stereochemical configuration while R10 has the beta stereochemical configuration or R7 may have the betastereochemical configuration while R10 has the alpha stereochemical configuration. Also among the preferred embodiments are taxanes corresponding to structure 1 or 2 wherein R10 is R10aR.sub.10bNCOO-- wherein R10a is ethyl and R10b is hydrido. In this embodiment, X3 is preferably cycloalkyl,isobutenyl, phenyl, substituted phenyl such as p-nitrophenyl, or heterocyclo, more preferably heterocyclo, still more preferably furyl, thienyl or pyridyl; and X5 is preferably benzoyl, alkoxycarbonyl, or heterocyclocarbonyl, more preferablybenzoyl, t-butoxycarbonyl or t-amyloxycarbonyl. In one alternative of this embodiment, X3 is heterocyclo; X5 is benzoyl, alkoxycarbonyl, or heterocyclocarbonyl, more preferably benzoyl, t-butoxycarbonyl or t-amyloxycarbonyl, still morepreferably t-butoxycarbonyl; R2 is benzoyl, R9 is keto and R14 is hydrido. In another alternative of this embodiment, X3 is heterocyclo; X5 is benzoyl, alkoxycarbonyl, or heterocyclocarbonyl, more preferably benzoyl,t-butoxycarbonyl or t-amyloxycarbonyl, still more preferably t-butoxycarbonyl; R2 is benzoyl, R9 is keto and R14 is hydrido. In another alternative of this embodiment, X3 is heterocyclo; X5 is benzoyl, alkoxycarbonyl, orheterocyclocarbonyl, more preferably benzoyl, t-butoxycarbonyl or t-amyloxycarbonyl, still more preferably t-butoxycarbonyl; R2 is benzoyl, R9 is keto and R14 is hydroxy. In another alternative of this embodiment, X3 is heterocyclo;X5 is benzoyl, alkoxycarbonyl, or heterocyclocarbonyl, more preferably benzoyl, t-butoxycarbonyl or t-amyloxycarbonyl, still more preferably t-butoxycarbonyl; R2 is benzoyl, R9 is hydroxy and R14 is hydroxy. In another alternative ofthis embodiment, X3 is heterocyclo; X5 is benzoyl, alkoxycarbonyl, or heterocyclocarbonyl, more preferably benzoyl, t-butoxycarbonyl or t-amyloxycarbonyl, still more preferably t-butoxycarbonyl; R2 is benzoyl, R9 is hydroxy andR14 is hydrido. In another alternative of this embodiment, X3 is heterocyclo; X5 is benzoyl, alkoxycarbonyl, or heterocyclocarbonyl, more preferably benzoyl, t-butoxycarbonyl or t-amyloxycarbonyl, still more preferably t-butoxycarbonyl;R2 is benzoyl, R9 is acyloxy and R14 is hydroxy. In another alternative of this embodiment, X3 is heterocyclo; X5 is benzoyl, alkoxycarbonyl, or heterocyclocarbonyl, more preferably benzoyl, t-butoxycarbonyl ort-amyloxycarbonyl, still more preferably t-butoxycarbonyl; R2 is benzoyl, R9 is acyloxy and R14 is hydrido. In each of the alternatives of this embodiment when the taxane has structure 1, R7 and R10 may each have the betastereochemical configuration, R7 and R10 may each have the alpha stereochemical configuration, R7 may have the alpha stereochemical configuration while R10 has the beta stereochemical configuration or R7 may have the betastereochemical configuration while R10 has the alpha stereochemical configuration. Taxanes having the general formula 1 may be obtained by carbamoylation of a suitably protected taxane intermediate having the structural formula: ##STR00005## wherein X3 and X5 are as previously defined, P2 is a hydroxy protecting group, and P7 is either hydrogen or a hydroxy protecting group, by reaction with an isocyanate or a carbamoyl chloride, followed by removalof the hydroxy protecting group(s). The intermediate taxane may be obtained by treatment of a β-lactam with an alkoxide having the taxane tetracyclic nucleus and a C-13 metallic oxide substituent to form compounds having a β-amido ester substituent at C-13 (as describedmore fully in Holton U.S. Pat. No. 5,466,834), followed by removal of either the C(10) protecting group, or both the C(10) and C(7) protecting groups. The β-lactam has the formula (3): ##STR00006## wherein P2 is a hydroxy protecting group and X3 and X5 are as previously defined and the alkoxide has the formula (4): ##STR00007## wherein M is a metal or ammonium, and P7 and P10 are hydroxy protecting groups. The alkoxide may be prepared from 10-deacetylbaccatin III by protection of the C-7 and C-10 hydroxyl groups (as described more fully in Holton et al., PCT Patent Application WO 99/09021) followed by treatment with a metallic amide. Derivatives of 10-deacetylbaccatin III having alternative substituents at C(2), C(9) and C(14) and processes for their preparation are known in the art. Taxane derivatives having acyloxy substituents other than benzoyloxy at C(2) may beprepared, for example, as described in Holton et al., U.S. Pat. No. 5,728,725 or Kingston et al., U.S. Pat. No. 6,002,023. Taxanes having acyloxy or hydroxy substituents at C(9) in place of keto may be prepared, for example as described in Holton etal., U.S. Pat. No. 6,011,056 or Gunawardana et al., U.S. Pat. No. 5,352,806. Taxanes having a beta hydroxy substituent at C(14) may be prepared from naturally occurring 14-hydroxy-10-deacetylbaccatin III. Processes for the preparation and resolution of the β-lactam starting material are generally well known. For example, the β-lactam may be prepared as described in Holton, U.S. Pat. No. 5,430,160 and the resulting enatiomeric mixturesof β-lactams may be resolved by a stereoselective hydrolysis using a lipase or enzyme as described, for example, in Patel, U.S. Pat. No. 5,879,929 Patel U.S. Pat. No. 5,567,614 or a liver homogenate as described, for example, in PCT PatentApplication No. 00/41204. In a preferred embodiment in which the β-lactam is furyl substituted at the C(4) position, the β-lactam can be prepared as illustrated in the following reaction scheme: ##STR00008## ##STR00009## wherein Ac is acetyl, NEt3 is triethylamine, CAN is ceric ammonium nitrate, and p-TsOH is p-toluenesulfonic acid. The beef liver resolution may be carried out, for example, by combining the enatiomericβ-lactam mixture with a beef liver suspension (prepared, for example, by adding 20 g of frozen beef liver to a blender and then adding a pH 8 buffer to make a total volume of 1 L). Compounds of formula 1 of the instant invention are useful for inhibiting tumor growth in mammals including humans and are preferably administered in the form of a pharmaceutical composition comprising an effective antitumor amount of a compoundof the instant invention in combination with at least one pharmaceutically or pharmacologically acceptable carrier. The carrier, also known in the art as an excipient, vehicle, auxiliary, adjuvant, or diluent, is any substance which is pharmaceuticallyinert, confers a suitable consistency or form to the composition, and does not diminish the therapeutic efficacy of the antitumor compounds. The carrier is "pharmaceutically or pharmacologically acceptable" if it does not produce an adverse, allergic orother untoward reaction when administered to a mammal or human, as appropriate. The pharmaceutical compositions containing the antitumor compounds of the present invention may be formulated in any conventional manner. Proper formulation is dependent upon the route of administration chosen. The compositions of the inventioncan be formulated for any route of administration so long as the target tissue is available via that route. Suitable routes of administration include, but are not limited to, oral, parenteral (e.g., intravenous, intraarterial, subcutaneous, rectal,subcutaneous, intramuscular, intraorbital, intracapsular, intraspinal, intraperitoneal, or intrasternal), topical (nasal, transdermal, intraocular), intravesical, intrathecal, enteral, pulmonary, intralymphatic, intracavital, vaginal, transurethral,intradermal, aural, intramammary, buccal, orthotopic, intratracheal, intralesional, percutaneous, endoscopical, transmucosal, sublingual and intestinal administration. Pharmaceutically acceptable carriers for use in the compositions of the present invention are well known to those of ordinary skill in the art and are selected based upon a number of factors: the particular antitumor compound used, and itsconcentration, stability and intended bioavailability; the disease, disorder or condition being treated with the composition; the subject, its age, size and general condition; and the route of administration. Suitable carriers are readily determined byone of ordinary skill in the art (see, for example, J. G. Nairn, in: Remington's Pharmaceutical Science (A. Gennaro, ed.), Mack Publishing Co., Easton, Pa., (1985), pp. 1492-1517, the contents of which are incorporated herein by reference). The compositions are preferably formulated as tablets, dispersible powders, pills, capsules, gelcaps, caplets, gels, liposomes, granules, solutions, suspensions, emulsions, syrups, elixirs, troches, dragees, lozenges, or any other dosage formwhich can be administered orally. Techniques and compositions for making oral dosage forms useful in the present invention are described in the following references: 7 Modern Pharmaceutics, Chapters 9 and 10 (Banker & Rhodes, Editors, 1979); Liebermanet al., Pharmaceutical Dosage Forms: Tablets (1981); and Ansel, Introduction to Pharmaceutical Dosage Forms 2nd Edition (1976). The compositions of the invention for oral administration comprise an effective antitumor amount of a compound of the invention in a pharmaceutically acceptable carrier. Suitable carriers for solid dosage forms include sugars, starches, andother conventional substances including lactose, talc, sucrose, gelatin, carboxymethylcellulose, agar, mannitol, sorbitol, calcium phosphate, calcium carbonate, sodium carbonate, kaolin, alginic acid, acacia, corn starch, potato starch, sodium saccharin,magnesium carbonate, tragacanth, microcrystalline cellulose, colloidal silicon dioxide, croscarmellose sodium, talc, magnesium stearate, and stearic acid. Further, such solid dosage forms may be uncoated or may be coated by known techniques; e.g., todelay disintegration and absorption. The antitumor compounds of the present invention are also preferably formulated for parenteral administration, e.g., formulated for injection via intravenous, intraarterial, subcutaneous, rectal, subcutaneous, intramuscular, intraorbital,intracapsular, intraspinal, intraperitoneal, or intrasternal routes. The compositions of the invention for parenteral administration comprise an effective antitumor amount of the antitumor compound in a pharmaceutically acceptable carrier. Dosage formssuitable for parenteral administration include solutions, suspensions, dispersions, emulsions or any other dosage form which can be administered parenterally. Techniques and compositions for making parenteral dosage forms are known in the art. Suitable carriers used in formulating liquid dosage forms for oral or parenteral administration include nonaqueous, pharmaceutically-acceptable polar solvents such as oils, alcohols, amides, esters, ethers, ketones, hydrocarbons and mixturesthereof, as well as water, saline solutions, dextrose solutions (e.g., DW5), electrolyte solutions, or any other aqueous, pharmaceutically acceptable liquid. Suitable nonaqueous, pharmaceutically-acceptable polar solvents include, but are not limited to, alcohols (e.g., α-glycerol formal, β-glycerol formal, 1, 3-butyleneglycol, aliphatic or aromatic alcohols having 2-30 carbon atoms such asmethanol, ethanol, propanol, isopropanol, butanol, t-butanol, hexanol, octanol, amylene hydrate, benzyl alcohol, glycerin (glycerol), glycol, hexylene glycol, tetrahydrofurfuryl alcohol, lauryl alcohol, cetyl alcohol, or stearyl alcohol, fatty acidesters of fatty alcohols such as polyalkylene glycols (e.g., polypropylene glycol, polyethylene glycol), sorbitan, sucrose and cholesterol); amides (e.g., dimethylacetamide (DMA), benzyl benzoate DMA, dimethylformamide, N-(β-hydroxyethyl)-lactamide,N,N-dimethylacetamide amides, 2-pyrrolidinone, 1-methyl-2-pyrrolidinone, or polyvinylpyrrolidone); esters (e.g., 1-methyl-2-pyrrolidinone, 2-pyrrolidinone, acetate esters such as monoacetin, diacetin, and triacetin, aliphatic or aromatic esters such asethyl caprylate or octanoate, alkyl oleate, benzyl benzoate, benzyl acetate, dimethylsulfoxide (DMSO), esters of glycerin such as mono, di, or tri-glyceryl citrates or tartrates, ethyl benzoate, ethyl acetate, ethyl carbonate, ethyl lactate, ethyloleate, fatty acid esters of sorbitan, fatty acid derived PEG esters, glyceryl monostearate, glyceride esters such as mono, di, or tri-glycerides, fatty acid esters such as isopropyl myristrate, fatty acid derived PEG esters such as PEG-hydroxyoleate andPEG-hydroxystearate, N-methyl pyrrolidinone, pluronic 60, polyoxyethylene sorbitol oleic polyesters such as poly(ethoxylated)30-60 sorbitol poly(oleate)2-4, poly(oxyethylene)15-20 monooleate, poly(oxyethylene)15-20 mono12-hydroxystearate, and poly(oxyethylene)15-20 mono ricinoleate, polyoxyethylene sorbitan esters such as polyoxyethylene-sorbitan monooleate, polyoxyethylene-sorbitan monopalmitate, polyoxyethylene-sorbitan monolaurate, polyoxyethylene-sorbitanmonostearate, and Polysorbate.RTM. 20, 40, 60 or 80 from ICI Americas, Wilmington, Del., polyvinylpyrrolidone, alkyleneoxy modified fatty acid esters such as polyoxyl 40 hydrogenated castor oil and polyoxyethylated castor oils (e.g., Cremophor.RTM. ELsolution or Cremophor.RTM. RH 40 solution), saccharide fatty acid esters (i.e., the condensation product of a monosaccharide (e.g., pentoses such as ribose, ribulose, arabinose, xylose, lyxose and xylulose, hexoses such as glucose, fructose, galactose,mannose and sorbose, trioses, tetroses, heptoses, and octoses), disaccharide (e.g., sucrose, maltose, lactose and trehalose) or oligosaccharide or mixture thereof with a C4-C.sub.22 fatty acid(s) (e.g., saturated fatty acids such as caprylic acid,capric acid, lauric acid, myristic acid, palmitic acid and stearic acid, and unsaturated fatty acids such as palmitoleic acid, oleic acid, elaidic acid, erucic acid and linoleic acid)), or steroidal esters); alkyl, aryl, or cyclic ethers having 2-30carbon atoms (e.g., diethyl ether, tetrahydrofuran, dimethyl isosorbide, diethylene glycol monoethyl ether); glycofurol (tetrahydrofurfuryl alcohol polyethylene glycol ether); ketones having 3-30 carbon atoms (e.g., acetone, methyl ethyl ketone, methylisobutyl ketone); aliphatic, cycloaliphatic or aromatic hydrocarbons having 4-30 carbon atoms (e.g., benzene, cyclohexane, dichloromethane, dioxolanes, hexane, n-decane, n-dodecane, n-hexane, sulfolane, tetramethylenesulfon, tetramethylenesulfoxide,toluene, dimethylsulfoxide (DMSO), or tetramethylenesulfoxide); oils of mineral, vegetable, animal, essential or synthetic origin (e.g., mineral oils such as aliphatic or wax-based hydrocarbons, aromatic hydrocarbons, mixed aliphatic and aromatic basedhydrocarbons, and refined paraffin oil, vegetable oils such as linseed, tung, safflower, soybean, castor, cottonseed, groundnut, rapeseed, coconut, palm, olive, corn, corn germ, sesame, persic and peanut oil and glycerides such as mono-, di- ortriglycerides, animal oils such as fish, marine, sperm, cod-liver, haliver, squalene, squalane, and shark liver oil, oleic oils, and polyoxyethylated castor oil); alkyl or aryl halides having 1-30 carbon atoms and optionally more than one halogensubstituent; methylene chloride; monoethanolamine; petroleum benzin; trolamine; omega-3 polyunsaturated fatty acids (e.g., alpha-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, or docosahexaenoic acid); polyglycol ester of 12-hydroxystearicacid and polyethylene glycol (Solutol.RTM. HS-15, from BASF, Ludwigshafen, Germany); polyoxyethylene glycerol; sodium laurate; sodium oleate; or sorbitan monooleate. Other pharmaceutically acceptable solvents for use in the invention are well known to those of ordinary skill in the art, and are identified in The Chemotherapy Source Book (Williams & Wilkens Publishing), The Handbook of PharmaceuticalExcipients, (American Pharmaceutical Association, Washington, D.C., and The Pharmaceutical Society of Great Britain, London, England, 1968), Modern Pharmaceutics, (G. Banker et al., eds., 3d ed.) (Marcel Dekker, Inc., New York, N.Y., 1995), ThePharmacological Basis of Therapeutics, (Goodman & Gilman, McGraw Hill Publishing), Pharmaceutical Dosage Forms, (H. Lieberman et al., eds.,) (Marcel Dekker, Inc., New York, N.Y., 1980), Remington's Pharmaceutical Sciences (A. Gennaro, ed., 19th ed.)(Mack Publishing, Easton, Pa., 1995), The United States Pharmacopeia 24, The National Formulary 19, (National Publishing, Philadelphia, Pa., 2000), A. J. Spiegel et al., and Use of Nonaqueous Solvents in Parenteral Products, JOURNAL OF PHARMACEUTICALSCIENCES, Vol. 52, No. 10, pp. 917-927 (1963). Preferred solvents include those known to stabilize the antitumor compounds, such as oils rich in triglycerides, for example, safflower oil, soybean oil or mixtures thereof, and alkyleneoxy modified fatty acid esters such as polyoxyl 40hydrogenated castor oil and polyoxyethylated castor oils (e.g., Cremophor.RTM. EL solution or Cremophor.RTM. RH 40 solution). Commercially available triglycerides include Intralipid.RTM. emulsified soybean oil (Kabi-Pharmacia Inc., Stockholm,Sweden), Nutralipid.RTM. emulsion (McGaw, Irvine, Calif.), Liposyn.RTM. II 20% emulsion (a 20% fat emulsion solution containing 100 mg safflower oil, 100 mg soybean oil, 12 mg egg phosphatides, and 25 mg glycerin per ml of solution; AbbottLaboratories, Chicago, Ill.), Liposyn.RTM. III 2% emulsion (a 2% fat emulsion solution containing 100 mg safflower oil, 100 mg soybean oil, 12 mg egg phosphatides, and 25 mg glycerin per ml of solution; Abbott Laboratories, Chicago, Ill.), natural orsynthetic glycerol derivatives containing the docosahexaenoyl group at levels between 25% and 100% by weight based on the total fatty acid content (Dhasco.RTM. (from Martek Biosciences Corp., Columbia, Md.), DHA Maguro.RTM. (from Daito Enterprises, LosAngeles, Calif.), Soyacal.RTM., and Travemulsion.RTM.. Ethanol is a preferred solvent for use in dissolving the antitumor compound to form solutions, emulsions, and the like. Additional minor components can be included in the compositions of the invention for a variety of purposes well known in the pharmaceutical industry. These components will for the most part impart properties which enhance retention of theantitumor compound at the site of administration, protect the stability of the composition, control the pH, facilitate processing of the antitumor compound into pharmaceutical formulations, and the like. Preferably, each of these components isindividually present in less than about 15 weight % of the total composition, more preferably less than about 5 weight %, and most preferably less than about 0.5 weight % of the total composition. Some components, such as fillers or diluents, canconstitute up to 90 wt. % of the total composition, as is well known in the formulation art. Such additives include cryoprotective agents for preventing reprecipitation of the taxane, surface active, wetting or emulsifying agents (e.g., lecithin,polysorbate-80, Tween.RTM. 80, pluronic 60, polyoxyethylene stearate), preservatives (e.g., ethyl-p-hydroxybenzoate), microbial preservatives (e.g., benzyl alcohol, phenol, m-cresol, chlorobutanol, sorbic acid, thimerosal and paraben), agents foradjusting pH or buffering agents (e.g., acids, bases, sodium acetate, sorbitan monolaurate), agents for adjusting osmolarity (e.g., glycerin), thickeners (e.g., aluminum monostearate, stearic acid, cetyl alcohol, stearyl alcohol, guar gum, methylcellulose, hydroxypropylcellulose, tristearin, cetyl wax esters, polyethylene glycol), colorants, dyes, flow aids, non-volatile silicones (e.g., cyclomethicone), clays (e.g., bentonites), adhesives, bulking agents, flavorings, sweeteners, adsorbents,fillers (e.g., sugars such as lactose, sucrose, mannitol, or sorbitol, cellulose, or calcium phosphate), diluents (e.g., water, saline, electrolyte solutions), binders (e.g., starches such as maize starch, wheat starch, rice starch, or potato starch,gelatin, gum tragacanth, methyl cellulose, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, polyvinylpyrrolidone, sugars, polymers, acacia), disintegrating agents (e.g., starches such as maize starch, wheat starch, rice starch, potatostarch, or carboxymethyl starch, cross-linked polyvinyl pyrrolidone, agar, alginic acid or a salt thereof such as sodium alginate, croscarmellose sodium or crospovidone), lubricants (e.g., silica, talc, stearic acid or salts thereof such as magnesiumstearate, or polyethylene glycol), coating agents (e.g., concentrated sugar solutions including gum arabic, talc, polyvinyl pyrrolidone, carbopol gel, polyethylene glycol, or titanium dioxide), and antioxidants (e.g., sodium metabisulfite, sodiumbisulfite, sodium sulfite, dextrose, phenols, and thiophenols). In a preferred embodiment, a pharmaceutical composition of the invention comprises at least one nonaqueous, pharmaceutically acceptable solvent and an antitumor compound having a solubility in ethanol of at least about 100, 200, 300, 400, 500,600, 700 or 800 mg/ml. While not being bound to a particular theory, it is believed that the ethanol solubility of the antitumor compound may be directly related to its efficacy. The antitumor compound can also be capable of being crystallized from asolution. In other words, a crystalline antitumor compound, such as compound 1393, can be dissolved in a solvent to form a solution and then recrystallized upon evaporation of the solvent without the formation of any amorphous antitumor compound. It isalso preferred that the antitumor compound have an ID50 value (i.e, the drug concentration producing 50% inhibition of colony formation) of at least 4, 5, 6, 7, 8, 9, or 10 times less that of paclitaxel when measured according to the protocol set forthin the working examples. Dosage form administration by these routes may be continuous or intermittent, depending, for example, upon the patient's physiological condition, whether the purpose of the administration is therapeutic or prophylactic, and other factors known toand assessable by a skilled practitioner. Dosage and regimens for the administration of the pharmaceutical compositions of the invention can be readily determined by those with ordinary skill in treating cancer. It is understood that the dosage of the antitumor compounds will bedependent upon the age, sex, health, and weight of the recipient, kind of concurrent treatment, if any, frequency of treatment, and the nature of the effect desired. For any mode of administration, the actual amount of antitumor compound delivered, aswell as the dosing schedule necessary to achieve the advantageous effects described herein, will also depend, in part, on such factors as the bioavailability of the antitumor compound, the disorder being treated, the desired therapeutic dose, and otherfactors that will be apparent to those of skill in the art. The dose administered to an animal, particularly a human, in the context of the present invention should be sufficient to effect the desired therapeutic response in the animal over a reasonableperiod of time. Preferably, an effective amount of the antitumor compound, whether administered orally or by another route, is any amount which would result in a desired therapeutic response when administered by that route. Preferably, the compositionsfor oral administration are prepared in such a way that a single dose in one or more oral preparations contains at least 20 mg of the antitumor compound per m2 of patient body surface area, or at least 50, 100, 150, 200, 300, 400, or 500 mg of theantitumor compound per m2 of patient body surface area, wherein the average body surface area for a human is 1.8 m2. Preferably, a single dose of a composition for oral administration contains from about 20 to about 600 mg of the antitumorcompound per m2 of patient body surface area, more preferably from about 25 to about 400 mg/m2, even more preferably, from about 40 to about 300 mg/m2, and even more preferably from about 50 to about 200 mg/m2. Preferably, thecompositions for parenteral administration are prepared in such a way that a single dose contains at least 20 mg of the antitumor compound per m2 Of patient body surface area, or at least 40, 50, 100, 150, 200, 300, 400, or 500 mg of the antitumorcompound per m2 of patient body surface area. Preferably, a single dose in one or more parenteral preparations contains from about 20 to about 500 mg of the antitumor compound per m2 of patient body surface area, more preferably from about 40to about 400 mg/m2, and even more preferably, from about 60 to about 350 mg/m2. However, the dosage may vary depending on the dosing schedule which can be adjusted as necessary to achieve the desired therapeutic effect. It should be notedthat the ranges of effective doses provided herein are not intended to limit the invention and represent preferred dose ranges. The most preferred dosage will be tailored to the individual subject, as is understood and determinable by one of ordinaryskill in the art without undue experimentation. The concentration of the antitumor compound in a liquid pharmaceutical composition is preferably between about 0.01 mg and about 10 mg per ml of the composition, more preferably between about 0.1 mg and about 7 mg per ml, even more preferablybetween about 0.5 mg and about 5 mg per ml, and most preferably between about 1.5 mg and about 4 mg per ml. Relatively low concentrations are generally preferred because the antitumor compound is most soluble in the solution at low concentrations. Theconcentration of the antitumor compound in a solid pharmaceutical composition for oral administration is preferably between about 5 weight % and about 50 weight %, based on the total weight of the composition, more preferably between about 8 weight % andabout 40 weight %, and most preferably between about 10 weight % and about 30 weight %. In one embodiment, solutions for oral administration are prepared by dissolving an antitumor compound in any pharmaceutically acceptable solvent capable of dissolving the compound (e.g., ethanol or methylene chloride) to form a solution. Anappropriate volume of a carrier which is a solution, such as Cremophor.RTM. EL solution, is added to the solution while stirring to form a pharmaceutically acceptable solution for oral administration to a patient. If desired, such solutions can beformulated to contain a minimal amount of, or to be free of, ethanol, which is known in the art to cause adverse physiological effects when administered at certain concentrations in oral formulations. In another embodiment, powders or tablets for oral administration are prepared by dissolving an antitumor compound in any pharmaceutically acceptable solvent capable of dissolving the compound (e.g., ethanol or methylene chloride) to form asolution. The solvent can optionally be capable of evaporating when the solution is dried under vacuum. An additional carrier can be added to the solution prior to drying, such as Cremophor.RTM. EL solution. The resulting solution is dried undervacuum to form a glass. The glass is then mixed with a binder to form a powder. The powder can be mixed with fillers or other conventional tabletting agents and processed to form a tablet for oral administration to a patient. The powder can also beadded to any liquid carrier as described above to form a solution, emulsion, suspension or the like for oral administration. Emulsions for parenteral administration can be prepared by dissolving an antitumor compound in any pharmaceutically acceptable solvent capable of dissolving the compound (e.g., ethanol or methylene chloride) to form a solution. An appropriatevolume of a carrier which is an emulsion, such as Liposyn.RTM. II or Liposyn.RTM. III emulsion, is added to the solution while stirring to form a pharmaceutically acceptable emulsion for parenteral administration to a patient. If desired, suchemulsions can be formulated to contain a minimal amount of, or to be free of, ethanol or Cremophor.RTM. solution, which are known in the art to cause adverse physiological effects when administered at certain concentrations in parenteral formulations. Solutions for parenteral administration can be prepared by dissolving an antitumor compound in any pharmaceutically acceptable solvent capable of dissolving the compound (e.g., ethanol or methylene chloride) to form a solution. An appropriatevolume of a carrier which is a solution, such as Cremophor.RTM. solution, is added to the solution while stirring to form a pharmaceutically acceptable solution for parenteral administration to a patient. If desired, such solutions can be formulated tocontain a minimal amount of, or to be free of, ethanol or Cremophor.RTM. solution, which are known in the art to cause adverse physiological effects when administered at certain concentrations in parenteral formulations. If desired, the emulsions or solutions described above for oral or parenteral administration can be packaged in IV bags, vials or other conventional containers in concentrated form and diluted with any pharmaceutically acceptable liquid, such assaline, to form an acceptable taxane concentration prior to use as is known in the art. Definitions The terms "hydrocarbon" and "hydrocarbyl" as used herein describe organic compounds or radicals consisting exclusively of the elements carbon and hydrogen. These moieties include alkyl, alkenyl, alkynyl, and aryl moieties. These moieties alsoinclude alkyl, alkenyl, alkynyl, and aryl moieties substituted with other aliphatic or cyclic hydrocarbon groups, such as alkaryl, alkenaryl and alkynaryl. Unless otherwise indicated, these moieties preferably comprise 1 to 20 carbon atoms. The "substituted hydrocarbyl" moieties described herein are hydrocarbyl moieties which are substituted with at least one atom other than carbon, including moieties in which a carbon chain atom is substituted with a hetero atom such as nitrogen,oxygen, silicon, phosphorous, boron, sulfur, or a halogen atom. These substituents include halogen, heterocyclo, alkoxy, alkenoxy, alkynoxy, aryloxy, hydroxy, protected hydroxy, keto, acyl, acyloxy, nitro, amino, amido, nitro, cyano, thiol, ketals,acetals, esters and ethers. Unless otherwise indicated, the alkyl groups described herein are preferably lower alkyl containing from one to eight carbon atoms in the principal chain and up to 20 carbon atoms. They may be straight or branched chain or cyclic and includemethyl, ethyl, propyl, isopropyl, butyl, hexyl and the like. Unless otherwise indicated, the alkenyl groups described herein are preferably lower alkenyl containing from two to eight carbon atoms in the principal chain and up to 20 carbon atoms. They may be straight or branched chain or cyclic and includeethenyl, propenyl, isopropenyl, butenyl, isobutenyl, hexenyl, and the like. Unless otherwise indicated, the alkynyl groups described herein are preferably lower alkynyl containing from two to eight carbon atoms in the principal chain and up to 20 carbon atoms. They may be straight or branched chain and include ethynyl,propynyl, butynyl, isobutynyl, hexynyl, and the like. The terms "aryl" or "ar" as used herein alone or as part of another group denote optionally substituted homocyclic aromatic groups, preferably monocyclic or bicyclic groups containing from 6 to 12 carbons in the ring portion, such as phenyl,biphenyl, naphthyl, substituted phenyl, substituted biphenyl or substituted naphthyl. Phenyl and substituted phenyl are the more preferred aryl. The terms "halogen" or "halo" as used herein alone or as part of another group refer to chlorine, bromine, fluorine, and iodine. The terms "heterocyclo" or "heterocyclic" as used herein alone or as part of another group denote optionally substituted, fully saturated or unsaturated, monocyclic or bicyclic, aromatic or nonaromatic groups having at least one heteroatom in atleast one ring, and preferably 5 or 6 atoms in each ring. The heterocyclo group preferably has 1 or 2 oxygen atoms, 1 or 2 sulfur atoms, and/or 1 to 4 nitrogen atoms in the ring, and may be bonded to the remainder of the molecule through a carbon orheteroatom. Exemplary heterocyclo include heteroaromatics such as furyl, thienyl, pyridyl, oxazolyl, pyrrolyl, indolyl, quinolinyl, or isoquinolinyl and the like. Exemplary substituents include one or more of the following groups: hydrocarbyl,substituted hydrocarbyl, keto, hydroxy, protected hydroxy, acyl, acyloxy, alkoxy, alkenoxy, alkynoxy, aryloxy, halogen, amido, amino, nitro, cyano, thiol, ketals, acetals, esters and ethers. The term "heteroaromatic" as used herein alone or as part of another group denote optionally substituted aromatic groups having at least one heteroatom in at least one ring, and preferably 5 or 6 atoms in each ring. The heteroaromatic grouppreferably has 1 or 2 oxygen atoms, 1 or 2 sulfur atoms, and/or 1 to 4 nitrogen atoms in the ring, and may be bonded to the remainder of the molecule through a carbon or heteroatom. Exemplary heteroaromatics include furyl, thienyl, pyridyl, oxazolyl,pyrrolyl, indolyl, quinolinyl, or isoquinolinyl and the like. Exemplary substituents include one or more of the following groups: hydrocarbyl, substituted hydrocarbyl, keto, hydroxy, protected hydroxy, acyl, acyloxy, alkoxy, alkenoxy, alkynoxy, aryloxy,halogen, amido, amino, nitro, cyano, thiol, ketals, acetals, esters and ethers. The term "acyl," as used herein alone or as part of another group, denotes the moiety formed by removal of the hydroxyl group from the group --COOH of an organic carboxylic acid, e.g., RC(O)--, wherein R is R1, R1O--, R1R.sup.2N--,or R1S--, R1 is hydrocarbyl, heterosubstituted hydrocarbyl, or heterocyclo and R2 is hydrogen, hydrocarbyl or substituted hydrocarbyl. The term "acyloxy," as used herein alone or as part of another group, denotes an acyl group as described above bonded through an oxygen linkage (--O--), e.g., RC(O)O-- wherein R is as defined in connection with the term "acyl." Unless otherwise indicated, the alkoxycarbonyloxy moieties described herein comprise lower hydrocarbon or substituted hydrocarbon or substituted hydrocarbon moieties. Unless otherwise indicated, the carbamoyloxy moieties described herein are derivatives of carbamic acid in which one or both of the amine hydrogens is optionally replaced by a hydrocarbyl, substituted hydrocarbyl or heterocyclo moiety. The terms "hydroxylprotecting group" and "hydroxy protecting group" as used herein denote a group capable of protecting a free hydroxyl group ("protected hydroxyl") which, subsequent to the reaction for which protection is employed, may beremoved without disturbing the remainder of the molecule. A variety of protecting groups for the hydroxyl group and the synthesis thereof may be found in "Protective Groups in Organic Synthesis" by T. W. Greene, John Wiley and Sons, 1981, or Fieser &Fieser. Exemplary hydroxylprotecting groups include methoxymethyl, 1-ethoxyethyl, benzyloxymethyl, (β-trimethylsilylethoxy)methyl, tetrahydropyranyl, 2,2,2-trichloroethoxycarbonyl, t-butyl(diphenyl)silyl, trialkylsilyl, trichloromethoxycarbonyl and2,2,2-trichloroethoxymethyl. As used herein, "Ac" means acetyl; "Bz" means benzoyl; "Et" means ethyl; "Me" means methyl; "Ph" means phenyl; "iPr" means isopropyl; "tBu" and "t-Bu" means tert-butyl; "R" means lower alkyl unless otherwise defined; "py" means pyridine orpyridyl; "TES" means triethylsilyl; "TMS" means trimethylsilyl; "LAH" means lithium aluminum hydride; "10-DAB" means 10-desacetylbaccatin III"; "amine protecting group" includes, but is not limited to, carbamates, for example,2,2,2-trichloroethylcarbamate or tertbutylcarba mate; "protected hydroxy" means --OP wherein P is a hydroxy protecting group; "tBuOCO" and "Boc" mean tert-butoxycarbonyl; "tAmOCO" means tert-amyloxycarbonyl; "2-FuCO" means 2-furylcarbonyl; "2-ThCO" means2-thienylcarbonyl; "2-PyCO" means 2-pyridylcarbonyl; "3-PyCO" means 3-pyridylcarbonyl; "4-PyCO" means 4-pyridylcarbonyl; "C4H.sub.7CO" means butenylcarbonyl; "EtOCO" means ethoxycarbonyl; "ibueCO" means isobutenylcarbonyl; "iBuCO" meansisobutylcarbonyl; "iBuOCO" means isobutoxycarbonyl; "iPrOCO" means isopropyloxycarbonyl; "nPrOCO" means n-propyloxycarbonyl; "nPrCO" means n-propylcarbonyl; "ibue" means isobutenyl; "THF" means tetrahydrofuran; "DMAP" means 4-dimethylamino pyridine;"LHMDS" means Lithium HexamethylDiSilazanide. The following examples illustrate the invention. EXAMPLE 1 ##STR00010## 7,10-(bis)-carbobenzyloxy-10-deacetyl baccatin III To a solution of 10-DAB (1.14 g, 2.11 mmol) in 20 mL of methylene chloride was added DMAP (6.20 g, 50.6 mmol) and benzyl chloroformate (1.8 mL, 12.7 mmol) slowly under a nitrogen atmosphere. The mixture was heated to 40-45° C., kept atthis temperature for 2 h, and an additional 1.8 mL (12.7 mmol) of benzyl chloroformate was added. Heating at 40-45° C. was continued for an additional 6 h, the mixture was diluted with 200 mL of CH2Cl.sub.2 and washed three times first with1N HCl and then with saturated sodium bicarbonate solution. The combined washings were extracted three times with 30 mL of CH2Cl.sub.2, the organic layers were combined, washed with brine, dried over Na2SO.sub.4, and concentrated under reducedpressure. Chromatography of the residue on silica gel eluting with CH2Cl.sub.2/EtOAc gave 1.48 g (86%) of 7,10-(bis)-carbobenzyloxy-10-deacetyl baccatin III. ##STR00011## 7,10-(bis)-carbobenzyloxy-3'-desphenyl-3'-(2-thienyl)-2'-O-triethylsilyl docetaxel To a solution of 425 mg (0.523 mmol) of 7,10-(bis)-carbobenzyloxy-10-deacetyl baccatin III in THF (4.5 mL) at -45° C. under a nitrogen atmosphere was added 0.80 mL of a solution of LHMDS (0.98 M) in THF dropwise. The mixture was kept at-45° C. for 1 h prior to addition of a solution of 341 mg (0.889 mmol) of cis-N-tbutoxycarbonyl-3-triethylsilyloxy-4-(2-thienyl) azetidin-2-one in 2 mL of THF. The mixture was allowed to warm to 0° C., and after 2 h was poured into 20 mLof saturated ammonium chloride solution. The aqueous layer was extracted three times with 50 mL of EtOAc/Hexanes (1:1) and the organic layers were combined, washed with brine, dried over Na2SO.sub.4 and concentrated. Chromatography of the residueon silica gel eluting with EtOAc/Hexanes gave 576 mg (92%) of 7,10-(bis)-carbobenzyloxy-3'-desphenyl-3'-(2-thienyl)-2'-O-triethylsilyl docetaxel. ##STR00012## 3'-Desphenyl-3'-(2-thienyl)-2'-O-triethylsilyl docetaxel A suspension of 550 mg of 7,10-(bis)-carbobenzyloxy-3'-desphenyl-3'-(2-thienyl)-2'-O-triethylsilyl docetaxel and 50 mg of 10% Pd/C in 30 mL of EtOH and 10 mL of EtOAc was stirred under a hydrogen atmosphere for 2 h at room temperature. Theslurry was filtered through a pad of celite 545 which was then washed with EtOAc. The washings were concentrated and the residue was purified by column chromatography on silica gel using EtOAc/Hexanes as eluent to give 405 mg (95%) of3'-desphenyl-3'-(2-thienyl)-2'-O-triethylsilyl docetaxel. ##STR00013## 3'-Desphenyl-3'-(2-thienyl)-2'-O-triethylsilyl-10-N-ethylcarbamoyl docetaxel To a slurry of 3'-desphenyl-3'-(2-thienyl)-2'-O-triethylsilyl docetaxel (201 mg, 0.217 mmol) and CuCl (43.0 mg, 0.434 mmol) in THF (3.5 mL) at -15° C. under a nitrogen atmosphere was added a solution of 51.5 mL (0.651 mmol) of ethylisocynate in 1.9 mL of THF. The mixture was warmed to 0° C. and after 1.4 h 5 mL of saturated aqueous sodium bicarbonate solution and 20 mL of ethyl acetate were added. The water layer was extracted three times with 50 mL of EtOAc/Hexanes(1:1). The organic layers were combined, dried over Na2SO.sub.4 and evaporated to give 218 mg of a residue which was used directly without purification. ##STR00014## 3'-Desphenyl-3'-(2-thienyl)-10-N-ethylcarbamoyl docetaxel (2722) To a solution of the 218 mg of 3'-desphenyl-3'-(2-thienyl)-2'-O-triethylsilyl-10-N-ethylcarbamoyl docetaxel obtained above in 6 mL of pyridine and 12 mL of CH3CN at 0° C. was added 1.0 mL of 49% aqueous HF. The mixture was warmed toroom temperature and after 2.5 h 50 mL of EtOAc was added. The mixture was washed with saturated aqueous sodium bicarbonate solution and brine, dried over sodium sulfate, and concentrated under reduced pressure. Chromatography of the residue on silicagel using CH2Cl.sub.2/MeOH as eluent gave 169 mg (88% for 2 steps) of 3'-desphenyl-3'-(2-thienyl)-10-N-ethylcarbamoyl docetaxel (2722). EXAMPLE 2 The procedures described in Example 1 were repeated, but other suitably protected β-lactams and acylating agents were substituted for the P-lactam and acylating agent of Example 1 to prepare the series of compounds having the combination ofsubstituents identified in the following table. The following table also includes characterization data for certain of these compounds, along with characterization data for the compound (2722) prepared in Example 1. ##STR00015## TABLE-US-00001 No. X3 m.p. (° C.) [α]D(CHCl3) Elemental Analysis 2600 2-pyridyl 173 175 -71.4 (c 0.22) Found: C, 60.70; H, 6.69 (Calcd. for C45H.sub.57N.sub.3O.sub.15.0.5H.sub.2O: C, 60.79; H, 6.58) 26163-pyridyl 183 185 -61.0 (c 0.20) Found: C, 58.96; H, 6.51 (Calcd. for C45H.sub.57N.sub.3O.sub.15.2H.sub.2O: C, 59.00; H, 6.69) 2622 3-thienyl 173 175 -68.1 (c 0.19) Found: C, 58.40; H, 6.42 (Calcd. for C44H.sub.56N.sub.2O.sub.15S.H.sub.2O: C,58.47; H, 6.47) 2633 i-propyl 170 172 -75.7 (c 0.22) Found: C, 60.10; H, 7.15 (Calcd. for C43H.sub.60N.sub.2O.sub.15.H.sub.2O: C, 59.84; H, 7.24) 2686 i-butenyl 167 169 -106.7 (c 0.17) Found: C, 61.12; H, 7.10 (Calcd. forC44H.sub.60N.sub.2O.sub.15.0.5H.sub.2O: C, 61.02; H, 7.10) 2692 4-pyridyl 203 205 -69.7 (c 0.18) Found: C, 60.19; H, 6.61 (Calcd. for C45H.sub.57N.sub.3O.sub.15.H.sub.2O: C, 60.13; H, 6.62) 2700 2-furyl 169 171 -73.6 (c 0.22) Found: C, 60.59;H, 6.58 (Calcd. for C44H.sub.56N.sub.2O.sub.16: C, 60.82; H, 6.50) 2717 3-furyl 165 167 -53.8 (c 0.23) Found: C, 60.07; H, 6.48 (Calcd. for C44H.sub.56N.sub.2O.sub.16.0.5H.sub.2O: C, 60.14; H, 6.54) 2722 2-thienyl 166 168 -52.2 (c 0.25) Found:C, 58.28; H, 6.32 (Calcd. for C44H.sub.56N.sub.2O.sub.15S.H.sub.2O: C, 58.47; H, 6.47) 2733 cyclobutyl 168 170 -73.9 (c 0.23) Found: C, 60.96; H, 7.02 (Calcd. for C44H.sub.60N.sub.2O.sub.15.0.5H.sub.2O: C, 61.02; H, 7.10) 2757 cyclopropyl 168170 -91.7 (c 0.23) Found: C, 60.07; H, 6.86 (Calcd. for C43H.sub.58N.sub.2O.sub.15.H.sub.2O: C, 59.98; H, 7.02) EXAMPLE 3 The procedures described in Example 1 were repeated, but other suitably protected β-lactams and were substituted for the cis-N-tbutoxycarbonyl-3-triethylsilyloxy-4-(2-thienyl) azetidin-2-one of Example 1 to prepare the series of compoundscorresponding to structure 14 and having the combination of substituents identified in the following table. TABLE-US-00002 (14) ##STR00016## Compound X5 X3 R10 2640 tBuOCO-- phenyl EtNHCOO-- 2743 tBuOCO-- p-nitrophenyl EtNHCOO-- 6015 tC3H.sub.5CO-- 2-furyl 3,4diFPhNHCOO-- 6024 tC3H.sub.5CO-- 2-furyl PhNHCOO-- 6072tC3H.sub.5CO-- 2-furyl EtNHCOO-- EXAMPLE 4 Following the processes described in Example 1 and elsewhere herein, the following specific taxanes having structural formula 14 and the combinations of substituents identified in the following table may be prepared, wherein R10 is aspreviously defined including wherein R10 is R10aR.sub.10bNCOO-- and (a) R10a and R10b are each hydrogen, (b) one of R10a and R10b is hydrogen and the other is (i) substituted or unsubstituted C1 to C8 alkyl such asmethyl, ethyl, or straight, branched or cyclic propyl, butyl, pentyl, or hexyl; (ii) substituted or unsubstituted C3 to C8 alkenyl such as ethenyl or straight, branched or cyclic propenyl, butenyl, pentenyl or hexenyl; (iii) substituted orunsubstituted C3 to C8 alkynyl such as ethynyl or straight or branched propynyl, butynyl, pentynyl, or hexynyl; (iv) substituted or unsubstituted phenyl, or (v) substituted or unsubstituted heteroaromatic such as furyl, thienyl, or pyridyl, or(c) R10a and R10b are independently (i) substituted or unsubstituted C1 to C8 alkyl such as methyl, ethyl, or straight, branched or cyclic propyl, butyl, pentyl, or hexyl; (ii) substituted or unsubstituted C2 to C8 alkenylsuch as ethenyl or straight, branched or cyclic propenyl, butenyl, pentenyl or hexenyl; (iii) substituted or unsubstituted C2 to C8 alkynyl such as ethynyl or straight or branched propynyl, butynyl, pentynyl, or hexynyl; (iv) substituted orunsubstituted phenyl, or (v) substituted or unsubstituted heteroaromatic such as furyl, thienyl, or pyridyl. For example, R10 may be R10aR.sub.10bNCOO-- wherein one of R10a and R10b is hydrogen and the other is methyl, ethyl, orstraight, branched or cyclic propyl. The substituents may be those identified elsewhere herein for substituted hydrocarbyl. TABLE-US-00003 (14) ##STR00017## X5 X3 R10 tBuOCO 2-furyl R10aR.sub.10bNCOO-- tBuOCO 3-furyl R10aR.sub.10bNCOO-- tBuOCO 2-thienyl R10aR.sub.10bNCOO-- tBuOCO 3-thienyl R10aR.sub.10bNCOO-- tBuOCO 2-pyridylR10aR.sub.10bNCOO-- tBuOCO 3-pyridyl R10aR.sub.10bNCOO-- tBuOCO 4-pyridyl R10aR.sub.10bNCOO-- tBuOCO isobutenyl R10aR.sub.10bNCOO-- tBuOCO isopropyl R10aR.sub.10bNCOO-- tBuOCO cyclopropyl R10aR.sub.10bNCOO-- tBuOCOcyclobutyl R10aR.sub.10bNCOO-- tBuOCO cyclopentyl R10aR.sub.10bNCOO-- tBuOCO phenyl R10aR.sub.10bNCOO-- benzoyl 2-furyl R10aR.sub.10bNCOO-- benzoyl 3-furyl R10aR.sub.10bNCOO-- benzoyl 2-thienyl R10aR.sub.10bNCOO-- benzoyl3-thienyl R10aR.sub.10bNCOO-- benzoyl 2-pyridyl R10aR.sub.10bNCOO-- benzoyl 3-pyridyl R10aR.sub.10bNCOO-- benzoyl 4-pyridyl R10aR.sub.10bNCOO-- benzoyl isobutenyl R10aR.sub.10bNCOO-- benzoyl isopropyl R10aR.sub.10bNCOO--benzoyl cyclopropyl R10aR.sub.10bNCOO-- benzoyl cyclobutyl R10aR.sub.10bNCOO-- benzoyl cyclopentyl R10aR.sub.10bNCOO-- benzoyl phenyl R10aR.sub.10bNCOO-- 2-FuCO-- 2-furyl R10aR.sub.10bNCOO-- 2-FuCO-- 3-furylR10aR.sub.10bNCOO-- 2-FuCO-- 2-thienyl R10aR.sub.10bNCOO-- 2-FuCO-- 3-thienyl R10aR.sub.10bNCOO-- 2-FuCO-- 2-pyridyl R10aR.sub.10bNCOO-- 2-FuCO-- 3-pyridyl R10aR.sub.10bNCOO-- 2-FuCO-- 4-pyridyl R10aR.sub.10bNCOO-- 2-FuCO--isobutenyl R10aR.sub.10bNCOO-- 2-FuCO-- isopropyl R10aR.sub.10bNCOO-- 2-FuCO-- cyclopropyl R10aR.sub.10bNCOO-- 2-FuCO-- cyclobutyl R10aR.sub.10bNCOO-- 2-FuCO-- cyclopentyl R10aR.sub.10bNCOO-- 2-FuCO-- phenylR10aR.sub.10bNCOO-- 2-ThCO-- 2-furyl R10aR.sub.10bNCOO-- 2-ThCO-- 3-furyl R10aR.sub.10bNCOO-- 2-ThCO-- 2-thienyl R10aR.sub.10bNCOO-- 2-ThCO-- 3-thienyl R10aR.sub.10bNCOO-- 2-ThCO-- 2-pyridyl R10aR.sub.10bNCOO-- 2-ThCO--3-pyridyl R10aR.sub.10bNCOO-- 2-ThCO-- 4-pyridyl R10aR.sub.10bNCOO-- 2-ThCO-- isobutenyl R10aR.sub.10bNCOO-- 2-ThCO-- isopropyl R10aR.sub.10bNCOO-- 2-ThCO-- cyclopropyl R10aR.sub.10bNCOO-- 2-ThCO-- cyclobutylR10aR.sub.10bNCOO-- 2-ThCO-- cyclopentyl R10aR.sub.10bNCOO-- 2-ThCO-- phenyl R10aR.sub.10bNCOO-- 2-PyCO-- 2-furyl R10aR.sub.10bNCOO-- 2-PyCO-- 3-furyl R10aR.sub.10bNCOO-- 2-PyCO-- 2-thienyl R10aR.sub.10bNCOO-- 2-PyCO--3-thienyl R10aR.sub.10bNCOO-- 2-PyCO-- 2-pyridyl R10aR.sub.10bNCOO-- 2-PyCO-- 3-pyridyl R10aR.sub.10bNCOO-- 2-PyCO-- 4-pyridyl R10aR.sub.10bNCOO-- 2-PyCO-- isobutenyl R10aR.sub.10bNCOO-- 2-PyCO-- isopropylR10aR.sub.10bNCOO-- 2-PyCO-- cyclopropyl R10aR.sub.10bNCOO-- 2-PyCO-- cyclobutyl R10aR.sub.10bNCOO-- 2-PyCO-- cyclopentyl R10aR.sub.10bNCOO-- 2-PyCO-- phenyl R10aR.sub.10bNCOO-- 3-PyCO-- 2-furyl R10aR.sub.10bNCOO-- 3-PyCO--3-furyl R10aR.sub.10bNCOO-- 3-PyCO-- 2-thienyl R10aR.sub.10bNCOO-- 3-PyCO-- 3-thienyl R10aR.sub.10bNCOO-- 3-PyCO-- 2-pyridyl R10aR.sub.10bNCOO-- 3-PyCO-- 3-pyridyl R10aR.sub.10bNCOO-- 3-PyCO-- 4-pyridyl R10aR.sub.10bNCOO--3-PyCO-- isobutenyl R10aR.sub.10bNCOO-- 3-PyCO-- isopropyl R10aR.sub.10bNCOO-- 3-PyCO-- cyclopropyl R10aR.sub.10bNCOO-- 3-PyCO-- cyclobutyl R10aR.sub.10bNCOO-- 3-PyCO-- cyclopentyl R10aR.sub.10bNCOO-- 3-PyCO-- phenylR10aR.sub.10bNCOO-- 4-PyCO-- 2-furyl R10aR.sub.10bNCOO-- 4-PyCO-- 3-furyl R10aR.sub.10bNCOO-- 4-PyCO-- 2-thienyl R10aR.sub.10bNCOO-- 4-PyCO-- 3-thienyl R10aR.sub.10bNCOO-- 4-PyCO-- 2-pyridyl R10aR.sub.10bNCOO-- 4-PyCO--3-pyridyl R10aR.sub.10bNCOO-- 4-PyCO-- 4-pyridyl R10aR.sub.10bNCOO-- 4-PyCO-- isobutenyl R10aR.sub.10bNCOO-- 4-PyCO-- isopropyl R10aR.sub.10bNCOO-- 4-PyCO-- cyclopropyl R10aR.sub.10bNCOO-- 4-PyCO-- cyclobutylR10aR.sub.10bNCOO-- 4-PyCO-- cyclopentyl R10aR.sub.10bNCOO-- 4-PyCO-- phenyl R10aR.sub.10bNCOO-- C4H.sub.7CO-- 2-furyl R10aR.sub.10bNCOO-- C4H.sub.7CO-- 3-furyl R10aR.sub.10bNCOO-- C4H.sub.7CO-- 2-thienylR10aR.sub.10bNCOO-- C4H.sub.7CO-- 3-thienyl R10aR.sub.10bNCOO-- C4H.sub.7CO-- 2-pyridyl R10aR.sub.10bNCOO-- C4H.sub.7CO-- 3-pyridyl R10aR.sub.10bNCOO-- C4H.sub.7CO-- 4-pyridyl R10aR.sub.10bNCOO--C4H.sub.7CO-- isobutenyl R10aR.sub.10bNCOO-- C4H.sub.7CO-- isopropyl R10aR.sub.10bNCOO-- C4H.sub.7CO-- cyclopropyl R10aR.sub.10bNCOO-- C4H.sub.7CO-- cyclobutyl R10aR.sub.10bNCOO-- C4H.sub.7CO-- cyclopentylR10aR.sub.10bNCOO-- C4H.sub.7CO-- phenyl R10aR.sub.10bNCOO-- EtOCO-- 2-furyl R10aR.sub.10bNCOO-- EtOCO-- 3-furyl R10aR.sub.10bNCOO-- EtOCO-- 2-thienyl R10aR.sub.10bNCOO-- EtOCO-- 3-thienyl R10aR.sub.10bNCOO-- EtOCO--2-pyridyl R10aR.sub.10bNCOO-- EtOCO-- 3-pyridyl R10aR.sub.10bNCOO-- EtOCO-- 4-pyridyl R10aR.sub.10bNCOO-- EtOCO-- isobutenyl R10aR.sub.10bNCOO-- EtOCO-- isopropyl R10aR.sub.10bNCOO-- EtOCO-- cyclopropyl R10aR.sub.10bNCOO--EtOCO-- cyclobutyl R10aR.sub.10bNCOO-- EtOCO-- cyclopentyl R10aR.sub.10bNCOO-- EtOCO-- phenyl R10aR.sub.10bNCOO-- ibueCO-- 2-furyl R10aR.sub.10bNCOO-- ibueCO-- 3-furyl R10aR.sub.10bNCOO-- ibueCO-- 2-thienylR10aR.sub.10bNCOO-- ibueCO-- 3-thienyl R10aR.sub.10bNCOO-- ibueCO-- 2-pyridyl R10aR.sub.10bNCOO-- ibueCO-- 3-pyridyl R10aR.sub.10bNCOO-- ibueCO-- 4-pyridyl R10aR.sub.10bNCOO-- ibueCO-- isobutenyl R10aR.sub.10bNCOO--ibueCO-- isopropyl R10aR.sub.10bNCOO-- ibueCO-- cyclopropyl R10aR.sub.10bNCOO-- ibueCO-- cyclobutyl R10aR.sub.10bNCOO-- ibueCO-- cyclopentyl R10aR.sub.10bNCOO-- ibueCO-- phenyl R10aR.sub.10bNCOO-- iBuCO-- 2-furylR10aR.sub.10bNCOO-- iBuCO-- 3-furyl R10aR.sub.10bNCOO-- iBuCO-- 2-thienyl R10aR.sub.10bNCOO-- iBuCO-- 3-thienyl R10aR.sub.10bNCOO-- iBuCO-- 2-pyridyl R10aR.sub.10bNCOO-- iBuCO-- 3-pyridyl R10aR.sub.10bNCOO-- iBuCO--4-pyridyl R10aR.sub.10bNCOO-- iBuCO-- isobutenyl R10aR.sub.10bNCOO-- iBuCO-- isopropyl R10aR.sub.10bNCOO-- iBuCO-- cyclopropyl R10aR.sub.10bNCOO-- iBuCO-- cyclobutyl R10aR.sub.10bNCOO-- iBuCO-- cyclopentylR10aR.sub.10bNCOO-- iBuCO-- phenyl R10aR.sub.10bNCOO-- iBuOCO-- 2-furyl R10aR.sub.10bNCOO-- iBuOCO-- 3-furyl R10aR.sub.10bNCOO-- iBuOCO-- 2-thienyl R10aR.sub.10bNCOO-- iBuOCO-- 3-thienyl R10aR.sub.10bNCOO-- iBuOCO--2-pyridyl R10aR.sub.10bNCOO-- iBuOCO-- 3-pyridyl R10aR.sub.10bNCOO-- iBuOCO-- 4-pyridyl R10aR.sub.10bNCOO-- iBuOCO-- isobutenyl R10aR.sub.10bNCOO-- iBuOCO-- isopropyl R10aR.sub.10bNCOO-- iBuOCO-- cyclopropylR10aR.sub.10bNCOO-- iBuOCO-- cyclobutyl R10aR.sub.10bNCOO-- iBuOCO-- cyclopentyl R10aR.sub.10bNCOO-- iBuOCO-- phenyl R10aR.sub.10bNCOO-- iPrOCO-- 2-furyl R10aR.sub.10bNCOO-- iPrOCO-- 3-furyl R10aR.sub.10bNCOO-- iPrOCO--2-thienyl R10aR.sub.10bNCOO-- iPrOCO-- 3-thienyl R10aR.sub.10bNCOO-- iPrOCO-- 2-pyridyl R10aR.sub.10bNCOO-- iPrOCO-- 3-pyridyl R10aR.sub.10bNCOO-- iPrOCO-- 4-pyridyl R10aR.sub.10bNCOO-- iPrOCO-- isobutenylR10aR.sub.10bNCOO-- iPrOCO-- isopropyl R10aR.sub.10bNCOO-- iPrOCO-- cyclopropyl R10aR.sub.10bNCOO-- iPrOCO-- cyclobutyl R10aR.sub.10bNCOO-- iPrOCO-- cyclopentyl R10aR.sub.10bNCOO-- iPrOCO-- phenyl R10aR.sub.10bNCOO--nPrOCO-- 2-furyl R10aR.sub.10bNCOO-- nPrOCO-- 3-furyl R10aR.sub.10bNCOO-- nPrOCO-- 2-thienyl R10aR.sub.10bNCOO-- nPrOCO-- 3-thienyl R10aR.sub.10bNCOO-- nPrOCO-- 2-pyridyl R10aR.sub.10bNCOO-- nPrOCO-- 3-pyridylR10aR.sub.10bNCOO-- nPrOCO-- 4-pyridyl R10aR.sub.10bNCOO-- nPrOCO-- isobutenyl R10aR.sub.10bNCOO-- nPrOCO-- isopropyl R10aR.sub.10bNCOO-- nPrOCO-- cyclopropyl R10aR.sub.10bNCOO-- nPrOCO-- cyclobutyl R10aR.sub.10bNCOO--nPrOCO-- cyclopentyl R10aR.sub.10bNCOO-- nPrOCO-- phenyl R10aR.sub.10bNCOO-- nPrOCO-- 2-furyl R10aR.sub.10bNCOO-- nPrOCO-- 3-furyl R10aR.sub.10bNCOO-- nPrOCO-- 2-thienyl R10aR.sub.10bNCOO-- nPrOCO-- 3-thienylR10aR.sub.10bNCOO-- nPrOCO-- 2-pyridyl R10aR.sub.10bNCOO-- nPrOCO-- 3-pyridyl R10aR.sub.10bNCOO-- nPrOCO-- 4-pyridyl R10aR.sub.10bNCOO-- nPrOCO-- isobutenyl R10aR.sub.10bNCOO-- nPrOCO-- isopropyl R10aR.sub.10bNCOO-- nPrOCO--cyclopropyl R10aR.sub.10bNCOO-- nPrOCO-- cyclobutyl R10aR.sub.10bNCOO-- nPrOCO-- cyclopentyl R10aR.sub.10bNCOO-- nPrOCO-- phenyl R10aR.sub.10bNCOO-- nPrCO-- 2-furyl R10aR.sub.10bNCOO-- nPrCO-- 3-furyl R10aR.sub.10bNCOO--nPrCO-- 2-thienyl R10aR.sub.10bNCOO-- nPrCO-- 3-thienyl R10aR.sub.10bNCOO-- nPrCO-- 2-pyridyl R10aR.sub.10bNCOO-- nPrCO-- 3-pyridyl R10aR.sub.10bNCOO-- nPrCO-- 4-pyridyl R10aR.sub.10bNCOO-- nPrCO-- isobutenylR10aR.sub.10bNCOO-- nPrCO-- isopropyl R10aR.sub.10bNCOO-- nPrCO-- cyclopropyl R10aR.sub.10bNCOO-- nPrCO-- cyclobutyl R10aR.sub.10bNCOO-- nPrCO-- cyclopentyl R10aR.sub.10bNCOO-- nPrCO-- phenyl R10aR.sub.10bNCOO-- EXAMPLE 5 Following the processes described in Example 1 and elsewhere herein, the following specific taxanes having structural formula 15 may be prepared, wherein R7 is hydroxy and R10 in each of the series (that is, each of series "A" through"K") is as previously defined, including wherein R10 is R10aR.sub.10bNCOO-- and one of R10a and R10b is hydrogen and the other is (i) substituted or unsubstituted C1 to C8 alkyl such as methyl, ethyl, or straight, branchedor cyclic propyl, butyl, pentyl, or hexyl; (ii) substituted or unsubstituted C2 to C8 alkenyl such as ethenyl or straight, branched or cyclic propenyl, butenyl, pentenyl or hexenyl; (iii) substituted or unsubstituted C2 to C8 alkynylsuch as ethynyl or straight or branched propynyl, butynyl, pentynyl, or hexynyl; (iv) phenyl or substituted phenyl such as nitro, alkoxy or halosubstituted phenyl, or (v) substituted or unsubstituted heteroaromatic such as furyl, thienyl, or pyridyl. The substituents may be those identified elsewhere herein for substituted hydrocarbyl. In one embodiment, preferred R10 substituents include R10aR.sub.10bNCOO-- wherein one of R10a and R10b is hydrogen and the other is methyl, ethyl,or straight, branched or cyclic propyl. In another embodiment, preferred R10 substituents include R10aR.sub.10bNCOO-- wherein one of R10a and R10b is hydrogen and the other is substituted methyl, ethyl, or straight, branched orcyclic propyl. In the "A" series of compounds, X10 is as otherwise as defined herein. Preferably, heterocyclo is substituted or unsubstitued furyl, thienyl, or pyridyl, X10 is substituted or unsubstitued furyl, thienyl, pyridyl, phenyl, or loweralkyl (e.g., tert-butyl), and R7 and R10 each have the beta stereochemical configuration. In the "B" series of compounds, X10 and R2a are as otherwise as defined herein. Preferably, heterocyclo is preferably substituted or unsubstitued furyl, thienyl, or pyridyl, X10 is preferably substituted or unsubstitued furyl,thienyl, pyridyl, phenyl, or lower alkyl (e.g., tert-butyl), R2a is preferably substituted or unsubstitued furyl, thienyl, pyridyl, phenyl, or lower alkyl, and R7 and R10 each have the beta stereochemical configuration. In the "C" series of compounds, X10 and R9a are as otherwise as defined herein. Preferably, heterocyclo is preferably substituted or unsubstitued furyl, thienyl, or pyridyl, X10 is preferably substituted or unsubstitued furyl,thienyl, pyridyl, phenyl, or lower alkyl (e.g., tert-butyl), R9a is preferably substituted or unsubstitued furyl, thienyl, pyridyl, phenyl, or lower alkyl, and R7, R9 and R10 each have the beta stereochemical configuration. In the "D" and "E" series of compounds, X10 is as otherwise as defined herein. Preferably, heterocyclo is preferably substituted or unsubstitued furyl, thienyl, or pyridyl, X10 is preferably substituted or unsubstitued furyl, thienyl,pyridyl, phenyl, or lower alkyl (e.g., tert-butyl), and R7, R9 (series D only) and R10 each have the beta stereochemical configuration. In the "F" series of compounds, X10, R2a and R9a are as otherwise as defined herein. Preferably, heterocyclo is preferably substituted or unsubstitued furyl, thienyl, or pyridyl, X10 is preferably substituted or unsubstituedfuryl, thienyl, pyridyl, phenyl, or lower alkyl (e.g., tert-butyl), R2a is preferably substituted or unsubstitued furyl, thienyl, pyridyl, phenyl, or lower alkyl, and R7, R9 and R10 each have the beta stereochemical configuration. In the "G" series of compounds, X10 and R2a are as otherwise as defined herein. Preferably, heterocyclo is preferably substituted or unsubstitued furyl, thienyl, or pyridyl, X10 is preferably substituted or unsubstitued furyl,thienyl, pyridyl, phenyl, or lower alkyl (e.g., tert-butyl), R2a is preferably substituted or unsubstitued furyl, thienyl, pyridyl, phenyl, or lower alkyl, and R7, R9 and R10 each have the beta stereochemical configuration. In the "H" series of compounds, X10 is as otherwise as defined herein. Preferably, heterocyclo is preferably substituted or unsubstitued furyl, thienyl, or pyridyl, X10 is preferably substituted or unsubstitued furyl, thienyl, pyridyl,phenyl, or lower alkyl (e.g., tert-butyl), R2a is preferably substituted or unsubstitued furyl, thienyl, pyridyl, phenyl, or lower alkyl, and R7 and R10 each have the beta stereochemical configuration. In the "I" series of compounds, X10 and R2a are as otherwise as defined herein. Preferably, heterocyclo is preferably substituted or unsubstitued furyl, thienyl, or pyridyl, X10 is preferably substituted or unsubstitued furyl,thienyl, pyridyl, phenyl, or lower alkyl (e.g., tert-butyl), R2a is preferably substituted or unsubstitued furyl, thienyl, pyridyl, phenyl, or lower alkyl, and R7 and R10 each have the beta stereochemical configuration. In the "J" series of compounds, X10 and R2a are as otherwise as defined herein. Preferably, heterocyclo is preferably substituted or unsubstitued furyl, thienyl, or pyridyl, X10 is preferably substituted or unsubstitued furyl,thienyl, pyridyl, phenyl, or lower alkyl (e.g., tert-butyl), R2a is preferably substituted or unsubstitued furyl, thienyl, pyridyl, phenyl, or lower alkyl, and R7, R9 and R10 each have the beta stereochemical configuration. In the "K" series of compounds, X10, R2a and R9a are as otherwise as defined herein. Preferably, heterocyclo is preferably substituted or unsubstitued furyl, thienyl, or pyridyl, X10 is preferably substituted or unsubstituedfuryl, thienyl, pyridyl, phenyl, or lower alkyl (e.g., tert-butyl), R2a is preferably substituted or unsubstitued furyl, thienyl, pyridyl, phenyl, or lower alkyl, and R7, R9 and R10 each have the beta stereochemical configuration. Any substituents of each of X3, X5, R2, R7, and R9 may be hydrocarbyl or any of the heteroatom containing substituents selected from the group consisting of heterocyclo, alkoxy, alkenoxy, alkynoxy, aryloxy, hydroxy,protected hydroxy, keto, acyloxy, nitro, amino, amido, thiol, ketal, acetal, ester and ether moieties, but not phosphorous containing moieties. TABLE-US-00004 TABLE 3 (15) ##STR00018## Series X5 X3 R10 R2 R9 R14 A1 --COOX10 heterocyclo R10aR.sub.10bNCOO-- C6H.sub.5COO-- - O H A2 --COX10 heterocyclo R10aR.sub.10bNCOO--C6H.sub.5COO-- O- H A3 --CONHX10 heterocyclo R10aR.sub.10bNCOO-- C6H.sub.5COO--- O H A4 --COOX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- O- H substituted C2 to C8 alkyl A5 --COX10 optionallyR10aR.sub.10bNCOO-- C6H.sub.5COO-- O - H substituted C2 to C8 alkyl A6 --CONHX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- - O H substituted C2 to C8 alkyl A7 --COOX10 optionallyR10aR.sub.10bNCOO-- C6H.sub.5COO-- O- H substituted C2 to C8 alkenyl A8 --COX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- O - H substituted C2 to C8 alkenyl A9 --CONHX10 optionallyR10aR.sub.10bNCOO-- C6H.sub.5COO-- - O H substituted C2 to C8 alkenyl A10 --COOX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- - O H substituted C2 to C8 alkynyl A11 --COX10 optionallyR10aR.sub.10bNCOO-- C6H.sub.5COO-- O- H substituted C2 to C8 alkynyl A12 --CONHX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO--- O H substituted C2 to C8 alkynyl B1 --COOX10 heterocycloR10aR.sub.10bNCOO-- R2aCOO-- O H B2 --COX10 heterocyclo R10aR.sub.10bNCOO-- R2aCOO-- O H B3 --CONHX10 heterocyclo R10aR.sub.10bNCOO-- R2aCOO-- O H B4 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO--O H substituted C2 to C8 alkyl B5 --COX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- O H substituted C2 to C8 alkyl B6 --CONHX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- O H substituted C2 to C8alkyl B7 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- O H substituted C2 to C8 alkenyl B8 --COX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- O H substituted C2 to C8 alkenyl B9 --CONHX10 optionallyR10aR.sub.10bNCOO-- R2aCOO-- O H substituted C2 to C8 alkenyl B10 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- O H substituted C2 to C8 alkynyl B11 --COX10 optionally R10aR.sub.10bNCOO--R2aCOO-- O H substituted C2 to C8 alkynyl B12 --CONHX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- O H substituted C2 to C8 alkynyl C1 --COOX10 heterocyclo R10aR.sub.10bNCOO-- C6H.sub.5COO-- -R9aCOO-- H C2 --COX10 heterocyclo R10aR.sub.10bNCOO-- C6H.sub.5COO-- R- 9aCOO-- H C3 --CONHX10 heterocyclo R10aR.sub.10bNCOO-- C6H.sub.5COO--- R9aCOO-- H C4 --CONX10 optionally R10aR.sub.10bNCOO--C6H.sub.5COO-- R- 9aCOO-- H substituted C2 to C8 alkyl C5 --COX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- R.- sub.9aCOO-- H substituted C2 to C8 alkyl C6 --CONHX10 optionallyR10aR.sub.10bNCOO-- C6H.sub.5COO-- - R9aCOO-- H substituted C2 to C8 alkyl C7 --CONX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- R- 9aCOO-- H substituted C2 to C8 alkenyl C8 --COX10optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- R.- sub.9aCOO-- H substituted C2 to C8 alkenyl C9 --CONHX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- - R9aCOO-- H substituted C2 to C8 alkenyl C10--COOX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- - R9aCOO-- H substituted C2 to C8 alkynyl C11 --COX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- R- 9aCOO-- H substituted C2 to C8alkynyl C12 --CONHX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO--- R9aCOO-- H substituted C2 to C8 alkynyl D1 --COOX10 heterocyclo R10aR.sub.10bNCOO-- C6H.sub.5COO-- - OH H D2 --COX10 heterocycloR10aR.sub.10bNCOO-- C6H.sub.5COO-- O- H H D3 --CONHX10 heterocyclo R10aR.sub.10bNCOO-- C6H.sub.5COO--- OH H D4 --COOX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- O- H H substituted C2 to C8 alkyl D5--COX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- OH- H substituted C2 to C8 alkyl D6 --CONHX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- - OH H substituted C2 to C8 alkyl D7 --COOX10optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- O- H H substituted C2 to C8 alkenyl D8 --COX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- OH- H substituted C2 to C8 alkenyl D9 --CONHX10 optionallyR10aR.sub.10bNCOO-- C6H.sub.5COO-- - OH H substituted C2 to C8 alkenyl D10 --COOX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- - OH H substituted C2 to C8 alkynyl D11 --COX10 optionallyR10aR.sub.10bNCOO-- C6H.sub.5COO-- O- H H substituted C2 to C8 alkynyl D12 --CONHX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO--- OH H substituted C2 to C8 alkynyl E1 --COOX10 heterocycloR10aR.sub.10bNCOO-- C6H.sub.5COO-- - O OH E2 --COX10 heterocyclo R10aR.sub.10bNCOO-- C6H.sub.5COO-- O- OH E3 --CONHX10 heterocyclo R10aR.sub.10bNCOO-- C6H.sub.5COO--- O OH E4 --COOX10 optionallyR10aR.sub.10bNCOO-- C6H.sub.5COO-- O- OH substituted C2 to C8 alkyl E5 --COX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- O - OH substituted C2 to C8 alkyl E6 --CONHX10 optionallyR10aR.sub.10bNCOO-- C6H.sub.5COO-- - O OH substituted C2 to C8 alkyl E7 --COOX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- O- OH substituted C2 to C8 alkenyl E8 --COX10 optionallyR10aR.sub.10bNCOO-- C6H.sub.5COO-- O - OH substituted C2 to C8 alkenyl E9 --CONHX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- - O OH substituted C2 to C8 alkenyl E10 --COOX10 optionallyR10aR.sub.10bNCOO-- C6H.sub.5COO-- - O OH substituted C2 to C8 alkynyl E11 --COX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- O- OH substituted C2 to C8 alkynyl E12 --CONHX10 optionallyR10aR.sub.10bNCOO-- C6H.sub.5COO--- O OH substituted C2 to C8 alkynyl F1 --COOX10 heterocyclo R10aR.sub.10bNCOO-- R2aCOO-- R- 9aCOO-- H F2 --COX10 heterocyclo R10aR.sub.10bNCOO-- R2aCOO-- R9-aCOO-- H F3 --CONHX10 heterocyclo R10aR.sub.10bNCOO-- R2aCOO-- R.sub- .9aCOO-- H F4 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- R9- aCOO-- H substituted C2 to C8 alkyl F5 --COX10 optionallyR10aR.sub.10bNCOO-- R2aCOO-- R9a- COO-- H substituted C2 to C8 alkyl F6 --CONHX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- R- 9aCOO-- H substituted C2 to C8 alkyl F7 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- R9- aCOO-- H substituted C2 to C8 alkenyl F8 --COX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- R9a-COO-- H substituted C2 to C8 alkenyl F9 --CONHX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- R- 9aCOO-- H substituted C2 to C8 alkenyl F10 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- R-9aCOO-- H substituted C2 to C8 alkynyl F11 --COX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- R9- aCOO-- H substituted C2 to C8 alkynyl F12 --CONHX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- R.sub-.9aCOO-- H substituted C2 to C8 alkynyl G1 --COOX10 heterocyclo R10aR.sub.10bNCOO-- R2aCOO-- OH H G2 --COX10 heterocyclo R10aR.sub.10bNCOO-- R2aCOO-- OH H G3 --CONHX10 heterocyclo R10aR.sub.10bNCOO--R2aCOO-- OH H G4 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- OH H substituted C2 to C8 alkyl G5 --COX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- OH H substituted C2 to C8 alkyl G6 --CONHX10optionally R10aR.sub.10bNCOO-- R2aCOO-- OH H substituted C2 to C8 alkyl G7 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- OH H substituted C2 to C8 alkenyl G8 --COX10 optionally R10aR.sub.10bNCOO--R2aCOO-- OH H substituted C2 to C8 alkenyl G9 --CONHX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- OH H substituted C2 to C8 alkenyl G10 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- OH H substitutedC2 to C8 alkynyl G11 --COX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- OH H substituted C2 to C8 alkynyl G12 --CONHX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- OH H substituted C2 to C8 alkynyl H1--COOX10 heterocyclo R10aR.sub.10bNCOO-- C6H.sub.5COO-- - OH OH H2 --COX10 heterocyclo R10aR.sub.10bNCOO-- C6H.sub.5COO-- O- H OH H3 --CONHX10 heterocyclo R10aR.sub.10bNCOO-- C6H.sub.5COO--- OH OH H4--COOX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- O- H OH substituted C2 to C8 alkyl H5 --COX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- OH- OH substituted C2 to C8 alkyl H6 --CONHX10optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- - OH OH substituted C2 to C8 alkyl H7 --COOX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- O- H OH substituted C2 to C8 alkenyl H8 --COX10 optionallyR10aR.sub.10bNCOO-- C6H.sub.5COO-- OH- OH substituted C2 to C8 alkenyl H9 --CONHX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- - OH OH substituted C2 to C8 alkenyl H10 --COOX10 optionallyR10aR.sub.10bNCOO-- C6H.sub.5COO-- - OH OH substituted C2 to C8 alkynyl H11 --COX10 optionally R10aR.sub.10bNCOO-- C6H.sub.5COO-- O- H OH substituted C2 to C8 alkynyl H12 --CONHX10 optionallyR10aR.sub.10bNCOO-- C6H.sub.5COO--- OH OH substituted C2 to C8 alkynyl I1 --COOX10 heterocyclo R10aR.sub.10bNCOO-- R2aCOO-- O OH I2 --COX10 heterocyclo R10aR.sub.10bNCOO-- R2aCOO-- O OH I3 --CONHX10heterocyclo R10aR.sub.10bNCOO-- R2aCOO-- O OH I4 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- O OH substituted C2 to C8 alkyl I5 --COX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- O OH substitutedC2 to C8 alkyl I6 --CONHX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- O OH substituted C2 to C8 alkyl I7 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- O OH substituted C2 to C8 alkenyl I8--COX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- O OH substituted C2 to C8 alkenyl I9 --CONHX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- O OH substituted C2 to C8 alkenyl I10 --COOX10 optionallyR10aR.sub.10bNCOO-- R2aCOO-- O OH substituted C2 to C8 alkynyl I11 --COX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- O OH substituted C2 to C8 alkynyl I12 --CONHX10 optionally R10aR.sub.10bNCOO--R2aCOO-- O OH substituted C2 to C8 alkynyl J1 --COOX10 heterocyclo R10aR.sub.10bNCOO-- R2aCOO-- OH OH J2 --COX10 heterocyclo R10aR.sub.10bNCOO-- R2aCOO-- OH OH J3 --CONHX10 heterocycloR10aR.sub.10bNCOO-- R2aCOO-- OH OH- J4 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- OH OH substituted to C8 alkyl J5 --COX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- OH OH substituted C2 to C8 alkyl J6--CONHX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- OH OH substituted C2 to C8 alkyl J7 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- OH OH substituted C2 to C8 alkenyl J8 --COX10 optionallyR10aR.sub.10bNCOO-- R2aCOO-- OH OH substituted C2 to C8 alkenyl J9 --CONHX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- OH OH substituted C2 to C8 alkenyl J10 --COOX10 optionally R10aR.sub.10bNCOO--R2aCOO-- OH OH substituted C2 to C8 alkynyl J11 --COX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- OH OH substituted C2 to C8 alkynyl J12 --CONHX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- OH OH-substituted C2 to C8 alkynyl K1 --COOX10 heterocyclo R10aR.sub.10bNCOO-- R2aCOO-- R- 9aCOO-- OH K2 --COX10 heterocyclo R10aR.sub.10bNCOO-- R2aCOO-- R9- aCOO-- OH K3 --CONHX10 heterocycloR10aR.sub.10bNCOO-- R2aCOO-- R.sub- .9aCOO-- OH K4 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- R9- aCOO-- OH substituted C2 to C8 alkyl K5 --COX10 optionally R10aR.sub.10bNCOO-- R2aCOO--R9a- COO-- OH substituted C2 to C8 alkyl K6 --CONHX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- R- 9aCOO-- OH substituted C2 to C8 alkyl K7 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO--R9- aCOO-- OH substituted C2 to C8 alkenyl K8 --COX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- R9a- COO-- OH substituted C2 to C8 alkenyl K9 --CONHX10 optionally R10aR.sub.10bNCOO-- R2aCOO--R- 9aCOO-- OH substituted C2 to C8 alkenyl K10 --COOX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- R- 9aCOO-- OH substituted C2 to C8 alkynyl K11 --COX10 optionally R10aR.sub.10bNCOO-- R2aCOO--R9- aCOO-- OH substituted C2 to C8 alkynyl K12 --CONHX10 optionally R10aR.sub.10bNCOO-- R2aCOO-- R.sub- .9aCOO-- OH substituted C2 to C8 alkynyl EXAMPLE 6 In Vitro Cytotoxicity Measured by the Cell Colony Formation Assay Four hundred cells (HCT116) were plated in 60 mm Petri dishes containing 2.7 mL of medium (modified McCoy's 5a medium containing 10% fetal bovine serum and 100 units/mL penicillin and 100 g/mL streptomycin). The cells were incubated in aCO2 incubator at 37° C. for 5 h for attachment to the bottom of Petri dishes. The compounds identified in Example 2 were made up fresh in medium at ten times the final concentration, and then 0.3 mL of this stock solution was added to the2.7 mL of medium in the dish. The cells were then incubated with drugs for 72 h at 37° C. At the end of incubation the drug-containing media were decanted, the dishes were rinsed with 4 mL of Hank's Balance Salt Solution (HBSS), 5 mL of freshmedium was added, and the dishes were returned to the incubator for colony formation. The cell colonies were counted using a colony counter after incubation for 7 days. Cell survival was calculated and the values of ID50 (the drug concentrationproducing 50% inhibition of colony formation) were determined for each tested compound. TABLE-US-00005 IN VITRO Compound ID 50 (nm) HCT116 taxol 2.1 docetaxel 0.6 2600 <1 2616 27 2622 <1 2633 <10 2686 <1 2692 <1 2700 <1 2717 <1 2722 <1 2733 <10 2757 <1 2640 <1 2743 <1 6015 <10 6024 <1 6072<1 * * * * * Other References
Field of SearchRing oxygen in the additional hetero ringThe hetero ring is four-membered Sulfur or halogen attached directly or indirectly to the hetero ring by nonionic bonding The additional hetero ring is one of the cyclos in a polycyclo ring system Oxygen containing hetero ring Chalcogen bonded directly to the hetero ring Ring oxygen in the additional hetero ring |
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