Patent 7198778 Issued on April 3, 2007. Estimated Expiration Date: September 3, 2023. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
424/9.6, Diagnostic or test agent produces in vivo fluorescence424/1.11, RADIONUCLIDE OR INTENDED RADIONUCLIDE CONTAINING; ADJUVANT OR CARRIER COMPOSITIONS; INTERMEDIATE OR PREPARATORY COMPOSITIONS424/1.65, In an organic compound424/9.1, IN VIVO DIAGNOSIS OR IN VIVO TESTING424/9.3, Magnetic imaging agent (e.g., NMR, MRI, MRS, etc.)424/9.4, X-ray contrast imaging agent (e.g., computed tomography, angiography, etc.)424/9.5, Ultrasound contrast agent548/146, 1,3-thiazoles (including hydrogenated)544/124, Six-membered ring consisting of one nitrogen and five carbons (e.g., pyridine, etc.)375/222Modems (data sets)
Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologs. The compounds may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350 to 1300 nm, the exact range being dependent upon the particular dye. The use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluoresence tumor imaging, detection and therapy.
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