U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Cannabinoids

Patent 7179800 Issued on February 20, 2007. Estimated Expiration Date: Icon_subject April 15, 2023. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Cyclohexenyl resorcinol derivatives
Patent #: 4092344
Issued on: 05/30/1978
Inventor: Matsumoto

Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor
Patent #: 4102902
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Inventor: Archer ,   et al.

Pinene derivatives and pharmaceutical compositions containing the same
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Inventor: Mechoulam ,   et al.

Carenadiol and derivatives
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Inventor: Martin ,   et al.

Neuroprotective pharmaceutical compositions of 4-phenylpinene derivatives and certain novel 4-phenylpinene compounds
Patent #: 5434295
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Inventor: Mechoulam, et al.

Alkylated resorcinol derivatives for the treatment of immune diseases
Patent #: 6274635
Issued on: 08/14/2001
Inventor: Travis

Vasodilator cannabinoid analogs
Patent #: 6563009
Issued on: 05/13/2003
Inventor: Kunos, et al.

Cannabinoids as antioxidants and neuroprotectants Patent #: 6630507
Issued on: 10/07/2003
Inventor: Hampson ,   et al.

Inventors

Assignee

Application

No. 10413539 filed on 04/15/2003

US Classes:

514/183, Heterocyclic carbon compounds containing a hetero ring having chalcogen (i.e., O,S,Se or Te) or nitrogen as the only ring hetero atoms DOAI568/731, Additional ring containing514/511, Two of the cyclos share at least three ring members (i.e., bridged)568/644, Polyoxy514/729, Alicyclic ring containing514/718, Plural oxygens568/743, The additional ring is six-membered514/454Tricyclo ring system having the hetero ring as one of the cyclos

Examiners

Primary: Barts, Samuel
Assistant: Gale, Kellette

Attorney, Agent or Firm

Foreign Patent References

  • WO 01/028329 WO 04/01/2001
  • WO 01/95899 WO 12/01/2001

International Classes

A61K 31/33
C07C 39/12

Abstract

Compounds of the formula: wherein R, R1 and R4 are defined in the specification, and pharmaceutically acceptable salts, esters and tautomers thereof, having activity at peripheral cannabinoid receptors, commonly designated the CB2 receptor class. The compounds are useful for therapy, especially in the treatment of pain, inflammation and autoimmune disease.

Other References

  • Drake, David J. et al; “Classical/Nonclassical Hybrid Cannabinoids: Southern Aliphatic Chain-Functionalized C-6β Methyl, Ethyl, and Propyl Analogues”; J. Med. Chem., No. 41, 1998, pp. 3596-3608, XP-002217966.
  • Gareau, Yves, et al; “Structure Activity Relationships of Tetrahydrocannabinol Analogues on Human Cannabinoid Receptors”; Biorg. Med. Chem. Lett., vol. 6, No. 2; 1996; pp. 189-194, XP004135106.
  • Baek, Seung-Hwa, et al; “Boron Trifluoride Etherate on Alimina—A Modified Lewis Acid Reagent. An Improved Synthesis of Cannabidiol”; Tetrahedron Letters, Elsevier Science Publ.; Amsterdam, NL, vol. 8, No. 26, 1985; pp. 1083-1086; XP001095309.
  • Baek, Seung-Hwa; et al; “Boron Trifluorideetherate on Alumina—A Modified Lewis Acid Reagent . . . Diacetate Derivatives”; Bull. Korean Chem. Soc., vol. 15, No. 6, 1994, pp. 507-508, XP00222251.
  • Chemical Abstracts Service, Columbus, OH; Baek, Seung-Hwa; “Simplified cannabidiols. Part 1. Boron trifluoride-diethyl ether on alumina: a modified Lewis acid reagent . . . allylic alcohols”; Database accession No. 122:132675; XP002222552; J. Chem. Research, 1994, pp. 2549-2561.
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