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AbstractCompounds of the formula: wherein R, R1 and R4 are defined in the specification, and pharmaceutically acceptable salts, esters and tautomers thereof, having activity at peripheral cannabinoid receptors, commonly designated the CB2 receptor class. The compounds are useful for therapy, especially in the treatment of pain, inflammation and autoimmune disease.Other References
| InventorsAssigneeApplicationNo. 10413539 filed on 04/15/2003US Classes:514/183, Heterocyclic carbon compounds containing a hetero ring having chalcogen (i.e., O,S,Se or Te) or nitrogen as the only ring hetero atoms DOAI568/731, Additional ring containing514/511, Two of the cyclos share at least three ring members (i.e., bridged)568/644, Polyoxy514/729, Alicyclic ring containing514/718, Plural oxygens568/743, The additional ring is six-membered514/454Tricyclo ring system having the hetero ring as one of the cyclosField of Search549/78, Chalcogen attached indirectly to the hetero ring by nonionic bonding568/743, The additional ring is six-membered568/747, Rings bonded directly to each other568/731, Additional ring containing514/438, The hetero ring is five-membered514/719, Alicyclic ring514/721, Plural benzene rings514/729, Alicyclic ring containing514/736, Additional benzene ring containing514/183Heterocyclic carbon compounds containing a hetero ring having chalcogen (i.e., O,S,Se or Te) or nitrogen as the only ring hetero atoms DOAIExaminersPrimary: Barts, SamuelAssistant: Gale, Kellette Attorney, Agent or FirmUS Patent References4092344, Cyclohexenyl resorcinol derivativesIssued on: 05/30/1978 Inventor: Matsumoto4102902, Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor Issued on: 07/25/1978 Inventor: Archer , et al.4282248, Pinene derivatives and pharmaceutical compositions containing the same Issued on: 08/04/1981 Inventor: Mechoulam , et al.4707559, Analgetic and antiemetic compositions Issued on: 11/17/1987 Inventor: Mechoulam , et al.4758597, Carenadiol and derivatives Issued on: 07/19/1988 Inventor: Martin , et al.5434295, Neuroprotective pharmaceutical compositions of 4-phenylpinene derivatives and certain novel 4-phenylpinene compounds Issued on: 07/18/1995 Inventor: Mechoulam, et al.6274635, Alkylated resorcinol derivatives for the treatment of immune diseases Issued on: 08/14/2001 Inventor: Travis6563009, Vasodilator cannabinoid analogs Issued on: 05/13/2003 Inventor: Kunos, et al.6630507Cannabinoids as antioxidants and neuroprotectants Issued on: 10/07/2003 Inventor: Hampson , et al. Foreign Patent References
International ClassesA61K 31/33C07C 39/12 |