U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Farnesyl transferase inhibiting benzoheterocyclic derivatives

Patent 7153958 Issued on December 26, 2006. Estimated Expiration Date: Icon_subject November 15, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3682892

5116971

Inventors

Assignee

Application

No. 10432292 filed on 11/15/2001

US Classes:

540/484, The hetero ring contains seven members including nitrogen and carbon540/492, Plural nitrogens in the hetero ring540/567, Bicyclo ring system which contains the hetero ring as one of the cyclos540/611Benzene ring bonded directly to the hetero ring

Examiners

Primary: Wilson, James O.
Assistant: Ward, Paul V.

Foreign Patent References

  • 0317564 EP 07/01/1995
  • 1435981 GB 05/01/1976
  • WO 96/20184 WO 07/01/1996
  • WO 97/16443 WO 05/01/1997
  • WO 97/21701 WO 06/01/1997
  • WO 98/40383 WO 09/01/1998
  • WO 98/49157 WO 11/01/1998
  • WO 98/55124 WO 12/01/1998
  • WO 00/01386 WO 01/01/2000
  • WO 00/01411 WO 01/01/2000
  • WO 00/12498 WO 03/01/2000
  • WO 00/12499 WO 03/01/2000
  • WO 00/39082 WO 07/01/2000
  • WO 00/47574 WO 08/01/2000
  • WO 01/53289 WO 07/01/2001

International Classes

C07D 223/00
C07D 487/02

Abstract

This invention comprises the novel compounds of formula (I)

wherein r, s, t, X, Z, R1, R2, R3, R4, R5, R6 and R7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.

Other References

  • Kohl et al., “Selective Inhibition of ras-Dependent Transformation by a Farnesyltransferase Inhibitor,” Science, 1993, pp. 1934-1937, vol. 260, No. 5116.
  • Rak et al., “ Mutant ras Oncogenes Upregulate VEGF/VPF Expression: Implications for Induction and Inhibition of Tumor Angiogenesis,” Cancer Research, 1995, pp. 4575-4580, vol. 55, No. 20.
  • PCT International Search Report for PCT Appln. No. PCT/EP01/13317, mailed Feb. 5, 2002 which relates to this corresponding U.S. Application, filed herewith.
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