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US Patent 7132262 - Papilloma virus sequences

US Patent Issued on November 7, 2006
Estimated Patent Expiration Date: Icon_subject July 30, 2023Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The present invention relates to methods and compositions useful in the treatment and prevention of human papilloma virus infections and the symptoms and diseases associated therewith. More particularly, the invention relates to polynucleotide sequences which encode human papilloma virus (HPV) amino acid amino acid sequences, wherein the codon usage pattern of the polynucleotide sequences resemble those of highly expressed mammalian genes.

Other References

  • Osen et al , 2001, Vaccine , vol. 19, pp. 4276-4286.
  • Yaegashi et al, Journal of Virology, Apr. 1992, vol. 66, No. 4, pp. 2008-2019.
  • Zhou Jian, et al., “Papillomavirus Capsid Protein Expression Level Depends on the Match Between Condon Usage and tRNA Availability”, Journal of Virology, vol. 73 No. 6:4972-4982, (Jun. 6, 1999).
  • Dartmann, et al., “The Nucleotide Sequence and Genome Organization of Human Papilloma Virus Type 11”, Virology, vol. 151: 124-130 (1986).
  • Schwarz, et al., “DNA Sequence and Genome Organization of Genital Human Papillomavirus Type 6b”, Embo Journal, vol. 2, No. 12: 2341-2348, (1983).
  • Gouy, et al., “Condon Usage In Bacteria Correlation With Gene Expressively”, Nucleic Acids Research, vol. 10, No. 22: 7055-7074, (1982).
  • Hale, et al., “Condon Optimization of the Gene Encoding a Domain From Human Type 1 Neurofibromin Protein Results in a Threefold Improvement in Expression Level in Escherichia coli”, Protein Expression and Purification, vol. 12: 185-188, (Mar. 1998).
  • Han, et al., “Protection of Rabbits from Viral Challenge by Gene Gun-Based Intracutaneous Vaccination with a Combination of Cottontail Rabbit Papillomavirus E1, E2, E6 and E7 Genes,” Journal of Virology, vol. 73, No. 8: pp. 7039-7043, (1999).

Inventors

Assignee

Application

No. 10630880 filed on 07/30/2003

US Classes:

435/69.1, Recombinant DNA technique included in method of making a protein or polypeptide435/6, Involving nucleic acid424/199.1, Recombinant virus encoding one or more heterologous proteins or fragments thereof435/5, Involving virus or bacteriophage514/44Polynucleotide (e.g., RNA, DNA, etc.)

Field of Search

435/6, Involving nucleic acid435/69.1, Recombinant DNA technique included in method of making a protein or polypeptide435/91.1Polynucleotide (e.g., nucleic acid, oligonucleotide, etc.)

Examiners

Primary: Salimi, Ali R.

Attorney, Agent or Firm

US Patent References

5786464, Overexpression of mammalian and viral proteins
Issued on: 07/28/1998
Inventor: Seed6114148High level expression of proteins
Issued on: 09/05/2000
Inventor: Seed, et al.

Foreign Patent References

  • 0523395 EP 01/01/1993
  • WO92/11290 WO 07/01/1992
  • WO 99/57283 WO 11/01/1993
  • WO 97/05164 WO 02/01/1997
  • WO 97/031115 WO 08/01/1997
  • WO 97/034640 WO 09/01/1997
  • WO 97/048370 WO 12/01/1997
  • WO01/14416 WO 03/01/2001
  • WO 01/14416 WO 03/01/2001

International Class

C12P 21/06

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