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T cell epitope peptide

Patent 7112329 Issued on September 26, 2006. Estimated Expiration Date: Icon_subject June 12, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventors

Assignee

Application

No. 09202464 filed on 06/12/1997

US Classes:

424/185.1, Amino acid sequence disclosed in whole or in part; or conjugate, complex, or fusion protein or fusion polypeptide including the same424/275.1, Allergen or component thereof (e.g., ragweed pollen, etc.)530/32615 to 23 amino acid residues in defined sequence

Examiners

Primary: Chan, Christina
Assistant: Huynh, Phuong

Attorney, Agent or Firm

Foreign Patent References

  • 0 655 500 EP 05/01/1995
  • 0 714 662 EP 06/01/1996
  • 0 923 940 EP 06/01/1999
  • 06-508994 JP 10/01/1994
  • 07-503362 JP 04/01/1995
  • A HEI 8-47392 JP 02/01/1996
  • 8-502163 JP 03/01/1996
  • 08-127591 JP 05/01/1996
  • 8-176192 JP 07/01/1996
  • 08-333391 JP 12/01/1997
  • 2005-15427 JP 05/01/2005
  • WO 93/01213 WO 01/01/1993
  • WO 93/28280 WO 04/01/1993
  • WO 93/19178 WO 09/01/1993
  • WO 94/01560 WO 01/01/1994
  • WO 94/11512 WO 05/01/1994
  • WO 95/27786 WO 10/01/1995
  • WO 94/505284 WO 06/01/1996
  • WO97/32600 WO 12/01/1997

International Class

A61K 39/00

Abstract

The T-cell epitope site on a Japanese cypress (hinoki) pollen allergen molecule has been identified by stimulating a T-cell line established from a patient suffering from Japanese cypress pollen allergy with an overlap peptide covering the primary structure of the Japanese cypress pollen allergen. The peptide is useful in peptide-based immunotherapy for patients with spring tree pollinosis including patients with Japanese cypress pollinosis having cross reactivity with Japanese cypress pollen. The peptide is also useful for diagnosing spring tree pollinosis.

Other References

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  • Matsushita et al., “Allele Specificity of Structural Requirement for Peptides . . . Syndrome,” J. Exp. Med. 180:873-883, 1994.
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  • Ngo et al, 1994, The Protein Folding Problem and Tertiary Struction Prediction, pp. 492-495.
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  • Webster's II New Riverside University Dictionary, p. 933, 1984.
  • Ngo et al, 1994, The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495
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