Patent 7112329 Issued on September 26, 2006. Estimated Expiration Date: June 12, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
424/185.1, Amino acid sequence disclosed in whole or in part; or conjugate, complex, or fusion protein or fusion polypeptide including the same424/275.1, Allergen or component thereof (e.g., ragweed pollen, etc.)530/32615 to 23 amino acid residues in defined sequence
The T-cell epitope site on a Japanese cypress (hinoki) pollen allergen molecule has been identified by stimulating a T-cell line established from a patient suffering from Japanese cypress pollen allergy with an overlap peptide covering the primary structure of the Japanese cypress pollen allergen. The peptide is useful in peptide-based immunotherapy for patients with spring tree pollinosis including patients with Japanese cypress pollinosis having cross reactivity with Japanese cypress pollen. The peptide is also useful for diagnosing spring tree pollinosis.
Berzofsky et al, in Fundamental Immunology 2nd edition, Raven Press, 1989.
Hoyne et al, Immunology and Cell Biology 74: 180-186, 1996.
Fasler et al., J. Allergy and Clinical Immunology 101(4 pt 1): 521-30, Apr. 1998.
Burks et al. Eur J Biochem 245: 334-339; 1997.
Stanley et al, Archives of Biochemistry and Biophysics 342(2): 244-253; Jun. 1997.
Ngo et al., 1994, The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495.
Ikagawa et al. Single amino acid substitutions on a Janpanese cedar pollen allergen (Cry j 1) derived peoptide induced aleterations in human T cell responses and T cell receptor antagonism, Jan. 1996, J Allergy Clin Immunol 97(1 pt 1): 53-64.
Ide et al., Allergy no Rinshou 11(3):174-178, 1991.
Taniai et al., “Epitopes on Cry j I and Cry j II for the Human IgE Antibodies Cross-Reactive . . . Pollen,” Molecular Immunology 30(2):183-189, 1993.
Okano et al., Allergy 43(9):1179-1184, 1994.
Saito et al., Chiryo 78(2): 1571-1576, 1996.
Swoboda et al., “Isoforms of Bet v 1, the Major Birch Pollen Allergen, Analyzed by Liquid Chromatography, Mass Spectrometry, and cDNA Cloning,” The Journal of Biological Chemistry 270(6):2607-2613, 1995.