Haptens, immunogens and antibodies to oxycodone and its metabolites

Patent 7026134 Issued on April 11, 2006. Estimated Expiration Date:

December 20, 2022. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies Patent #: 4939264
Issued on: 07/03/1990
Inventor: Heiman, et al.

Inventors

Assignee

Randox Laboratories Ltd.

Application

No. 10323850 filed on 12/20/2002

US Classes:

435/7.93, Competitive assay530/388.9, Binds drug, hapten, hapten--carrier complex, or specifically-identified chemical structure (e.g., theophylline, digoxin, etc.)530/389.8, Binds drug, hapten, hapten-carrier complex, or specifically-identified chemical structure (e.g., theophylline, digoxin, etc.)530/404, Sulfur containing reactant530/405, Nitrogen containing reactant546/43Two of the cyclos share at least three ring members (i.e., bridged)

Examiners

Primary: Ceperley, Mary E.

Attorney, Agent or Firm

Oliff & Berridge, PLC

Foreign Patent References

WO 93/20079 WO 10/01/1993

International Classes

G01N 33/535
C07K 16/44
C12P 21/08
C07D 471/08

Abstract

Novel haptens, which can be conjugated to form immunogens, are of formula I, II or III

wherein R is a divalent alkyl, cycloalkyl or aryl group having 1 to 10 carbon atoms, and X is a functional group.

Other References

M. Smith et al, J. Analytical Toxicology (2000), 24(7), 522-529.
R. Fogerson et al, J. Analytical Toxicology (1997), 21(6), 451-458.
K. Aoki et al, Forensic Science International (1996), 81(2,3), 125-132.
Findlay, John W.A. et al.; “Relationships between Immunogen Structure and Antisera Specificity in the Narcotic Alkaloid Series” Clinical Chemistry vol. 27, No. 9 1981; pp. 1524-1535.
Klein, Peter et al.; “O³-(2-Carbomethoxyallyl) Ethers of Opioid Ligands Derived from Oxymorphone, Naltrexone, Etorphine, Diphrenorphine, Norbinaltorphimine, and Naltrindole. Unexpected O³Dealkylation in the Opioid Radioligand Displacement Assay” Journal of Medicinal Chemistry vol. 35, No. 24 1992; pp. 4589-4594.
Lester, M. G. et al.; “Vilsmeier Reactions with Cyclic Ketals of 14-Hydroxydihydrocodeinone and some New Cyclic Derivatives of 14-Hydroxydihydrocodeinone” Elsevier Science Publishers, Amsterdam vol. 21, No. 4 1965; pp. 771-778.