U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Combination of loteprednol and antihistamines

Patent 7022687 Issued on April 4, 2006. Estimated Expiration Date: Icon_subject September 26, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Soft steroids having anti-inflammatory activity
Patent #: 4710495
Issued on: 12/01/1987
Inventor: Bodor

Soft steroids having anti-inflammatory activity Patent #: 4996335
Issued on: 02/26/1991
Inventor: Bodor

Inventors

Assignee

Application

No. 10089436 filed on 09/26/2000

US Classes:

514/179, Modified C-ring (except methyl in 13-position) (e.g., double bond containing, substituted, etc.)514/217.05, Plural ring hetero atoms in the additional hetero ring514/330C=X bonded directly to the piperidine ring (X is chalcogen)

Examiners

Primary: Cook, Rebecca

Attorney, Agent or Firm

Foreign Patent References

  • 0 709 099 EP 05/01/1996
  • WO 97/01337 WO 01/01/1997

International Classes

A61K 31/56
A61K 31/55
A61K 31/47

Abstract

The present invention relates to a novel combination of a soft steroid, in particular loteprednol, and at least one antihistamine, such as, for example, azelastine and/or levocabastine, for simultaneous, sequential or separate administration in the local treatment of allergies and airway disorders, for example of allergic rhinitis (rhinoconjunctivitis).

Other References

  • Friedlaender, Current Opinion in Ophthalmology 1998, 9/4 54-58.
  • Isaac, Lancet, Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema, vol. 351, pp. 1225-1332, Aug. 25, 1998.
  • I. Annesi-Maesano et al., Revue Francaise d'Allergologie, “La rhinite de l'adolescent Resultats de l'enquete ISAAG” vol. 38, pp. 283-289, 1998.
  • Medline, E. Norman et al., European Journal of Allergy, “Prevalence and incidence of asthma and rhinoconjunctivitis in Swedish teenagers,” vol. 53, pp. 28-35, 1998, abstract.
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