U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Tolterodine salts

Patent 7005449 Issued on February 28, 2006. Estimated Expiration Date: Icon_subject April 23, 2022. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

5382600

3,3-diphenylpropylamines, their use and preparation
Patent #: 5559269
Issued on: 09/24/1996
Inventor: Johansson, et al.

Process to prepare tolterodine Patent #: 5922914
Issued on: 07/13/1999
Inventor: Gage, et al.

Inventors

Assignee

Application

No. 10127875 filed on 04/23/2002

US Classes:

514/555, Benzene ring in acid moiety562/490, Naphthyl group564/395, Preparing directly by amination564/413Preparing directly from hetero ring containing compound

Examiners

Primary: Taang, Cecilia J.
Assistant: Oh, Taylor V.

Attorney, Agent or Firm

Foreign Patent References

  • WO9829402 WO 07/01/1998
  • WO0234245 WO 05/01/2002

International Classes

A61K 31/205
C07C 215/56
C07C 209/00

Abstract

The present invention concerns novel pharmaceutically active compounds, pharmaceutical compositions containing the same, the compounds for use as medicaments, and use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the compounds.Specifically, the compounds are pharmaceutically acceptable salts of tolterodine or hydroxytolterodine, wherein the salt is of an acid selected from the group consisting of aliphatic mono- and dicarboxylic acids comprising from 7 to 24 carbon atoms, alkanedisulfonic acids comprising from 2 to 4 carbon atoms, naphthoic acid derivatives comprising from 11 to 27 carbon atoms, maleic acid and fumaric acid.

Other References

  • Postlind et al, Drug Metabolism and Disposition, 26(4):289-293.
  • Mooney et al, Journal of Pharmaceutical Sciences, 70(1):13-22 (1981).
  • Nilvebrant et al, Pharmacology & Toxicology, 81:169-172 (1997).
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