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US Patent 6987093 - Single dose azithromycin

US Patent Issued on January 17, 2006
Estimated Patent Expiration Date: Icon_subject July 25, 2023Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The present invention relates to a method of treating a bacterial respiratory or acute otitis media infections in humans by administering a single dose of azithromycin wherein the dose is about 40 mg/kg body weight or greater.

Other References

  • Block et al., “Single Dose Azithromycin (30 mg/kg) in Acute Otitis Media”, 38th annual meeting of the Infectious Disease Society of america, New Orleans, La., Sep. 7-10, 2000.
  • P/S/L Consulting Group, Inc., “Single-Dose Zithromax (azithromycin) as effective as 10 days of Augmentin (Amozcillin/Clavulenate) for Otitis Media”, Doctor's, Guide; Sep. 14, 2000.
  • Law et al., “Single-Dose Azithromycin for Respiratory Tract Infections”, The Annals of Pharmacotherapy, vol. 38, pp 433-439, Mar. 2004.
  • Arguedas, A., Single-Dose Therapy in Otitis Media, Poster Presentation at 9th European Congress of Clinical Microbiology and Infectious Diseases, Berlin, Germany, Mar. 21-24, 1999, Clin. Microbiol. Infect. 1999:5 (Supp. Mar. 3):28 (Abstr).
  • S. Block et al., Single-Dose Azithromycin (30 mg/kg) in Acute Otitis Media, 38th Annual Meeting of the Infectious Disease Society of America, New Orleans, LA, Sep. 7-10, 2000 (Abstract 174).
  • P/S/L Consulting Group Inc., Single-Dose Zithromax (Azithromycin) as Effective as 10 Days of Augmentin (Amoxcillin/Clavulenate) for Otitis Media, Doctor's Guide; Sep. 14, 2000.
  • FDA Briefing Package: Zithromax® (Azithromycin) Oral Suspension Single-Dose and Three Day Treatment of Acute Otitis Media, Anti-Infective Drugs Advisory Committee, Nov. 7, 2001.
  • Schonwald, S., et al., Infection, Germany, vol. 27, No. 3, May 1999, pp. 198-202 XP008018295.
  • Amsden, G.W., et al., The J. of Antimicrobial Chemotherapy, 47(1), pp. 61-66 (2001) XP001159703.
  • Mulier O., The J. of Antimicrobial Chemotherapy, England, Jun. 1993, vol. 31, suppl. E, Jun. 1993, pp. 137-146 XP008018300.
  • Nightingale C.H., et al., J. of Infectious Disease Pharmacotherapy 1999, vol. 4, No. 1, pp. 17-24 XP008018297.
  • Aoki N., Japanese Journal of Chemotherapy 1995, Japan, vol. 43, No. Suppl 6, pp. 234-238 XP008018296.
  • Morris, D.L., et al., vol. 10, No. 10., Oct. 1991, pp. 859-861, European J. of Clinical Microbiology & Infectious Disease: Official Publication of the European Society of Clinical Microbiology, Germany XP008018299.
  • Klepser, M., et al., International J. of Antimicrobial Agents, vol. 17, No. Supp 1, Jun. 2001, p. S157, 22nd International Congress of Chemotherapy; Amsterdam, Jun. 30-Jul. 3, 2001 XP002244592.
  • Bergogne-Berezin Eugenie, Pathologie Biologie, vol. 43, No. 6, 1995, pp. 498-504, “Azithromycin: Tissue pharmacokinetic data” XP008018308.

Inventor

Assignee

Application

No. 10628102 filed on 07/25/2003

US Classes:

514/29The hetero ring has exactly 13 ring carbons (e.g., erythromycin, etc.)

Field of Search

514/29The hetero ring has exactly 13 ring carbons (e.g., erythromycin, etc.)

Examiners

Primary: Wilson, James O.
Assistant: McIntosh, III, Traviss C.

Attorney, Agent or Firm

US Patent References

4328334, 11-Aza-10-deoxo-10-dihydroerythromycin A and derivatives thereof as well as a process for their preparation
Issued on: 05/04/1982
Inventor: Kobrehel ,   et al.4474768, N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
Issued on: 10/02/1984
Inventor: Bright4517359, 11-Methyl-11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl-7,1 3,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one and derivatives thereof
Issued on: 05/14/1985
Inventor: Kobrehel ,   et al.4963531, Azithromycin and derivatives as antiprotozoal agents
Issued on: 10/16/1990
Inventor: Remington5498699, Complexes and chelates of azithromycin with bivalent and/or trivalent metals and their use as antiulcer
Issued on: 03/12/1996
Inventor: Djokic, et al.5605889, Method of administering azithromycin
Issued on: 02/25/1997
Inventor: Curatolo, et al.5633006, Taste-masking composition of bitter pharmaceutical agents
Issued on: 05/27/1997
Inventor: Catania, et al.5686587, Intermediate for azithromycin
Issued on: 11/11/1997
Inventor: Yang6068859, Controlled-release dosage forms of Azithromycin
Issued on: 05/30/2000
Inventor: Curatolo, et al.6110965Ketolides from the class of 15-membered lactams
Issued on: 08/29/2000
Inventor: Lazarevski, et al.

International Classes

A01N 43/04
A61K 31/70

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