U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Oral pharmaceutical products containing 17 β-estradiol-3-lower alkanoate, method of administering the same and process of preparation

Patent 6962908 Issued on November 8, 2005. Estimated Expiration Date: Icon_subject December 21, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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3478070

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Issued on: 10/01/1985
Inventor: Pasquale

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Patent #: 5382434
Issued on: 01/17/1995
Inventor: de Haan, et al.

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Patent #: 5824667
Issued on: 10/20/1998
Inventor: Spona, et al.

Intravaginal drug delivery devices for the administration of 17ଲ-oestradiol precursors
Patent #: 5855906
Issued on: 01/05/1999
Inventor: McClay

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Patent #: 5928668
Issued on: 07/27/1999
Inventor: Greaves, et al.

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Patent #: 5976570
Issued on: 11/02/1999
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Contraceptive method employing buccal delivery of steroidal active agents
Patent #: 6200593
Issued on: 03/13/2001
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Inventors

Assignee

Application

No. 10023748 filed on 12/21/2001

US Classes:

514/170, Plural Compounds containing cyclopentanohydrophenanthrene ring systems514/178, Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system424/409, Solid as carrier or diluent552/625, The A ring is a benzene ring (e.g., estrones, estradiols, etc.)424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/433, Depot, pellet, matrix, or suppository424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/470, Where particles are granulated424/435Mouth

Examiners

Primary: Hui, San-Ming

Attorney, Agent or Firm

International Classes

A61K031/56
A01N025/08

Abstract

A pharmaceutical dosage unit for oral administration to a human female comprising a therapeutically effective amount of 17β-estradiol-3-lower alkanoate, most preferably 17β-estradiol-3-acetate, and a pharmaceutically acceptable carrier is disclosed. Also disclosed is a method for treating a human female in need of 17β-estradiol and a contraceptive method by oral administration of the pharmaceutical dosage unit and a method of preparing a pharmaceutical composition that may be used to form the pharmaceutical dosage unit of the invention.

Other References

  • Mar., Advanced Organic Chemistry, 3rd et al., 1985, pp. 334-338.
  • Remington: The Science and Pratice of Pharmacy, 19th ed., 1995, pp. 1413, 1623-1626.
  • Wolfe et al., Journal of Lipid Research, 2000;41:368-375.
  • Lieveritz, R.W., Amer. J. of Obstetrics and Gynecology, vol. 156, pp 1289-1293, 1987.
  • Stumpf, P.G., Obstetrics and Gynecology, vol. 75 (suppl) pp 9S-17S, 1990.
  • Marsh, M.S., et al., British Medical Bulletin, vol. 48, pp. 426-457, 1992.
  • Lobo, R.A., et al., J. of Reproductive Medicine, vol. 37, pp. 77-84, 1992.
  • Woolfson, D., et al., J. of Controlled Release, vol. 61, pp. 319-328, 1999.
  • Kuhl, H., Maturitas, vol. 12, pp. 171-197, 1990.
  • Powers, M., et al., Amer. J. of Obstetrics and Gynecology, vol. 152, pp. 1099-1106, 1985.
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