Invasive microwave antenna array for hyperthermia and brachytherapy
Patent 6957108 Issued on October 18, 2005. Estimated Expiration Date: June 2, 2023. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
607/101, Microwave or RF (high frequency)600/2, Combined with other radiant or wave energy source (e.g., electromagnetic, thermal, microwave etc.)607/102With temperature sensing
A microwave hyperthermia apparatus that can be inserted into the body which includes a hollow central tube for the insertion of radioactive therapy sources. The use of a coaxial transmission line impedance transformation along the insertable portion of the coaxial cable enables a reduction in the characteristic impedance by increasing the outer diameter of the inner coaxial conductor so that the center conductor can be a metal tube. If the ratio of the outer coaxial conductor diameter vs. the inner coaxial conductor is decreased, the characteristic impedance of the transmission line is lowered. This enables the inner conductor diameter to increase sufficiently to make the central hollow opening large enough to receive standard radioactive sources therein. This provides for a good impedance match that improves microwave energy efficiency while at the same time permitting a large hollow center opening. The combination of the microwave antenna device and brachytherapy sources provides for enhanced effectiveness when the two treatments are delivered simultaneously or in close time proximity to each other.
Other References
Overgaard, Simultaneous and Sequential Hyperthermia and Radiation Treatment of an Experimental Tumor and Its Surrounding Normal Tissue in Vivo, 1980, Int.J. Radiation.Onc. Biol. Phys. vol. 6, pp. 1507-1517.
Overgaard, The Future of Hyperthermic Oncology, Proceedings of the 6th International Congress on Hyperthermia Oncology, vol. 2, 1992, pp. 87-92.
Stone and Dewey, Biologic Basis and Clinical Potential of Local-Regional Hyperthermia, Radiation Oncology, vol. 2 Editor Phillips and Wara, 1987 Raven Press, NY., pp. 1-33.
Steeves et al., Thermoradiotherapy of Intraocular Tumors in an Animal Model: Concurrent vs. Sequential Brachytherapy and Ferromagnetic Hyperthermia, 1995, Int. J. of Radiation Oncology, Biology, Physics, vol. 33 (3), pp. 659-662.
Turner, Interstitial Equal-Phase Arrays for EM Hyperthermia, IEEE Trans. MTT-34(5),May 1986,572-578.
Meyerson et al. Simultaneous superficial hyperthermia and external radiotherapy: Report of thermal dosimetry and tolerance to treatment, Int. J. of Hyperthermia 1999; 15(4):251-266.
Goss et al., Abstract, An Examination of Simultaneous Multi-Frequency Planar Array Ultrasound Applicators for Hyperthermia, Proc., 15th Annual Meeting of the North American Hyperthermia Society, Apr. 16, 1995, p. 107.
Hand, Microwave Techniques for Interstitial Hyperthermia, Interstitial and Intracavitary Thermoradiotherapy, Chapter 6, Springer—Verlag, 1993, NY,pp. 43-48.
Diederich et al., Combination of transurethral and interstitial ultrasound applicators for high-temperature prostate thermal therapy, Int. J. of Hyperthermia, 2000, 16(5),385-403.
Leybovich et al., A modified technique for RF-LCF interstitital hyperthermia, Int. J. of Hyperthermia, 2000,16(5),405-413.
Kim et al., Effect of simultaneous pulsed hyperthermia and pulsed radiation treatment on survival of SiHa cells, Int. J. of Hyperthermia, 1998, 14(6),573-581.
Diederich et al. Direct-coupled interstitial ultrasound applicators for simultaneous thermobrachytherapy: a feasibility study, Int. J. of Hyperthermia 12(3):401-419, 1996.
Straube et al., Dosimetry and techniques for simultaneous hyperthermia and external beam radiation therapy, Int. J. of Hyperthermia, 2001, 17(1),48-62.
Seegenschmiedt et al., Iridium-192 brachytherapy plus interstitial microwave hyperthermia in the treatment of head & neck tumours, 1993, SELECTRON Brachytherapy Journal,7(1),21-33.
Mechling et al., A theoretical comparison of the temperature distributions produced by three interstitial hyperthermia systems, Int. J. Radiation Oncology Biology Physics 1986, vol. 12 2137-2149.
Kapp et al., Interstitial hyperthermia and high dose rate brachytherapy in the treatment of anal cancer: a phase I/II study, Int. J. of Radiation Oncology, Biology, Physics, 1994, vol. 28, 189-199.
Petrovich et al., Interstitial microwave hyperthermia combined with iridium-192 radiotherapy for recurrent tumors, Am. J. Clinical Oncology (CCT), 1989,12(3),264-268.
Linares et al., Interstitial Hyperthermia and brachytherapy: A Preliminary Report, Endocurie, Hypertherm, Oncology Journal 1986, vol. 2,pp.S39-S44.
Kaatee et al., A 27 MHz current source interstitial hyperthermia system for small animals, Int. J. of Hyperthermia, 1995,11(6),785-796.
Corry et al., Hyperthermia with chronically implanted electrodes for tumors in the thorax, abdomen and pelvis, Proceedings of the 5th International Symposium on Hyperthermia Oncology, 1988, vol. 2, 658-661.
Corry et al., Thermobrachytherapy: Requirements for the Future, Interstitial and Intracavitary Thermoradiotherapy, Chapter 41, Springer—Verlag, 1993, NY,pp. 373-379.
Kasai et al., Improved reliability of repetitive RF interstitial heating in combination with brachytherapy: the effective use of water, Int. J. of Hyperthermia, 2001, 17(2),160-171.
Goldson et al., Simultaneous Intraoperative Radiation Therapy and Intraoperative Interstitital Hyperthermia for Unresectable Adenocarcinoma of the Pancreas, Endocurie, Hypertherm, Oncology Journal,ISSN 8756-1687, Oct. 1987,pp. 201-207.
Sneed, et al., Survival Benefit of Hyperthermia in a Prospective Randomized Trial of Brachytherapy Boost ± Hyperthermia for Glioblastoma Multiforme, 1998, Int. J. of Radiation Oncology, Biology, Physics, vol. 40 (2), pp. 287-295.
Cumberlin et al., New Directions In Brachytherapy, 2002, Int. J. of Radiation Oncology, Biology, Physics, vol. 53, No. 1, pp. 6-11.
June 2, 2023. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
