Survivin, a protein that inhibits cellular apoptosis and its modulation
Patent 6943150 Issued on September 13, 2005. Estimated Expiration Date: October 18, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
514/21, Produced by or extracted from animal tissue514/12, 25 or more peptide repeating units in known peptide chain structure514/13, 16 to 24 peptide repeating units in known peptide chain514/14, 12 to 15 peptide repeating units in known peptide chain514/15, 9 to 11 peptide repeating units in known peptide chain530/324, 25 or more amino acid residues in defined sequence530/326, 15 to 23 amino acid residues in defined sequence530/327, 11 to 14 amino acid residues in defined sequence530/328, 8 to 10 amino acid residues in defined sequence435/455Introduction of a polynucleotide molecule into or rearrangement of nucleic acid within an animal cell
The present invention provides the amino acid of a protein that inhibits cellular apoptosis, herein termed the Survivin protein and nucleic acid molecules that encode Survivin. Based on this disclosure, the present invention provides isolated Survivin protein, isolated Survivin encoding nucleic acid molecules, methods of isolating other members of the Survivin family of proteins, methods for identifying agents that block Survivin mediated inhibition of cellular apoptosis, methods of using agents that block Survivin mediated inhibition or Survivin expression to modulate biological and pathological processes, and methods of assaying Survivin activity.
The abstract of Ghosh et al (Accession No. 2003: 837371 Caplus on STN), 2003.
The abstract of Dumas et al (Accession No. AAG02311, Dgene on STN), 2003.
Mathews and Van Holde, Biochemistry, 1996, pp. 165-171.
Matthews, B. Genetic and Structural Analysis of the Protein Stability Problem, In: Perspectives in Biochemistry, 1989, vol. 1, p 6-9, Ed. Hans Neurath.
Bork, Genome Research, 1998, vol. 10, pp. 398-400.
The abstract of Aziz et al (Accession No. 2002:833060, Caplus on STN), 2002.
Skipper et al, Journal of Experimental Medicine, 1996, vol. 183, pp. 527-534.
Hiraki et al, Clinical Cancer Research, 1999, vol. 5, pp. 933-936.
Welt and Ritter, Seminars in Oncology, 1999, vol. 26, pp. 683-690.
Becker et al, International Immunology, 1993, vol. 5, pp. 1501-1508.
Paul et al, PNAS, 1998, vol. 14, pp. 401-405.
Ada, Immunology and Cell biology, 1999, vol. 77, pp. 180-185.
Altieri Dario C., Xa receptor EPR-1, FASEB J(1995) 9:860-865.
Ambrosini G. et al., “Molecular Dissection of Effector Cell Protease Receptor-1 Recognition of Factor Xa”, the Journal of Biological Chemistry, vol. 271, No. 2, Jan. 12, 1996, p. 1243-1248.
Ambrosini et al., “A Novel Anti-Apoptosis Gene, Survivin, Expressed in Cancer and Lymphoma”, Nature Medicine, vol. 3, No. 8, pp. 917-921 (Aug. 1997).
Birnbaum, M.J. et al., An Apoptosis-inhibiting Gene from a Nuclear Polyhedrosis Virus Encoding a Polypeptide with CYS/HIS Sequence Motifs—J Virology (1994) 68:2521-2528.
Clem et al., “Anti-apoptotic Genes of Baculovirus”, Death and Differentiation, vol. 3, pp. 9-16 (Jan. 1996).
Clem, R.J. et al., Control of Programmed Cell Death by the Baculovirus Gene p35 and iap—Mol Cell Biol (1994) 14:5212-5222.
Duchosal, M.A. et al., “In vivo Immunosuppresion by Targeting a Novel POrotease Receptor”, Letters to Nature, vol. 380, Mar. 28, 1996, pp. 352-356.
Duckett, C.S. et Al., A Conserved Family of Cellular Genes Related to the Baculovirus Iap Gene and Encoding Apoptosis Inhibitors—EMBO J (1996) 15:2685-2694.
Hay, B.A. et al., Drosophila Homologs of Baculovirus Inhibitor of Apoptosis Proteins Function to Block Cell Death—Cell(1995) 83:1253-1262.
International Search Report.
Liston, P. et al., Suppression of Apoptosis in Mammalian Cells by Naip and a Related Family of Iap Genes—Nature (1996) 379:349-353.
Rothe, M. et al., The TNFR2-TRAF Signaling Complex Contains Two Novel Proteins Related to Baculoviral Inhibitor of Apoptosis Proteins, Cell(1995) 83:1243-1252.
Roy, N. et al., the Gene for Neuronal Apoptosis Inhibitory Protein Is Partially Deleted in Individuals with Spinal Muscular Atrophy, Cell(1995) 80:167-178.