U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Liquid dispensing apparatus and method

Patent 6943035 Issued on September 13, 2005. Estimated Expiration Date: Icon_subject May 19, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Multi-well bioassay tray with evaporation protection and method of use
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Test sample card with polymethylpentene tape
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Apparatus for accessing a sealed container
Patent #: 5935523
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Universal washing apparatus for microtiter plate and the like
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Multi-well plate
Patent #: 5972694
Issued on: 10/26/1999
Inventor: Mathus

Self-resealing, puncturable container cap
Patent #: 6030582
Issued on: 02/29/2000
Inventor: Levy

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Inventors

Assignee

Application

No. 09573998 filed on 05/19/2000

US Classes:

436/180, Volumetric liquid transfer436/174, INCLUDING SAMPLE PREPARATION436/177, Liberation or purification of sample or separation of material from a sample (e.g., filtering, centrifuging, etc.)436/179, Dilution422/99, Miscellaneous laboratory apparatus and elements, per se422/100, Pipette or other volumetric fluid transfer means422/102, Container210/131, By movement of separation medium73/864.21, With sample supply to analyzer436/530, Cellulose or derivative436/178, Including use of a solid sorbent, semipermeable membrane, or liquid extraction436/48, With step of insertion or removal from test line436/18, Preservative, buffer, anticoagulant or diluent134/21, Including use of vacuum, suction, or inert atmosphere435/288.4, Including multiple compartments (e.g., wells, etc.)422/65, Means is conveyor and rack422/130Bench scale

Examiners

Primary: Warden, Jill
Assistant: Handy, Dwayne K

Attorney, Agent or Firm

Foreign Patent References

  • 98/36260 WO 08/01/1998
  • 00/01798 WO 01/01/2000

International Class

G01N001/10

Abstract

A multiwell plate for microarraying comprising a self-sealing lower membrane and optionally also a self-sealing upper membrane. Spotting is performed by pushing a pin down through the liquid and then on to pierce the self-sealing lower membrane. A slide having an upper spotting surface is arranged under the well plate. The liquid sample forced through the lower membrane by the pin tip can thus be deposited directly onto the spotting surface. The pin is then withdrawn upwards through the lower membrane, which automatically reseals preventing further loss of liquid. The optional resealable upper membrane also prevents loss of sample liquid by evaporation and spillage. By contrast to the prior art, there is the major advantage that the pin head does not have to traverse between the well plate and slide to collect sample liquid, thus dramatically increasing operational speed for an automated microarraying apparatus employing the multiwell plate. Excellent spot reproducibility is also observed.

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