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US Patent 6899099 - Method for treating a respiratory disease

US Patent Issued on May 31, 2005
Estimated Patent Expiration Date: Icon_subject April 7, 2023Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The invention provides a novel method of treating respiratory diseases, e.g., pediatric asthma, in a continuing regimen with not more than one daily dose of the drug budesonide using a nebulizer.

Other References

  • International Patient Package Leaflet for Pulmicort® suspension for nebulisation 0.125 mg/ml, 0.25 mg/ml and 0.5 mg/ml, ASTRA, approved by Thor-Bjorn Conradson, Aug. 18, 1994 version, pp. 1-8.
  • Dunn et al., “Inhaled Corticosteroids in Severe Bronchopulmonary Dysplasia (BDP),” No. 1263, Pediatric Research 25 (4 Part 2):213A, 1989.
  • Dunn et al., “Nebulized Steroids for Bronchopulmonary Dysplasia (BDP)-A Randomised, Double-Blind Cross-Over Study,” Pediatr. Res. 31 (4 pt 2):201A, 1992.
  • Georgitis, “A Study of Once-A -Day Budesonide Nebulizing Suspension (BNS) and Placebo (PBO) in Asthmatic Children Aged Six Months to Eight Years,” Chest 112(3):375, Sep. 1997 Supplement.
  • Goodwin, “An uncontrolled assessment of nebulised budesonide in the treatment of acute infantile bronchiolitis,” British Journal of Clinical Research 6:113-119, 1995.
  • Husby et al., “Treatment of croup with nebulised steroid (budesonide): a double blind, placebo controlled study,” Archives of Disease in Childhood 68:352-355, 1993.
  • Jonasson et al., #P1441 “Clinical efficacy of a low dose inhaled budesonide in children with mild asthma previously not treated with steroids,” The European Respiratory Journal 10(25):221s-222s, 1997.
  • McCarty, “of ‘Nebuhaler’ and face-mask in young asthmatic children,” The Lancet 335:983-984, 1990.
  • McCarthy, “The use of a once daily inhaled glucocorticosteroid (budesonide) in the management of childhood asthma,” British Jounal of Clinical Research 4:55-61, 1993.
  • Möller et al., #0778 “Administration of Budesonide via Turbuhaler® . . . in Children with Asthma,” Eur.Respir.J. 9(23):115s, 1996.
  • Morice et al., “A comparison of nebulized budesonide with oral prednisolone in the treatment of exacerbations of obstructive pulmonary disease,” Clinical Pharmacology & Therapeutics 60:675-678, 1996.
  • Pearlman, P42 “HPA-Axis function in Asthmatic Infants & Young Children Treated with Budesonide Nebulizing Suspension (BNS) or Placebo (PBO) Once-A-Day (QD),” Annual Meeting ACAAI, San Diego, CA (USA) Nov. 7-12, 1997.
  • Reijonen et al., “Anti-inflammatory Therapy Reduces Wheezing After Branchiolitis,” Arch Pediatr. Adolesc. Med. 150:512-517, 1996.
  • Takao et al., “Effects of Inhaled Nebulized Steroids (Budesonide) on Acute and Chronic Lung Function in Heart-Lung Transplant Patients,” Transplantation Proceedings 27:1284-1285, 1995.
  • Weiner et al., “Long term clinical comparison of single versus twice daily administration of inhaled budesonide in moderate asthma,” Thorax 50:1270-1273, 1995.
  • de Blic et al., “Efficacy of neubulized budesonide in treatment of severe infantile asthma: A double-blind study”, J. Allergy Clin. Immunol. 98:14-20, 1996.
  • Godrey et al., “Nebulised Budesonide in Severe Infantile Asthma”, The Lancet, II:851-852, 1987.
  • Grimfeld, “Long-term Study of Nebulised Budesonide in Young Children With Moderate to Severe Asthma”, Eur. Resp. J., 7:27s, 1994.
  • Ijangovan et al., “Treatment of severe steroid dependent preschool asthma with nebulised budesonide suspension”, Archives of Disease in Childhood, 68:356-359, 1993.
  • Vikre-Jorgensen et al., “Dose Titration of Nebulized Budesonide in Young Children”, Pediatric Pulmonology, 23:270-277, 1997.
  • Pedersen et al., “Budesonide suspension for nebulisation in children with asthma”, Eur. Respir. J., 2(Suppl. 8):647S, 1989.
  • Volovitz et al., “Rapid induction of clinical response with a short-term high-dose starting schedule of budesonide nebulizing suspension in young children with recurrent wheezing episodes”, J. Allergy Clin. Immunol. 101:464-469, 1998.
  • Wennergren et al., “Nebulized budesonide for the treatment of moderate to severe asthma in infants and toddlers”, Acta Paediatr, 85:183-189, 1996.

Inventors

Assignee

Application

No. 10409398 filed on 04/07/2003

US Classes:

128/200.14, LIQUID MEDICAMENT ATOMIZER OR SPRAYER128/203.12Means for mixing treating agent with respiratory gas

Field of Search

128/200.14, LIQUID MEDICAMENT ATOMIZER OR SPRAYER128/200.23, Pre-pressurized container holding medicament128/203.12, Means for mixing treating agent with respiratory gas128/203.15Particulate treating agent carried by breathed gas

Examiners

Primary: Lewis, Aaron J.

Attorney, Agent or Firm

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International Class

A61M011/00

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