U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Multi-stream microfludic mixers

Patent 6890093 Issued on May 10, 2005. Estimated Expiration Date: Icon_subject January 11, 2022. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3856270

Apparatus and method for dilution and mixing of liquid samples
Patent #: 4946795
Issued on: 08/07/1990
Inventor: Gibbons, et al.

Method for producing a sheet member containing at least one enclosed channel
Patent #: 5070606
Issued on: 12/10/1991
Inventor: Hoopman, et al.

Sensor devices
Patent #: 5194133
Issued on: 03/16/1993
Inventor: Clark, et al.

Capillary mixing device
Patent #: 5222808
Issued on: 06/29/1993
Inventor: Sugarman, et al.

Capillary stop-flow junction having improved stability against accidental fluid flow
Patent #: 5230866
Issued on: 07/27/1993
Inventor: Shartle, et al.

Microfluidic structure and process for its manufacture
Patent #: 5376252
Issued on: 12/27/1994
Inventor: Ekstrom, et al.

Solid state chemical micro-reservoirs
Patent #: 5385709
Issued on: 01/31/1995
Inventor: Wise, et al.

Method of producing a sealing means in a microfluidic structure and a microfluidic structure comprising such sealing means
Patent #: 5443890
Issued on: 08/22/1995
Inventor: Ohman

Integrated chemical processing apparatus and processes for the preparation thereof
Patent #: 5534328
Issued on: 07/09/1996
Inventor: Ashmead, et al.

More ...

Inventors

Assignee

Application

No. 10046071 filed on 01/11/2002

US Classes:

366/336, STATIONARY DEFLECTOR (DIVIDING AND RECOMBINING TYPE) IN FLOW-THROUGH MIXING CHAMBER366/341, STATIONARY MIXING CHAMBER422/188, Including plural reaction stages422/100, Pipette or other volumetric fluid transfer means137/833Structure of body of device

Examiners

Primary: Soohoo, Tony G.

Attorney, Agent or Firm

Foreign Patent References

  • 0 107 631 EP 05/01/1984
  • 0 933 126 EP 08/01/1999
  • 1 123 734 EP 08/01/2001
  • WO 9700125 WO 01/01/1997
  • WO 9712665 WO 04/01/1997
  • WO 9845693 WO 10/01/1998
  • WO 9856505 WO 12/01/1998
  • WO 9917093 WO 04/01/1999
  • WO 9917917 WO 04/01/1999
  • WO 9929497 WO 06/01/1999
  • WO 9960397 WO 11/01/1999
  • WO 0021659 WO 04/01/2000
  • WO 0022436 WO 04/01/2000
  • WO 0128670 WO 04/01/2001
  • WO 01025138 WO 04/01/2001
  • WO 0178893 WO 10/01/2001
  • WO 0210732 WO 02/01/2002

International Classes

B81B001/00
B81B007/00

Abstract

Robust microfluidic mixing devices mix multiple fluid streams passively, without the use of moving parts. In one embodiment, these devices contain microfluidic channels that are formed in various layers of a three-dimensional structure. Mixing may be accomplished with various manipulations of fluid flow paths and/or contacts between fluid streams. In various embodiments, structures such as channel overlaps, slits, converging/diverging regions, turns, and/or apertures may be designed into a mixing device. Mixing devices may be rapidly constructed and prototyped using a stencil construction method in which channels are cut through the entire thickness of a material layer, although other construction methods including surface micromachining techniques may be used.

Other References

  • Strock, Abraham D. et al., “Chaotic Mixer for Microchannels,” Science Magazine, vol. 295, pp. 647-651, Jan. 25, 2002.
  • Liu, Robin H. et al., “Plastic In-Line Chaotic Micromixer for Biological Applications,” Micro Total Analysis Systems, J.M. Ramsey and A. van den Berg (eds.), 2001 Kluwer Academic Publishers, The Netherlands, pp. 163-164.
  • Jacoby, Mitch, Chemistry Flows Like Clockwork —Flow system used to make simple devices for time-dependent studies, “Channels & Engineering News,” Feb. 24, 2003, p. 5.
  • Dshmukh, Ajay A. et al., A.P. (2000), “Continuouse Micromixer with Pulsatile Micropumps,” Solid-State Sensor and Achuator Workshop, Hilton Head Island, SC, USA, Jun. 4-8, 2000, pp. 73-76.
  • Martin, P.M. et al., Laser micromachined and laminated microchannel components for chemical sensors and heat transfer applications, “Micromachined Devices and Components III,” SPIE—The International Society for Optical Engineering, vol. 3224, Bellingham, Washington, USA, pp. 258-265.
  • Tracey, M.C. et al., “Microfluidic Mixer Employing temporally-Interleaved Liquid Slugs and Parabolic Flow,” Micro Total Analysis Systems, J.M. Ramsey and A. van den Berg (eds.) 2001 Kluwer Academic Publishers, The Netherlands, pp. 141-142.
  • Ehrfeld, W. et al., Potentials and Reallization of Microreactors, “DECHEMA Monographs,” vol. 132, VCH Verlagsgesellschaft, 1996, pp. 1-28.
  • Johnson, Timothy J. et al., Rapid Microfluidic Mixing, “Analytical Chemistry,” vol. 74, No. 1, Jan. 1, 2002, pp. 45-51.
  • Verporte, Elisabeth M.J. et al., “Silicon-based Chemical Microsensors and Microsystems,” Interfacial Design and Chemical Sensing, American Chemical Society, 1994, Chapter 21, pp. 244-254.
  • Yang, Xing et al., “A MEMS Thermopneumatic Silicone Membrane Valve,” (1998) Sensors and Actuators A: Physical, vol. 64, pp. 101-108.
  • Schulta, Thomas, “The Development of Pratical Microfluidic-Based Systems for Chemical and Blood Analysis,” (1999) in Drug-Discovery Technology for the New Millenium Chapter 13, pp 127-135. Conference proceeding: IBC USA Conferences, Inc.: 4th Annual Conference on Microfabrication and Microfluidic Tehcnologies.
  • Becker, Holger et al., “Silicon as Tool Materials for Polymer Hot Embossing,” (1999) Proceedings MEMS'99 Orlando, 228-231.
  • Jeon, Noo Li et al., “Large-Area Patterning by Vacuum-Assisted Micromolding,” (1999) Adv. Mater.. 11, No. 11:946-950.
  • Jackman, Rebecca J., et al., “Electrochemistry and soft Lithograph: A route 3-D microstructures”, (May 1999) Cehmtech 18-30.
  • Folch, A., et al., “Molding of Deep Polydimethylsiloxane Microstructures for Microfluidics and Biological Applications”(Feb. 1999) Journal of Biomechanical Engineering 121:28-34.
  • Duffy, David C., et al., “Rapid Prototypling of Microfluidic Systems in Poly(dimethylsiloxane)”, (Dec. 1998) Analytical Chemistry 70:4974-4984.
  • Grzybowski, B, et al., “Generation of Micrometer-Szied Patterns for Miccranalytical Application Using a Laser Driect-Write Method and Microcontant Printing”, (Nov 1998) Anaylitical Chemistry 70:4645-4652.
  • Gonzalez, C., et al., “Fluidic internconects for modular assembly of Chemical Microsystems”, (Jan 1998), Sensors and Actuators B 49:40-45.
  • Qin, Dong, et al., “Microfabrication, and Microsystems”, (1998) Topics in Current Chemistry 194:1-19.
  • Fuhr, G., et al., “Biological Application of Microstructures”, (1998) Topics in Current Chemistry 194:83-116.
  • Cordova, Emilio, et al., “Noncovalent Polycationnic Coatings for Capillaries in Capillary Electrophoresis of Proteins” (Apr. 1997) Analytical Chemistry 69:1370-1379.
  • McCormick, Rnady M., et al., “Microchannel Electrochannel Electrophoretic Separations of DNA in Injection-Molded Plastic Substrates”(Dec. 1997) Analytical Chemistry 69:2626-2630.
  • Martynova, Larisa et al., “Fabrication of Plastics Microfluid Channels by Imprinting Methods” (1997) Anal. Chem. 69:4783-4789.
  • Kovacs, Gregory T.A. et al., “Silicon Micromachining Sensors to Systems” (Jul. 1996) Analytical Chemistry News & Features 407A-412A.
  • Shoji, Shuchi, et al., “Microflow Devices and Systems” (Oct. 1994). J. Micromech. Microeng. 4:157-171.
  • Schomburg, W.K., et al., “Microfluidic Components in LIGA Technique” (Feb. 1994) J. Micromech.Microeng. 4:186-191.
  • Verport, Elisabeth M.J., et al., “Three-Dimensional Micro Flow Manifolds for Miniaturized Chemical Analysis Systems”(Oct. 1994) J. Micromech. Microeng. 4:246-256.
  • Groisman, et al., Microfluidic Memory and Control Devices, “Science Magazine,” vol. 300, May 9, 2003, pp. 955-958.
  • Ehrfeld, et al., Injection of Many Small Substreams of One Component into a Main Stream of Another Component, “Microreactors—New Technology for Modern Chemistry,” Vch. Verlagsgesellschaft Mbh; 1st edition, Jun. 15, 2000, pp. 53-55.
  • Branebjerg, Jens, et al., “Fast Mixing by Lamination,” Proc. Micro Electro Mechanical Systems Workshop, pp. 441-446, IEEE (1996).
  • Miyake, Ryo et al., “Micro Mixer with Fast Diffusion,” Proc. Micro Electro Mechanical Systems Workshop, pp. 248-253, IEEE (1993).
  • Mensinger, H., et al., “Microreactor With Integrated Static Mixer and Analysis System,” Micro Total Analysis Systems, pp. 237-240, Kluwer, The Netherlands (1995).
  • Larsen, Ulrik D., et al.. “Fast Mixing by Parallel Multilayer Lamination,” Analytical Methods & Instrumentation, Proc. 2nd International Symposium Miniaturized Total Analysis Systems, μTAS-96, pp. 228-230 (1996).
  • Bertsch, Arnaud, et al., “Static Micromixers Based on Large-Scale Industrial Mixer Geometry,” Lab On A Chip, vol. 1, pp. 56-60, 2001.
  • Voldman, Joel, et al., “An Integrated Liquid Mixer/Valve,” Journal of Microelectromechanical Sys., vol. 9, No. 3, Sept. 2000.
  • Weigl, Bernhard H., et al., “Passive Microfluidics—Ultra low-cost plastic disposable lab-on-a-chip,” μTAS 2000, Twente, the Netherlands, May 14-18, 2000.
  • Merkel, Tobias, et al., “A NEw Technology for Fluidic Microsystems Based on PCB Technology,” Sensors and Actuators 77 A:Physical, pp. 98-105, 1999.
  • McNeely, Michael R., et al., “Hydrophobic Microfluidics,” SPIE Microfluidic Devices & Systems II, vol. 3877, Sept. 1999.
  • Ehrfeld, Wolfgang et al., “Characterization of Mixing in Micromixers by a Test Reaction: Single Mixing Units and Mixer Arrays,” Ind. Eng. Chem. Res. 1999, 38 1075-1082, Jan. 23, 1999.
  • Bökenkamp, Dirk , et al., “Microfabricated Silicon Mixers for Submillisecond Quench-Flow Analysis,” Anal. Chem. 70, pp. 232-236, 1998.
  • Shoji, Shuichi, “Fluids for Sensor Systems,”Topics in Current Chemistry, vol. 194, 1998.
  • Knight, James B., et al., “Hydrodynamic Focusing on a Silicon Chip: Mixing Nanoliters in Microseconds,” Physical Review Letters, vol. 80, No. 17, Apr. 27, 1998.
  • Desai, Amish et al., Microfludic Sub-millisecond Mixers For The Study of Chemical Reaction Kinetics, Tranducers 97 (1997 Int'l Conf. On Solid-State Sensors and Actuators), vol. 1 pp. 167-170, Jun. 16-19, 1997.
  • Svasek,P., et al., “Dry Film Resist Based Fluid Handling Components for μTAS” Institute für Allgemeine Elektrotechnik und Elektronik, Technische Universität Wien, (Undated).
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
PatentsPlus: add to cart
PatentsPlus: add to cartIntelligent turbocharged patent PDFs with marked up images
$16.95more info
 
Sign InRegister
Username  
Password   
forgot password?