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US Patent 6858228 - Solid oral dosage forms of valsartan

US Patent Issued on February 22, 2005
Estimated Patent Expiration Date: Icon_subject September 20, 2022Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The present invention is concerned with solid oral dosage forms of comprising a) an active agent selected from valsartan and optionally HCTZ, and b) Pharmaceutically acceptable additives suitable for the preparation of solid oral dosage forms by compression methods.

Other References

  • “Hydrochlorothiazide”—Martindale 89 pp. 991-993.
  • “Innovatives Antihypertensives,” Therapiewoche 36, pp. 1982-1985 (1996).
  • Chemical Abstracts 124:220073 (1996).
  • DIALOG: Derwent Drug File—Abstract AN:96-09445 (1996).
  • DIALOG: Drug Data Report—Abstract AN 185987 (1992).
  • DIALOG: JICST EPlus—Abstract AN:96A0157433 (1995).
  • EMBASE: Abstract 96015489 (1995).
  • EMBASE: Abstract 96-374183 (1996).
  • EMBASE: Abstract AN-97-027003 (1997).
  • Fujimara Y. et al., “Antihypertensive effect of a combination of Valsartan . . . ”, Yakuri To Chiryo, vol. 23, No. 12, 1995, pp. 3241-3247.
  • Grun, A. et al., “A comparison of the efficacy and tolerability . . . ”,European Heart Journal, vol. 161, No. Sup. (1995) p. 61.
  • Lachman, L. et al., “The Theory and Practice of Industrial Pharmacy,” Lea & Febiger, 1986, pp. 318-320.
  • Markham, A., et al., “Valsartan: a review of its pharmacology and therapeutic use . . . ,” DRUGS, vol. 54, No. 2, (1997) pp. 299-311.
  • TOXLIT: Abstract AN-96:69983 (1995).
  • Fujimura et al., “Antihypertensive Effect of a Combination of Valsartan and Hydroclorothiazide, Nifedipine or Propranolol in Spontaneously Hypertensive Rats,” Japan Pharmacol Ther, vol. 23(12), pp. 3241-3247 (1995). English Translation Included.

Inventors

Assignee

Application

No. 10251009 filed on 09/20/2002

US Classes:

424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/464, Tablets, lozenges, or pills424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)514/223.5, With additional active ingredient514/223.2, 1,2,4 - Benzothiadiazine - 1,1 - dioxides (including hydrogenated)514/222.8, Polycyclo ring system having the six-membered hetero ring as one of the cyclos514/381, Tetrazoles (including hydrogenated)424/488, Polysaccharides (e.g., cellulose, etc.)514/382Additional chalcogen containing hetero ring

Field of Search

424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/464, Tablets, lozenges, or pills424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)514/223.5, With additional active ingredient514/223.2, 1,2,4 - Benzothiadiazine - 1,1 - dioxides (including hydrogenated)514/222.8Polycyclo ring system having the six-membered hetero ring as one of the cyclos

Examiners

Primary: Page, Thurman K.
Assistant: Di Nola-Baron, Liliana

Attorney, Agent or Firm

US Patent References

3200039, 4353887, Divisible tablet having controlled and delayed release of the active substance
Issued on: 10/12/1982
Inventor: Hess ,   et al.
5399578, Acyl compounds
Issued on: 03/21/1995
Inventor: Buhlmayer, et al.
5464854, Method of modifying ovarian hormone-regulated AT1 receptor activity as treatment of incapacitating symptom(s) of P.M.S.
Issued on: 11/07/1995
Inventor: dePadova
5486364, Readily available konjac glucomannan as a sustained release excipient
Issued on: 01/23/1996
Inventor: King, et al.
6218414, Use of an angiotensin II antagonist and a benzofuran derivative in the treatment of cardiovascular complaints
Issued on: 04/17/2001
Inventor: Nisato
6294197, Solid oral dosage forms of valsartan
Issued on: 09/25/2001
Inventor: Wagner, et al.
6485745Solid oral dosage forms of valsartan
Issued on: 11/26/2002
Inventor: Wagner, et al.

Foreign Patent References

  • 2421 273 DE 11/01/1974
  • 11 490 EP 05/01/1980
  • 70 127 EP 01/01/1983
  • 396 335 EP 11/01/1990
  • 9315732 WO 08/01/1993
  • 94 09778 WO 05/01/1994
  • 95 24901 WO 09/01/1995
  • 95 28927 WO 11/01/1995
  • 95 29674 WO 11/01/1995

International Class

A61K009/20

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