Patent 6849736 Issued on February 1, 2005. Estimated Expiration Date: September 6, 2022. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Provided are novel polymorphs and pseudopolymorphs of valacyclovir hydrochloride and pharmaceutical compositions containing these. Also provided are methods for making the novel polymorphs and pseudopolymorphs, which include valacyclovir hydrochloride monohydrate and valacyclovir hydrochloride dihydrate.
Other References
Goodman & Gilman's, The Pharmacological Basis of Therapeutics, pp. 1193-1198 (9th ed. 1996).
G.M. Wall, “Pharmaceutical Applications of Drug Crystal Studies,” Pharmaceutical Manufacturing, vol. 3, No. 2, Feb. 1986, pp. 33-42.
J. Haleblian and W. McCrone, “Pharmaceutical Applications of Polymorphism,” Journal of Pharmaceutical Sciences, vol. 58, No. 8, Aug. 1969, pp. 911-929.
J.K. Haleblian, “Characterization of Habits and Crystalline Modification of Solids and Their Pharmaceutical Applications,” Journal of Pharmaceutical Sciences, vol. 64, No. 8, Aug. 1975, pp. 1269-1288.
Pharmacopeial Forum, vol. 24, No. 1, (Jan.-Feb. 1998) p. 5438-5440.