U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Crystalline forms of valacyclovir hydrochloride

Patent 6849736 Issued on February 1, 2005. Estimated Expiration Date: Icon_subject September 6, 2022. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Methods and compositions for treating viral infections and guanine acyclic nucleosides
Patent #: 4199574
Issued on: 04/22/1980
Inventor: Schaeffer

Therapeutic valine esters of acyclovir and pharmaceutically acceptable salts thereof
Patent #: 4957924
Issued on: 09/18/1990
Inventor: Beauchamp

Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
Patent #: 5756736
Issued on: 05/26/1998
Inventor: Arzeno, et al.

Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
Patent #: 5840890
Issued on: 11/24/1998
Inventor: Arzeno, et al.

2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
Patent #: 5840891
Issued on: 11/24/1998
Inventor: Nestor, Jr., et al.

Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
Patent #: 6040446
Issued on: 03/21/2000
Inventor: Dvorak, et al.

Guanine derivative Patent #: 6107302
Issued on: 08/22/2000
Inventor: Carter, et al.

Inventors

Assignee

Application

No. 10236729 filed on 09/06/2002

US Classes:

544/276Nitrogen attached directly or indirectly to the purine ring system by nonionic bonding

Examiners

Primary: Berch, Mark L.

Attorney, Agent or Firm

Foreign Patent References

  • WO 9725989 WO 07/01/1997
  • WO 9727194 WO 07/01/1997
  • WO 9803553 WO 01/01/1998

International Classes

C07D47318
A61K 31522
A61K 3152
C07D47300
C07D47300

Abstract

Provided are novel polymorphs and pseudopolymorphs of valacyclovir hydrochloride and pharmaceutical compositions containing these. Also provided are methods for making the novel polymorphs and pseudopolymorphs, which include valacyclovir hydrochloride monohydrate and valacyclovir hydrochloride dihydrate.

Other References

  • Goodman & Gilman's, The Pharmacological Basis of Therapeutics, pp. 1193-1198 (9th ed. 1996).
  • G.M. Wall, “Pharmaceutical Applications of Drug Crystal Studies,” Pharmaceutical Manufacturing, vol. 3, No. 2, Feb. 1986, pp. 33-42.
  • J. Haleblian and W. McCrone, “Pharmaceutical Applications of Polymorphism,” Journal of Pharmaceutical Sciences, vol. 58, No. 8, Aug. 1969, pp. 911-929.
  • J.K. Haleblian, “Characterization of Habits and Crystalline Modification of Solids and Their Pharmaceutical Applications,” Journal of Pharmaceutical Sciences, vol. 64, No. 8, Aug. 1975, pp. 1269-1288.
  • Pharmacopeial Forum, vol. 24, No. 1, (Jan.-Feb. 1998) p. 5438-5440.
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