Peanut allergens and methods

Patent 6835824 Issued on December 28, 2004. Estimated Expiration Date:

November 13, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3645852

3720760

Method of forming polymeric layers Patent #: 4535010
Issued on: 08/13/1985
Inventor: Axen , et al.

Inventors

Application

No. 09191593 filed on 11/13/1998

US Classes:

536/23.6, Encodes a plant polypeptide536/25.32, Labels or markers utilized (e.g., radiotracer, affinity, fluoroescent, phosphorescent, markers, etc.)424/275.1, Allergen or component thereof (e.g., ragweed pollen, etc.)435/320.1, VECTOR, PER SE (E.G., PLASMID, HYBRID PLASMID, COSMID, VIRAL VECTOR, BACTERIOPHAGE VECTOR, ETC.) BACTERIOPHAGE VECTOR, ETC.)427/246Coagulating or jelling the coating

Examiners

Primary: Scheiner, Laurie

Attorney, Agent or Firm

International Class

C07H 2104

Abstract

One of the major peanut allergens, Ara h I, was selected from cDNA expression library clones using Ara h I specific oligo-nucleotides and polymerase chain reaction technology. The Ara h I clone identified a 2.3 kb mRNA species on a Northern blot containing peanut poly A+RNA. DNA sequence analysis of the cloned inserts revealed that the Ara h I allergen has significant homology with the vicilin seed storage protein family found in most higher plants. The isolation of the Ara h I clones allowed the synthesis of this protein in E. coli cells and subsequent recognition of this. recombinant protein in immunoblot analysis using serum IgE from patients with peanut hypersensitivity.

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