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US Patent 6829753 - Microfluidic design automation method and system

US Patent Issued on December 7, 2004
Estimated Patent Expiration Date: Icon_subject June 27, 2021Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The present invention generally relates to microfluidics and more particularly to the design of customized microfluidic systems using a microfluidic computer aided design system. In one embodiment of the present invention a microfluidic circuit design method is provided. The method includes developing synthesizable computer code for a design. Next, a microfluidic circuit schematic, including a plurality of symbols for microfluidic components, is generated either interactively or using the synthesizable computer code. The microfluidic circuit schematic is then functionally simulated. The microfluidic components are placed and routed on a template to form a physical layout. Then the physical layout is physically simulated using dynamic simulation models of the microfluidic components; and the physical layout is written to a layout file.

Other References

  • Chou, Hou-Pu, et al., “Microfabricated Devices for Sizing DNA and Sorting Cells,” Micro- and Nanofabricated Structures and Devices for Biomedical Enviornmental Applications, (1998) vol. 3258:pp 187-7.
  • Chou, Hou-Pu, et al. “Disposable Microdevices for DNA Analysis and Cell Sorting,” Proc. Solid-State Sensor and Actuator Workshop, (Jun. 1998) pp:11-14.
  • Chou, Hou-Pu, et al., “A Microfabricated Device for Sizing and Sorting DNA Molecules,” Proc. Natl. Acad. Sci. USA, (Jan. 1999) vol. 96:pp 11-13.
  • Chou, Hou-Pu, et al., “Integrated Elastomer Fluidic Lab-on-a-Chip-Surface Patterning and DNA Diagnostics,” Departments of Electrical Engineering and Applied Physics, Caltech, Pasadena, California 91125, USA.
  • Fu, Anne Y., et al., “A Microfabricated Fluorescence-Activated Cell Sorter,” Nature Biotechnology, (Nov. 1999) vol. 17:pp 1109-1111.
  • Quake, Stephen R., et al., “From Micro- to Nanofabrication with Soft Materials,” Science (Nov. 2000) vol. 290:pp 1536-1540.
  • Thorsen, Todd, et al., “Dynamic Pattern Formation in a Vesicle-Generating Microfluidic Device,” Physical Letters Review (Apr. 2001) vol. 86 No. (18):pp 4163-4166.
  • Unger, Marc A., et al., “Monolithic Microfabricated valves and Pumps by Multilayer Soft Lithography,” Science (Apr. 2000) vol. 288:pp 113-116.
  • Weigl, Bernhard H., “Microfluidics-Based Lab-on-a-Chip Systems,” www.devicelink.cm/archive/00/11/008.h.

Inventors

Assignee

Application

No. 09894857 filed on 06/27/2001

US Classes:

716/5, Design verification (e.g., wiring line capacitance, fan-out checking, minimum path width)716/1CIRCUIT DESIGN

Field of Search

422/98, Analysis based on electrical measurement422/99, Miscellaneous laboratory apparatus and elements, per se422/100, Pipette or other volumetric fluid transfer means716/1, CIRCUIT DESIGN716/11, Layout editor (e.g., updating)716/12, Routing (e.g., routing map, netlisting)716/14, Detailed routing (e.g., channel routing, switch box routing)716/17Programmable integrated circuit (e.g., basic cell, standard cell, macrocell)

Examiners

Primary: Lee, Wilson

Attorney, Agent or Firm

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International Class

G06F 945

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