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US Patent 6776978 - Delivery of opioids through an inhalation route

US Patent Issued on August 17, 2004
Estimated Patent Expiration Date: Icon_subject May 21, 2022Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The present invention relates to the delivery of opioids through an inhalation route. Specifically, it relates to aerosols containing opioids that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an opioid. In a method aspect of the present invention, an opioid is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an opioid, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an opioid through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an opioid; and, b) a device that forms an opioid aerosol from the composition, for inhalation by the mammal.

Other References

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Inventors

Assignee

Application

No. 10153839 filed on 05/21/2002

US Classes:

424/45, Organic pressurized fluid424/46, Powder or dust containing424/450, Liposomes424/780, EXTRACT OR MATERIAL CONTAINING OR OBTAINED FROM A MICRO-ORGANISM AS ACTIVE INGREDIENT (E.G., BACTERIA, PROTOZOA, ETC.)514/54, Polysaccharide514/220, Tricyclo ring system having the seven-membered hetero ring as one of the cyclos128/200.14, LIQUID MEDICAMENT ATOMIZER OR SPRAYER128/200.24RESPIRATORY METHOD OR DEVICE

Field of Search

424/45, Organic pressurized fluid424/450, Liposomes424/46, Powder or dust containing424/780, EXTRACT OR MATERIAL CONTAINING OR OBTAINED FROM A MICRO-ORGANISM AS ACTIVE INGREDIENT (E.G., BACTERIA, PROTOZOA, ETC.)128/200.14, LIQUID MEDICAMENT ATOMIZER OR SPRAYER128/200.24, RESPIRATORY METHOD OR DEVICE514/54, Polysaccharide514/220Tricyclo ring system having the seven-membered hetero ring as one of the cyclos

Examiners

Primary: Hartley, Michael G.
Assistant: Haghighatian, Mina

Attorney, Agent or Firm

US Patent References

3393197, RE30285, 5388574, Aerosol delivery article
Issued on: 02/14/1995
Inventor: Ingebrethsen5451408, Pain management with liposome-encapsulated analgesic drugs
Issued on: 09/19/1995
Inventor: Mezei, et al.5543434, Nasal administration of ketamine to manage pain
Issued on: 08/06/1996
Inventor: Weg5544646, Systems for the intrapulmonary delivery of aerosolized aqueous formulations
Issued on: 08/13/1996
Inventor: Lloyd, et al.5655523, Dry powder inhalation device having deagglomeration/aerosolization structure responsive to patient inhalation
Issued on: 08/12/1997
Inventor: Hodson, et al.5694919, Lockout device for controlled release of drug from patient-activated dispenser
Issued on: 12/09/1997
Inventor: Rubsamen, et al.5724957, Intrapulmonary delivery of narcotics
Issued on: 03/10/1998
Inventor: Rubsamen, et al.5735263, Lockout device for controlled release of drug from patient-activated dispenser
Issued on: 04/07/1998
Inventor: Rubsamen, et al.5758637, Liquid dispensing apparatus and methods
Issued on: 06/02/1998
Inventor: Ivri, et al.5910301, Method of intrapulmonary administration of a narcotic drug
Issued on: 06/08/1999
Inventor: Farr, et al.5915378, Creating an aerosolized formulation of insulin
Issued on: 06/29/1999
Inventor: Lloyd, et al.5934272, Device and method of creating aerosolized mist of respiratory drug
Issued on: 08/10/1999
Inventor: Lloyd, et al.5957124, Dynamic particle size control for aerosolized drug delivery
Issued on: 09/28/1999
Inventor: Lloyd, et al.5960792, Device for aerosolized delivery of peptide drugs
Issued on: 10/05/1999
Inventor: Lloyd, et al.6041777, Methods and apparatus for closed-circuit ventilation therapy
Issued on: 03/28/2000
Inventor: Faithfull, et al.6095153, Vaporization of volatile materials
Issued on: 08/01/2000
Inventor: Kessler, et al.6102036, Breath activated inhaler
Issued on: 08/15/2000
Inventor: Slutsky, et al.6306431, Apparatus for heating to a desired temperature for improved administration of pharmaceutically active compounds
Issued on: 10/23/2001
Inventor: Zhang, et al.6514482, Pulmonary delivery in treating disorders of the central nervous system
Issued on: 02/04/2003
Inventor: Bartus, et al.6591839Filter material for reducing harmful substances in tobacco smoke
Issued on: 07/15/2003
Inventor: Meyer, et al.

Foreign Patent References

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  • WO 9107947 WO 06/01/1991
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International Classes

A61K 912
A61K 914

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