10-Aryl-11h-benzo[b]fluorene derivatives and analogs for medicinal use
Patent 6756375 Issued on June 29, 2004. Estimated Expiration Date: 
August 17, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
August 17, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorsAssigneeApplicationNo. 10362555 filed on 08/17/2001US Classes:514/238.8, Chalcogen attached indirectly to the morpholine ring by acyclic nonionic bonding514/730, Benzene ring containing514/765, Polycyclo ring system544/154, Polycyclo-carbocyclic ring system having at least three cyclos544/294, Polycyclo-carbocyclic ring system having at least three cyclos544/357, Plural diazine rings546/195, The additional ring is one of the cyclos in a polycyclo ring system546/285, Polycyclo-carbocyclic ring system having at least three cyclos548/528, Polycyclo carbocyclic ring system having at least three cyclos548/160, Polycyclo-carbocyclic ring system having at least three cyclos568/812, Halogen containing568/817, Polycyclo ring system568/719, Polycyclo ring system568/633, Polyoxy549/365, The ring oxygens are in the 1,2- or 1,3-positions of the hetero ring564/280Phenol or thiophenol addition saltsExaminersPrimary: Ramsuer, Robert W.Assistant: Small, Andrea D. Attorney, Agent or FirmForeign Patent References
International ClassesC07C32128C07C 4323 A61K 3105 A61P 506 C07D29508 AbstractThe invention provides for a non-steroidal compound having the formula wherein Re and ′Re are OH, optionally independently etherified or esterified; Z is —CH2— or —CH2CH2—; R1 is H, halogen, CF3, or (1C-4C)alkyl; R2, R3 and R4 are independently H, halogen, —CF3, —OCF3, (1C-8C)Alkyl, hydroxy, (1C-8C)alkyloxy, aryloxy, aryl(1C-8C)alkyl, halo(1C-8C)alkyl, —O(CH2)mX, wherein X is halogen or phenyl and m=2-4; —O(CH2)mNRaRb, —S(CH2)mNRaRb or —(CH2)mNRaRb, wherein m=2-4 and Ra, Rb are independently (1C-8C)alkyl, (2C-8C)alkenyl, (2C-8C)alkynyl, or aryl, optionally substituted with halogen, —CF3, —OCF3, —CN, —NO2, —OH, (1C-8C)alkoxy, aryloxy, carboxyl, (1C-8C)alkylthio, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl, halo(1C-8C)alkyl or Ra and Rb form a 3-8 membered ring structure, optionally substituted with halogen, —CF3, —OCF3, —CN, —NO2, hydroxy, hydroxy(1C-4C)alkyl, (1C-8C)alkoxy, aryloxy, (1C-8C)alkylthio, carboxyl, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl, halo(1C-8C)alkyl. The compounds can be used for the preparation of a medicine, in particular for use in estrogen-receptor-related treatments.Field of SearchBenzene ring containingPolycyclo ring system Chalcogen attached indirectly to the morpholine ring by acyclic nonionic bonding Halogen containing Polycyclo ring system Polycyclo ring system Polycyclo-carbocyclic ring system having at least three cyclos Polycyclo-carbocyclic ring system having at least three cyclos Plural diazine rings The additional ring is one of the cyclos in a polycyclo ring system Polycyclo-carbocyclic ring system having at least three cyclos Polycyclo carbocyclic ring system having at least three cyclos Polycyclo-carbocyclic ring system having at least three cyclos The ring oxygens are in the 1,2- or 1,3-positions of the hetero ring Phenol or thiophenol addition salts |
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