Topically applied idebenone-containing agent with protective and regenerative effect
Patent 6756045 Issued on June 29, 2004. Estimated Expiration Date: 
May 19, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 19, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMethod of and composition for preventing sunburn while affording tanning Skin treatment methods Method for therapy of ischemic disease Nerve growth factor secretion inducing composition Pharmaceutical composition for treatment of dementia Animal models of human amyloidoses Use of retinoids to treat high blood pressure and other cardiovascular disease Nutritional supplement for cerebral metabolic insufficiencies Patent #: 6537969 InventorsApplicationNo. 10030842 filed on 05/19/2000US Classes:424/401, Cosmetic, antiperspirant, dentifrice424/78.03, Skin cosmetic coating514/675, Ketone DOAI514/763, Carbocyclic514/845Liquid make-upExaminersPrimary: Wang, ShengjunAttorney, Agent or FirmForeign Patent References
International ClassesA61K 700A61K 3174 A61K 3112 A61K 31015 A01N 2500 ClaimsWhat is claimed is: 1. A method for treating a skin change comprising applying a topical preparation to the skin, the preparation comprising an amount of an agent effective for treating the skin change, the agent comprising idebenone, a derivative of idebenone, or a combination of idebenone and the derivative of idebenone. 2. The method as recited in claim 1 wherein the skin change includes an aging of the skin. 3. The method as recited in claim 1 wherein the skin change includes a wrinkling of the skin. 4. The method as recited in claim 1 wherein the skin change includes a damage of the skin by ultraviolet light. 5. The method as recited in claim 1 wherein the skin change includes an oxidative process. 6. The method as recited in claim 1 wherein the skin change includes a degenerative process. 7. The method as recited in claim 1 wherein the agent acts as an antioxidant. 8. The method as recited in claim 1 wherein the agent acts as a radical scavenger. 9. The method as recited in claim 1 wherein the agent acts as a stabilizer of skin cells. 10. The method as recited in claim 1 wherein the agent acts as a stabilizer of mitocondria membranes of skin cells. 11. The method as recited in claim 1 wherein the agent supports cellular respiration of skin cells so as to promote regeneration of the cells. 12. The method as recited in claim 1 wherein the agent protects the skin upon damage to the skin using an anti-apoptotic property of the respective idebenone, a derivative of idebenone, or a combination of idebenone and a derivative of idebenone. 13. The method as recited in claim 1 wherein the derivative of idebenone is a hydrophilic ester of idebenone. 14. The method as recited in claim 1 wherein the derivative of idebenone is a sulfonic acid ester of idebenone. 15. The method as recited in claim 1 wherein the derivative of idebenone is at least one of an ester of idebenone and an ester of the derivative of idebenone. 16. The method as recited in claim 1 wherein the topical preparation further comprises at least one of a glycosaminoglycan, a derivative of a glycosaminoglycan and a hyaluronidase inhibitor. 17. The method as recited in claim 1 wherein the topical preparation further comprises a cosmetic auxiliary. 18. The method as recited in claim 1 wherein the agent stabilizes another component of the preparation. 19. The method as recited in claim 18 wherein the other component includes at least one of vitamin A, a derivative of vitamin A, vitamin B, a derivative of vitamin B, vitamin C, a derivative of vitamin C, vitamin E, a derivative of vitamin C, hyaluronic acid and a derivative of hyaluronic acid. 20. The method as recited in claim 19 wherein the at least one of hyaluronic acid and a derivative of hyaluronic acid has a molecular weight of up to 1,000,000. 21. The method as recited in claim 1 wherein the topical preparation further comprises another antioxidant. 22. The method as recited in claim 1 wherein the agent protects another component of the preparation from an oxidation process. 23. The method as recited in claim 1 wherein the preparation further comprises at least one ultraviolet filter. 24. The method as recited in claim 1 wherein the preparation includes an emulsion. 25. The method as recited in claim 1 wherein the preparation includes a gel. 26. The method as recited in claim 1 wherein the idebenone, a derivative of idebenone, or a combination of idebenone and a derivative of idebenone has a concentration of from about 0.0001 to about 30% by weight of the preparation. 27. The method as recited in claim 1 wherein idebenone, a derivative of idebenone, or a combination of idebenone and a derivative of idebenone has a concentration of from about 0.05 to about 5% by weight of the preparation. 28. The method as recited in claim 1 wherein the idebenone, a derivative of idebenone, or a combination of idebenone and a derivative of idebenone has a concentration of from about 0.1 to about 2.0% by weight of the preparation. 29. The method as recited in claim 1 wherein the preparation is a cosmetic preparation. 30. The method as recited in claim 1 wherein the preparation is a dermatological preparation. 31. A method for treating a skin change comprising: providing a person in need of treatment of the skin change, the skin change being responsive to an application of idebenone, a derivative of idebenone, or a combination of idebenone and the derivative of idebenone; and applying an amount of the idebenone, the derivative of idebenone, or the combination of idebenone and the derivative of idebenone, effective for treating the skin change. 32. The method as recited in claim 31 wherein the skin change includes an aging of the skin. 33. The method as recited in claim 31 wherein the skin change includes a wrinkling of the skin. 34. The method as recited in claim 31 wherein the skin change includes an oxidative process. 35. The method as recited in claim 31 wherein the skin change includes a degenerative process. 36. The method as recited in claim 31 wherein the applying is included in a cleansing of the skin. 37. The method as recited in claim 31 wherein the applying is included in a cosmetic treatment of the skin. 38. A method for protecting a component of a topical skin preparation from an oxidation process, the method comprising including an amount of idebenone, a derivative of idebenone, or a combination of idebenone and the derivative of idebenone effective to protect the component from the oxidation process. 39. The method as recited in claim 13 wherein the topical skin preparation further comprises at least one compound selected from the group consisting of an alpha-hydroxy acid, vitamin A and a vitamin A derivative. 40. The method as recited in claim 39 wherein the alpha-hydroxy acid is at least one of citric acid, lactic acid, malic acid and mandelic acid. 41. The method as recited in claim 39 wherein the at least one compound has a concentration of from about 0.0001 to about 30% by weight of the preparation. 42. The method as recited in claim 41 wherein the at least one compound has a concentration of from about 0.05 to about 20% by weight of the preparation. 43. The method as recited in claim 42 wherein the at least one compound has a concentration of about 1 to about 10% by weight of the preparation. 44. The method as recited in claim 39 wherein the at least one compound is selected from the group consisting of vitamin A and a vitamin A derivative, the at least one compound having a concentration of from about 0.0001 to about 10% by weight of the preparation. Other References
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