U.S. patents available from 1976 to present.
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Method and apparatus for feedback controlled electrospray

Patent 6744046 Issued on June 1, 2004. Estimated Expiration Date: Icon_subject May 24, 2022. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Electrospray methods and apparatus for trace analysis
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Electrospray employing corona-assisted cone-jet mode
Patent #: 5873523
Issued on: 02/23/1999
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Laser-assisted particle analysis
Patent #: 5977540
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Inventors

Assignee

Application

No. 10154767 filed on 05/24/2002

US Classes:

250/288, With sample supply means250/287, With time-of-flight indicator250/423R, ION GENERATION239/3, Including electrostatic charging239/704With fluid entrainment

Examiners

Primary: Lee, John D.
Assistant: Fernandez, Kalimah

Attorney, Agent or Firm

International Classes

H01J 4900
B05B 503

Abstract

A feedback control system for an electrospray nozzle and counter-electrode, comprising a source of light which intersects, one or snore of the liquid cone, jet and plume of the fluid exiting the nozzle, one or more photo detectors to detect light patterns and generate photo-electronic signals in response thereto, an electronic detection and amplification system to convert the photo-electronic signals to electronic signals, a computer or micro-processor to interpret said electronic signals and a second computer or microprocessor to communicate with the first computer and generate a signal to a controller which adjusts the electric field surrounding the nozzle either by changing the distance between the nozzle and counter-electrode or changing the voltage of the nozzle or counter-electrode.

Other References

  • Carney, L., A. Nguyen, et al. (2001). Reproducibility and Conductivity effects on Current Oscillations in Electrosprays. Proceedings of the 49th Annual Conference on Mass Spectrometry and Allied Topics, Chicago, IL.
  • Cloupeu, M. and B. Prunet-Foch (1994). “Electrohydrodynamic Spraying Functioning Modes: A Critical Review.” J. Aerosol Sci. 25(6): 1021-1036.
  • DeJuan, L. and J. Fernandez De La Mora (1997). “Charge and Size Distributions of Electrospray Drops.” J. Colloid and Interface Sci. 186: 280-293.
  • Gomez, A. and K. Tang (1994): “Charge and Fission of Droplets in Electrostatic Sprays.” Phys. Fluids 6(1): 404-414.
  • Grace, J.M. and J.C.M. Marignissen (1994). “A Review of the Liquid Atomization by Electrical Means.” J. Aerosol Sci. 25(6): 1005-1019.
  • Jaworek, A. and A. Krupa (1999). “Classification of the Modes of EHD Spraying.” J. Aerosol Sci. 30(7): 873-893.
  • Juraschek, R. and F.W. Rollgen (1998): “Pulsation Phenomena During Electrospray Ionization.” Int. J. Mass Spectrom. 177: 1-15.
  • Abstract- “Dependence of Electrospray Ionization Efficiency on Axial Spray Modes.”, Juraschek, R., A. Schmidt, et al. (1998) .Adv. Mass Spectrom..
  • Naqwi, A. (1994). “In Situ Measurement of Submicron Droplets in Electrosprrays Using a Planar Phase Doppler System.” J. Aerosol Sci. 25(6): 1201-1211.
  • Olumee, Z., J.H. Callahan, et al. (1998). “Droplet Dynamics Changes in Electrostatic Sprays of Methanol-Water Mixtures.” J. Phys. Chem. 102: 9154-9160.
  • Tang, K. and A. Gomez (1994). “On the Structure of an Electrostatic Spray of Monodisperse Droplets.” Phys. Fluids 6: 2317-2332.
  • Tang, K., and A. Gomez (1995). “Generation of Monodisperse Water Droplets from Electrosprays in a Corona-Assisted Cone-Jeft Mode.” J. Colloid and Interface Sci. 175: 326-332.
  • Taylor, G. (1964). “Disintegration of Water Drops in an Electric Field.” Pro. R. Soc. A A280: 383-397.
  • Zeleny, J. (1914). “The Electrical Discharge from Liquid Points, and A Hydrostatic Method of Measuring the Electric Intensity at Their Surfaces.” Phys. Rev. 3(2): 69-91.
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  • Zhou, S., A.G. Edwards, et al. (1999). “Investigation of the Electrospray Plume by Laser-induced Fluorescence Spectroscopy.” Anal. Chem. 71: 769-776.
  • Product Literature, New Objective, Inc. 2002.
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