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Signal detection techniques for the detection of analytes

Patent 6740518 Issued on May 25, 2004. Estimated Expiration Date: Icon_subject September 17, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Covalently coupled cofactor modified electrodes and methods of synthesis and use
Patent #: 4704193
Issued on: 11/03/1987
Inventor: Bowers ,   et al.

Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
Patent #: 4707352
Issued on: 11/17/1987
Inventor: Stavrianopoulos

Nucleic acid hybridization assay and detectable molecules useful in such assay
Patent #: 4707440
Issued on: 11/17/1987
Inventor: Stavrianopoulos

Modified nucleotides and methods of preparing and using same
Patent #: 4711955
Issued on: 12/08/1987
Inventor: Ward ,   et al.

Composition and method for the detection of the presence of a polynucleotide sequence of interest
Patent #: 4755458
Issued on: 07/05/1988
Inventor: Rabbani ,   et al.

Method and means for annealing complementary nucleic acid molecules at an accelerated rate
Patent #: 4787963
Issued on: 11/29/1988
Inventor: MacConnell

Electrochemical assay for nucleic acids and nucleic acid probes
Patent #: 4840893
Issued on: 06/20/1989
Inventor: Hill ,   et al.

Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
Patent #: 4849513
Issued on: 07/18/1989
Inventor: Smith ,   et al.

Analyte detection by means of energy transfer
Patent #: 4868103
Issued on: 09/19/1989
Inventor: Stavrianopoulos ,   et al.

Application of tetrathiafulvalenes in bioelectrochemical processes
Patent #: 4882013
Issued on: 11/21/1989
Inventor: Turner, et al.

More ...

Inventors

Application

No. 09397957 filed on 09/17/1999

US Classes:

435/287.2, Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid435/6, Involving nucleic acid435/7.1, Involving antigen-antibody binding, specific binding protein assay or specific ligand-receptor binding assay435/91.1, Polynucleotide (e.g., nucleic acid, oligonucleotide, etc.)435/287.1Including measuring or testing

Examiners

Primary: Whisenant, Ethan
Assistant: Lu, Frank

Attorney, Agent or Firm

Foreign Patent References

  • 2 090904 CA 09/01/1993
  • 0 63879 EP 11/01/1982
  • 0 234938 EP 02/01/1987
  • 0 229943 EP 07/01/1987
  • 0 599337 EP 01/01/1994
  • 0 668 502 EP 08/01/1995
  • 0515615 EP 09/01/1996
  • 6-41183 JP 02/01/1994
  • 238166 JP 10/01/1998
  • WO 8605815 WO 03/01/1985
  • WO 9005303 WO 05/01/1990
  • 9005732 WO 05/01/1990
  • 9210757 WO 06/01/1992
  • 9310267 WO 05/01/1993
  • 9322678 WO 11/01/1993
  • 9323425 WO 11/01/1993
  • 9422889 WO 10/01/1994
  • 9515971 WO 06/01/1995
  • 960712 WO 12/01/1996
  • 9701646 WO 01/01/1997
  • WO 9857159 WO 06/01/1997
  • 9727329 WO 07/01/1997
  • WO 9731256 WO 08/01/1997
  • WO 9741425 WO 11/01/1997
  • 9744651 WO 11/01/1997
  • WO 9746568 WO 12/01/1997
  • WO 9812539 WO 03/01/1998
  • 9820162 WO 05/01/1998
  • 9827229 WO 06/01/1998
  • 9828444 WO 07/01/1998
  • WO 9831839 WO 07/01/1998
  • 9835232 WO 08/01/1998
  • WO 9851823 WO 11/01/1998
  • WO 9857158 WO 12/01/1998
  • 9914596 WO 03/01/1999
  • WO 9929711 WO 06/01/1999
  • WO 9937819 WO 07/01/1999
  • WO 9957317 WO 11/01/1999
  • WO 9957319 WO 11/01/1999
  • 9967425 WO 12/01/1999

International Classes

C12M 134
C12Q 168
G01N 3353
C12P 1934

Abstract

The invention relates to the use of signal processing methods in order to acheive higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.

Other References

  • Livache et al., Polypyrrole DNA chip on a silicon device: example of Hepatitis C virus genotyping. Anal. Biochem. 225, 188-194, Jan. 1998.*
  • Physics: Principles with Applications, Third Edition, 1991, edited by Douglas C. Giancoli, published by Prentice Hall, Englewood Cliffs, New Jersey 07632.*
  • Lnederlof et al., Quantification of fluorescence in situ hybridization signal by image cytometry. Cytometry, 12, 846-852, 1992.*
  • Wood et al., Time-frequency transforms: a new approach to first heart sound frequency dynamics. IEEE Transactions on Biomedical Engineering, 39, 730-740, 1992.*
  • Singhai et al., Direct electrochemical detection of purine- and pyrimidine-based nucleotides with sinusoidal voltammetry. Anal. Biochem. 69, 3552-3557, 1997.*
  • Cheever et al., Fast Fourier transform-based correlation of DNA sequences using complex plane encoding. Comput. Appl. Biosci (CABIOS), 7, 143-154, 1991.*
  • Bain et al., “Formation of Monolayers by the Coadsorption of Thiols on Gold: Variation in the Length of the Alkyl Chain,” J. Am. Chem. Soc. 111:7164-7175 (1989).
  • Bamdad, C. “A DNA self-assembled monolayer for the specific attachment of unmodified double—or single stranded DNA,” Biophysical Journal, 75:1997-2003 (1988).
  • Beattie et al., “Genosensor Technology,” Clinical Chemistry, 39(4): 719-722 (1993).
  • Ihara et al., “Gene sensor using ferrocenyl oligonucleotide,” Chem. Commun., 1609-1610 (1997).
  • Langen et al.,“Electron Tunneling in Proteins: Coupling Through a ββ Strand,” Science, 268:1733-1735, 1995.
  • McGee et al., “Novel Nucleosides via Intramolecular Functionalization of 2,2′-Anhydrouridine Derivatives,” Tetrahedron Letters, 37(12) 1995-1998 (1996).
  • Sloop et al., “Metalloorganic labels for DNA sequencing and mapping,” New. J. Chem., 18: 317-326 (1994).
  • Alleman, K.S., et al., “Electrochemical Rectification at a Monolayer-Modified Electrode,” J. Phys. Chem., 100:17050-17058 (1996).
  • Arkin et al. “Evidence for Photoelectron Transfer Through DNA Intercalation,” J. Inorganic Biochem. Abstracts, 6th International Conference on Bioinorganic Chemistry, 51(1) & (2):526 (1993).
  • Barisci et al., “Conducting Polymer Sensors,” TRIP, 4(9):307-311 (1996).
  • Baum, R. M., “Views on Biological, Long-Range Electron Transfer Stir Debate,” C&EN, pp 20-23 (1993).
  • Bechtold, R., et al., “Ruthenium-Modified Horse Heart Cytochrome c: Effect of pH and Ligation on the Rate of Intramolecular Electron Transfer between Ruthenium(II) and Heme(III),” J. Phys. Chem., 90(16):3800-3804 (1986).
  • Bidan, “Electroconducting conjugated polymers: new sensitive matrices to build up chemical or electrochemical sensors. A Review.,” Sensors and Actuators, B6:45-56 (1992).
  • Biotechnology and Genetics: Genetic Screening Integrated Circuit, The Economist (Feb. 25-Mar. 3, 1995).
  • Boguslavsky, L. et al., “Applications of redox polymers in biosensors,” Solid State Ionics, 60:189-197 (1993).
  • Bowler, B. E., et al., “Long-Range Electron Transfer in Donor (Spacer) Acceptor Molecules and Proteins,” Progress in Inorganic Chemistry: Bioinorganic Chemistry, 38:259-322 (1990).
  • Brun, A. M., et al., “Photochemistry of Intercalated Quaternary Diazaaromatic Salts,” J. Am. Chem. Soc., 113:8153-8159 (1991).
  • Bumm, et al., “Are Single Molecular Wires Conducting?,” Science 271:1705-1707 (1996).
  • Cantor, C.R. et al., “Report on the Sequencing by Hybridization Workshop,” Genomics, 13:1378-1383 (1992).
  • Chang, I-Jy, et al., “High-Driving-Force Electron Transfer in Metalloproteins: Intramolecular Oxidation of Ferrocytochrome c by Ru(2,2′-bpy)2(im)(His-33)3+,” J. Am. Chem. Soc., 113:7056-7057 (1991).
  • Chidsey, C.E.D., et al., “Free Energy and Temperature Dependence of Electron Transfer at the Metal Electrolyte Interface,” Science, 251:919-923 (1991).
  • Chidsey, et al., “Coadsorption of Ferrocene-Terminated and Unsubstituted Alkanethiols on Gold” Electroactive Self-Assembled Monolayers, J. Am. Chem. Soc., 112:4301-4306 (1990).
  • Chrisey, et al., “Covalent attachment of synthetic DNA to self-assembled monolayer films,” Nucleic Acids Research, 24(15):3031-3039 (1996).
  • Clery, “DNA Goes Electric,” Science, 267:1270 (1995).
  • Commerce Business Daily Issue of Sep. 26, 1996 PSA#1688.
  • Database WPI, Derwent Publications Ltd., London, GB; AN 88-320199 & JP, A, 53 238 166 (Mitsubishi Denki KK), Oct. 4, 1988.
  • Davis, L. M., et al., “Electron Donor Properties of the Antitumour Drug Amsacrine as Studied by Fluorescence Quenching of DNA-Bound Ethidium,” Chem.-Biol. Interactions, 62:45-58 (1987).
  • Davis, L. M., et al., “Elements of biosensor construction,” Enzyme Microb. Technol. 17:1030-1035 (1995).
  • Degani et al., “Direct Electrical Communication between Chemically Modified Enzymes and Metal Electrodes. 2. Methods for Bonding Electron-Transfer Relays to Glucose Oxidase and D-Amino-Acid Oxidase,” J. Am. Chem. Soc. 110:2615-2620 (1988).
  • Degani, Y., et al., “Electrical Communication between Redox Centers of Glucose Oxidase and Electrodes via Electrostatically and Covalently Bound Redox Polymers,” J. Am. Chem. Soc., 111:2357-2358 (1989).
  • Degani, Y., et al., “Direct Electrical Communication between Chemically Modified Enzymes and Metal Electrodes. 1. Electron Transfer from Glucose Oxidase to Metal Electrodes via Electron Relays, Bound Covalently to the Enzyme,” J. Phys. Chem., 91(6):1285-1288 (1987).
  • Deinhammer, R.S., et al., “Electronchemical Oxidation of Amine-containing compounds: A Route to the Surface Modification of glassy carbon electrodes,” Langmuir, 10:1306-1313 (1994).
  • Dreyer, G. B., et al., “Sequence-specific cleavage of single-stranded DNA: Oligodeoxynucleotide-EDTA•Fe(III),” Proc. Natl. Acad. Sci. USA, 82:968-972 (1985)
  • Durham, B., et al., “Photoinduced Electron-Transfer Kinetics of Singly Labeled Ruthenium Bis(bipyridin) Dicarboxybipyridine Cytochrome c Derivatives,” Biochemistry, 28:8659-8665 (1989).
  • Durham, B., et al., “Electron-Transfer Kinetics of Singly Labeled Ruthenium(II) Polypyridine Cytochrome c Derivatives,” Advances in Chemistry Series, 226:181-193 (1990).
  • Elias, H., et al., “Electron-Transfer Kinetics of Zn-Substituted Cytochrome c and Its Ru(NH3)5(Histidine-33) Derivative,” J. Am. Chem. Soc., 110:429-434 (1988).
  • Farver, O., et al., “Long-range intramolecular electron transfer in azurins,” Proc. Natl. Acad. Sci. USA, 86:6968-6972 (1989).
  • Fox, L. S., et al., “Gaussian Free-Energy Dependence of Electron-Transfer Rates in Iridium Complexes,” Science, 247:1069-1071 (1990).
  • Fox, M. A., et al., “Light-Harvesting Polymer Systems,” C&EN, pp. 38-48 (Mar. 15, 1993).
  • Francois, J-C., et al., “Periodic Cleavage of Poly(dA) by Oligothymidylates Covalently Linked to the 1,10-Phenanthroline-Copper Complex,” Biochemistry, 27:2272-2276 (1988).
  • Friedman, A. E., et al., “Molecular ‘Light Switch’ for DNA: Ru(bpy)2(dppz)2+,” J. Am. Chem. Soc., 112:4960-4962 (1990).
  • Fromherz, P., et al., “Photoinduced Electron Transfer in DNA Matrix from Intercalated Ethidium to Condensed Methylviologen,” J. Am. Chem. Soc., 108:5361-5362 (1986).
  • Gardner, et al., “Application of conducting polymer technology in microsystems,” Sensors and Actuators, A51:57-66 (1995).
  • Gregg, B. A., et al., “Cross-linked redox gels containing glucose oxidase for amperometric biosensor applications,” Anal. Chem., 62:258-263 (1990).
  • Gregg, B. A., et al., “Redox Polymer Films Containing Enzymes. 1. A Redox-Conducting Epoxy Cement: Synthesis, Characterization, and Electrocatalytic Oxidation of Hydroquinone,” J. Phys. Chem., 95:5970-5975 (1991).
  • Hashimoto, et al., “Sequence-Specific Gene Detection with a Gold Electrode Modified with DNA Probes and an Electrochemically Active Dye,” Anal. Chem. 66:3830-3833 (1994).
  • Hegner, et al., “Immibolizing DNA on gold via thiol modification for atomic force microscopy imaging in buffer solutions,” FEBS 336(3):452-456 (1993).
  • Heller, A., et al., “Amperometric biosensors based on three-dimensional hydrogel-forming epoxy networks,” Sensors and Actuators, 13-14:180-183 (1993).
  • Heller, A., “Electrical Wiring of Redox Enzymes,” Acc. Chem. Res., 23:128-134 (1990).
  • Heller et al., “Fluorescent Energy Transfer Oligonucleotide Probes,” Feb. Proc. 46(6):1968 (1987) Abstract No. 248.
  • Ho “DNA-Mediated Electron Transfer and Application to ‘Biochip’Development,” Abstract. Office of Naval Research (Report Date: Jul. 25, 1991) 1-4, RR04106.
  • Hobbs et al. “Polynucleotides Containing 2′-Amino-2′deoxyribose and 2′-Azido-2′-deoxyriose,” Biochemistry, 12(25):5138-5145 (1973).
  • Hsung, et al., “Synthesis and Characterization of Unsymmetric Ferrocene-Terminated Phenylethynyl Oligomers,” Organometallics, 14:4808-4815 (1995).
  • Hsung, et al., “Thiophenol Protecting Groups for the Palladium-Catalyzed Heck Reaction: Efficient Syntheses of Conjugated Arylthiols,” Tetrahedron Letters. 36(26):4525-4528 (1995).
  • Jenkins et al., A Sequence-Specific Molecular Light Switch: Tebhering of an Oligonucleotide to a Dipyridophenazine Complex of Ruthenium (II), J. Am. Chem. Soc., 114:8736-8738 (1992).
  • Katritzky, et al., “Pyridylethylation—A New Protection Method for Active Hydrogen Compounds,” Tetrahedron Letters,25(12):1223-1226 (1984).
  • Kelley, S.O. and J.K. Barton, “Electrochemically of Methylene Blue Bound to a DNA-Modified Electrode,” Bioconjugate Chem., 8:31-37 (1997).
  • Kojima et al., “A DNA Probe of Ruthenium Bipyridine Complex Using Photocatalytic Activity,” Chemistry Letter, pp 1889-1982 (1989).
  • Laviron, E., “A.C. Polarography and Faradaic Impedance of Strongly Adsorbed Electroactive Species. Part I: Theoretical and Experimental Study of a Quasi-Reversible Reaction in the Case of a Langmuir Isotherm,” J. Electroanal. Chem., 97:135-149 (1979).
  • Laviron, E., “A.C. Polarography and Faradaic Impedance of Strongly Adsorbed Electoactive Species. Part III: Theoretical Complex Plane Analysis for a Surface Redox Reaction,” J. Electroanal. Chem., 105:35-42 (1979).
  • Lee, et al., “Direct Measurement of the Forces Between Complementary Strands of DNA,” Science, 266:771-773 (1994).
  • Lenhard, J.R., et al., “Part VII Covalent Bonding of a Reversible- Electrode Reactanbt to Pt Electrodes Using an organosilane Reagent” J. Electroanal. Chem., 78:195-201 (1977).
  • Lipkin “Identifying DNA by the Speed of Electrons,” Science News, 147(8):117 ( 1995).
  • Maskos, et al., “Oligonucleotide hybridisations on glass supports: a novel linker for oligonucleotide synthesis and hybridisation properties of oligonucleotides synthesised in situ,” Nucleic Acids Research, 20(7):1679-1684 (1992).
  • Mazzocchi, Ph.H. and G. Fritz, “Photolysis of N-(2-Methyl-2-Propenyl)phthalimide in Methanol. Evidence Supporting Radical-Radical Coupling of a Photochemically Generated Radical Ion Pair,” Journal of the American Chemical Society, 108(18):5361-5362 (1986).
  • McGee, et al., “2′-Amino-2′-deoxyuridine via an Intramolecular Cyclization of a Trichloroacetimidate,” J. Org. Chem., 61:781-785 (1996).
  • Meade, T. J., “Driving-Force Effects on the Rate of Long-Range Electron Transfer in Ruthenium-Modified Cytochrome c,” J. Am. Chem. Soc., 111:4353-4356 (1989).
  • Meade, T. J., et al., “Electron Transfer through DNA: Site-Specific Modification of Duplex DNA with Ruthenium Donors and Acceptors,” Angew Chem. Int. Ed. Engl., 34:352 (1995).
  • Mestel, “‘Electron Highway’ Points to Identity of DNA,” New Scientist, p. 21 (1995).
  • Millan, et al., “Voltammetric DNA Biosensor for Cystic Fibrosis Based on a Modified Carbon Paste Electrode,” Anal. Chem., 66:2943-2948 (1994).
  • Millan, K.M., et al., “Covalent Immobilization of DNA onto Glassy Carbon Electrodes,” Electroanalysis, 4(10):929-932 (1992).
  • Millan, K.M. and Mikkelsen, S.R., “Sequence-Selective Biosensor for DNA Based on Electroactive Hybridization Indicators,” Anal. Chem., 65:2317-2323 (1993).
  • Miller, C., “Absorbed ω-Hydroxy Thiol Monolayers on Gold Electrodes: Evidence for Electron Tunneling to Redox Species in Solution,” J. Phys. Chem., 95:877-886 (1991).
  • Murphy, C. J., et al., “Long-Range Photoinduced Electron Transfer Through a DNA Helix,” Science, 262:1025-1029 (1993).
  • Orellana, G., et al., “Photoinduced Electron Transfer Quenching of Excited Ru(II) Polypyridyls Bound to DNA: The Role of the Nucleic Acid Double Helix,” Photochemistry and Photobiology, 54(4):499-509 (1991).
  • Palecek, “From Polarography of DNA to Microanalysis with Nucleic Acid-Modified Electrodes,” Electroanalysis. 8(1):7-14 (1996).
  • Paterson, “Electric Genes: Current Flow in DNA Could Lead to Faster Genetic Testing,” Scientific American, 33-34 (May 1995).
  • Purugganan, M. D., et al., Accelerated Electron Transfer Between Metal Complexes Mediated by DNA, Science, 241:1645-1649 (1988).
  • Rhodes, D. And A. Klug, “Helical Periodicity of DNA Determined by Enzyme Digestion,” Nature, 286:573-578 (1980).
  • Risser, S. M., et al., “Electron Transfer in DNA: Predictions of Exponential Growth and Decay of Coupling with Donor-Acceptor Distance,” J. Am. Chem. Soc., 115(6):2508-2510 (1993).
  • Sato, Y., et al., “Unidirectional Electron Transfer at Self-Assembled Monolayers of 11-Ferrocenyl-1-undecanethiol on Gold,” Bull. Chem. Soc. Jpn., 66(4):1032-1037 (1993).
  • Satyanarayana, S., et al., “Neither Λ- nor Δ-Tris(phenanthroline)ruthenium(II) Binds to DNA by Classical Intercalation,” Biochemistry, 31(39):9319-9324 (1992).
  • Schreiber, et al., “Bis(purine) Complexes of trans-a2PtII: Preparation and X-Ray Structures of Bis(9-methyladenine) and Mixed 9-Methyladenine, 9-Methylguanine Complexes and Chemistry Relevant to Metal-Modified Nucelobase Triples and Quartets,” J. Am. Chem. Soc. 118:4124-4132 (1996).
  • Schuhmann, W., et al., “Electron Transfer between Glucose Oxidase and Electrodes via Redox Mediators Bound with Flexible Chains to the Enzyme Surface,” J. Am. Chem. Soc., 113:1394-1397 (1991).
  • Schumm, et al., “Iterative Divergent/Convergent Approach to Linear Conjugated Oligomers by Successive Doubling of the Molecular Length: A Rapid Route to a 128 Å-Long Potential Molecular Wire,” Angew. Chem. Int. Ed. Engl., 33(11):1360-1363 (1994).
  • Sigal et al., “A Self-Assembled Monolayer for the Binding and Study of Histidine-Tagged Proteins by Surface Plasmon Resonance,” Anal. Chem., 68(3):490-497 (1996).
  • Southern, et al., “Arrays of complementary oligonucleotides for analysing the hybridisation behaviour of nucleic acids,” Nucleic Acids Research, 22(8):1368-1373 (1994).
  • Strobel, S. A., et al., “Site-Specific Cleavage of a Yeast Chromosome by Oligonucleotide-Directed Triple-Helix Formation,” Science, 249:73-75 (1990).
  • Su, et al., “Interfacial Nucleic Acid Hybridization Studied by Random Primer 32P Labelling and Liquid-Phase Acoustic Network Analysis,” Analytical Chemistry, 66(6):769-777 (1994).
  • Telser, J., et al., “DNA Duplexes Covalently Labeled at Two Sites: Synthesis and Characterization by Steady-State and Time-Resolved Optical Spectroscopies,” J. Am. Chem. Soc., 111:7226-7232 (1989).
  • Telser, J., et al., “DNA Oligomers and Duplexes Containing a Covalently Attached Derivative of Tris(2,2′-bipyridine)ruthenium(II): Synthesis and Characterization by Thermodynamic and Optical Spectroscopic Measurements,” J. Am. Chem. Soc., 111:7221-7226 (1989).
  • Tour, “Conjugated Macromolecules of Precise Length and Constitution. Organic Synthesis for the Construction of Nanoarchitectures,” Chem. Rev., 96:537-553 (1996).
  • Tour, et al., “Self-Assembled Monolayers and Multilayers of Conjugated Thiols, α-ω-Dithiols, and Thioacetyl-Containing Adsorbates. Understanding Attachments between Potential Molecular Wires and Gold Surfaces,” J. Am. Chem. Soc., 117:9529-9534 (1995).
  • Tullius, T.D. and B.A. Dombroski, “Iron(II) EDTA Used to Measure the Helical Twist Along Any DNA Molecule,” Science, 230:679-681 (1985).
  • Turro, N., et al. “Photoelectron Transfer Between Molecules Adsorbed in Restricted Spaces,” Photochem. Convers. Storage Sol. Energy, Proc. Int. Conf., 8th, pp 121-139 (1990).
  • Turro, N. J., et al., “Molecular Recognition and Chemistry in Restricted Reaction Spaces. Photophysics and Photoinduced Electron Transfer on the Surfaces of Micelles, Dendrimers, and DNA,” Acc. Chem. Res., 24:332-340 (1991).
  • Uosake, K., et al., “A Self-Assembled Monolayer of Ferrocenylalkane Thiols on Gold as an Electron Mediator for the Reduction of Fe(III)-EDTA in Solution,” Electrochemica Acta., 36(11/12):1799-1801 (1991).
  • Van Ness, J., et al., “A Versatile Solid Support System for Oligodeoxynucleotide Probe-Based Hybridization Assays,” Nucleic Acids Research, 19(12):3345-3349 (1991).
  • Weber, et al., “Voltammetry of Redox-Active Groups Irreversibly Adsorbed onto Electrodes. Treatment Using the Marcus Relation between Rate and Overpotential,” Anal. Chem., 66:3164-3172 (1994).
  • Williams, et al., “Studies of oligonucleotide interactions by hybridisation to arrays: the influence of dangling ends on duplex yield,” Nucleic Acids Research, 22(8):1365-1367 (1994).
  • Winkler, J. R., et al., “Electron Transfer in Ruthenium-Modified Proteins,” Chem. Rev., 92:369-379 (1992).
  • Xu, et al., “Immobilization of DNA on an Aluminum(III) alkaneobisphosphonate Thin Film with Electrogenerated Chemiluminescent Detection,” J. Am. Chem. Soc., 116:8386-8387 (1994).
  • Xu, et al., “Immobilization and Hybridization of DNA on an Aluminum(III) Alkanebisphosphonate Thin Film with Electrogenerated Chemiluminescent Detection,” J. Am. Chem. Soc., 117:2627-2631 (1995).
  • Yang, et al., “Growth and Characterization of Metal(II) Alkaneobisphosphonate Multilayer Thin Films on Gold Surfaces,” J. Am. Chem. Soc., 115:11855-11862 (1993).
  • Zhou, et al., “Fluorescent Chemosensors Based on Energy Migration in Conjugated Polymers: The Molecular Wire Approach to Increased Sensitivity,” J. Am. Chem. Soc., 117:12593-12602 (1995).
  • Mucic et al., “Synthesis and Characterization of DNA with Ferrocenyl Groups Attached to their 5′-Termini: Electrochemical Characterization of a Redox-Active Nucleotide Monolayer,” Chem. Commun., pp. 555-557 (1996).
  • Carr et al., “Novel Electrochemical Sensors for Neutral Molecules,” Chem. Commun., 1649-1650 (1997).
  • Carter et al., “Voltammetric Studies of the Interaction of Metal Chelates with DNA. 2. Tris-Chelated Complexes of Cobalt(III) and Iron(II) with 10-Phenanthroline and 2,2′-Bipyridine,” J. Am. Chem. Soc., 11:8901-8911 (1989).
  • Johnston et al., “Trans-Dioxorhenium(V)-Mediated Electrocatalytic Oxidation of DNA at Indium Tin-Oxide Electrodes: Voltammetric Detection of DNA Cleavage in Solution,” Inorg. Chem., 33:6388-6390 (1994).
  • Korri-Youssoufi et al., “Toward Bioelectronics: Specific DNA Recognition Based on an Oligonucleotide-Functionalized Polypyrrole,” J. Am. Chem. Soc., 119(31):7388-7389 (1997).
  • Aizawa et al., “Integrated Molecular Systems for Biosensors,” Sensors and Actuators, B, B@$ (Nos 1/3) Part 1:1-5 (Mar. 1995).
  • Reimers et al., “Toward Efficient Molecular Wires and Switches: the Brooker Ions,” Biosystems, 35:107-111 (1995).
  • Albers et al., “Design of Novel Molecular Wires for Realizing Long-Distance Electron Transfer,” Biochemistry and Bioenergetics, 42:25-33 (1997).
  • Lincoln et al., “Shorting Circuiting the Molecular Wire,” J. Am. Chem. Soc., 119(6)1454-1455 (1997).
  • Velev et al., “In Situ Assembly of Colloidal Particles into Miniaturized Biosensors,” The ACS Journal of Surfaces and Colloids, Langmuir, 15(11):3693-3698 (1999).
  • Blonder et al., “Three-dimensional Redox-Active layered Composites of Au-Au, Ag-Ag and Au-Ag Colloids,” Chem. Commun. 1393-1394 (1998).
  • Mirkin et al., “A DNA-based Method for Ratioally Assembling Nonoparticles into Macroscopic Materials,” Nature, 382:607-609 (1996).
  • Elghanian et al., “Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles,” Science, 277:1078-1081 (1997).
  • Storhoff et al., “One-Pot Colorimetric Differentiation of Polynucleotides with Single Base Imperfections Using Gold Nanoparticles Probes,” J. Am. Chem. Soc., 120:1959-1964 (1998).
  • Watson et al., “Hybrid Nanoparticles with Block Copolymer Shell Structures,” J. Am. Chem. Soc., 121:462-463 (1999).
  • Mucic et al., “DNA-Directed Synthesis of Binary Nanoparticle Network Materials,” J. Am. Chem. Soc., 120:12674-12675 (1998).
  • Mitchell et al., “Programmed Assembly of DNA Functionalized Quantum Dots,” J. Am. Chem. Soc., 121:8122-8123 (1999).
  • Kamat et al., J. Phys. chem., 93(4):1405-1409 (1989). Abstract.
  • Fotin, A. et al., “Parallel Thermodynamic Analysis of Duplexes on Oligodeoxyribonucleotide Microchips,” Nucleic Acids Research, 216(6):1515-1521 (1998).
  • Guschin, D. et al., “Manual Manufacturing of Oligonucleotide, DNA, and Protein Microchips,” Analytical Biochemistry, 250:203-211 (1997).
  • Dubiley, S. et al., “Fractionation, phosphorylation and Ligation on Oligonucleotide Microchips to Enhance Sequencing by Hybridization,” Nucleic Acids Research, 25(12):2259-2265 (1997).
  • Guschin, D. et al., “Oligonucleotide Microchips as Genosensors for Determinative and Environmental Studies in Microbiology,” 63(6):2397-2402 (1997).
  • Drobyshev, A. et al., “Sequence Analysis by Hybridization with Oligonucleotide Microchip: Identification of β-thalassemia Mutations,” Gene, 188:45-52 (1997).
  • Proudnikov, D. et al., “Chemical Methods of DNA and RNA Fluorescent Labeling,” Nucleic Acids Research, 24(22):4535-4542 (1996).
  • Timofeev, E. et al., “Methidium Intercalator Inserted into Synthetic Oligonucleotides,” Tetrahedron Letters, 37(47):8467-8470 (1996).
  • Livshits, M. et al., “Theoretical Analysis of the Kinetics of DNA Hybridization with Gel-Immobilized Oligonucleotides,” Biophysical Journal, 71:2795-2801 (1996).
  • Timofeev, E. et al., “Regioselective Immobilization of Short Oligonucleotides to Acrylic Copolymer Gel,” Nucleic Acids Research, 24(16): 3142-3148 (1996).
  • Parinov, S., “DNA Sequencing by Hybridization to Microchip octa- and Decanucleotides Extended by Stacked Pentanucleotides, ” Nucleic Acids Research, 24(15):2998-3004 (1996).
  • Yershov, G. et al., “DNA Analysis and Diagnostics on Oligonucleotide Microchips,” Proc. Natl. Acad. Sci. USA, 93:4913-4918 (1996).
  • Mirzabekov, A. et al., “Dna Sequencing by Hybridization—a Megasequencing Method and a Diagnostic Tool,” Tibtech, 12:27-32 (1994).
  • Brodolin, K. et al., “Conformational changes in E. coli RNA Polymerase During Promoter Recognition,” Nucleic Acids Research, 24(24):5748-5753 (1993).
  • Proudnikov, D. “Immobilization of DNA in Polyacrylamide Gel for the manufacture of DNA and DNA-Oligonucleotide Microchips,” Analytical Biochemistry, 259:34-41 (1998).
  • Esipova, N.G. et al., “Investigation of Sites of Strong DNA-protein Interactions in DNA-binding Proteins by Theoretical and DNA-protein Cross-Linking Methods, ” Journal of Bimolecular Structure & Dynamics, 12(6):A049 (1995).
  • Glover et al., “Alternating current Polarography in the Harmonic Multiplex Mode,” Analytical Chemistry, 45(11):1869-1877 (1973).
  • Singhal et al., “Direct Electrochemical Detection of Purin-and Pyrimidine-Based Nucleotides with Sinusoidal Voltammetry,” Anal. Chem. 69:3552-3557 (1997).
  • Singhai et al., “Sinusoidal Voltammetry for the Analysis of Carbohydrates at Copper Electrodes,” Anal. Chem. 69:1662-1668 (1997).
  • Singhal and Kuhr, “Ultrasensitive Voltammetric Detection of Underivatized Oligonucleotides and DNA,” Anal. Chem. 69:4828-4832 (1997).
  • Dontha et al., “Generation of Biotin/Avidin/Enzyme Nanostructures with Maskless Photolithography,” Anal. Chem. 69:2619-2625 (1997).
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