Medical device for delivering a therapeutic substance and method therefor

Patent 6730120 Issued on May 4, 2004. Estimated Expiration Date:

January 26, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

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Inventors

Assignee

Medtronic, Inc.

Application

No. 09769423 filed on 01/26/2001

US Classes:

623/1.42, Drug delivery604/266, With anticlogging means on conduit (e.g., anticlotting, decalcification, tissue occulsion, etc.)604/269, With anticoagulant supply means604/891.1, Implanted dynamic device or system604/265, With body soluble, antibactericidal or lubricating materials on conduit623/1.43Antithrombogenic

Examiners

Primary: Hayes, Michael J.
Assistant: Thissell, Jeremy

Attorney, Agent or Firm

Sterne, Kessler, Goldstein & Fox P.L.L.C.

Foreign Patent References

649 916 CH 06/01/1985
0 366 564 EP 05/01/1990
815 806 EP 01/01/1998
2084466 GB 04/01/1982
8606729 WO 11/01/1986
8907932 WO 09/01/1989
9112779 WO 09/01/1991
WO 9117744 WO 11/01/1991
9417108 WO 08/01/1994
9427612 WO 12/01/1994
WO 9503083 WO 02/01/1995
WO 9510989 WO 04/01/1995
WO 9632907 WO 10/01/1996
9707973 WO 03/01/1997
WO 9710011 WO 03/01/1997
9742911 WO 11/01/1997
WO 9916386 WO 04/01/1999

International Class

A61F 206

Abstract

A device useful for localized delivery of a therapeutic material is provided. The device includes a structure including a porous material; and a water-insoluble salt of a therapeutic material dispersed in the porous material. The water-insoluble salt is formed by contacting an aqueous solution of a therapeutic salt with a heavy metal water-soluble salt dispersed throughout a substantial portion of the porous material. The heavy metal water-soluble salt can be dispersed in the porous material so that the device can be sterilized and the therapeutic material can be loaded in the device in situ, for example, just prior to use. The therapeutic material is preferably a heparin or heparin derivative or analog which renders the material antithrombotic as an implantable or invasive device.

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