U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Electronic device for performing active biological operations and method of using same

Patent 6726880 Issued on April 27, 2004. Estimated Expiration Date: Icon_subject June 19, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Semi-conductor non-volatile optical memory device
Patent #: 3950738
Issued on: 04/13/1976
Inventor: Hayashi ,   et al.

Mobile ion film memory
Patent #: 3995190
Issued on: 11/30/1976
Inventor: Salgo

Programmable master controller communicating with plural controllers
Patent #: 4283773
Issued on: 08/11/1981
Inventor: Daughton ,   et al.

Detection of microbial nucleic acids by a one-step sandwich hybridization test
Patent #: 4563419
Issued on: 01/07/1986
Inventor: Ranki ,   et al.

Sample-scanning photometer
Patent #: 4580895
Issued on: 04/08/1986
Inventor: Patel

Process and apparatus for electrically desorbing components selectively sorbed on an electrolytically conducting barrier
Patent #: 4584075
Issued on: 04/22/1986
Inventor: Goldstein ,   et al.

Process and apparatus for electrically desorbing components selectively sorbed on granules
Patent #: 4594135
Issued on: 06/10/1986
Inventor: Goldstein

Methods and kits for performing nucleic acid hybridization assays
Patent #: 4751177
Issued on: 06/14/1988
Inventor: Stabinsky

Method and means for annealing complementary nucleic acid molecules at an accelerated rate
Patent #: 4787963
Issued on: 11/29/1988
Inventor: MacConnell

Automatic test equipment
Patent #: 4807161
Issued on: 02/21/1989
Inventor: Comfort ,   et al.

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Inventors

Assignee

Application

No. 09596657 filed on 06/19/2000

US Classes:

422/68.1, Means for analyzing liquid or solid sample422/50, ANALYZER, STRUCTURED INDICATOR, OR MANIPULATIVE LABORATORY DEVICE422/129, CHEMICAL REACTOR435/6, Involving nucleic acid435/7.1Involving antigen-antibody binding, specific binding protein assay or specific ligand-receptor binding assay

Examiners

Primary: Marschel, Ardin H.

Attorney, Agent or Firm

Foreign Patent References

  • 0228075 EP 07/01/1987
  • 2156074 GB 10/01/1985
  • 2247889 GB 03/01/1992
  • WO8603782 WO 07/01/1986
  • WO8808528 WO 11/01/1988
  • WO8901159 WO 02/01/1989
  • WO8910977 WO 11/01/1989
  • WO9001564 WO 02/01/1990
  • WO9204470 WO 03/01/1992
  • WO9322678 WO 11/01/1993
  • WO9507363 WO 03/01/1995
  • WO9601836 WO 01/01/1996
  • WO9801758 WO 01/01/1998
  • WO9851819 WO 11/01/1998
  • 57087 YU 08/01/1990

International Classes

G01N 1500
G01N 100
G01N 3353
C12Q 168

Abstract

An electronic device for performing biological operations includes a support substrate and an array of microlocations disposed on the substrate. The array of microlocations include electronically addressable electrodes. A first collection electrode is disposed on the substrate and adjacent to a first side of the array of microlocations. A second collection electrode is disposed on the substrate and adjacent to a second side of the array of microlocations, the second side of the array being opposite of the first side such that the array of microlocations is disposed between the first and second collection electrodes. A flow cell is supported on the substrate. Preferably, the combined area of the collection electrodes is a substantial fraction, preferably at least 50% of the area of the footprint of the flow cell.

Other References

  • Abrams et al. “Comprehensive Detection of Single Base Changes In Human Genomic DNA Using Denaturing Gradient Gel Electrophoresis & a GC Clamp”. Genomics, 7, 1990, 463-475.
  • Anand and Southern “Pulsed Field Gel Electrophoresis,” Gel Electrophoresis of Nucleic Acids—A Practical Approach, 2d. Ed., D. Rickwood and B.D. Hames (New York:IRL Press 1990), pp 101-123.
  • Anderson and Young, “Quantitative Filter Hybridization,” Nucleic Acid Hybridization—A Practical Approach, Eds. B.D. Hames and S.J. Higgins (Washington, D.C. :IRL Press 1985) pp 73-111.
  • Bains, “Setting a Sequence to Sequence a Sequence,” Bio/Technology, 10:757-758 (1992).
  • Barinaga, “Will ‘DNA Chip’ Speed Genome Initiative?”, Science, 253:1489 (1991).
  • Beattie et al., “Genosensor Technology,” The 1992 San Diego Conference: Genetic Recognition, pp 1-5 (Nov., 1992).
  • Beltz et al., “Isolation of Multigene Families and Determination of Homologies by Filter Hybridization Methods,” Methods in Enzymology, 100:266-285 (1983).
  • Brown et al. “Electrochemically Induced Adsorption of Radio-Labelled DNA on Gold and HOPG Substrates for STM Investigations”. Ultramicroscopy, 38, 1991, 253-264.
  • Conner et al., “Detection of Sickle Cell β3-Globin Allele by Hybridization With Synthetic Oligonucleotides,” Proc. Natl. Acad. Sci. USA, 80:278-282 (1983).
  • Drmanac et al., “Sequencing of Megabase Plus DNA by Hybridization: Theory of the Method,” Genomics, 4:114-128 (1989).
  • Drmanac et al., “DNA Sequence Determination by Hybridixation: A Strategy for Efficeint Large-Scale Sequencing,” Science, 260: 1649-1652 (1993).
  • Eggers et al. “Biochip Technology Development”, BioChip Technology Development, Lincoln Laboratory Technical Report 901, Nov. 9, 1990.
  • Fiaccabrino et al., “Array of Individually Addressable Microelectrodes”, Sensors and Actuators B, 18-19 (1994) 675-677.
  • Fodor et al., “Multiplexed Biochemical Assays With Biological Chips,” Nature, 364:555-556 (1993).
  • Fodor et al., “Light-Directed, Spatially Addressable Parallel Chemical Synthesis,” Science, 251:767-773 (1992).
  • Horejsi, “Some Theoretical Aspects of Affinity Electrophoresis,” Journal of Chromatography, 178:1-13 (1979).
  • Horejsi et al., Determination of Dissociation Constants of Lectin Sugar Complexes by Means of Affinity Electrophoresis, Biochimica at Biophysica Acta, 499:200-300 (1977).
  • Kakerow et al., “A Monolithic Sensor Array of Individually Addressable Microelectrodes”, Sensors and Acuators A, 43 (1994) 296-301.
  • Mathews, Kricka. “Analytical Strategies For The Use Of DNA Probes”. Analytical Biochemistry, 169, 1988, 1-25.
  • Palecek, “New Trends in Electrochemical Analysis of Nucleic Acids”. Bioelectrochemistry and Bioenergetics, 20, 1988, 179-194.
  • Ranki et al., “Sandwich Hybridization as a Convenient Method for the Detection of Nucleic Acids in Crude Samples,” Gene, 21:77-85 (1983).
  • Saiki, “Amplification of Genomic DNA,” PCR Protocols: A Guide to Methods and Applications, (Academic Press, Inc. 1990), pp 13-20.
  • Southern et al., “Analyzing and Comparing Nucleic Acid Sequences by Hybridization to Arrays of Oligonucleotides Evaluation Using Experimental Models,” Genomics, 13:1008-1017 (1992).
  • Stezoska et al., “DNA Sequencing by Hybridization: 100 Bases Read by a Non-Gel-Based Method”, Proc. Natl. Acad. Sci. USA, 88:10089-93 (1991).
  • Wallace et al., “Hybridization of Synthetic Oligodexribonucleotides to φ×174 DNA: The Effect of Single Base Pair Mismatch,” Nucleic Acid Res., 6:3543-3557 (1979).
  • Washizu, “Electrostatic Manipulatiaon of Biological Objects,” Journal of Electrostatics, 25:109-123 (1990).
  • Washizu and Kurosawa, “Electrostatic Manipulation of DNA in Microfabricated Structures,” IEEE Transactions on Industry Applications, 26:1165-1172 (1990).
  • Brown et al., “Electrochemically Induced Adsorption of Radio-Labelled DNA on Gold and HOPG Substrates for STM Investigations”, Ultramicroscopy, 38 (1991) pp 253-264.
  • Palacek, “New Trends in Electrochemical Analysis of Nucleic Acids”, Bioelectrochemistry and Bioenergetics, 20 (1988) pp 179-194.
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