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US Patent 6703370 - Use of ribose to treat fibromyalgia

US Patent Issued on March 9, 2004
Estimated Patent Expiration Date: Icon_subject October 26, 2020Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The present invention relates to methods and compositions comprising ribose for the treatment of fibromyalgia syndrome. The methods and compositions of the invention are especially suitable for oral administration and are useful for alleviating the symptoms of pain, fatigue, and irritable bowel syndrome in fibromyalgia syndrome.

Other References

  • Batista, R., et al., "Partial left ventriculectomy--the Batista procedure", European Journal of Cardio-Thoracic Surgery, 15 (Suppl, 1), pp. S12-S19, (Jan. 1999)
  • Bax, J.J., et al., "Accuracy of Currently Available Techniques for Prediction of Functional Recovery After Revasularization in Patients With Left Ventricular Dysfunction Due to Chronic Coronary Artery Disease: Comparison of Pooled Data", Journal of the American College of Cardiology, 30 (6), pp. 1451-1460, (Nov. 15, 1997)
  • Furnary, A.P., et al., "Multicenter Trial of Dynamic Cardiomyoplasty for Chronic Heart Failure", Journal of the American College of Cardiology, 28 (5), pp. 1175-1180, (Nov. 1, 1996)
  • Gross, M., et al., "Metabolism of D-Ribose Administered Continuously to Healthy Persons and to Patients with Myoadenylate Deaminase Deficiency", Klinische Wochenschrift, 67, pp. 1205-1213, (1989)
  • Hegewald, M.G., et al., "Ribose Infusion Accelerates Thallium Redistribution With Early Imaging Compared With Late 24-Hour Imaging Without Ribose", JACC, 18 (7), pp. 1671-1681, (Dec. 1991)
  • Jessup, M., "Optimizing Medical Management of the Patient with Severe Heart Failure Awaiting Cardiac Transplanting", Cardiology--In Review, 4 (5), pp. 286-291, (Sep. 1996)
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  • Nagueh, S.F., et al., "Identification of Hibernating Myocardium: comparative accuracy of myocardial contrast echocardiography, rest-redistribution thallium-201 tomography and dobutamine echocardiography", JACC vol. 29, No. 5, pp. 985-993, (Apr. 1997)
  • Sawada, S.G., et al., "Echocardiographic Detection of Coronary Artery Disease During Dobutamine Infusion", Circulation, 83 (5), pp. 1605-1614, (May 1991)
  • Tan, Z.T., et al., "Verapamil, ribose andadenine enhance resynthesis of postischemic myocardial ATP", Life Sciences, 55 (18), pp. PL 345-PL 349, (1994)
  • Tullson, P.C., et al., "Adenine Nucleotide Syntheses in Exercising and Endurance-trained Skeletal Muscle", The American Journal of Physiology, 261 (2), pp. C342-C347, (1991)
  • Tullson, P.C., et al., "IMP Metabolism in Human Skeletal Muscle After Exhaustive Exercise", The American Journal of Physiology, pp. 146-152, (1995)
  • Wagner, D.R., et al., "Effects of oral ribose on muscle metabolism during bicycle ergometer in AMPD-deficient patients", Annals of Nutrition and Metabolism, 35 (5), pp. 297-302, (1991)

Inventors

Application

No. 09/697034 filed on 10/26/2000

US Classes:

514/23, Carbohydrate (i.e., saccharide radical containing) DOAI536/1.11Carbohydrates or derivatives

Examiners

Primary: Wilson, James O.
Assistant: McIntosh, III, Traviss C.

Attorney, Agent or Firm

US Patent References

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Issued on: 08/12/1986
Inventor: Foker
4719201, Method for stimulating recovery from ischemia
Issued on: 01/12/1988
Inventor: Foker
4824660, Method of determining the viability of tissue in an organism
Issued on: 04/25/1989
Inventor: Angello ,   et al.
4871718, Composition of matter for increasing intracellular ATP levels and physical performance levels and for increasing the rate of wound repair
Issued on: 10/03/1989
Inventor: Carniglia
4877798, Treatment of fibromyalgia
Issued on: 10/31/1989
Inventor: Sorensen
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Inventor: Cotter, et al.
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Inventor: Brevetti
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Issued on: 05/19/1992
Inventor: Stray-Gundersen
5292538, Improved sustained energy and anabolic composition and method of making
Issued on: 03/08/1994
Inventor: Paul, et al.
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Issued on: 02/21/1995
Inventor: Carniglia, et al.
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Issued on: 12/26/1995
Inventor: McAfee, et al.
5707971, Modulation of glycolytic ATP production
Issued on: 01/13/1998
Inventor: Fahy
5714515, Pharmaceutical alpha-keto carboxylic acid compositions, method of making and use thereof
Issued on: 02/03/1998
Inventor: Bunger
5853753, Liposomes, method of preparing the same and use thereof in the preparation of drugs
Issued on: 12/29/1998
Inventor: Maierhofer, et al.
5895787, Treatment of fibromyalgia and related disorders
Issued on: 04/20/1999
Inventor: Arffmann, et al.
5922703, Urethane-containing aminosteroid compounds
Issued on: 07/13/1999
Inventor: Yu, et al.
6139819, Targeted contrast agents for diagnostic and therapeutic use
Issued on: 10/31/2000
Inventor: Unger, et al.
6159942, Compositions for increasing energy in vivo
Issued on: 12/12/2000
Inventor: St. Cyr, et al.
6159943Use of ribose to prevent cramping and soreness in muscles
Issued on: 12/12/2000
Inventor: Butler, et al.

International Classes

A01N 43/02 (20060101)
A01N 43/04 (20060101)
A61K 31/185 (20060101)
C07H 1/00 (20060101)
A61K 31/70 (20060101)
A61K 31/19 (20060101)
A61K 31/506 (20060101)
A61K 31/51 (20060101)

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