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Method and compositions for regulation of 5-alpha reductase activity

Patent 6696484 Issued on February 24, 2004. Estimated Expiration Date: Icon_subject April 24, 2022. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Issued on: 10/05/1999
Inventor: Murad

More ...

Inventors

Assignee

Application

No. 10/132050 filed on 04/24/2002

US Classes:

514/456, Bicyclo ring system having the hetero ring as one of the cyclos (e.g., chromones, etc.)514/337, The additional hetero ring is one of the cyclos in a polycyclo ring system514/453, Polycyclo ring system having the hetero ring as one of the cyclos514/455, Chalcogen bonded directly to ring carbon of the hetero ring514/457, Coumarins (including hydrogenated)514/532, Z-C(=O)-O-Y, wherein Z contains a benzene ring514/544, C(=O)O attached directly through the carbon to a benzene ring514/557, Carboxylic acid, percarboxylic acid, or salt thereof (e.g., peracetic acid, etc.)514/558, Higher fatty acid or salt thereof514/617, R contains benzene ring514/622, C-O- group in R514/646, Benzene ring containing514/655, The aryl ring or aryl ring system and amino nitrogen are bonded directly to the same acylic carbon, which carbon additionally has only hydrogen or acyclic hydrocarbyl substituents bonded directly thereto514/678, Benzene ring containing514/679, Plural rings514/680, Polycyclo ring system514/681, Bicyclo514/682, Naphthyl ring system514/683, Alicyclic ring514/720, Acyclic carbon to carbon unsaturation514/729, Alicyclic ring containing514/731, C of C-O- group is nuclear C of a benzene ring (e.g., phenol, phenolate, etc.)514/732Polycyclo ring system (e.g., naphthols, etc.)

Examiners

Primary: Owens, Amelia

Attorney, Agent or Firm

International Classes

A61K 31/12 (20060101)
A61K 31/075 (20060101)
C07C 49/255 (20060101)
C07C 49/248 (20060101)
C07C 49/00 (20060101)
A61K 31/00 (20060101)
A61K 31/35 (20060101)
A61K 31/44 (20060101)
C07D 311/00 (20060101)
C07D 311/62 (20060101)

Abstract

Pharmaceutical compositions and methods for treating androgen related disorders. The pharmaceutical compositions may include a 5଱-reductase inhibitor, such as natural and synthetic flavanoids, catechols, curcumin-related substances, quinones, catechins, particularly epigallocatechin derivatives, fatty acids, and the salts, esters, analogues, pro-drugs, isomers, racemic mixtures, or derivatives of any of the foregoing. The use of testosterone (or DHT) combinations with the aforementioned 5଱-reductase inhibitor compounds is also contemplated.

Other References

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