Synthesis of 3-ethoxy-4-ethoxycarbonyl phenyl acetic acid, a key acid synthon of repaglinide

Patent 6686497 Issued on February 3, 2004. Estimated Expiration Date:

September 20, 2022. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Phenylacetic acid benzylamides
Patent #: 5216167
Issued on: 06/01/1993
Inventor: Grell, et al.

Phenylacetic acid benzylamides Patent #: 5312924
Issued on: 05/17/1994
Inventor: Grell, et al.

Inventors

Assignee

Banbaxy Laboratories Limited

Application

No. 130579 filed on 09/20/2002

US Classes:

560/64, Ester function attached directly to a ring546/234Plural carbocyclic rings containing

Examiners

Primary: Rotman, Alan L.
Assistant: Reyes, Hector M

Attorney, Agent or Firm

Deshmukh, Esq.; Jayadeep R., Hare, Esq.; William D., Heibel, Esq.; George E.

Foreign Patent References

WO 93/00337 WO 01/10/1993

International Class

C07C 069/76

Foreign Application Priority Data

1999-11-16 IN

Abstract

The present invention relates to a new and industrially advantageous process for the preparation of 3-ethoxy-4-ethoxy-carbonyl-phenyl acetic acid. This compound is a key intermediate for the synthesis of Repaglinide, an oral hypoglycemic agent.

Other References

Grell et al, J. Med. Chem., 1988, vol. 41, pp. 5219-5246.
Grell et al., Repaglinide and Related Hypoglycemic Benzoic Acid Derivatives, J. Med. Chem., 1998, 41, pp. 5219-524