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US Patent 6686497 - Synthesis of 3-ethoxy-4-ethoxycarbonyl phenyl acetic acid, a key acid synthon of repaglinide

US Patent Issued on February 3, 2004
Estimated Patent Expiration Date: Icon_subject September 20, 2022Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The present invention relates to a new and industrially advantageous process for the preparation of 3-ethoxy-4-ethoxy-carbonyl-phenyl acetic acid. This compound is a key intermediate for the synthesis of Repaglinide, an oral hypoglycemic agent.

Other References

  • Grell et al, J. Med. Chem., 1988, vol. 41, pp. 5219-5246.
  • Grell et al., Repaglinide and Related Hypoglycemic Benzoic Acid Derivatives, J. Med. Chem., 1998, 41, pp. 5219-524

Inventors

Assignee

Application

No. 130579 filed on 09/20/2002

US Classes:

560/64, Ester function attached directly to a ring546/234Plural carbocyclic rings containing

Field of Search

560/64, Ester function attached directly to a ring546/234, Plural carbocyclic rings containing514/326, The additional ring is a hetero ring514/619, Nitrogen in R514/331Nitrogen attached indirectly to the piperidine ring by nonionic bonding

Examiners

Primary: Rotman, Alan L.
Assistant: Reyes, Hector M

Attorney, Agent or Firm

US Patent References

5216167, Phenylacetic acid benzylamides
Issued on: 06/01/1993
Inventor: Grell, et al.
5312924Phenylacetic acid benzylamides
Issued on: 05/17/1994
Inventor: Grell, et al.

Foreign Patent References

  • WO 93/00337 WO 01/09/1993

International Class

C07C 069/76

Foreign Application Priority Data

1999-11-16 IN

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