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ApplicationNo. 804580 filed on 03/12/2001
US Classes:435/285.2, With means for applying an electric current or charge (e.g., electrofusion, electroporation, etc.)435/287.1, Including measuring or testing435/288.4, Including multiple compartments (e.g., wells, etc.)435/288.7Including optical measuring or testing means
ExaminersPrimary: Redding, David A.
Attorney, Agent or Firm
Foreign Patent References
International ClassC12M 001/42
AbstractDrug candidate screening methods are applied to discover compounds with activity against ion channel targets. The method may include modulating the transmembrane potential of host cells in a plurality of sample wells with a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.