ApplicationNo. 08/817494 filed on 04/15/1997
US Classes:424/199.1, Recombinant virus encoding one or more heterologous proteins or fragments thereof424/233.1, Adenoviridae, adeno-like virus, or Parvoviridae (e.g., adenovirus, canine parvovirus, mink enteritis virus, hemorrhagic enteritis virus, feline panleukopenia virus, egg drop syndrome virus, etc.)435/320.1, VECTOR, PER SE (E.G., PLASMID, HYBRID PLASMID, COSMID, VIRAL VECTOR, BACTERIOPHAGE VECTOR, ETC.) BACTERIOPHAGE VECTOR, ETC.)435/69.1, Recombinant DNA technique included in method of making a protein or polypeptide536/23.72Viral protein
ExaminersPrimary: Salimi, Ali R.
Attorney, Agent or Firm
International ClassesC12N 15/861 (20060101)
C07K 14/005 (20060101)
C07K 14/075 (20060101)
A61K 48/00 (20060101)
Foreign Application Priority Data1994-10-17 FR
AbstractNovel adenovirus-derived viral vectors, the preparation thereof, and the use of such vectors in gene therapy, are disclosed. In particular, defective adenoviruses having a genome that includes a first recombinant DNA containing a therapeutic gene and a second recombinant DNA containing an immunoprotective gene, are disclosed.