Curcumin analogs with anti-tumor and anti-angiogenic properties
Patent 6664272 Issued on December 16, 2003. Estimated Expiration Date: December 4, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
514/327, Chalcogen bonded directly to ring carbon of the piperidine ring514/151, Acyclic C-N=N-N containing514/210.2, The additional hetero ring contains ring nitrogen514/252.14, The additional hetero ring is a 1,3 diazine ring514/252.18, Additional six-membered hetero ring consisting of five ring carbons and one ring nitrogen attached directly or indirectly to the 1,3-diazine by nonionic bonding514/255.06, Nitrogen or -C(=X)-, wherein X is chalcogen, bonded directly to ring carbon of the 1,4-diazine ring514/256, 1,3-diazines (e.g., pyrimidines, etc.)514/304, Tropanes (including nor or dehydro form)514/318, The additional ring is a six-membered hetero ring consisting of one nitrogen and five carbon atoms514/332, Plural six-membered hetero rings consisting of one nitrogen and five carbon atoms514/333, Additional hetero ring other than the six-membered hetero rings514/432, The hetero ring is six-membered514/460, Chalcogen bonded directly to ring carbon of the hetero ring544/295, Plural diazine rings544/296, Plural 1,3-diazine rings546/216, Chalcogen bonded directly to ring carbon of the piperidine ring549/28, Chalcogen or nitrogen attached directly to the hetero ring by nonionic bonding549/416, Chalcogen bonded directly to the hetero ring552/1, Azides568/327Bicyclo ring system
The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.
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